David Mosser

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
    Suzanne A Miles
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Exp Med 201:747-54. 2005
  2. pmc Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
    Ricardo Goncalves
    Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20782, USA
    J Exp Med 208:1253-65. 2011
  3. pmc Extrinsic and intrinsic control of macrophage inflammatory responses
    Heather B Cohen
    1 Rm 3102, Bioscience Research Bldg, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 94:913-9. 2013
  4. pmc Interleukin-10: new perspectives on an old cytokine
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Immunol Rev 226:205-18. 2008
  5. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
  6. ncbi request reprint The many faces of macrophage activation
    David M Mosser
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 73:209-12. 2003
  7. pmc Activation of murine macrophages
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
    Curr Protoc Immunol . 2008
  8. pmc NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    Shanjin Cao
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 281:26041-50. 2006
  9. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
  10. pmc Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 177:1282-8. 2006

Research Grants

  1. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2005
  2. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2007
  3. Innate and adaptive immune responses to Leishmania
    David Mosser; Fiscal Year: 2007
  4. Fluorescence-activated cell sorter-FACSAria
    David Mosser; Fiscal Year: 2007
  5. Regulatory and Effector Functions of Macrophages
    David Mosser; Fiscal Year: 2003
  6. Innate and adaptive immune responses to Leishmania
    David Mosser; Fiscal Year: 2009
  7. MACROPHAGE AND IMMUNE DEVIATION
    David Mosser; Fiscal Year: 2002
  8. MACROPHAGE RECEPTORS FOR LEISHMANIA
    David Mosser; Fiscal Year: 2002
  9. MACROPHAGE AND IMMUNE DEVIATION
    David Mosser; Fiscal Year: 2000
  10. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2009

Collaborators

  • Dalit Strauss-Ayali
  • Xia Zhang
  • Justin P Edwards
  • Charles F Anderson
  • Ziyan Yang
  • Sean M Conrad
  • Patricia A Darrah
  • Heather B Cohen
  • Mark Lucas
  • Ricardo Goncalves
  • Shanjin Cao
  • Ann E Field
  • Suzanne A Miles
  • Illya Tietzel
  • Alain Debrabant
  • Heather Cohen
  • Matthias Mack
  • Kenneth A Frauwirth
  • Renata G Alves
  • Vikram Prasanna
  • Selma M B Jeronimo
  • Mary K Hondalus
  • Maria Chiara G Monaco
  • Douglas T Golenbock
  • Shruti Jain
  • Laila GutiĆ©rrez-Kobeh
  • Jeffrey S Gerber

