Christopher Moskaluk

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Adenoid cystic carcinoma: clinical and molecular features
    Christopher A Moskaluk
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Head Neck Pathol 7:17-22. 2013
  2. pmc Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma
    Mikiko Takikita
    Tissue Array Research Program, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:126. 2011
  3. pmc Fully covered self-expanding metal stents placed temporarily in the bile duct: safety profile and histologic classification in a porcine model
    Mihir R Bakhru
    Digestive Health, University of Virginia, Charlottesville, VA, USA
    BMC Gastroenterol 11:76. 2011
  4. ncbi request reprint Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays
    Christopher A Moskaluk
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mod Pathol 16:913-9. 2003
  5. doi request reprint Development and characterization of xenograft model systems for adenoid cystic carcinoma
    Christopher A Moskaluk
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 91:1480-90. 2011
  6. ncbi request reprint Agarose mold embedding of cultured cells for tissue microarrays
    Christopher A Moskaluk
    Department of Pahology, University of Virginia Health System, Charlottesville, Virginia, USA
    Diagn Mol Pathol 11:234-8. 2002
  7. ncbi request reprint Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas
    Andy Beckler
    Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer 98:1547-51. 2003
  8. pmc Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis
    Adam H Johnson
    Digestive Health Center of Excellence, University of Virginia Health System, P O Box 800708, Charlottesville, VA 22908 0708, USA
    Am J Pathol 167:577-84. 2005
  9. pmc Hepatocellular ballooning in NASH
    Stephen Caldwell
    GI Hepatology, University of Virginia, Charlottesville, VA, USA
    J Hepatol 53:719-23. 2010
  10. pmc Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma
    Henry F Frierson
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0214, USA
    Am J Pathol 161:1315-23. 2002

Research Grants

  1. Tumor suppressor gene at 6q in adenoid cystic carcinoma
    Christopher Moskaluk; Fiscal Year: 2006
  2. Tissue procurement and processing for molecular analysis
    Christopher Moskaluk; Fiscal Year: 2007

