Brooke T Mossman

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. doi request reprint Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs)
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Crit Rev Toxicol 43:632-60. 2013
  2. pmc Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    BMC Cancer 13:400. 2013
  3. pmc Silica induces NLRP3 inflammasome activation in human lung epithelial cells
    Paul M Peeters
    Department of Respiratory Medicine, Maastricht University Medical Centre MUMC, Maastricht University, Maastricht, The Netherlands
    Part Fibre Toxicol 10:3. 2013
  4. pmc New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Am J Pathol 182:1065-77. 2013
  5. pmc Oxidants and signaling by mitogen-activated protein kinases in lung epithelium
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 34:666-9. 2006
  6. ncbi request reprint Introduction to serial reviews on the role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1115-6. 2003
  7. ncbi request reprint Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles"
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 43:504-5. 2007
  8. pmc Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Toxicol Environ Health B Crit Rev 14:76-121. 2011
  9. pmc ERK2 is essential for the growth of human epithelioid malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:1075-86. 2011
  10. pmc Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Clin Cancer Res 19:2071-83. 2013

Research Grants

  1. Meeting on Inhaled Mineral Dusts/Nanoparticles
    Brooke Mossman; Fiscal Year: 2005
  2. ENVIRONMENTAL PATHOLOGY TRAINING GRANT
    Brooke Mossman; Fiscal Year: 2007

Detail Information

Publications75

  1. doi request reprint Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs)
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Crit Rev Toxicol 43:632-60. 2013
    ..Our analysis of these data suggests similar occupational exposure limits (OELs) for these minerals in the workplace...
  2. pmc Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    BMC Cancer 13:400. 2013
    ..The systemic toxicities of these treatments emphasize the need for more effective, localized treatment regimens...
  3. pmc Silica induces NLRP3 inflammasome activation in human lung epithelial cells
    Paul M Peeters
    Department of Respiratory Medicine, Maastricht University Medical Centre MUMC, Maastricht University, Maastricht, The Netherlands
    Part Fibre Toxicol 10:3. 2013
    ..Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we investigated lung epithelial cells as a target for silica-induced inflammasome activation...
  4. pmc New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Am J Pathol 182:1065-77. 2013
    ....
  5. pmc Oxidants and signaling by mitogen-activated protein kinases in lung epithelium
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 34:666-9. 2006
    ....
  6. ncbi request reprint Introduction to serial reviews on the role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1115-6. 2003
  7. ncbi request reprint Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles"
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 43:504-5. 2007
  8. pmc Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Toxicol Environ Health B Crit Rev 14:76-121. 2011
    ....
  9. pmc ERK2 is essential for the growth of human epithelioid malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:1075-86. 2011
    ..After injection of sarcomatoid human MM (PPMMill) cells into SCID mice, both shERK1 and shERK2 lines showed significant decreased tumor growth, suggesting heterogeneous effects of ERKs in individual MMs...
  10. pmc Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Clin Cancer Res 19:2071-83. 2013
    ..Malignant mesothelioma is a devastating disease with a need for new treatment strategies. In the present study, we showed the importance of extracellular signal-regulated kinase 5 (ERK5) in malignant mesothelioma tumor growth and treatment...
  11. ncbi request reprint Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo
    Astrid Haegens
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    J Immunol 178:1800-8. 2007
    ..05) in Tg(+) vs Tg(-) mice. Our findings demonstrate that airway epithelial NF-kappaB activity plays a role in orchestrating the inflammatory response as well as cell proliferation in response to asbestos...
  12. pmc Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Ann N Y Acad Sci 1203:7-14. 2010
    ..Results suggest that inflammation and cytokine production precede and may be critical to the development of MMs...
  13. pmc Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington VT 05405, USA
    Mol Cancer 6:81. 2007
    ..These results suggest that Fra-1 is associated with cell migration in human MMs and that Fra-1 modulation of CD44 may govern migration of selected MMs...
