David M Mosser

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint The many faces of macrophage activation
    David M Mosser
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 73:209-12. 2003
  2. pmc A sensitive flow cytometric methodology for studying the binding of L. chagasi to canine peritoneal macrophages
    Ricardo Goncalves
    Faculdade de Medicina, DAPML, Universidade Federal de Minas Gerais, Brazil
    BMC Infect Dis 5:39. 2005
  3. pmc The regulation of Th1 responses by the p38 MAPK
    Ziyan Yang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 185:6205-13. 2010
  4. pmc Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 177:1282-8. 2006
  5. doi request reprint The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:4674-86. 2011
  6. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
  7. pmc The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophages
    Justin P Edwards
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 182:1929-39. 2009
  8. pmc NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    Shanjin Cao
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 281:26041-50. 2006
  9. pmc Activation of murine macrophages
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
    Curr Protoc Immunol . 2008
  10. pmc Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages
    Sean M Conrad
    Department of Cell Biology and Molecular Genetics, Rm 1103 Microbiology Bldg, University of Maryland, College Park, MD 20742, USA
    Infect Immun 75:653-65. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint The many faces of macrophage activation
    David M Mosser
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 73:209-12. 2003
  2. pmc A sensitive flow cytometric methodology for studying the binding of L. chagasi to canine peritoneal macrophages
    Ricardo Goncalves
    Faculdade de Medicina, DAPML, Universidade Federal de Minas Gerais, Brazil
    BMC Infect Dis 5:39. 2005
    ..In this study we propose a novel methodology using flow cytometry to study this interaction, and compare it with a previously described "in vitro" binding assay...
  3. pmc The regulation of Th1 responses by the p38 MAPK
    Ziyan Yang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 185:6205-13. 2010
    ..major plus CpG without SB203580. Thus, this work suggests that MAPK/p38 inhibitors may be applied as adjuvants to bias immune responses and improve vaccinations against intracellular pathogens...
  4. pmc Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 177:1282-8. 2006
    ..This exposure is essential for the efficient induction of IL-10 gene expression in macrophages. To our knowledge, this represents a unique way in which the expression of a cytokine gene is regulated in macrophages...
  5. doi request reprint The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:4674-86. 2011
    ..Thus, our findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs...
  6. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  7. pmc The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophages
    Justin P Edwards
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 182:1929-39. 2009
    ..These observations indicate that in addition to the secretion of the anti-inflammatory cytokine IL-10, another novel characteristic of regulatory macrophages is the production of angiogenic HB-EGF...
  8. pmc NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages
    Shanjin Cao
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 281:26041-50. 2006
    ..The reciprocal regulation of pro- and anti-inflammatory cytokine production by NF-kappaB1 (p50) may provide potential new ways to manipulate the innate immune response...
  9. pmc Activation of murine macrophages
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
    Curr Protoc Immunol . 2008
    ..As our understanding of the various macrophage populations increases, so does the potential for therapeutic intervention based on targeting specific populations of activated macrophages...
  10. pmc Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages
    Sean M Conrad
    Department of Cell Biology and Molecular Genetics, Rm 1103 Microbiology Bldg, University of Maryland, College Park, MD 20742, USA
    Infect Immun 75:653-65. 2007
    ..This work suggests that the parasite-derived MCP-1 can recruit a restrictive population of CCR2-positive macrophages into lesions that can be optimally stimulated by MCP-1 and IFN-gamma to efficiently kill Leishmania parasites...
  11. ncbi request reprint Innate immune responses to Rhodococcus equi
    Patricia A Darrah
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 173:1914-24. 2004
    ..equi. We conclude that the efficient activation of innate immunity by R. equi may account for the relative lack of virulence of this organism in immunocompetent adults...
  12. pmc Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages
    Ziyan Yang
    Laboratory of Macrophage Biology, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 178:1077-85. 2007
    ..Thus, our findings reveal an important role of MAPK, ERK signaling in the pathogenesis of Leishmania infection...
  13. ncbi request reprint ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus
    Mark Lucas
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 175:469-77. 2005
    ..The rapid and transient regulation of transcription factor accessibility to the IL-10 promoter by MAPK activation represents a novel way that the production of this cytokine is regulated...
  14. ncbi request reprint A novel phenotype for an activated macrophage: the type 2 activated macrophage
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 72:101-6. 2002
    ..These studies demonstrate that FcgammaR ligation on activated macrophages can change the phenotype of these APCs to cells that preferentially drive a Th2-like response. We have termed these cells type 2 activated macrophages...
  15. pmc TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses
    Heather B Cohen
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD
    Blood 122:1935-45. 2013
    ..We propose that therapeutics targeting the release and hydrolysis of ATP by macrophages may represent new ways to treat inflammatory diseases. ..
