Research Topics
Genomes and Genes | K MostovSummaryAffiliation: University of California Country: USA Publications
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Publications
Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesisPascale Leroy
Department of Anatomy, University of California, San Francisco, CA 94158 2517, USA
Mol Biol Cell 18:1943-52. 2007..We conclude that in epithelial cells, promoting cell survival can be a primary function of Slug, rather than being acquired concomitantly with EMT...- From cells to organs: building polarized tissueDavid M Bryant
Department of Anatomy, University of California San Francisco, California 94143 2140, USA
Nat Rev Mol Cell Biol 9:887-901. 2008.... 
Polarized epithelial membrane traffic: conservation and plasticityKeith Mostov
Department of Anatomy, Genentech Hall, 600 16th Street, University of California, San Francisco, CA 94143 2140, USA
Nat Cell Biol 5:287-93. 2003....- Membrane traffic in polarized epithelial cellsK E Mostov
Department of Anatomy, University of California, San Francisco, 94143 0452, USA
Curr Opin Cell Biol 12:483-90. 2000..Endocytosis at the apical surface is regulated by ARF6. Transcytosis of IgA is regulated by the p62Yes tyrosine kinase... - mTOR is out of control in polycystic kidney diseaseKeith E Mostov
Department of Anatomy, School of Medicine, University of California-San Francisco, Genentech Hall Room N212B, Box 2140, 600 16th Street, San Francisco, CA 94147, USA
Proc Natl Acad Sci U S A 103:5247-8. 2006 - ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cellsY Altschuler
Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
J Cell Biol 147:7-12. 1999..We conclude that ARF6 is an important modulator of clathrin-mediated endocytosis at the apical surface of epithelial cells... - Signal transduction. A new thread in an intricate webM von Zastrow
Departments of Psychiatry, University of California, San Francisco, CA 94143, USA
Science 294:1845-7. 2001..In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events... - Genetic control of single lumen formation in the zebrafish gutMichel Bagnat
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158 2324, USA
Nat Cell Biol 9:954-60. 2007..This work shows that single lumen formation is genetically controlled and appears to be driven by the accumulation of fluid... - Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrityAnne L Pollack
Department of Anatomy, Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California 94143 2140, USA
Am J Physiol Cell Physiol 286:C482-94. 2004.... - ERK and MMPs sequentially regulate distinct stages of epithelial tubule developmentKitty Tang
Department of Anatomy, Department of Biochemistry and Biophysics and The Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 7:21-32. 2004..Thus, ERK and MMPs define two regulatory subprograms that act in sequence. By inducing these reciprocal signals, HGF directs the morphogenetic progression of tubule development... - Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarityWei Yu
Department of Anatomy, Neurology, University of California, San Francisco, California 94143, USA
EMBO Rep 9:923-9. 2008..These results might be relevant to the hyperactivation of RhoA and disruption of normal polarity frequently observed in human epithelial cancers... - Beta1-integrin orients epithelial polarity via Rac1 and lamininWei Yu
Department of Anatomy, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Mol Biol Cell 16:433-45. 2005..Together, our results suggest a signaling pathway in which the activation of beta1-integrins orients the apical pole of polarized cysts via a mechanism that requires Rac1 activation and laminin organization into the basement membrane... - Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structuresWei Yu
Department of Biochemistry and Biophysics, University of California, San Francisco, 94143-0452, USA
Mol Biol Cell 14:748-63. 2003..Our results demonstrate the power of direct observation in investigating how individual cell behaviors, such as polarization, movement, and division are coordinated in the very complex process of producing multicellular structures... - Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesisPAUL R BRAKEMAN
Division of Pediatric Nephrology, Department of Pediatrics, University of California, Box 0748, San Francisco, California 94143 0748, USA
Am J Physiol Renal Physiol 296:F564-74. 2009.... - Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell culturesWei Yu
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
Methods Enzymol 406:676-91. 2006..These protocols enable the regulation of epithelial morphogenesis to be explored at a detailed molecular level... - The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cellsMartin B A ter Beest
Department of Anatomy and Biochemistry, University of California, San Francisco, San Francisco, CA 94143-2140, USA
Mol Biol Cell 16:5784-92. 2005..We suggest that syntaxins may play a role in determining the specificity of membrane targeting by permitting fusion with only certain target membranes... - Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesisMinji Kim
Departments of Anatomy, and Biochemistry and Biophysics, University of California School of Medicine, San Francisco, CA 94158, USA
J Cell Sci 120:2309-17. 2007..We conclude that a PAR6-aPKC-GSK-3beta mechanism links cell polarity and apoptosis... - A molecular network for de novo generation of the apical surface and lumenDavid M Bryant
Department of Anatomy, University of California, San Francisco, CA 94143 2140, USA
Nat Cell Biol 12:1035-45. 2010..This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization... - The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptorMarcel Verges
Department of Anatomy, University of California, San Francisco, CA 94143 2140, USA
Nat Cell Biol 6:763-9. 2004..Here, we show a function for the mammalian Vps35-Vps29-Vps26 retromer subcomplex in promoting pIgR-pIgA transcytosis... - Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathwayKathleen D Liu
Division of Nephrology, University of California, San Francisco, Box 2140, San Francisco, CA 94143 2140, USA