  14. pmc Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 41:114-23. 2009
    ..Results reveal that ATF3 modulates production of inflammatory cytokines (IL-1 beta, IL-13, G-CSF) and growth factors (VEGF and PDGF-BB) in human mesothelial cells...
  15. pmc Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos
    Christopher B Manning
    Environmental Pathology Program, University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:618-26. 2008
    ..These results suggest a critical role of MEK1 signaling in epithelial cell proliferation and lung remodeling after toxic injury...
  16. pmc A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Histochem Cytochem 60:658-74. 2012
    ....
  17. pmc Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Am J Pathol 175:2197-206. 2009
    ..Since activated CREB1 also is increased endogenously in human MM and modifies migration and resistance to Dox-induced apoptosis, inhibition of CREB1 may be a new strategy for MM therapy...
  18. pmc A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos
    Sylke A Buder-Hoffmann
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Pathol 174:449-59. 2009
    ..PKCdelta-dependent PKD phosphorylation by asbestos is causally linked to a cellular pathway that involves the phosphorylation of both ERK1/2 and JNK1/2, which play opposing roles in the apoptotic response induced by asbestos...
  19. pmc Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Part Fibre Toxicol 7:26. 2010
    ....
  20. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
    ..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
  21. ncbi request reprint Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2
    Christy A Barlow
    Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1361-9. 2007
    ....
  22. pmc HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway
    Maria E Ramos-Nino
    University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue HSRF 216, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:209-17. 2008
    ..Data suggest that HGF-induced effects in some MM cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway that might explain tumor-specific effects of c-Met inhibitors on MM and other tumors...
  23. pmc Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:233-44. 2011
    ..These results suggest APMS are efficacious for the localized delivery of lower effective DOX concentrations in MM and represent a novel means of treating intracavitary tumors...
  24. ncbi request reprint Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice
    Astrid Haegens
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05404, USA
    Cancer Res 65:9670-7. 2005
    ..These results support the hypothesis that myeloperoxidase status modulates early asbestos-induced oxidative stress, epithelial cell proliferation, and inflammation...
  25. pmc Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells
    Timothy N Perkins
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Part Fibre Toxicol 9:6. 2012
    ..Finally, primary human bronchial epithelial cells (NHBE) were used to comparatively assess silica particle-induced alterations in gene expression...
  26. pmc Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis
    Tara Sabo-Attwood
    Department of Pathology, University of Vermont, 89 Beaumont Ave, HSRF 218, Burlington, VT 05405, and the Pediatric Pulmonary Division, Children s Hospital of Pittsburgh, PA, USA
    Am J Pathol 167:1243-56. 2005
    ..Identification of genes involved in lung injury and remodeling after asbestos exposure could aid in defining mechanisms of airborne particulate-induced disease and in developing therapeutic strategies...
  27. pmc An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA
    Am J Respir Cell Mol Biol 45:906-14. 2011
    ..They also indicate that ERK2 plays a role in modulating asbestos toxicity by regulating genes critical to cell injury and survival that are differentially expressed in human mesotheliomas...
  28. pmc Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells
    Christy A Barlow
    Department of Pharmacology, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Apoptosis 13:681-92. 2008
    ..Together these data reveal a novel role for crosstalk between PKA, ERK1/2 and CREB that mediates cell survival during oxidant stress...
  29. pmc Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice
    Arti Shukla
    Department of Pathology, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Am J Pathol 170:140-51. 2007
    ..These results also implicate targeted interruption of PKC-delta as a potential therapeutic option in asbestos-induced lung diseases...
  30. ncbi request reprint Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Cancer Res 62:6065-9. 2002
    ..In summary, we demonstrate that ERK-dependent Fra-1 is elevated in AP-1 complexes in response to asbestos fibers and is critical to the transformation of mesothelial cells...
  31. pmc Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1)
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    J Toxicol Environ Health A 73:423-36. 2010
    ....
