Tim R Mosmann

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint T helper cytokine patterns: defined subsets, random expression, and external modulation
    Tim R Mosmann
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, NY 14642, USA
    Immunol Res 45:173-84. 2009
  2. pmc In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-gamma, and can subsequently differentiate into IL-4- or IFN-gamma-secreting cells
    X Wang
    David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Exp Med 194:1069-80. 2001
  3. pmc Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness
    Shannon P Hilchey
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 183:6157-66. 2009
  4. ncbi request reprint Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells
    Anagha A Divekar
    David H Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 176:1465-73. 2006
  5. ncbi request reprint Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection
    F Eun Hyung Lee
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Infect Dis 195:1779-88. 2007
  6. ncbi request reprint T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    James J Kobie
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 177:6780-6. 2006
  7. ncbi request reprint Amphiregulin, a TH2 cytokine enhancing resistance to nematodes
    Dietmar M Zaiss
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Science 314:1746. 2006
  8. pmc Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion
    Jonathan A Rebhahn
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Comput Methods Programs Biomed 92:54-65. 2008
  9. pmc Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 9:e104781. 2014
  10. ncbi request reprint CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells
    Li Yang
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 175:6458-64. 2005

Collaborators

Detail Information

Publications37

  1. doi request reprint T helper cytokine patterns: defined subsets, random expression, and external modulation
    Tim R Mosmann
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, NY 14642, USA
    Immunol Res 45:173-84. 2009
    ..Additional contributions to diversity may include new committed subsets, random expression of only part of the committed pattern, and modification of the expression patterns by cytokines and other mediators...
  2. pmc In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-gamma, and can subsequently differentiate into IL-4- or IFN-gamma-secreting cells
    X Wang
    David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Exp Med 194:1069-80. 2001
    ....
  3. pmc Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness
    Shannon P Hilchey
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 183:6157-66. 2009
    ..In addition, these studies suggest that the A(2A/B) AR as well as CD39 are novel pharmacological targets for augmenting cancer immunotherapy...
  4. ncbi request reprint Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells
    Anagha A Divekar
    David H Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 176:1465-73. 2006
    ..This has implications for the design of more effective vaccines against pathogens requiring strong CD4 effector T cell responses...
  5. ncbi request reprint Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection
    F Eun Hyung Lee
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Infect Dis 195:1779-88. 2007
    ..Illness severity is likely multifactorial; however, unlike other viral infections, both type 1 and type 2 cytokine responses have been implicated in severe disease...
  6. ncbi request reprint T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    James J Kobie
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 177:6780-6. 2006
    ..Infiltration of either Treg or Thpp cells at inflammatory sites could potentially convert 5'-AMP generated by neutrophils or dying cells into the anti-inflammatory mediator adenosine, thus dampening excessive immune reactions...
  7. ncbi request reprint Amphiregulin, a TH2 cytokine enhancing resistance to nematodes
    Dietmar M Zaiss
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Science 314:1746. 2006
    ..This newly recognized link between T(H)2 cells and epithelial proliferation should help in planning therapeutic interventions for helminth infections and other diseases that involve both cell proliferation and allergy, such as asthma...
  8. pmc Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion
    Jonathan A Rebhahn
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Comput Methods Programs Biomed 92:54-65. 2008
    ..The utility of Exploraspot is demonstrated by identification of single-, double- and triple-secreting T cells; tolerance of variable background fluorescence; and estimation of the numbers of genuine versus random multiple events...
  9. pmc Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 9:e104781. 2014
    ..Overall, our analysis is consistent with accepted concepts in many regards, but it also indicates novel features of the B cell response to influenza that warrant further investigation. ..
  10. ncbi request reprint CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells
    Li Yang
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 175:6458-64. 2005
    ..CD73 and Ly-6A/E expression therefore identify a population of Thpp-like cells in C57BL/6 mice and at least some other Ly-6.2 mice...
  11. pmc Enumeration of cytotoxic CD8 T cells ex vivo during the response to Listeria monocytogenes infection
    Dietmar M W Zaiss
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Infect Immun 76:4609-14. 2008
    ..These data indicate that cytotoxic effector function during the response to infection is regulated independently from IFN-gamma secretion or expansion or contraction of the overall CD8 T-cell response...
  12. pmc Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 146421, USA
    J Virol 84:6687-98. 2010
    ..Also, simulation studies were performed to understand the relative contributions of biological parameters to IAV clearance. This study provides a basis to better understand and predict influenza virus immunity...
  13. pmc The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin
    Yilin Qi
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e39072. 2012
    ..This may be appropriate for a cytokine more involved in repair than attack functions during most inflammatory responses...
  14. pmc Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination
    Xi Li
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Vaccine 30:4581-4. 2012
    ....
  15. pmc Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization
    Matthew M Seavey
    David H Smith Center for Vaccine Biology and Immunology, and the Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, United States
    Vaccine 27:2342-9. 2009
    ..The estradiol-induced mucus barrier may thus prevent exposure to antigens delivered intravaginally, supplementing additional estradiol-dependent mechanism(s) that inhibit CD8(+) T cell priming after insemination or vaginal vaccination...
  16. pmc Human basophils express amphiregulin in response to T cell-derived IL-3
    Yilin Qi
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Allergy Clin Immunol 126:1260-6.e4. 2010
    ..Amphiregulin produced by mouse hematopoietic cells contributes to the elimination of a nematode infection by a type 2 effector response...
