Research Topics
Genomes and Genes
| Jorge MoscatSummaryAffiliation: University of Cincinnati Country: USA Publications
Research Grants
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Detail Information
Publications
Cell signaling and function organized by PB1 domain interactionsJorge Moscat
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
Mol Cell 23:631-40. 2006..Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions...- Signal integration and diversification through the p62 scaffold proteinJorge Moscat
Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
Trends Biochem Sci 32:95-100. 2007..The availability of mice in which p62 has been genetically inactivated is providing new insight into the mechanism and function of p62 at a whole-organism level... 
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitisAngeles Duran
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
EMBO J 23:4595-605. 2004..In contrast, Par-4-/- mice have increased sensitivity to ConA-induced liver damage and IL-4 signaling. This unveils a novel and critical involvement of PKCzeta in the IL-4/Stat6 signaling pathway in vitro and in vivo...- The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesisAngeles Duran
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
Dev Cell 6:303-9. 2004..These observations demonstrate that p62 is an important mediator during osteoclastogenesis and induced bone remodeling... - Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivoAnita S Galvez
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267, USA
Mol Cell Biol 29:104-15. 2009..We also show that PKCzeta represses histone acetylation at the C/EBPbeta element in the IL-6 promoter. Therefore, PKCzeta, by controlling the production of IL-6, is a critical signaling molecule in tumorigenesis... - Regulation of mature T lymphocyte proliferation and differentiation by Par-4Maria Jose Lafuente
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
EMBO J 22:4689-98. 2003..This is compelling evidence that Par-4 is a novel modulator of the immune response through its ability to impact aPKC activity, which translates into lower JNK signaling... - Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivoJun Qi Yang
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Proc Natl Acad Sci U S A 106:1099-104. 2009..Therefore PKC lambda/iota emerges as a critical regulator of Th 2 activation... - PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intoleranceSang Jun Lee
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
Cell Metab 12:65-77. 2010..These results establish PKCzeta as a critical negative regulator of IL-6 in the control of obesity-induced inflammation in adipocytes... - NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivoJun Qi Yang
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
EMBO J 29:3421-33. 2010..These results establish NBR1 as a novel PB1 adapter in Th2 differentiation and asthma... 
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesisSang Jun Lee
Department of Cancer and Cell Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
EMBO Rep 11:226-32. 2010..These results establish genetically that p62 is a crucial regulator of ERK1 in metabolism...- Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formationAmitava Sengupta
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 108:9957-62. 2011.... - Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesisJayashree Joshi
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
EMBO J 27:2181-93. 2008.... - Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblastsCarlota García-Hoz
Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, 28049 Madrid, Universidad Autonoma de Madrid, Spain
J Biol Chem 287:7792-802. 2012..Taken together, our results show that PKCζ is essential for Gq-dependent ERK5 activation in cardiomyocytes and cardiac fibroblasts and indicate a key cardiac physiological role for the Gα(q)/PKCζ/ERK5 signaling axis... - The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesisAngeles Duran
Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Cancer Cell 13:343-54. 2008.... - Control of T helper 2 cell function and allergic airway inflammation by PKCzetaPilar Martin
Centro de Biología Molecular Severo Ochoa and Departamento de Inmunologia y Oncologia Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Proc Natl Acad Sci U S A 102:9866-71. 2005..Moreover, PKCzeta-/- mice display dramatic inhibition of ovalbumin-induced allergic airway disease, strongly suggesting that PKCzeta can be a therapeutic target in asthma... - NF-kappaB activation by protein kinase C isoforms and B-cell functionJorge Moscat
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, Spain
EMBO Rep 4:31-6. 2003..These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB... - Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activationAngeles Duran
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
EMBO J 22:3910-8. 2003..These results demonstrate the mechanism whereby zetaPKC regulates NF-kappaB activation in vivo... - The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammationPilar Martin
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
EMBO J 25:3524-33. 2006.... - Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62Angelina Rodriguez
