Arthur Moss

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Reduction in inappropriate therapy and mortality through ICD programming
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 0653, USA
    N Engl J Med 367:2275-83. 2012
  2. ncbi Selection of high-risk patients for device intervention with the new advances in technology
    Arthur J Moss
    Division of Cardiology of the Department of Medicine, University of Rochester Medical Center, Rochester, NY Electronic address
    J Electrocardiol 45:670-2. 2012
  3. ncbi Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome
    A J Moss
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York, USA
    Am J Cardiol 84:876-9. 1999
  4. ncbi MADIT-II: substudies and their implications
    Arthur J Moss
    University of Rochester Medical Center, Rochester, New York, USA
    Card Electrophysiol Rev 7:430-3. 2003
  5. ncbi Introductory note to a classic article by Augustus D. Waller
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 9:187-8. 2004
  6. ncbi Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
  7. ncbi Introductory note to a classic article by Robert A. Bruce
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 9:290. 2004
  8. ncbi Temporal aspects of improved survival with the implanted defibrillator (MADIT-II)
    Arthur J Moss
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 94:312-5. 2004
  9. ncbi Introductory note to a classic article on the auriculo-ventricular bundle by Keith and Flack
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 9:399. 2004
  10. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004

Research Grants

  1. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur J Moss; Fiscal Year: 2010
  2. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
  3. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
  4. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur Moss; Fiscal Year: 2009
  5. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur Moss; Fiscal Year: 2006
  6. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
  7. LONG QT SYNDROME--POPULATION, GENETIC & CARDIAC STUDIES
    Arthur Moss; Fiscal Year: 2002
  8. LONG QT SYNDROME--GENETIC ASPECTS
    Arthur Moss; Fiscal Year: 1993
  9. LONG QT SYNDROME--POPULATION, GENETIC & CARDIAC STUDIES
    Arthur Moss; Fiscal Year: 1993