  32. pmc Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
    Part Fibre Toxicol 10:39. 2013
    ..Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear...
  33. ncbi request reprint The duration of nuclear extracellular signal-regulated kinase 1 and 2 signaling during cell cycle reentry distinguishes proliferation from apoptosis in response to asbestos
    Ziqiang Yuan
    Department of Pathology, Environmental Pathology Program, and Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Cancer Res 64:6530-6. 2004
    ....
  34. pmc Inhaled asbestos exacerbates atherosclerosis in apolipoprotein E-deficient mice via CD4+ T cells
    Naomi K Fukagawa
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Environ Health Perspect 116:1218-25. 2008
    ....
  35. ncbi request reprint Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-alpha
    Muyao Li
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 197:418-25. 2003
    ..This may contribute to the increased risk for vascular disease associated with aging and diabetes mellitus (DM)...
  36. pmc Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways
    Nicholas H Heintz
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    Am J Respir Cell Mol Biol 42:133-9. 2010
    ..An understanding of the pathogenic features of asbestos fibers and dysregulation of signaling pathways allows strategies for the prevention and therapy of asbestos-related diseases...
  37. ncbi request reprint A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression
    Christopher B Manning
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Cancer Res 62:4169-75. 2002
    ....
  38. pmc Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant
    Jamie Levis
    Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:16-25. 2008
    ..Irradiation and bone marrow transplantation alters inflammatory and fibrotic responses to asbestos, likely through modulation of soluble inflammatory mediators...
  39. pmc Persistent localization of activated extracellular signal-regulated kinases (ERK1/2) is epithelial cell-specific in an inhalation model of asbestosis
    Andrew B Cummins
    Department of Pathology and Microscopy Imaging Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Pathol 162:713-20. 2003
    ....
  40. pmc Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer
    Kai Cheng
    Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA
    ACS Appl Mater Interfaces 2:2489-95. 2010
    ..In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome...
  41. ncbi request reprint Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1018-25. 2003
    ..Studies collectively indicate that mitochondria are initial targets of asbestos-induced DNA damage and apoptosis via an oxidant-related mechanism...
  42. pmc Oxidant-mediated cAMP response element binding protein activation: calcium regulation and role in apoptosis of lung epithelial cells
    Christy A Barlow
    Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 34:7-14. 2006
    ..These data support a novel communication between Ca2+-ERK1/2 and CREB elicited by H2O2, and further provide evidence that CREB is an important regulator of apoptosis in oxidant-mediated responses of lung epithelial cells...
  43. ncbi request reprint Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos
    Luca Scapoli
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Oncogene 23:805-13. 2004
    ..These observations may have broad relevance to cell proliferation by carcinogenic mineral fibers and oxidants...
  44. ncbi request reprint Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1117-29. 2003
    ..There is strong evidence supporting the premise that oxidants contribute to asbestos-induced lung injury; thus, strategies for reducing oxidant stress to pulmonary cells may attenuate the deleterious effects of asbestos...
  45. ncbi request reprint The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity
    Arti Shukla
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Cancer Res 64:7780-6. 2004
    ..Our work shows that the glutathione-controlled redox status of the epithelial cell plays a pivotal role in asbestos-induced epidermal growth factor receptor and proto-oncogene activation as well as AP-1 activity...
  46. ncbi request reprint Asbestos-induced apoptosis is protein kinase C delta-dependent
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 29:198-205. 2003
    ..However, H2O2-induced apoptosis was not inhibited by cell lines stably expressing either dnPKC delta or dnPKC alpha, suggesting that activation of PKC delta has a distinct role in the development of asbestos-induced apoptosis...
  47. ncbi request reprint Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase
    Maria E Ramos-Nino
    Department of Pathology, College of Medicine, University of Vermont College of Medicine, 89 Beaumont Avenue, HSRF 215, Burlington, VT 05405, USA
    Mol Cancer Ther 4:835-42. 2005
    ..Our results suggest that kinase screening of individual malignant mesotheliomas for endogenous levels of activated PI3-K/AKT may be predictive of the efficacy of Onconase and possibly other chemotherapeutic agents...