Collaborators

Detail Information

Publications52

  1. pmc Adenoid cystic carcinoma: clinical and molecular features
    Christopher A Moskaluk
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Head Neck Pathol 7:17-22. 2013
    ..The molecular consequences of this alteration are incompletely understood, as are secondary molecular alterations that contribute to the neoplastic phenotype of ACC...
  2. pmc Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma
    Mikiko Takikita
    Tissue Array Research Program, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:126. 2011
    ..The overexpression of Her2 and Her3 receptors have been identified in various solid tumors, but its prognostic relevance in HNSCC remains controversial...
  3. pmc Fully covered self-expanding metal stents placed temporarily in the bile duct: safety profile and histologic classification in a porcine model
    Mihir R Bakhru
    Digestive Health, University of Virginia, Charlottesville, VA, USA
    BMC Gastroenterol 11:76. 2011
    ..Fully covered Self-Expanding metal stents (FCSEMS) have been shown efficacious in palliating malignant biliary obstructions. There is little data analyzing mucosal response to their temporary placement in the bile duct...
  4. ncbi request reprint Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays
    Christopher A Moskaluk
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mod Pathol 16:913-9. 2003
    ..Cdx2 shows a limited range of expression in the spectrum of human tissues and neoplasia and thus may have utility in determining the site of origin of tumors in certain clinical situations...
  5. doi request reprint Development and characterization of xenograft model systems for adenoid cystic carcinoma
    Christopher A Moskaluk
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 91:1480-90. 2011
    ....
  6. ncbi request reprint Agarose mold embedding of cultured cells for tissue microarrays
    Christopher A Moskaluk
    Department of Pahology, University of Virginia Health System, Charlottesville, Virginia, USA
    Diagn Mol Pathol 11:234-8. 2002
    ..Histologic sections of TMAs prepared in this manner were validated in immunohistochemical and in situ hybridization assays...
  7. ncbi request reprint Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas
    Andy Beckler
    Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer 98:1547-51. 2003
    ..Recently, DARPP-32 and a truncated isoform, t-DARPP, have been cloned in gastric carcinoma. The extent of DARPP-32 and t-DARPP expression in human epithelial tissues and carcinomas remained unknown...
  8. pmc Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis
    Adam H Johnson
    Digestive Health Center of Excellence, University of Virginia Health System, P O Box 800708, Charlottesville, VA 22908 0708, USA
    Am J Pathol 167:577-84. 2005
    ..001). These results suggest that Cldn7 expression is an early event in gastric tumorigenesis that is maintained throughout tumor progression...
  9. pmc Hepatocellular ballooning in NASH
    Stephen Caldwell
    GI Hepatology, University of Virginia, Charlottesville, VA, USA
    J Hepatol 53:719-23. 2010
    ..Fat droplets are emerging as important organelles in cell metabolism. To address a possible relation between fat droplets and ballooning, we studied fat staining, H&E, and keratin 18 staining in human NASH...
  10. pmc Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma
    Henry F Frierson
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0214, USA
    Am J Pathol 161:1315-23. 2002
    ....
  11. ncbi request reprint Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinoma
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Surg Pathol 30:744-9. 2006
    ....
  12. ncbi request reprint Measurement of the invasion depth of extrahepatic bile duct carcinoma: An alternative method overcoming the current T classification problems of the AJCC staging system
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Surg Pathol 31:199-206. 2007
    ....
  13. ncbi request reprint p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance
    Seung Mo Hong
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    J Mol Histol 38:167-75. 2007
    ..Our results strongly imply that the p53 family members have different functions in EBD carcinomas. Our data also indicate that interactions between p63 and p73 play an important role in tumorigenesis of EBD carcinoma...
  14. pmc Clustering of molecular alterations in gastroesophageal carcinomas
    Natalie Koon
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Neoplasia 6:143-9. 2004
    ..The observed phenomenon of the presence of large amplification areas, yet clustering of overexpressed genes to relatively small loci, may suggest a high organization of chromatin and cancer-related genes in the nucleus...
  15. ncbi request reprint Gastric cancers overexpress S100A calcium-binding proteins
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:6823-6. 2002
    ..Our results indicate that S100A proteins may be important for gastric tumorigenesis. Additional investigations are required to elucidate the biological role of calcium-binding proteins in cancer...
  16. ncbi request reprint Cdx2 as a marker of epithelial intestinal differentiation in the esophagus
    Roy W Phillips
    Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 27:1442-7. 2003
    ..Acid mucin in non-goblet columnar cells is a common feature of Barrett's and junctional-type epithelium and may not always be indicative of intestinal metaplasia...
  17. ncbi request reprint Intestinal ischemia and peripheral gangrene in a patient with chronic renal failure
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
    Gastroenterology 122:495-9. 2002
    ..Prompt diagnosis is crucial, as parathyroidectomy may result in clinical improvement in up to two thirds of patients who present with elevated parathyroid hormone levels...
  18. ncbi request reprint Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:4061-4. 2002