Detail Information

Publications22

  1. pmc A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
    Suzanne A Miles
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Exp Med 201:747-54. 2005
    ..We conclude that IgG can cause a novel form of immune enhancement due to its ability to induce IL-10 production from macrophages...
  2. pmc Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
    Ricardo Goncalves
    Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20782, USA
    J Exp Med 208:1253-65. 2011
    ..This work points to a new role for platelets in host defense involving the selective recruitment of a subpopulation of effector monocytes from the blood to efficiently kill this intracellular parasite...
  3. pmc Extrinsic and intrinsic control of macrophage inflammatory responses
    Heather B Cohen
    1 Rm 3102, Bioscience Research Bldg, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 94:913-9. 2013
    ..Thus, macrophages can respond to endogenous and exogenous cues to regulate their activation state, and without these controlled regulatory responses, M1 would persist to the detriment of the host. ..
  4. pmc Interleukin-10: new perspectives on an old cytokine
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Immunol Rev 226:205-18. 2008
    ..In this review, we summarize what is known about the regulation of IL-10 gene expression by various immune cells. We speculate on the promise that this cytokine holds to influence immune responses and mitigate immune pathologies...
  5. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
    ..We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations...
  6. ncbi request reprint The many faces of macrophage activation
    David M Mosser
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 73:209-12. 2003
  7. pmc Activation of murine macrophages
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
    Curr Protoc Immunol . 2008
    ..As our understanding of the various macrophage populations increases, so does the potential for therapeutic intervention based on targeting specific populations of activated macrophages...
  8. pmc NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    Shanjin Cao
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 281:26041-50. 2006
    ..The reciprocal regulation of pro- and anti-inflammatory cytokine production by NF-kappaB1 (p50) may provide potential new ways to manipulate the innate immune response...
  9. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  10. pmc Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 177:1282-8. 2006
    ..This exposure is essential for the efficient induction of IL-10 gene expression in macrophages. To our knowledge, this represents a unique way in which the expression of a cytokine gene is regulated in macrophages...
  11. ncbi request reprint Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 168:3697-701. 2002
    ..These studies demonstrate that the ligation of FcgammaR on activated macrophages can reverse the Th1 biasing that occurs as a result of innate immune responses to microbial products...
  12. ncbi request reprint A novel phenotype for an activated macrophage: the type 2 activated macrophage
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 72:101-6. 2002
    ..These studies demonstrate that FcgammaR ligation on activated macrophages can change the phenotype of these APCs to cells that preferentially drive a Th2-like response. We have termed these cells type 2 activated macrophages...
  13. ncbi request reprint Modulating macrophage function with IgG immune complexes
    Charles F Anderson
    Cell Biology and Molecular Genetics, University of Maryland, College Park 20742, USA
    J Endotoxin Res 8:477-81. 2002
    ..Thus, immune complexes change the physiology of activated macrophages, converting them to anti-inflammatory cells that induce Th2-like immune responses. We have termed these cells type II activated macrophages...
  14. pmc Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages
    Ziyan Yang
    Laboratory of Macrophage Biology, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 178:1077-85. 2007
    ..Thus, our findings reveal an important role of MAPK, ERK signaling in the pathogenesis of Leishmania infection...
  15. pmc The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophages
    Justin P Edwards
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 182:1929-39. 2009
    ..These observations indicate that in addition to the secretion of the anti-inflammatory cytokine IL-10, another novel characteristic of regulatory macrophages is the production of angiogenic HB-EGF...
  16. ncbi request reprint ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus
    Mark Lucas
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 175:469-77. 2005
    ..The rapid and transient regulation of transcription factor accessibility to the IL-10 promoter by MAPK activation represents a novel way that the production of this cytokine is regulated...
  17. ncbi request reprint T cell biasing by activated dendritic cells
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 173:955-61. 2004
    ..We conclude that APCs expressing FcgammaR on their surface can respond to immune complexes by shutting off IL-12 biosynthesis, to prevent the Th1-type T cell biasing that normally accompanies innate immune activation...
  18. pmc Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages
    Sean M Conrad
    Department of Cell Biology and Molecular Genetics, Rm 1103 Microbiology Bldg, University of Maryland, College Park, MD 20742, USA
    Infect Immun 75:653-65. 2007
    ..This work suggests that the parasite-derived MCP-1 can recruit a restrictive population of CCR2-positive macrophages into lesions that can be optimally stimulated by MCP-1 and IFN-gamma to efficiently kill Leishmania parasites...
  19. ncbi request reprint Innate immune responses to Rhodococcus equi
    Patricia A Darrah
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 173:1914-24. 2004
    ..equi. We conclude that the efficient activation of innate immunity by R. equi may account for the relative lack of virulence of this organism in immunocompetent adults...
  20. pmc The expression of exogenous genes in macrophages: obstacles and opportunities
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA
    Methods Mol Biol 531:123-43. 2009
    ..In the present chapter we discuss some of the gene expression techniques that have met with success and review the advantages and disadvantages of each...
  21. pmc The regulation of Th1 responses by the p38 MAPK
    Ziyan Yang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 185:6205-13. 2010
    ..major plus CpG without SB203580. Thus, this work suggests that MAPK/p38 inhibitors may be applied as adjuvants to bias immune responses and improve vaccinations against intracellular pathogens...
  22. ncbi request reprint The modulation of macrophage activation by tyrosine phosphorylation
    Illya Tietzel
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Front Biosci 7:d1494-502. 2002
    ..The observations relating to a modulation of macrophage effector mechanisms by these receptors open unexplored avenues for the development of pharmacological immunomodulators with the potential to exploit elements of this common pathway...