  48. ncbi request reprint Role of mitogen-activated protein kinases (MAPK) in cell injury and proliferation by environmental particulates
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington 05404, USA
    Mol Cell Biochem 234:111-8. 2002
    ....
  49. pmc Assessing nanotoxicity in cells in vitro
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:219-31. 2010
    ..Conversely, intrathoracic or intrapleural injection of nanomaterials into rodents can be misleading because they bypass normal clearance mechanisms, and non-pathogenic fibers and particles can test positively in these assays...
  50. pmc Unique uptake of acid-prepared mesoporous spheres by lung epithelial and mesothelioma cells
    Steven R Blumen
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Respir Cell Mol Biol 36:333-42. 2007
    ..In the treatment of lung and pleural diseases, APMS-TEG may be useful tools to deliver chemotherapeutic drugs or molecular constructs...
  51. ncbi request reprint Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats
    Muyao Li
    Departments of Medicine, Pathology, and Biochemistry, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 281:40429-39. 2006
    ....
  52. pmc Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos
    Karen M Lounsbury
    Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Pathol 160:1991-2000. 2002
    ..These studies show that activated PKC delta in pulmonary epithelial cells is a consequence of inhalation of asbestos and may be linked to the activation of cell proliferation...
  53. ncbi request reprint Multifluorescence labeling techniques and confocal laser scanning microscopy on lung tissue
    Maria Stern
    Department of Pathology, University of Vermont, Burlington, VT, USA
    Methods Mol Biol 319:67-76. 2006
    ..Moreover, we are able to determine whether various signaling proteins colocalize in cells and the sites affected by asbestos fibers...
  54. pmc Cellular and molecular parameters of mesothelioma
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 98:723-34. 2006
    ..These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors...
  55. ncbi request reprint Paclitaxel and vinorelbine cause synergistic increases in apoptosis but not in microtubular disruption in human lung adenocarcinoma cells (A-549)
    Michael Jung
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Histochem Cell Biol 121:115-21. 2004
    ....
  56. pmc Redox-based regulation of signal transduction: principles, pitfalls, and promises
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 45:1-17. 2008
    ..We also attempt to highlight some of the current pitfalls and the approaches needed to advance this important area of biochemical and biomedical research...
  57. pmc Assessment of the pathogenic potential of asbestiform vs. nonasbestiform particulates (cleavage fragments) in in vitro (cell or organ culture) models and bioassays
    Brooke T Mossman
    University of Vermont College of Medicine, Burlington, VT 0540, USA
    Regul Toxicol Pharmacol 52:S200-3. 2008
    ..The available studies show that cleavage fragments are less bioreactive and cytotoxic than asbestiform fibers...
  58. ncbi request reprint Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse transcriptase-polymerase chain reaction
    Christopher B Manning
    Department of Pathology, University of Vermont, Burlington, VT, USA
    Methods Mol Biol 319:231-6. 2006
    ..A detailed description of the preparation of cDNA from bronchiolar epithelial cells obtained by LCM is described in this work...
  59. ncbi request reprint Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Cancer Res 63:3539-45. 2003
    ..These studies suggest that inhibition of fra-1 signaling pathways may be a strategy for therapy of malignant mesothelioma...
  60. ncbi request reprint Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung
    Arti Shukla
    Department of Pharmacology, University of Vermont College of Medicine, 89 Beaumont Ave Burlington, Vermont 05405, USA
    FASEB J 20:997-9. 2006
    ..These data reveal a potentially important link between asbestos signaling and integrity of the extracellular matrix (ECM) that likely contributes to asbestos-induced lung remodeling and diseases...
  61. ncbi request reprint Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells
    Cynthia R Timblin
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Toxicol Appl Pharmacol 179:98-104. 2002
    ....