    ..Our results reveal for the first time the presence of these signaling molecules in human cancer and suggest that they may be important for gastric tumorigenesis...
  19. doi request reprint Intracellular localization of GASP/ECOP/VOPP1
    Alexander Baras
    Department of Pathology, University of Virginia, Charlottesville, 22908, USA
    J Mol Histol 41:153-64. 2010
    ..These findings throw into doubt the hypothesis that VOPP1 interacts directly with cytoplasmic mediators of the NF kappa B pathway, and suggest that the prosurvival phenotype conferred by this gene product is mediated by other mechanisms...
  20. ncbi request reprint RhoGDI2 is an invasion and metastasis suppressor gene in human cancer
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 62:6418-23. 2002
    ..These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human cancer, and a promising target for therapy...
  21. ncbi request reprint Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays
    Yongtao Yu
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 87:430-9. 2007
    ..Our data suggest that gene mutation and/or epigenetic events that cannot be detected by assay of gross alteration of chromosomal structure are likely to underlie the malignant transformation events of this tumor type...
  22. ncbi request reprint Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma
    Sue Rutherford
    Department of Pathology, University of Virginia, P O Box 800214 Health Sciences Center, Charlottesville VA 22908, USA
    Cancer Lett 236:309-17. 2006
    ..Analysis of gene expression showed no substantial differences between samples of normal salivary gland and ACC, eliminating the most obvious candidate genes in this locus as tumor suppressors in ACC...
  23. pmc Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas
    Charles A Fox
    Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 7:407-16. 2005
    ..These potential biomarkers, as well as the relative expression of genes from BE1 versus those from BE2, may be validated in the future to aid in risk stratification and guide treatment protocols in patients with BE and associated AC...
  24. ncbi request reprint Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas
    Andrew D Beckler
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Cancer 98:2184-91. 2003
    ..As loss of trefoil factor 1 (TFF1) expression leads to neoplastic growth in the antropyloric mucosa of mice, the authors sought to comprehensively study the human TFF1 gene in primary gastric carcinomas...
  25. pmc A functional proteomic method for biomarker discovery
    Fred Reynolds
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e22471. 2011
    ..For proof of principle, the method successfully identified molecular binding partners, three of them novel, for 15 peptides specific for pancreatic cancer...
  26. ncbi request reprint Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma
    Sue Rutherford
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Lab Invest 85:1076-85. 2005
    ..This combined genetic and genomic analysis provides several candidate genes to test for functional tumor suppressor activity in ACC...
  27. ncbi request reprint CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, USA
    Am J Clin Pathol 124:361-70. 2005
    ..05). Expression of CDX2 and MUC2 supports that intestinal differentiation is present in specific subtypes of EBD carcinomas, and their expression status correlates with patients' overall survival...
  28. pmc Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor
    Sarah E Aiyar
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Genes Dev 18:2134-46. 2004
    ..We suggest that this new level of regulation may be important to control the duration and magnitude of a rapid and reversible hormonal response...
  29. ncbi request reprint Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas
    Henry F Frierson
    Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
    Hum Pathol 34:605-9. 2003
    ....
  30. ncbi request reprint PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
    Oncogene 23:6788-97. 2004
    ....
  31. doi request reprint Proteomic anatomy of human skin
    Leann M Mikesh
    Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA
    J Proteomics 84:190-200. 2013
    ....
  32. pmc Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy
    COURTNEY POLLARD
    Department of Molecular Physiology, University of Virginia, Charlottesville, 22908, USA
    Am J Pathol 175:1824-30. 2009
    ..Although these predictive results were obtained on tumor tissues, the presence of GGH and DBI in urine serves as a rationale for developing them as urinary markers of clinical outcomes for patients treated with neoadjuvant MVAC...
  33. doi request reprint Predicting residual neck disease in patients with oropharyngeal squamous cell carcinoma treated with radiation therapy: utility of p16 status
    David C Shonka
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Arch Otolaryngol Head Neck Surg 135:1126-32. 2009
    ..To identify factors that predict complete response of cervical nodal disease to radiation therapy (RT) in patients with oropharyngeal squamous cell carcinoma (OP-SCCA)...
  34. pmc Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis
    Ok Jae Lee
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Neoplasia 7:854-61. 2005
    ....
  35. doi request reprint Intensity-modulated radiotherapy outcomes for oropharyngeal squamous cell carcinoma patients stratified by p16 status
    Asal Shoushtari
    Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA
    Cancer 116:2645-54. 2010
    ..Patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with intensity-modulated radiotherapy (IMRT) were stratified by p16 status, neck dissection, and chemotherapy to correlate these factors with outcomes...
  36. doi request reprint Clinical nodal staging of T1-2 tonsillar squamous cell carcinoma stratified by p16 status and implications for ipsilateral neck irradiation
    Asal N Shoushtari
    Departments of Radiation Oncology, University of Virginia, Charlottesville, VA 22903, USA
    Cancer J 16:284-7. 2010
