Research Topics
| Thomas MosleySummaryAffiliation: University of Mississippi Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA StudyJennifer A Smith
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
BMC Med Genomics 2:16. 2009....- SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA studyKristin J Meyers
Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, USA
BMC Med Genet 11:160. 2010.... - The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohortsJan Bressler
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
BMC Med Genet 10:56. 2009..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants... 
Cerebral MRI findings and cognitive functioning: the Atherosclerosis Risk in Communities studyT H Mosley
Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
Neurology 64:2056-62. 2005..To examine the association between prevalent cerebral abnormalities identified on MRI and cognitive functioning in a predominantly middle-aged, population-based study cohort...- Left ventricular architecture and survival in African-Americans free of coronary heart disease (from the Atherosclerosis Risk in Communities [ARIC] study)Herman A Taylor
University of Mississippi Medical Center, Jackson, MS, USA
Am J Cardiol 99:1413-20. 2007..In men, an association between concentric LV hypertrophy and mortality risk remained... - Echocardiographic left ventricular mass index predicts incident stroke in African Americans: Atherosclerosis Risk in Communities (ARIC) StudyErvin R Fox
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, 2500, N State St, Jackson, MS 39216, USA
Stroke 38:2686-91. 2007..Despite theories that link stroke to left ventricular mass, few large, population-based studies have examined the predictive value of echocardiographically derived left ventricular mass index (LVMI) to incident stroke in African Americans... - Epidemiology of pure valvular regurgitation in the large middle-aged African American cohort of the Atherosclerosis Risk in Communities studyErvin R Fox
University of Mississippi Medical Center, Jackson, MS 39216, USA
Am Heart J 154:1229-34. 2007..There are limited data on the prevalence and the clinical and echocardiographic correlates of pure valvular regurgitation in African Americans despite the higher rates of cardiovascular disease in this group... - Heritability and genetic linkage of left ventricular mass, systolic and diastolic function in hypertensive African Americans (From the GENOA Study)Ervin R Fox
Department of Medicine, University of Mississippi School of Medicine, Jackson, USA
Am J Hypertens 23:870-5. 2010..We used pedigree information from 454 tandem markers across the genome to estimate the heritability and linkage of various echocardiographic measures of LV structure and function in a cohort of African-American hypertensive siblings... - Association of serum osteoprotegerin with left ventricular mass in African American adults with hypertensionAmit Noheria
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Am J Hypertens 23:767-74. 2010..Serum osteoprotegerin level has been reported to be associated with LVH. We investigated the association of osteoprotegerin with LV mass (LVM) in 898 African-Americans with hypertension (mean age 65 years, 71% women)... - The predictive value of left atrial size for incident ischemic stroke and all-cause mortality in African Americans: the Atherosclerosis Risk in Communities (ARIC) StudyHarsha S Nagarajarao
University of Mississippi Medical Center, Jackson, MS 39216, USA
Stroke 39:2701-6. 2008.... - Sociocultural methods in the Jackson Heart Study: conceptual and descriptive overviewThomas J Payne
School of Medicine, Examination Center, Jackson Heart Study, University of Mississippi Medical Center, Jackson 39216-4505, USA
Ethn Dis 15:S6-38-48. 2005..This paper describes the rationale and overall approach for sociocultural assessment in the JHS, both generally and for each content area... - Associations of microalbuminuria with brain atrophy and white matter hyperintensities in hypertensive sibshipsDavid S Knopman
Division of Behavioral Neurology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
J Neurol Sci 271:53-60. 2008..Because of similarities between brain and kidney microvascular disease, there may be a relationship between measures of renal microvascular disease and brain structural changes in middle aged or elderly individuals... - Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacksKristin J Meyers
Department of Epidemiology, University of Michigan, Ann Arbor, USA
Hypertension 49:992-9. 2007..We identified genetic variation that significantly influences left ventricular traits with replicable effects in a cohort of hypertensive, black siblings... - Risk factors for ischemic stroke subtypes: the Atherosclerosis Risk in Communities studyTetsuya Ohira
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Minneapolis, MN 55454-1015, USA
Stroke 37:2493-8. 2006..CONCLUSIONS: The impact of traditional and nontraditional risk factors other than hypertension on the incidence of ischemic stroke varied according to its subtype... - Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities StudyTien Yin Wong
Department of Ophthalmology, University of Wisconsin, Madison, USA
Stroke 33:1487-92. 2002..Here, we examine the relation of retinal microvascular abnormalities with cognitive function in middle-aged persons free of stroke... - Cardiovascular risk factors and cerebral atrophy in a middle-aged cohortDavid S Knopman
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Neurology 65:876-81. 2005..Because cardiovascular (CV) risk factors have been associated with declines in cognitive functions and late life dementia, CV risk factors should also be associated with brain atrophy... - Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities StudyTien Yin Wong