  17. pmc SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 1: algorithm design
    Iftekhar Naim
    Department of Computer Science, University of Rochester, Rochester, New York
    Cytometry A 85:408-21. 2014
    ..A companion paper (Part 2) highlights the use of SWIFT, in combination with additional computational tools, for more challenging biological problems...
  18. pmc Increase in IFNγ(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza
    Jason M Weaver
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e57275. 2013
    ....
  19. pmc An animated landscape representation of CD4+ T-cell differentiation, variability, and plasticity: insights into the behavior of populations versus cells
    Jonathan A Rebhahn
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical School, Rochester, NY, USA
    Eur J Immunol 44:2216-29. 2014
    ..While not a quantitative representation of actual differentiation, our model is intended to provoke discussion of T-cell differentiation pathways, particularly highlighting a probabilistic view of transitions between states. ..
  20. pmc Simulation and prediction of the adaptive immune response to influenza A virus infection
    Ha Youn Lee
    Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA
    J Virol 83:7151-65. 2009
    ..We further compared alternative model structures, for example, B-cell activation directly by the virus versus that through professional antigen-presenting cells or dendritic cell licensing of CD8 T cells...
  21. ncbi request reprint HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses
    Jennifer E Snyder-Cappione
    David H Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    J Immunol 176:2662-8. 2006
    ..Analysis of the frequency of directly cytotoxic HIV-specific T cells may be of considerable value in the assessment of disease progression and the potential efficacy of HIV vaccines...
  22. ncbi request reprint Paternal antigen-bearing cells transferred during insemination do not stimulate anti-paternal CD8+ T cells: role of estradiol in locally inhibiting CD8+ T cell responses
    Matthew M Seavey
    David H Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 177:7567-78. 2006
    ....
  23. pmc An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform
    Jyh Chiang E Wang
    Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol Methods 341:106-16. 2009
    ..Taken together, this assay is a rapid and cost-effective method that avoids manipulation of PBDC while providing direct ex vivo high-dimensional flow cytometry data for PBDC studies...
  24. pmc Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma
    Jonathan W Friedberg
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Br J Haematol 146:282-91. 2009
    ..This study is the first to histologically confirm perturbation of the local immune microenvironment following systemic biological therapy of follicular lymphoma...
  25. pmc Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models
    Ha Youn Lee
    Department of Biostatistics and Computational Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Bull Math Biol 71:1649-70. 2009
    ..The most profound effect of the presence of IL-4 was decreased death rates for smaller division classes, which supports a role of IL-4 in the protection of B cells from apoptosis...
  26. ncbi request reprint The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects
    F Eun Hyung Lee
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Mech Ageing Dev 126:1223-9. 2005
    ..A similar trend was seen for influenza. IFNgamma-secreting CD4 T cells contributed significantly more to anti-RSV than anti-influenza responses in both groups...
  27. pmc CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens
    Sharad K Sharma
    Center for Infectious Disease and Immunology, Research Institute, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 31:3090-7. 2013
    ..We conclude that adults have circulating memory CD4(+) T cells (CD45RA(-)) that can be stimulated by all the tested Spn and NTHi protein vaccine candidate antigens, whereas young children have a more limited response...
  28. doi request reprint Immunoregulation of fetal and anti-paternal immune responses
    Matthew M Seavey
    David H Smith Center for Vaccine Biology and Immunology and the Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunol Res 40:97-113. 2008
    ..It's the intricate communication and interplay between the immune system and the endocrine system that will ultimately decide the success or fate of the developing fetus...
  29. pmc Label-free, arrayed sensing of immune response to influenza antigens
    Charles R Mace
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
    Talanta 83:1000-5. 2011
    ....
  30. pmc Microbubble array diffusion assay for the detection of cell secreted factors
    Bryan Bobo
    Department of Biomedical Engineering, University of Rochester, 601 Elmwood Ave Box 697, Rochester, NY 14642, USA
    Lab Chip 14:3640-50. 2014
    ..The proof-of-concept assays presented herein lay the groundwork for the progression of MB well arrays as an advanced on-chip cell sorting technology. ..
  31. ncbi request reprint Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing
    Jennifer E Snyder
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, New York, USA
    Nat Med 9:231-5. 2003
    ..The simultaneous enumeration of cytokine-secreting and cytotoxic cells should be invaluable for ex vivo analysis of immune responses during infection and autoimmunity...
  32. doi request reprint Optimization of the cytokine secretion assay for human IL-2 in single and combination assays
    Nan Deng
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, 14642
    Cytometry A 87:777-83. 2015
    ..However, the longer secretion times possible in the modified assay also improved detection of other cytokines in multi-cytokine combinations. © 2015 International Society for Advancement of Cytometry...
  33. pmc Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFNγ- Thpp cells
    Nan Deng
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 9:e95986. 2014
    ..Thus expression of IL-2 in the anti-influenza response may be regulated mainly by short term variability, whereas different T cell subsets, Th1 and Thpp, may contribute to variability in IFNγ expression. ..
  34. pmc Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab
    Shannon P Hilchey
    James P Wilmot Cancer Center, Aab Institute of Biomedical Sciences, and Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    Blood 113:3809-12. 2009
    ..Our data thus provide "proof of principle" for the ability of passive immunotherapy with rituximab to elicit an active FL-specific cellular response...
  35. pmc SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 2: biological evaluation
    Tim R Mosmann
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, University of Rochester, Rochester, New York
    Cytometry A 85:422-33. 2014
    ..A companion manuscript (Part 1) details the algorithmic development of SWIFT...
  36. ncbi request reprint Dendritic cells: the immune information management experts
    Tim R Mosmann
    Nat Immunol 5:564-6. 2004
  37. ncbi request reprint How to "spot" a real killer
    Jennifer E Snyder
    Trends Immunol 24:231; author reply 231-2. 2003

