S B Moss

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Conservation and function of a bovine sperm A-kinase anchor protein homologous to mouse AKAP82
    S B Moss
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 61:335-42. 1999
  2. ncbi request reprint A-kinase anchor proteins in endocrine systems and reproduction
    S B Moss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 12:434-40. 2001
  3. ncbi request reprint An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail
    R M Turner
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:32135-41. 1998
  4. ncbi request reprint Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation
    P E Visconti
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104 6080, USA
    Dev Biol 192:351-63. 1997
  5. pmc Targeting of a germ cell-specific type 1 hexokinase lacking a porin-binding domain to the mitochondria as well as to the head and fibrous sheath of murine spermatozoa
    A J Travis
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6080, USA
    Mol Biol Cell 9:263-76. 1998
  6. ncbi request reprint Sperm from mice carrying two t haplotypes do not possess a tyrosine phosphorylated form of hexokinase
    P Olds-Clarke
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Mol Reprod Dev 43:94-104. 1996
  7. ncbi request reprint Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases
    P E Visconti
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 6142, USA
    Genomics 77:163-70. 2001
  8. ncbi request reprint Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolic pathways in murine spermatozoa
    A J Travis
    Center for Research on Reproduction and Women's Health, Biomedical Research Building II/III, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6142, USA
    J Biol Chem 276:7630-6. 2001
  9. ncbi request reprint Molecular evaluation of two major human sperm fibrous sheath proteins, pro-hAKAP82 and hAKAP82, in stump tail sperm
    R M Turner
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Fertil Steril 76:267-74. 2001
  10. ncbi request reprint A novel NH(2)-terminal, nonhydrophobic motif targets a male germ cell-specific hexokinase to the endoplasmic reticulum and plasma membrane
    A J Travis
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 274:34467-75. 1999

Research Grants

  1. Inhibition of Male Germ Cell Proteins by RNAi
    Stuart Moss; Fiscal Year: 2005

Collaborators

  • J A Foster
  • J C Herr
  • P Patrizio
  • B T Storey
  • M S Bartolomei
  • H Tseng
  • W Tang
  • S H Pilder
  • A J Travis
  • G S Kopf
  • P E Visconti
  • R M Turner
  • G L Gerton
  • L R Johnson
  • T Merdiushev
  • B H Jones
  • M A Purdon
  • T L Davis
  • P Olds-Clarke
  • M G Mahoney
  • L Haig-Ladewig
  • D M Dess
  • H E Chemes
  • J R Testa
  • R W Nipper
  • M P Musse
  • L Diaz-Cueto
  • P Stein
  • K Klotz
  • A Mandal
  • Z Hao
  • B R Balsara
  • G R Hunnicutt
  • C J Jorgez
  • F C Jayes
  • J Galatioto
  • L A Vargas
  • J E Wilson
  • K D Riedel
  • D Sui
  • N R Hofmann
  • G J Yang
  • J M Trasler
  • M M Xiang
  • N A Rosenbaum
  • J R Stanley
  • C S Rubin
  • H VanScoy
  • M Fornes
  • M Oyaski
  • J M Orth
  • M De las Heras
  • P Kalab