Collaborators

Detail Information

Publications85

  1. ncbi Reduction in inappropriate therapy and mortality through ICD programming
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 0653, USA
    N Engl J Med 367:2275-83. 2012
    ..The implantable cardioverter-defibrillator (ICD) is highly effective in reducing mortality among patients at risk for fatal arrhythmias, but inappropriate ICD activations are frequent, with potential adverse effects...
  2. ncbi Selection of high-risk patients for device intervention with the new advances in technology
    Arthur J Moss
    Division of Cardiology of the Department of Medicine, University of Rochester Medical Center, Rochester, NY Electronic address
    J Electrocardiol 45:670-2. 2012
    ....
  3. ncbi Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome
    A J Moss
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York, USA
    Am J Cardiol 84:876-9. 1999
    ..The clinical profile and genotype findings of patients with LQTS who experience cardiac events related to acute auditory stimuli are quite different from those who experience events accompanying swimming activities...
  4. ncbi MADIT-II: substudies and their implications
    Arthur J Moss
    University of Rochester Medical Center, Rochester, New York, USA
    Card Electrophysiol Rev 7:430-3. 2003
    ..Computations from the MADIT-II database indicate that 9 patients need to be treated with an ICD to save one life during a 4-year period. The findings from MADIT-II have implications for patients, physicians, and society...
  5. ncbi Introductory note to a classic article by Augustus D. Waller
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 9:187-8. 2004
  6. ncbi Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
    ..We evaluated the effect of location, coding type, and biophysical function of KCNQ1 mutations on the clinical phenotype of this disorder...
  7. ncbi Introductory note to a classic article by Robert A. Bruce
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 9:290. 2004
  8. ncbi Temporal aspects of improved survival with the implanted defibrillator (MADIT-II)
    Arthur J Moss
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 94:312-5. 2004
    ..In the early period, the rate of nonsudden cardiac death was significantly higher in the ICD group than in the conventional therapy group (p = 0.003). Rates of late nonsudden cardiac death were similar in the 2 treatment arms (p = 0.11)...
  9. ncbi Introductory note to a classic article on the auriculo-ventricular bundle by Keith and Flack
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 9:399. 2004
  10. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
    ..This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD...
  11. ncbi 25th anniversary of the International Long-QT Syndrome Registry: an ongoing quest to uncover the secrets of long-QT syndrome
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 111:1199-201. 2005
  12. ncbi Introductory Note to Alfred Nobel's Will
    Arthur J Moss
    From the Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 12:79-80. 2007
  13. ncbi Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 96:177-82. 2005
    ....
  14. ncbi Long QT syndrome: from channels to cardiac arrhythmias
    Arthur J Moss
    Heart Research Follow Up Program, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Invest 115:2018-24. 2005
    ....
  15. ncbi History of Wolff-Parkinson-White syndrome: introductory note to a classic article by Louis Wolff, MD, John Parkinson, MD, and Paul D White, MD
    Arthur J Moss
    University of Rochester Medical Center, Rochester, NY, USA
    Ann Noninvasive Electrocardiol 11:338-9. 2006
  16. ncbi Safety and efficacy of flecainide in subjects with Long QT-3 syndrome (DeltaKPQ mutation): a randomized, double-blind, placebo-controlled clinical trial
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:59-66. 2005
    ..In vitro studies have shown that flecainide provides correction of the impaired inactivation associated with the DeltaKPQ deletion...
  17. ncbi Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome
    Arthur J Moss
    Division of Cardiology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8653, USA
    J Cardiovasc Electrophysiol 19:1289-93. 2008
    ..Ranolazine reduces late sodium channel current, and we hypothesized that ranolazine would have beneficial effects on electrical and mechanical cardiac function in LQT3 patients with the SCN5A-DeltaKPQ mutation...
  18. ncbi Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:34-43. 2005
    ..30), and prolonged intraventricular conduction (QRS duration>or=130 ms)...
  19. ncbi Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome
    A J Moss
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Circulation 101:616-23. 2000
    ..beta-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of beta-blockers in this disorder have not been evaluated...
  20. ncbi Survival benefit with an implanted defibrillator in relation to mortality risk in chronic coronary heart disease
    A J Moss
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 88:516-20. 2001
    ..In patients with chronic coronary heart disease, the magnitude of the survival benefit from the implanted defibrillator is directly related to the severity of cardiac dysfunction and its associated mortality risk...
  21. ncbi What we have learned from the family of multicenter automatic defibrillator implantation trials
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Circ J 74:1038-41. 2010
    ..The family of MADIT ICD and CRT-D trials have provided a firm foundation for improving the clinical management of at-risk cardiac patients as the second decade of the 21(st) century begins...
  22. ncbi Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 105:794-9. 2002
    ..We investigated the clinical features and prognostic implications of mutations involving pore and nonpore regions of the HERG channel in the LQT2 form of this disorder...
  23. ncbi Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 346:877-83. 2002
    ..This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients...
  24. ncbi T-wave patterns associated with the hereditary long QT syndrome
    Arthur J Moss
    Department of Medicine, Division of Cardiology, University of Rochester Medical Center, Rochester, New York, USA
    Card Electrophysiol Rev 6:311-5. 2002
    ..This review highlights the genotype-phenotype associations related to ventricular repolarization that have been reported in the LQTS literature, with particular focus on ECG T-wave patterns in LQT1, LQT2, and LQT3 genotypes...
  25. ncbi The multicenter research group
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Ann Noninvasive Electrocardiol 7:271-7. 2002
  26. ncbi MADIT-II: clinical implications
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Card Electrophysiol Rev 6:463-5. 2002
    ..These preliminary findings raise questions about the clinical usefulness of electrophysiologic testing as a risk stratifier in patients with advanced left ventricular dysfunction...
  27. ncbi Long QT Syndrome
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    JAMA 289:2041-4. 2003
  28. ncbi Cardiac-resynchronization therapy for the prevention of heart-failure events
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    N Engl J Med 361:1329-38. 2009
    ....
  29. ncbi Introductory note to a classic article by Francis Galton
    Arthur J Moss
    Cardiology Unit, Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14641, USA
    Ann Noninvasive Electrocardiol 8:170. 2003
  30. ncbi MADIT-I and MADIT-II