Research Grants22

  1. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2005
    ..Finally, in vivo models will be developed to determine the extent to which inflammatory responses can be blunted by Fc-gammaR ligation. ..
  2. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2007
    ..2. The role for NF-?B1 in IL-10 gene regulation. 3. The heterogeneity of activated macrophages. Our goal is to understand how IL-10 is regulated so we can develop molecules to enhance or inhibit its production. ..
  3. Innate and adaptive immune responses to Leishmania
    David Mosser; Fiscal Year: 2007
    ..They may also provide important basic information about the role of antibody during infections with intracellulars, and about the ability of APCs to influence the nature of an adaptive immune response. ..
  4. Fluorescence-activated cell sorter-FACSAria
    David Mosser; Fiscal Year: 2007
    ..A variety of scientific programs on campus spanning a number of disciplines, including pathogen research, immunology, human performance, and neurobiology will be substantially enhanced by the addition of this instrument. ..
  5. Regulatory and Effector Functions of Macrophages
    David Mosser; Fiscal Year: 2003
    ..These discussions should lead to a better understanding of how specific alterations in macrophage physiology can contribute to inflammation, immune deviation, and the elimination of microbial pathogens. ..
  6. Innate and adaptive immune responses to Leishmania
    David Mosser; Fiscal Year: 2009
    ..They may also provide important basic information about the role of antibody during infections with intracellulars, and about the ability of APCs to influence the nature of an adaptive immune response. ..
  7. MACROPHAGE AND IMMUNE DEVIATION
    David Mosser; Fiscal Year: 2002
    ..The fourth aim will examine the extent to which macrophages and dendritic cells can influence T cell responses to antigens in vivo. ..
  8. MACROPHAGE RECEPTORS FOR LEISHMANIA
    David Mosser; Fiscal Year: 2002
    ....
  9. MACROPHAGE AND IMMUNE DEVIATION
    David Mosser; Fiscal Year: 2000
    ..The fourth aim will examine the extent to which macrophages and dendritic cells can influence T cell responses to antigens in vivo. ..
  10. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2009
    ..2. The role for NF-?B1 in IL-10 gene regulation. 3. The heterogeneity of activated macrophages. Our goal is to understand how IL-10 is regulated so we can develop molecules to enhance or inhibit its production. ..
  11. MACROPHAGE RECEPTORS FOR LEISHMANIA
    David Mosser; Fiscal Year: 2001
    ....
  12. Joint Meeting of the Society for Leukocyte Biology (SLB) and the International En
    David Mosser; Fiscal Year: 2006
    ..4. To provide an opportunity for young scientists to present their research at organized poster sessions and to recognize outstanding research by providing a platform for oral presentations. ..
  13. Innate and adaptive immune responses to Leishmania
    David Mosser; Fiscal Year: 2006
    ..They may also provide important basic information about the role of antibody during infections with intracellulars, and about the ability of APCs to influence the nature of an adaptive immune response. ..
  14. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2001
    ..Finally, in vivo models will be developed to determine the extent to which inflammatory responses can be blunted by Fc-gammaR ligation. ..
  15. Innate and adaptive immune responses to Leishmania
    David Mosser; Fiscal Year: 2005
    ..They may also provide important basic information about the role of antibody during infections with intracellulars, and about the ability of APCs to influence the nature of an adaptive immune response. ..
  16. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2004
    ..Finally, in vivo models will be developed to determine the extent to which inflammatory responses can be blunted by Fc-gammaR ligation. ..
  17. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2003
    ..Finally, in vivo models will be developed to determine the extent to which inflammatory responses can be blunted by Fc-gammaR ligation. ..
  18. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David Mosser; Fiscal Year: 2002
    ..Finally, in vivo models will be developed to determine the extent to which inflammatory responses can be blunted by Fc-gammaR ligation. ..
  19. MACROPHAGE AND IMMUNE DEVIATION
    David Mosser; Fiscal Year: 2001
    ..The fourth aim will examine the extent to which macrophages and dendritic cells can influence T cell responses to antigens in vivo. ..
  20. MODULATING HOST RESPONSES TO BACTERIAL PRODUCTS
    David M Mosser; Fiscal Year: 2010
    ..2. The role for NF-?B1 in IL-10 gene regulation. 3. The heterogeneity of activated macrophages. Our goal is to understand how IL-10 is regulated so we can develop molecules to enhance or inhibit its production. ..