Research Grants5

  1. RSV Specific Responses in Viral Elimination & Disease
    Tim Mosmann; Fiscal Year: 2004
    ..Definition of immune responses associated with severe symptoms and viral clearance should aid in the future design of immunotherapy and vaccines for RSV disease in infants. ..
  2. Differentiation & function, precursor & effector T cells
    Tim Mosmann; Fiscal Year: 2005
    ....
  3. HIGH-RESOLUTION ANALYSIS T CELL RESPONSE TO HIV ANTIGENS
    Tim Mosmann; Fiscal Year: 2001
    ..Together, this information should identify the particular immune effector functions that are induced by HIV vaccines or natural HIV infection, and also define the potential for modification of immune responses by therapeutic vaccines. ..
  4. Bi-directional interactions between immunity & pregnancy
    Tim Mosmann; Fiscal Year: 2005
    ..A clearer understanding of alterations in maternal immunity may aid the design of vaccines for use during pregnancy, and may also lead to improved strategies for inhibiting autoimmunity. ..
  5. Positive and negative effects of T cell subsets on anti-tumor immunity.
    Tim Mosmann; Fiscal Year: 2008
    ..There are nearly 1.5 million cases of cancer diagnosed each year and this research will generate insight into how to design vaccines and immunotherapy for cancer. [unreadable] [unreadable] [unreadable]..