  62. ncbi request reprint Diseases caused by asbestos: mechanisms of injury and disease development
    Christopher B Manning
    Department of Pathology, College of Medicine, University of Vermont, Burlington 05405, USA
    Int Immunopharmacol 2:191-200. 2002
    ....
  63. ncbi request reprint SV40, growth factors, and mesothelioma: another piece of the puzzle
    Brooke T Mossman
    Departments of Pathology and Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 26:167-70. 2002
  64. ncbi request reprint Modern criteria to determine the etiology of human carcinogens
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, 215 HSRF, 89 Beaumont Ave, Burlington, VT 05405, USA
    Semin Cancer Biol 14:449-52. 2004
    ..These approaches should be combined with molecular epidemiology and molecular pathology to identify human carcinogens with more emphasis on evaluating combinations of suspect agents and mechanisms of action of epigenetic carcinogens...
  65. ncbi request reprint Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice
    Andrea K Hubbard
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269, USA
    Am J Physiol Lung Cell Mol Physiol 282:L968-75. 2002
    ....
  66. pmc ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo
    Patty J Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 116:163-73. 2006
    ..ERK1/2 regulators may be useful in the treatment of IL-13-induced diseases and disorders...
  67. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  68. pmc TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
    Haining Yang
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:10397-402. 2006
    ....
  69. ncbi request reprint In vitro and in vivo activation of extracellular signal-regulated kinases by coal dusts and quartz silica
    Catrin Albrecht
    Particle Research Core, Institut für umweltmedizinische Forschung IUF an der Heinrich Heine Universität, 40225 Dusseldorf, Germany
    Toxicol Appl Pharmacol 184:37-45. 2002
    ..Immunohistochemistry on lung sections of CMD-exposed rats showed chronic activation of phosphorylated ERKs in epithelial cells, supporting the possible role of this signal cascade in proliferation of pulmonary epithelium by PSP in vivo...
  70. ncbi request reprint Role and regulation of activator protein-1 in toxicant-induced responses of the lung
    Sekhar P M Reddy
    Department of Environmental Health Sciences and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1161-78. 2002
    ..These studies might offer a unique opportunity to use AP-1 family members and transactivation as potential diagnostic markers or drug targets for early detection and/or prevention of various lung diseases...
  71. ncbi request reprint Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 24:6080-9. 2005
    ..These findings also suggest that mouse models of MM may be useful for future preclinical studies of pharmaceuticals targeting the PI3K/AKT pathway...
  72. ncbi request reprint Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression
    Muyao Li
    University of Alabama at Birmingham, Birmingham, Alabama, USA corrected
    J Cell Physiol 206:518-25. 2006
    ..Furthermore, MEK inhibitors increased nuclear Nrf2 and Nrf2/ARE binding. These data suggest opposing effects of Nrf2 and ERK1/2 signaling in the modulation of GCLC expression in old animals...
  73. ncbi request reprint Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum
    Kenneth B Adler
    Am J Respir Cell Mol Biol 34:523-6. 2006
  74. ncbi request reprint Chromium (VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells
    Kimberley A O'Hara
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15260, USA
    J Cell Physiol 209:113-21. 2006
    ..The data also have important implications for understanding the toxic mechanisms of low level, mixed metal exposures in the lung...
  75. pmc Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Science 320:674-7. 2008
    ..Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor...

Research Grants3

  1. Meeting on Inhaled Mineral Dusts/Nanoparticles
    Brooke Mossman; Fiscal Year: 2005
    ..This meeting will provide a forum for exchange of research ideas and collaborations that will advance the field of public health in understanding individual susceptibility to and mechanisms of particulate-induced lung diseases. ..
  2. ENVIRONMENTAL PATHOLOGY TRAINING GRANT
    Brooke Mossman; Fiscal Year: 2007
    ..The short term training slots for medical students, which were largely unfilled during the past term of this program, have been deleted from the current application. ..