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14542, USA
    J Cardiovasc Electrophysiol 14:S96-8. 2003
    ....
  31. ncbi History of atrial fibrillation
    Arthur J Moss
    Cardiology Unit, Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Ann Noninvasive Electrocardiol 8:90-1. 2003
  32. ncbi Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
    ..However, limited data exist regarding the efficacy and limitations of this form of medical management within high-risk subsets of these populations...
  33. ncbi Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
    ....
  34. ncbi Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
    ..We compared the clinical course of Caucasian and Japanese long QT type-1 (LQT1) patients who were matched for mutations in the KCNQ1 gene...
  35. ncbi Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:395-400. 2009
    ..There are limited data on the effect of the primary types of HF medications, angiotensin converting enzyme inhibitors (ACE-I), and beta-blockers on HF progression in ICD-treated patients...
  36. ncbi Mutation-specific risk in two genetic forms of type 3 long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:210-3. 2010
    ..The findings highlight the importance of knowing the specific mutation in risk stratification of patients with long QT syndrome type 3...
  37. ncbi QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Am Coll Cardiol 44:1481-7. 2004
    ....
  38. ncbi Gender differences and risk of ventricular tachycardia or ventricular fibrillation
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Heart Rhythm 6:180-6. 2009
    ..The role of repolarization duration and stability in arrhythmogenesis in men and women with structural heart disease has not been explored...
  39. ncbi Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval
    Jean-Philippe Couderc
    Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York
    Heart Rhythm 3:1460-6. 2006
    ..CONCLUSION: Abnormal T-wave morphology is a phenotypic expression of LQT2, and its quantification could be used to identify patients with suspected LQTS who do not have overt QTc prolongation (QTc >470)...
  40. ncbi Long QT syndrome and pregnancy
    Rahul Seth
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 49:1092-8. 2007
    ..This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years...
  41. ncbi Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome)
    Li Ning
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 8:246-50. 2003
    ..This study investigated the molecular pathology of a family with clinical evidence of JLNS...
  42. ncbi Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
    ..We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients...
  43. ncbi Effectiveness of the implantable cardioverter defibrillator in blacks versus whites (from MADIT-II)
    Gabriel Vorobiof
    Heart Research Follow-up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:1383-6. 2006
    ..In conclusion, ICD therapy in MADIT-II was associated with a reduction in total mortality, cardiac death, and sudden cardiac death in whites but not in blacks...
  44. ncbi Gender-related differences in electrocardiographic parameters and their association with cardiac events in patients after myocardial infarction
    Hanna Mieszczanska
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 101:20-4. 2008
    ..ST-segment elevation in anterior leads is a significant predictor of events in women, whereas ST depression in lateral leads is a significant predictor in men...
  45. ncbi Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:181-4. 2007
    ..The aim of this study was to evaluate the risk of ventricular tachyarrhythmias and sudden death by BMI in patients after myocardial infarction with severe left ventricular dysfunction...
  46. ncbi Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Ritesh Dhar
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Heart Rhythm 5:807-13. 2008
    ..There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs)...
  47. ncbi Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction
    Brian Morray
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 99:1100-5. 2007
    ..15, p = 0.01, respectively). In conclusion, our findings suggest that high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms are independently associated with a significantly earlier occurrence of coronary events...
  48. ncbi Congenital long QT syndrome: considerations for primary care physicians
    Ethan Levine
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 8679, USA
    Cleve Clin J Med 75:591-600. 2008
    ..We can now classify some types of congenital long QT syndrome according to their genetic mutations and their triggers, such as exercise, rest, or startle...
  49. ncbi Differences in outcomes between patients treated with single- versus dual-chamber implantable cardioverter defibrillators: a substudy of the Multicenter Automatic Defibrillator Implantation Trial II
    Loren D Berenbom
    Mid America Cardiology and the Department of Internal Medicine, Division of Cardiology, University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Ann Noninvasive Electrocardiol 10:429-35. 2005
    ....
  50. ncbi Association between inflammatory markers, hemostatic, and lipid factors in postinfarction patients
    Tareq S Harb
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 91:1120-3. 2003
  51. ncbi Comparison of efficacy of implanted cardioverter-defibrillator in patients with versus without diabetes mellitus
    Stephen M Wittenberg
    Department of Medicine, Tufts University School of Medicine and Baystate Medical Center, Springfield, Massachusetts, USA
    Am J Cardiol 96:417-9. 2005
    ..38 to 0.98) and nondiabetics (HR 0.71; 95% CI 0.49 to 1.05), with no evidence of interaction. Thus, diabetic patients derive a similar benefit from ICD therapy despite being sicker and having a higher mortality rate overall...
  52. ncbi Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Atherosclerosis 187:191-7. 2006
    ..023). We conclude that in non-diabetic postinfarction patients, elevated HDL is predictive of risk of recurrent coronary events within a subgroup of patients characterized by simultaneous elevations in serum CRP and total cholesterol...
  53. ncbi Factors associated with ventricular inducibility in the MADIT-II study population
    Henry W Sesselberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Cardiol 91:1002-4, A7. 2003
  54. ncbi Denaturing high-performance liquid chromatography quickly and reliably detects cardiac ion channel mutations in long QT syndrome
    Li Ning
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Genet Test 7:249-53. 2003
    ..We conclude that the dHPLC technology is a highly sensitive and efficient method for the molecular analysis of LQTS, and the same PCR amplicons developed for SSCP testing can be directly used for dHPLC assay...
  55. ncbi Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction
    Tareq S Harb
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 89:216-21. 2002
  56. ncbi Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome
    Gregory Ouellet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Cardiol 105:87-9. 2010
    ..In conclusion, diabetes and prolonged QTc interval contributed independent mortality risks in adult patients with LQTS, with no interaction between these 2 risk factors...
  57. ncbi The cost effectiveness of implantable cardioverter-defibrillators: results from the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II
    Jack Zwanziger