    ..We analyzed the nodal staging of T1-2 tonsillar squamous cell carcinoma stratified for p16 status, a marker of human papillomavirus positivity...
  37. ncbi request reprint Interpretation of RET immunostaining in follicular lesions of the thyroid
    Lisa A Cerilli
    Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health Sciences Center, Charlottesville, USA
    Am J Clin Pathol 118:186-93. 2002
    ..Further study is warranted to determine whether this represents activation by gene fusion or some other mechanism in this subset of thyroid neoplasms...
  38. doi request reprint Microchip-based solid-phase purification of RNA from biological samples
    Kristin A Hagan
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA
    Anal Chem 80:8453-60. 2008
    ..RNA was purified using the microchip-based method from neat semen, a mock semen stain, and cultured cells from a common pediatric cancer, alveolar rhabdomyosarcoma...
  39. doi request reprint Clinical challenges and images in GI. Ganglioneuromatosis polyposis
    Talat M Nazir
    Departments of Pathology and Colorectal Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Gastroenterology 134:386, 646. 2008
  40. doi request reprint Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers
    Andrew M Bellizzi
    Department of Pathology, The Ohio State University Medical Center Columbus, OH, USA
    Am J Surg Pathol 33:1608-14. 2009
    ..Differential p16 and p53 expression in BSCC suggests that these tumors are molecularly distinct from conventional esophageal squamous cell carcinomas...
  41. ncbi request reprint The prevalence of pancreatic intraepithelial neoplasia in pancreata with uncommon types of primary neoplasms
    Edward B Stelow
    Department of Pathology, University of Virginia Health Sciences, Box 800214, Charlottesville, VA 22908, USA
    Am J Surg Pathol 30:36-41. 2006
    ..Because of the ubiquitous nature of PanIN, it should not be used histologically to assist in the diagnosis and subclassification of pancreatic neoplasia...
  42. ncbi request reprint CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray
    Brenda Y Hernandez
    Hawaii Tumor Registry Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Hum Pathol 36:275-81. 2005
    ..This well-characterized TMA offers a powerful tool for testing hypotheses regarding colorectal carcinogenesis, including the identification of potential markers of neoplastic development and progression...
  43. pmc Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum
    John B Welsh
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3410-5. 2003
    ....
  44. ncbi request reprint Alterations in Barrett's-related adenocarcinomas: a proteomic approach
    Dunfa Peng
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Int J Cancer 122:1303-10. 2008
    ..In conclusion, we have identified and validated several novel proteins that are involved in Barrett's carcinogenesis...
  45. ncbi request reprint Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expression
    Mohammad H Razvi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Genes Chromosomes Cancer 46:914-28. 2007
    ..ANPEP is a secreted protein that may have diagnostic and/or prognostic significance for Barrett's progression. The use of genomic approaches in this study provided useful information about the molecular pathobiology of BAs...
  46. pmc Expression of calcium-binding proteins S100A2 and S100A4 in Barrett's adenocarcinomas
    Ok Jae Lee
    Department of Surgery and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neoplasia 8:843-50. 2006
    ..027). These results demonstrate frequent cytosolic overexpression of S100A2 and S100A4 in BAs. Further studies are ongoing to understand the biological significance of these S100A proteins in Barrett's tumorigenesis...
  47. ncbi request reprint Vanishing prostate cancer syndrome: symptom of a larger clinical issue
    Christopher A Moskaluk
    Am J Surg Pathol 29:561-3. 2005
  48. ncbi request reprint Standardization of clinical immunohistochemistry: why, how, and by whom?
    Christopher A Moskaluk
    Am J Clin Pathol 118:669-71. 2002
  49. ncbi request reprint Genetic analysis of invasive carcinoma arising in intraductal oncocytic papillary neoplasm of the pancreas
    Shetal A Patel
    Department of Pathology, University of Virginia, Charlottesville 22908, U S A
    Am J Surg Pathol 26:1071-7. 2002
    ..The lack of mutation in these genes may be an explanation for the typically indolent clinical behavior of intraductal oncocytic papillary neoplasms...
  50. ncbi request reprint Tissue processing re-visited: a shifting paradigm in surgical pathology
    Christopher A Moskaluk
    Diagn Mol Pathol 14:125-6. 2005
  51. ncbi request reprint Tissues from population-based cancer registries: a novel approach to increasing research potential
    Marc T Goodman
    Etiology Program, Hawaii Tumor Registry, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Hum Pathol 36:812-20. 2005
    ..SEER-based tissue resources represent a step forward in true, population-based tissue repositories of tumors from US patients and may serve as a foundation for molecular epidemiology studies of cancer in this country...
  52. ncbi request reprint Re: the feasibility of gene expression profiling generated in fine-needle aspiration specimens from patients with follicular lymphoma and diffuse large B-cell lymphoma
    Edward B Stelow
    Cancer 111:200-1; author reply 201-2. 2007

Research Grants7

  1. Tumor suppressor gene at 6q in adenoid cystic carcinoma
    Christopher Moskaluk; Fiscal Year: 2006
    ..Since AGO appears to have a smaller number of genetic changes than these other malignancies, it may serve as a simpler system to identify the 6q tumor suppressor gene. ..
  2. Tissue procurement and processing for molecular analysis
    Christopher Moskaluk; Fiscal Year: 2007
    ..Improvement of the CHTN will be provided by partcipating in organizational quality management\par practices and offering leadership in integrating new technological and bio- informatic advances.\fs20\par \par } ..