Am J Physiol Renal Physiol 293:F1633-40. 2007..This effect cannot be overcome by constitutively active Rac1, demonstrating that both Rac1 and atypical PKC are required for reorientation of cellular polarity... - Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional cultureNaoki Tanimizu
Department of Anatomy, University of California San Francisco, San Francisco, CA 94143 2140, USA
Mol Biol Cell 18:1472-9. 2007.... - Epithelial polarity and tubulogenesis in vitroMirjam M P Zegers
Department of Anatomy, Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0452, USA
Trends Cell Biol 13:169-76. 2003..In vitro systems can be used to study tube formation and might help to define common principles underlying the formation of diverse types of tubular organ... - Opinion: Building epithelial architecture: insights from three-dimensional culture modelsLucy Erin O'Brien
Department of Anatomy, and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Nat Rev Mol Cell Biol 3:531-7. 2002.... - Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cellsSven C D Van IJzendoorn
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 2:219-28. 2002..Overexpression of GTP-locked rab3b inhibits dIgA-stimulated transcytosis. Together, our data demonstrate that a rab protein can bind directly to a specific cargo protein and thereby control its trafficking... - Pak1 and PIX regulate contact inhibition during epithelial wound healingMirjam M P Zegers
Department of Anatomy and Biochemistry and Biophysics, University of California San Francisco, Box 2140, 600 16th Street, San Francisco, CA 94143, USA
EMBO J 22:4155-65. 2003..Thus, recruitment of activated Pak and PIX to cell-cell contacts is pivotal to transduction of growth-inhibitory signals from neighboring cells in epithelial wound healing... - Interaction of bacterial pathogens with polarized epitheliumB I Kazmierczak
Department of Medicine, University of California, San Francisco, California 94143 0654, USA
Annu Rev Microbiol 55:407-35. 2001..This review outlines bacterial-host epithelial cell interactions in the context of the distinct apical and basolateral surfaces of the polarized epithelium that lines the lumens of our organs... - Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cellsA R Hauser
Department of Medicine, University of California, San Francisco, 94143, USA
Infect Immun 66:1413-20. 1998..These results are consistent with type III secretion of an inhibitor of internalization that requires PepB and PepD for translocation into the host cell... - Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cellsB I Kazmierczak
Department of Medicine, University of California, San Francisco 94143-0654, USA
Cell Microbiol 3:85-98. 2001..Models consistent with these data are presented... - The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalizationA Kierbel
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Mol Biol Cell 16:2577-85. 2005..Together, these results demonstrate that the PI3K signaling pathway is necessary and sufficient for the P. aeruginosa entry and provide the first example of a bacterium that requires Akt for uptake into epithelial cells... - Identification of a cytoplasmic signal for apical transcytosisFrederic Luton
Department of Anatomy, and Biochemistry and Biophysics, and Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2140, USA
Traffic 10:1128-42. 2009..This apical transcytosis sorting signal was not involved in polarized biosynthetic traffic of the pIgR... 
In silico simulation of epithelial cell tubulogenesisJesse A Engelberg
UCSF UC Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA 94143, USA
Conf Proc IEEE Eng Med Biol Soc 2008:1036-9. 2008....- Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptorMarcel Verges
Department of Anatomy, Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California School of Medicine, San Francisco, California 94143 2140, USA
Exp Cell Res 313:707-18. 2007..These data implicate PI3K in controlling retromer's role in pIgR-pIgA transcytosis... - A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaQi-Wen Fan
Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
Cancer Cell 9:341-9. 2006..PI-103 showed significant activity in xenografted tumors with no observable toxicity. These data demonstrate an emergent efficacy due to combinatorial inhibition of mTOR and PI3 kinase alpha in malignant glioma... - Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesisNaoki Tanimizu
Departments of Anatomy, and Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 2140, USA
Mol Biol Cell 20:2486-94. 2009.... - Role of rab proteins in epithelial membrane trafficSven C D Van IJzendoorn
Department of Membrane Cell Biology, University of Groningen, Groningen 9713AV, The Netherlands
Int Rev Cytol 232:59-88. 2003..This review discusses the role of rabs in epithelial membrane transport... - The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulumJoshua H Lipschutz
Department of Medicine and the Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:20954-60. 2003..Although the exact mechanism remains to be elucidated, the exocyst/Sec61beta interaction represents an important link between the cellular membrane trafficking and protein synthetic machinery... - EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherinDavid M Bryant
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
J Cell Sci 120:1818-28. 2007..Together, these findings demonstrate a role for SNX1 in retrieval of E-cadherin from a degradative endosomal pathway and in membrane trafficking pathways that regulate E-cadherin recycling... - Epithelial polarity and morphogenesisKeith E Mostov
Methods 30:189-90. 2003 - Simulating properties of in vitro epithelial cell morphogenesisMark R Grant
University of California San Francisco University of California Berkeley Joint Graduate Group in Bioengineering, University of California Berkeley, Berkeley, California, United States of America
PLoS Comput Biol 2:e129. 2006..Analogue design facilitates gaining deeper insight into such phenomena by making it easy to replace low-resolution components with increasingly detailed and realistic components...