  16. ncbi request reprint Modulating macrophage function with IgG immune complexes
    Charles F Anderson
    Cell Biology and Molecular Genetics, University of Maryland, College Park 20742, USA
    J Endotoxin Res 8:477-81. 2002
    ..Thus, immune complexes change the physiology of activated macrophages, converting them to anti-inflammatory cells that induce Th2-like immune responses. We have termed these cells type II activated macrophages...
  17. pmc Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
    Ricardo Goncalves
    Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20782, USA
    J Exp Med 208:1253-65. 2011
    ..This work points to a new role for platelets in host defense involving the selective recruitment of a subpopulation of effector monocytes from the blood to efficiently kill this intracellular parasite...
  18. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
    ..We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations...
  19. pmc The expression of exogenous genes in macrophages: obstacles and opportunities
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA
    Methods Mol Biol 531:123-43. 2009
    ..In the present chapter we discuss some of the gene expression techniques that have met with success and review the advantages and disadvantages of each...
  20. pmc Extrinsic and intrinsic control of macrophage inflammatory responses
    Heather B Cohen
    1 Rm 3102, Bioscience Research Bldg, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 94:913-9. 2013
    ..Thus, macrophages can respond to endogenous and exogenous cues to regulate their activation state, and without these controlled regulatory responses, M1 would persist to the detriment of the host. ..
  21. pmc Reduced pathology following infection with transgenic Leishmania major expressing murine CD40 ligand
    Ann E Field
    University of Maryland, 1103 Microbiology Building Building 231, College Park, MD 20742, USA
    Infect Immun 75:3140-9. 2007
    ..These results demonstrate that transgenic organisms expressing CD40L are less virulent than wild-type organisms while retaining full immunogenicity...
  22. pmc The influence of IgG density and macrophage Fc (gamma) receptor cross-linking on phagocytosis and IL-10 production
    Paul Gallo
    Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Immunol Lett 133:70-7. 2010
    ..Thus, the myriad events emanating from FcγR ligation depends on the density of immune complexes, allowing the Fc receptors to fine-tune cellular responses depending on the extent of receptor cross-linking...
  23. pmc A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
    Suzanne A Miles
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Exp Med 201:747-54. 2005
    ..We conclude that IgG can cause a novel form of immune enhancement due to its ability to induce IL-10 production from macrophages...
  24. doi request reprint Regulatory macrophages: setting the threshold for therapy
    Bryan D Fleming
    Department of Cell Biology and Molecular Genetics, and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA
    Eur J Immunol 41:2498-502. 2011
    ..Therefore, a better understanding of the various macrophage phenotypes may pave the way for new therapies that are directed at modulating macrophage functions or manipulating individual macrophage subsets...
  25. pmc Measuring opsonic phagocytosis via Fcγ receptors and complement receptors on macrophages
    David M Mosser
    University of Maryland and The Maryland Pathogen Research Institute, College Park, Maryland, USA
    Curr Protoc Immunol . 2011
    ..This unit describes assays that are used to measure these two types of macrophage phagocytosis...
  26. pmc Interleukin-10: new perspectives on an old cytokine
    David M Mosser
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Immunol Rev 226:205-18. 2008
    ..In this review, we summarize what is known about the regulation of IL-10 gene expression by various immune cells. We speculate on the promise that this cytokine holds to influence immune responses and mitigate immune pathologies...
  27. doi request reprint Cardiac macrophages: how to mend a broken heart
    Heather B Cohen
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Immunity 40:3-5. 2014
    ..2014) in this issue of Immunity demonstrates that diverse subpopulations of macrophages reside in the adult heart and can be maintained by multiple mechanisms involving both local proliferation and contributions from monocytes...
  28. ncbi request reprint Monocyte subpopulations and their differentiation patterns during infection
    Dalit Strauss-Ayali
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    J Leukoc Biol 82:244-52. 2007
    ..However, these models may provide interesting springboards to permit us to speculate about the topic of monocyte heterogeneity in humans...
  29. ncbi request reprint T cell biasing by activated dendritic cells
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 173:955-61. 2004
    ..We conclude that APCs expressing FcgammaR on their surface can respond to immune complexes by shutting off IL-12 biosynthesis, to prevent the Th1-type T cell biasing that normally accompanies innate immune activation...
  30. pmc The isolation and characterization of murine macrophages
    Xia Zhang
    Department of Cell Biology and Molecular Genetics, The Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
    Curr Protoc Immunol . 2008
    ..The important roles of macrophages in maintaining homeostasis and in contributing to tissue remodeling and wound healing is sometimes overlooked because of their vital role in host defense...
  31. ncbi request reprint The modulation of macrophage activation by tyrosine phosphorylation
    Illya Tietzel
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Front Biosci 7:d1494-502. 2002
    ..The observations relating to a modulation of macrophage effector mechanisms by these receptors open unexplored avenues for the development of pharmacological immunomodulators with the potential to exploit elements of this common pathway...
  32. ncbi request reprint Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 168:3697-701. 2002
    ..These studies demonstrate that the ligation of FcgammaR on activated macrophages can reverse the Th1 biasing that occurs as a result of innate immune responses to microbial products...