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Am Coll Cardiol 47:2310-8. 2006
    ..We sought to evaluate the cost implications of the implantable cardioverter-defibrillator (ICD), using utilization, cost, and survival data from the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II...
  58. ncbi Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  59. ncbi Serum glucose and triglyceride determine high-risk subgroups in non-diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Atherosclerosis 183:293-300. 2005
    ..Finding different within-subgroup predictors of risk underscores the notion of context-dependent risk, an observation that may be relevant for determining optimal use of emerging risk factors...
  60. ncbi Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome
    Jenny B Hobbs
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    JAMA 296:1249-54. 2006
    ..Among patients with recent syncope, beta-blocker treatment was associated with reduced risk...
  61. ncbi Treatment of arrhythmias and use of implantable cardioverter-defibrillators to improve survival in elderly patients with cardiac disease
    Ilan Goldenberg
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Geriatr Med 23:205-19. 2007
    ....
  62. ncbi Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
    ..However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified...
  63. ncbi QT interval: how to measure it and what is "normal"
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:333-6. 2006
  64. ncbi Health-related quality of life consequences of implantable cardioverter defibrillators: results from MADIT II
    Katia Noyes
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA
    Med Care 45:377-85. 2007
    ..Implantable cardioverter defibrillators (ICDs) improve survival and extend lives of patients with severe heart disease...
  65. ncbi Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter defibrillator (WCD)
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:353-67. 2010
    ..Additionally, data are reported on the clinical experience with the WCD based on 354 patients from Germany hospitalized between 2000 and 2008 who wore the WCD for a mean of 3 months...
  66. ncbi Time dependence of life-threatening ventricular tachyarrhythmias after coronary revascularization in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 7:1421-7. 2010
    ..Coronary revascularization (CR) may confer electrical stability in patients with ischemic cardiomyopathy. However, data regarding the effect of CR on the development of ventricular tachyarrhythmias in this population are limited...
  67. ncbi Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with atrial fibrillation
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Heart Rhythm 3:631-7. 2006
    ..Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited...
  68. ncbi Polymorphism in the angiotensinogen gene, hypertension, and ethnic differences in the risk of recurrent coronary events
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    Hypertension 48:693-9. 2006
    ..The presence of hypertension significantly augments the risk associated with this genetic mutation...
  69. ncbi Clinical course and implantable cardioverter defibrillator therapy in postinfarction women with severe left ventricular dysfunction
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Cardiovasc Electrophysiol 16:1265-70. 2005
    ..The aim of this study was to evaluate the risk of cardiac events and effects of ICD therapy in women as compared to men enrolled in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II)...
  70. ncbi Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affe
    Stephan E Lehnart
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, P and S 9 401 box 22, 630 W 168 St, New York, NY 10032, USA
    Circulation 116:2325-45. 2007
    ....
  71. ncbi Risk stratification using heart rate turbulence and ventricular arrhythmia in MADIT II: usefulness and limitations of a 10-minute holter recording
    Alexander Berkowitsch
    Cardiology Unit of Kerckhoff-Clinic, Bad Nauheim, Germany
    Ann Noninvasive Electrocardiol 9:270-9. 2004
    ..HRT obtained from 10-min Holter ECG showed a trend toward the association with mortality in univariate analysis but HRT parameters were not predictive of the outcome in multivariate analyses...
  72. ncbi Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome
    Zhiqing Wang
    Department of Medicine Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 75:308-16. 2002
    ..Interestingly, mutations resulting in truncation of the protein appear to be benign, with heterozygous carriers being asymptomatic...
  73. ncbi Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations
    Jesaia Benhorin
    Department of Cardiology, Bikur Cholim Hospital, Jerusalem, Israel
    Ann Noninvasive Electrocardiol 7:40-6. 2002
    ..These findings highlight the complexity of the clinical phenotype in this Mendelian dominant disorder and suggest that one or more modifier genes contribute to the variable expression of this syndrome...
  74. ncbi Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:67-83. 2005
    ..However, data on the benefit and cost-effectiveness of device therapy in high-risk patients with inherited cardiac disorders are limited...
  75. ncbi Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome
    Ilan Goldenberg
    Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:1161-8. 2006
    ....
  76. ncbi ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Societ
    Douglas P Zipes
    Eur Heart J 27:2099-140. 2006
  77. ncbi Risk factors for sudden cardiac death in patients with chronic renal insufficiency and left ventricular dysfunction
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Am J Nephrol 27:7-14. 2007
    ..It is, however, unclear if the risk and risk factors of SCD in these patients is modulated by the coexistence of mild chronic renal insufficiency...
  78. ncbi Identification of sotalol-induced changes in repolarization with T wave area-based repolarization duration parameters
    Jean Philippe Couderc
    Cardiology Unit, Heart Research Follow Up Program, University of Rochester, NY 14642, USA
    J Electrocardiol 36:115-20. 2003
    ..In conclusion, morphological parameters of T wave are able to identify the changes in repolarization interval induced by sotalol. These parameters are more stable and thus more reliable than the traditional QT interval measurements...
  79. ncbi Life versus death
    Arthur J Moss
    Circulation 117:1912-3. 2008
  80. ncbi Repolarization variability in the risk stratification of MADIT II patients
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Europace 9:717-23. 2007
    ....
  81. ncbi Risk of death in the long QT syndrome when a sibling has died
    Elizabeth S Kaufman
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA
    Heart Rhythm 5:831-6. 2008
    ..Sudden death of a sibling is thought to be associated with greater risk of death in long QT syndrome (LQTS). However, there is no evidence of such an association...
  82. ncbi What resides in T-wave residuum?
    Arthur J Moss
    J Cardiovasc Electrophysiol 16:952-3. 2005
  83. ncbi Ventricular repolarization
    Arthur J Moss
    Ann Noninvasive Electrocardiol 8:267-8. 2003
  84. ncbi ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Com
    Douglas P Zipes
    J Am Coll Cardiol 48:e247-346. 2006
  85. ncbi Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 51:288-96. 2008
    ..The study was designed to develop a simple risk stratification score for primary therapy with an implantable cardioverter-defibrillator (ICD)...