Detail Information

Publications17

  1. ncbi request reprint Conservation and function of a bovine sperm A-kinase anchor protein homologous to mouse AKAP82
    S B Moss
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 61:335-42. 1999
    ..Finally, bAKAP82 bound the regulatory subunit of protein kinase A. These data support the idea that bAKAP82 functions as an anchoring protein for the subcellular localization of protein kinase A in the flagellum...
  2. ncbi request reprint A-kinase anchor proteins in endocrine systems and reproduction
    S B Moss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 12:434-40. 2001
    ..In addition, other signaling proteins bind to AKAPs, as do some newly described proteins of unknown function, suggesting that proteins of various pathways are anchored through AKAPs...
  3. ncbi request reprint An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail
    R M Turner
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:32135-41. 1998
    ..2, indicating that defects in this gene are maternally inherited. These studies suggest several roles for hAKAP82 in sperm motility, including the regulation of signal transduction pathways...
  4. ncbi request reprint Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation
    P E Visconti
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104 6080, USA
    Dev Biol 192:351-63. 1997
    ....
  5. pmc Targeting of a germ cell-specific type 1 hexokinase lacking a porin-binding domain to the mitochondria as well as to the head and fibrous sheath of murine spermatozoa
    A J Travis
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6080, USA
    Mol Biol Cell 9:263-76. 1998
    ..The unusual distribution of HK1-sc in sperm suggests novel functions, such as extramitochondrial energy production, and also demonstrates that a hexokinase without a classical porin-binding domain can localize to mitochondria...
  6. ncbi request reprint Sperm from mice carrying two t haplotypes do not possess a tyrosine phosphorylated form of hexokinase
    P Olds-Clarke
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Mol Reprod Dev 43:94-104. 1996
    ..Since the mutant sperm are unable to complete fertilization, there could be a relationship between sterility and the lack of tyrosine phosphorylation of HK1 in these mutant sperm...
  7. ncbi request reprint Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases
    P E Visconti
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 6142, USA
    Genomics 77:163-70. 2001
    ..Fluorescence in situ hybridization with both the human and mouse cDNA clones revealed syntenic localization on chromosomes 1p34-p35 and 4E1, respectively...
  8. ncbi request reprint Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolic pathways in murine spermatozoa
    A J Travis
    Center for Research on Reproduction and Women's Health, Biomedical Research Building II/III, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6142, USA
    J Biol Chem 276:7630-6. 2001
    ..The relationship between these pathways suggests that spermatozoa offer a model system for the study of integration of compartmentalized metabolic and signaling pathways...
  9. ncbi request reprint Molecular evaluation of two major human sperm fibrous sheath proteins, pro-hAKAP82 and hAKAP82, in stump tail sperm
    R M Turner
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Fertil Steril 76:267-74. 2001
    ..To determine whether mutations in the pro-hAKAP82 gene and the resulting pro-hAKAP82 and hAKAP82 proteins were associated with the infertility seen in a patient with stump tail sperm...
  10. ncbi request reprint A novel NH(2)-terminal, nonhydrophobic motif targets a male germ cell-specific hexokinase to the endoplasmic reticulum and plasma membrane
    A J Travis
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 274:34467-75. 1999
    ..Such processing might constitute a regulatory mechanism governing the spatial and/or temporal expression of the protein...
  11. ncbi request reprint Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis
    M G Mahoney
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 59:388-94. 1998
    ..The dual presence of basonuclin in differentiated spermatozoa and oocytes suggests that it may play a role in their differentiation and the early development of an embryo...
  12. ncbi request reprint Molecular genetic analysis of two human sperm fibrous sheath proteins, AKAP4 and AKAP3, in men with dysplasia of the fibrous sheath
    R M Turner
    The Center for Research on Reproduction and Women's Health, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, USA
    J Androl 22:302-15. 2001
    ..Our results did not find evidence to support the hypothesis that mutations in either gene are responsible for DFS in humans...
  13. ncbi request reprint Expression and localization of caveolin-1, and the presence of membrane rafts, in mouse and Guinea pig spermatozoa
    A J Travis
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6142, USA
    Dev Biol 240:599-610. 2001
    ....
  14. ncbi request reprint Assembly of AKAP82, a protein kinase A anchor protein, into the fibrous sheath of mouse sperm
    L R Johnson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104 6080, USA
    Dev Biol 192:340-50. 1997
    ..These data indicate that pro-AKAP82 is synthesized in the cell body, transported down the axoneme to its site of assembly in the fibrous sheath, and then proteolytically clipped to form mature AKAP82...
  15. ncbi request reprint Mapping of a haploid transcribed and translated sperm-specific gene to the mouse X chromosome
    S B Moss
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104 6080, USA
    Mamm Genome 8:37-8. 1997
  16. ncbi request reprint Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis
    T L Davis
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genomics 58:18-28. 1999
    ..The maternal allele becomes hypermethylated in this region during meiotic prophase. Thus, the parental H19 alleles acquire methylation differentially in the male germline...
  17. ncbi request reprint Properties and localization of a tyrosine phosphorylated form of hexokinase in mouse sperm
    P E Visconti
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104 6080, USA
    Mol Reprod Dev 43:82-93. 1996
    ..These results suggest that mouse sperm contain at least one HK1 isoform that is present on the sperm head, has an extracellular domain, and behaves as an integral membrane protein...

Research Grants1

  1. Inhibition of Male Germ Cell Proteins by RNAi
    Stuart Moss; Fiscal Year: 2005
    ..g., the threshold levels at which proteins function properly. ..