Singapore Eye Research Institute and Department of Ophthalmology, National University of Singapore, Singapore
Am J Ophthalmol 134:828-35. 2002..We describe the association between cognitive function and ARM in middle-aged persons... - Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) studyJingzhong Ding
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room 6009, Baltimore, MD 21205, USA
Stroke 35:16-21. 2004..We examined the associations of alcohol intake with MRI-defined cerebral abnormalities in a middle-aged, population-based cohort... - Ethnic differences in peripheral arterial disease in the NHLBI Genetic Epidemiology Network of Arteriopathy (GENOA) studyIftikhar J Kullo
Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
Vasc Med 8:237-42. 2003..Identifying additional 'novel' risk factors that account for the ethnic differences in PAD is an important next step towards understanding why such differences exist and developing more effective strategies to reduce the burden of PAD... - Sequence variations in PCSK9, low LDL, and protection against coronary heart diseaseJonathan C Cohen
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
N Engl J Med 354:1264-72. 2006..We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population... - Genome scan for hypertension in nonobese African Americans: the National Heart, Lung, and Blood Institute Family Blood Pressure ProgramAlanna C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
Am J Hypertens 17:834-8. 2004..For this reason, we sought to identify genomic regions influencing susceptibility to hypertension in a nonobese sample of hypertensive African American families... - Association of soluble cell adhesion molecules with ankle-brachial index in a biethnic cohort of predominantly hypertensive individualsMahyar Khaleghi
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
Clin Chem 54:1788-95. 2008.... - Relation between cognitive function and mortality in middle-aged adults: the atherosclerosis risk in communities studyValory N Pavlik
Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX 77005, USA
Am J Epidemiol 157:327-34. 2003..97; hazard ratio 7-point DSST score increment = 0.86, 95% confidence interval: 0.80, 0.93). Cognitive function measured in middle age appears to have prognostic importance for life expectancy similar to that reported in elderly adults... - Cerebral white matter lesions, retinopathy, and incident clinical strokeTien Yin Wong
Department of Ophthalmology, University of Wisconsin, Madison, USA
JAMA 288:67-74. 2002..White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to have a microvascular etiology and to precede the development of clinical stroke. However, few clinical data are available to support these hypotheses... - Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC studyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA
Am J Hypertens 21:533-8. 2008.... - Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA studyStephen T Turner
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Hypertension 45:793-8. 2005.... - Association of novel risk factors with the ankle brachial index in African American and non-Hispanic white populationsFarhan J Khawaja
Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 82:709-16. 2007.... - A genome-wide linkage scan for ankle-brachial index in African American and non-Hispanic white subjects participating in the GENOA studyIftikhar J Kullo
Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
Atherosclerosis 187:433-8. 2006..In conclusion, ABI is a modestly heritable trait in AA and NHW hypertensive sibships. Quantitative trait linkage analyses identified several chromosomal regions that may harbor genes influencing ABI... - Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities studyAndrea Grosso
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
Am J Ophthalmol 143:157-9. 2007..To examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes... - Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injuryMyriam Fornage
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
Hum Genet 120:671-80. 2007..They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease... - A comparison of serum creatinine-based methods for identifying chronic kidney disease in hypertensive individuals and their siblingsAndrew D Rule
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Am J Hypertens 19:608-14. 2006..The MDRD equation, derived using kidney disease patients, may misrepresent the gender- and ethnicity-specific risk of kidney disease... - Influence of genomic loci on measures of chronic kidney disease in hypertensive sibshipsStephen T Turner
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester MN 55905, USA
J Am Soc Nephrol 17:2048-55. 2006..62, at 85 cM from pter; P = 0.00023). These findings support the utility of genetic linkage analyses for identification of novel risk factors that influence measures of chronic kidney disease, particularly among black individuals... - Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participantsKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
Am J Epidemiol 164:342-8. 2006..The ApoE epsilon2 and epsilon4 alleles were associated with carotid IMT measures in both racial groups, but, after adjusting for lipid parameters, only the epsilon4 allele was associated with carotid IMT measures in African Americans... - Novel genomic loci influencing plasma homocysteine levelsIftikhar J Kullo
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
Stroke 37:1703-9. 2006..We performed linkage analyses to identify genomic regions that influence homocysteine levels in blacks and non-Hispanic whites...
Research Grants
- GENETIC DETERMINANTS OF HIGH BLOOD PRESSURE (GENOA)Thomas Mosley; Fiscal Year: 2004..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
- The ARIC and Neurocognitive Longitudinal StudyThomas Mosley; Fiscal Year: 2004..abstract_text> ..