Research Grants45

  1. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur J Moss; Fiscal Year: 2010
    ..This enhanced knowledge should lead to more effective strategies for prevention of sudden death in a broad spectrum of genetic and acquired cardiac disorders with meaningful public health benefits. ..
  2. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
    ..The significance of this work relates to the future use of molecular therapeutics to treat ion-channel disorders associated with congenital and acquired cardiac repolarization disorders. ..
  3. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
    ....
  4. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur Moss; Fiscal Year: 2009
    ..This enhanced knowledge should lead to more effective strategies for prevention of sudden death in a broad spectrum of genetic and acquired cardiac disorders with meaningful public health benefits. ..
  5. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur Moss; Fiscal Year: 2006
    ..abstract_text> ..
  6. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
    ..abstract_text> ..
  7. LONG QT SYNDROME--POPULATION, GENETIC & CARDIAC STUDIES
    Arthur Moss; Fiscal Year: 2002
    ..This integrated research program is intended to: 1) improve the presymptomatic diagnosis and treatment of LQTS; and 2) provide a fundamental understanding of the molecular basis of repolarization-related cardiac arrhythmias. ..
  8. LONG QT SYNDROME--GENETIC ASPECTS
    Arthur Moss; Fiscal Year: 1993
    ..This integrated research program offers a substantial prospect of: 1) improving the diagnosis and treatment of LQTS; and 2) providing a fundamental understanding of the molecular basis of repolarization-related cardiac arrhythmias...
  9. LONG QT SYNDROME--POPULATION, GENETIC & CARDIAC STUDIES
    Arthur Moss; Fiscal Year: 1993
    ....