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Cell Metab 3:211-22. 2006..We propose that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity... - DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in DrosophilaSol Sotillos
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Univerisidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
J Cell Biol 166:549-57. 2004..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC... - The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathwayAntonia Avila
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
Mol Cell Biol 22:8787-95. 2002..Collectively, these results demonstrate the conservation of the p62-aPKC complex for the control of innate immunity signal transduction in Drosophila melanogaster... - Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferationJuan F Linares
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267, USA
Mol Cell Biol 31:105-17. 2011..Therefore, p62 emerges as a node for the control of not only cell survival but also cell transit through mitosis... - G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR)Carlota García-Hoz
Departamento de Biologia Molecular, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28049 Madrid, Spain
J Biol Chem 285:13480-9. 2010..These data put forward a novel function of G alpha(q) as a scaffold protein involved in the modulation of the ERK5 cascade by GPCR that could be relevant in G(q)-mediated physiological functions... - Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38Isabel Garcia-Cao
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
EMBO Rep 4:307-12. 2003..Higher levels of an anti-apoptotic JNK-inhibitor protein, X-chromosome-linked inhibitor of apoptosis, in Par4(-/-) EFs might explain the inhibition of JNK activation in these cells... - Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4Maria T Diaz-Meco
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Cell Cycle 7:2817-20. 2008.... - The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapiesJorge Moscat
, , Canto Blanco, 28049 Madrid, Spain
Adv Enzyme Regul 42:173-9. 2002 - p62 at the crossroads of autophagy, apoptosis, and cancerJorge Moscat
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Cell 137:1001-4. 2009..2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival... - Par-4 keeps the atypical PKCs at bayJorge Moscat
, , Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
Cell Cycle 2:71-2. 2003 - Role of zeta PKC in B-cell signaling and functionPilar Martin
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, E 28049 Madrid, Spain
EMBO J 21:4049-57. 2002..Furthermore, zeta PKC-/- mice are unable to mount an optimal T-cell-dependent immune response. Collectively, these results genetically establish a critical role for zeta PKC in B-cell function in vitro and in vivo... - Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteinsMarie W Wooten
Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
J Biol Chem 283:6783-9. 2008..Thus, p62 has a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to balance the turnover of Lys63-polyubiquitinated proteins such as TrkA... - The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitinationMarie W Wooten
Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
J Biol Chem 280:35625-9. 2005..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway... - OPR, PC and AID: all in the PB1 familyChris P Ponting
Trends Biochem Sci 27:10. 2002 - The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signalingCarme Sole
Group Cell Signalling and Apoptosis, Department of Basic Medical Sciences, Universitat de Lleida, 25008 Lleida, Spain
J Cell Biol 167:479-92. 2004..These results reveal a new function of FAIM in promoting neurite outgrowth by a mechanism involving activation of the Ras-ERK pathway and NF-kappa B... - Tumour-suppression activity of the proapoptotic regulator Par4Isabel Garcia-Cao
Spanish National Cancer Center CNIO, 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
EMBO Rep 6:577-83. 2005..These data show that Par4 has an important role in tumour suppression, with a particular relevance in the endometrium and prostate... - Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegenerationJ Ramesh Babu
Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
J Neurochem 106:107-20. 2008..Thus, these findings provide new insight into manifestation of sporadic Alzheimer disease and the impact of obesity...
Research Grants
- Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lungJorge Moscat; Fiscal Year: 2009..It is expected that the knowledge gained through this work will contribute to the development of new, more specific and, thus, more effective drug therapies for this type of cancer. ..
- Obesity-induced inflammation and insulin resistance by the p62/PKCzeta signalingJorge Moscat; Fiscal Year: 2010....
- The p62/atypical PKC signaling complex in Th2 differentiation and asthmaJorge Moscat; Fiscal Year: 2010....
- Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lungJorge Moscat; Fiscal Year: 2010..It is expected that the knowledge gained through this work will contribute to the development of new, more specific and, thus, more effective drug therapies for this type of cancer. ..