David MosserSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Publications
Interleukin-10: new perspectives on an old cytokineDavid M Mosser
Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
Immunol Rev 226:205-18. 2008..In this review, we summarize what is known about the regulation of IL-10 gene expression by various immune cells. We speculate on the promise that this cytokine holds to influence immune responses and mitigate immune pathologies...- Exploring the full spectrum of macrophage activationDavid M Mosser
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
Nat Rev Immunol 8:958-69. 2008..We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations... 
The many faces of macrophage activationDavid M Mosser
Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 73:209-12. 2003- NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophagesShanjin Cao
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
J Biol Chem 281:26041-50. 2006..The reciprocal regulation of pro- and anti-inflammatory cytokine production by NF-kappaB1 (p50) may provide potential new ways to manipulate the innate immune response... - Activation of murine macrophagesDavid M Mosser
Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
Curr Protoc Immunol . 2008..As our understanding of the various macrophage populations increases, so does the potential for therapeutic intervention based on targeting specific populations of activated macrophages... - Biochemical and functional characterization of three activated macrophage populationsJustin P Edwards
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 80:1298-307. 2006..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions... - Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptorsCharles F Anderson
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 168:3697-701. 2002..These studies demonstrate that the ligation of FcgammaR on activated macrophages can reverse the Th1 biasing that occurs as a result of innate immune responses to microbial products... - Dynamic and transient remodeling of the macrophage IL-10 promoter during transcriptionXia Zhang
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 177:1282-8. 2006..This exposure is essential for the efficient induction of IL-10 gene expression in macrophages. To our knowledge, this represents a unique way in which the expression of a cytokine gene is regulated in macrophages... - Modulating macrophage function with IgG immune complexesCharles F Anderson
Cell Biology and Molecular Genetics, University of Maryland, College Park 20742, USA
J Endotoxin Res 8:477-81. 2002..Thus, immune complexes change the physiology of activated macrophages, converting them to anti-inflammatory cells that induce Th2-like immune responses. We have termed these cells type II activated macrophages... - A novel phenotype for an activated macrophage: the type 2 activated macrophageCharles F Anderson
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 72:101-6. 2002..These studies demonstrate that FcgammaR ligation on activated macrophages can change the phenotype of these APCs to cells that preferentially drive a Th2-like response. We have termed these cells type 2 activated macrophages... - The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophagesJustin P Edwards
Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 182:1929-39. 2009..These observations indicate that in addition to the secretion of the anti-inflammatory cytokine IL-10, another novel characteristic of regulatory macrophages is the production of angiogenic HB-EGF... - ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locusMark Lucas
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 175:469-77. 2005..The rapid and transient regulation of transcription factor accessibility to the IL-10 promoter by MAPK activation represents a novel way that the production of this cytokine is regulated... - Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophagesZiyan Yang
Laboratory of Macrophage Biology, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 178:1077-85. 2007..Thus, our findings reveal an important role of MAPK, ERK signaling in the pathogenesis of Leishmania infection... - Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophagesSean M Conrad
Department of Cell Biology and Molecular Genetics, Rm 1103 Microbiology Bldg, University of Maryland, College Park, MD 20742, USA
Infect Immun 75:653-65. 2007..This work suggests that the parasite-derived MCP-1 can recruit a restrictive population of CCR2-positive macrophages into lesions that can be optimally stimulated by MCP-1 and IFN-gamma to efficiently kill Leishmania parasites... - T cell biasing by activated dendritic cellsCharles F Anderson
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 173:955-61. 2004..We conclude that APCs expressing FcgammaR on their surface can respond to immune complexes by shutting off IL-12 biosynthesis, to prevent the Th1-type T cell biasing that normally accompanies innate immune activation... - Innate immune responses to Rhodococcus equiPatricia A Darrah
Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 173:1914-24. 2004..equi. We conclude that the efficient activation of innate immunity by R. equi may account for the relative lack of virulence of this organism in immunocompetent adults... - The modulation of macrophage activation by tyrosine phosphorylationIllya Tietzel
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
Front Biosci 7:d1494-502. 2002..The observations relating to a modulation of macrophage effector mechanisms by these receptors open unexplored avenues for the development of pharmacological immunomodulators with the potential to exploit elements of this common pathway... - A role for IgG immune complexes during infection with the intracellular pathogen LeishmaniaSuzanne A Miles
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Exp Med 201:747-54. 2005..We conclude that IgG can cause a novel form of immune enhancement due to its ability to induce IL-10 production from macrophages... - The expression of exogenous genes in macrophages: obstacles and opportunitiesXia Zhang
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA
Methods Mol Biol 531:123-43. 2009..In the present chapter we discuss some of the gene expression techniques that have met with success and review the advantages and disadvantages of each... - The regulation of Th1 responses by the p38 MAPKZiyan Yang
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Immunol 185:6205-13. 2010..major plus CpG without SB203580. Thus, this work suggests that MAPK/p38 inhibitors may be applied as adjuvants to bias immune responses and improve vaccinations against intracellular pathogens...
Research Grants
- Joint Meeting of the Society for Leukocyte Biology (SLB) and the International EnDavid Mosser; Fiscal Year: 2006..4. To provide an opportunity for young scientists to present their research at organized poster sessions and to recognize outstanding research by providing a platform for oral presentations. ..
- MODULATING HOST RESPONSES TO BACTERIAL PRODUCTSDavid Mosser; Fiscal Year: 2007..2. The role for NF-?B1 in IL-10 gene regulation. 3. The heterogeneity of activated macrophages. Our goal is to understand how IL-10 is regulated so we can develop molecules to enhance or inhibit its production. ..
- Fluorescence-activated cell sorter-FACSAriaDavid Mosser; Fiscal Year: 2007..A variety of scientific programs on campus spanning a number of disciplines, including pathogen research, immunology, human performance, and neurobiology will be substantially enhanced by the addition of this instrument. ..
- Innate and adaptive immune responses to LeishmaniaDavid Mosser; Fiscal Year: 2009..They may also provide important basic information about the role of antibody during infections with intracellulars, and about the ability of APCs to influence the nature of an adaptive immune response. ..
- MODULATING HOST RESPONSES TO BACTERIAL PRODUCTSDavid Mosser; Fiscal Year: 2005..Finally, in vivo models will be developed to determine the extent to which inflammatory responses can be blunted by Fc-gammaR ligation. ..
- MACROPHAGE RECEPTORS FOR LEISHMANIADavid Mosser; Fiscal Year: 2002....
- MACROPHAGE AND IMMUNE DEVIATIONDavid Mosser; Fiscal Year: 2002..The fourth aim will examine the extent to which macrophages and dendritic cells can influence T cell responses to antigens in vivo. ..
- Regulatory and Effector Functions of MacrophagesDavid Mosser; Fiscal Year: 2003..These discussions should lead to a better understanding of how specific alterations in macrophage physiology can contribute to inflammation, immune deviation, and the elimination of microbial pathogens. ..
- MODULATING HOST RESPONSES TO BACTERIAL PRODUCTSDavid M Mosser; Fiscal Year: 2010..2. The role for NF-?B1 in IL-10 gene regulation. 3. The heterogeneity of activated macrophages. Our goal is to understand how IL-10 is regulated so we can develop molecules to enhance or inhibit its production. ..