- A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditionsHunter N B Moseley
Department of Chemistry and Center for Regulatory and Environmental Analytical Metabolomics CREAM, University of Louisville, Louisville, KY 40292, USA
BMC Biol 9:37. 2011..UDP-GlcNAc is an activated building block for protein glycosylation, which is an important regulatory mechanism in the development of many prominent human diseases including cancer and diabetes...
- Correcting for the effects of natural abundance in stable isotope resolved metabolomics experiments involving ultra-high resolution mass spectrometryHunter Nb Moseley
Department of Chemistry, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, Kentucky, USA
BMC Bioinformatics 11:139. 2010..This peak resolution and identification come from the very high mass resolution and accuracy of FT-ICR-MS and present an analytically solvable deisotoping problem, even in the context of stable-isotope enrichment...
- Automated protein resonance assignments of magic angle spinning solid-state NMR spectra of β1 immunoglobulin binding domain of protein G (GB1)Hunter N B Moseley
Department of Chemistry, University of Louisville, KY 40292, USA
J Biomol NMR 48:123-8. 2010..1% assignment of the N, CO, CA, and CB resonances with no errors using peak lists from NCACX 3D, CANcoCA 3D, and CANCOCX 4D experiments. This proof of concept demonstrates the tractability of this problem...