Jorge Moscat

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Cell signaling and function organized by PB1 domain interactions
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    Mol Cell 23:631-40. 2006
  2. ncbi request reprint Signal integration and diversification through the p62 scaffold protein
    Jorge Moscat
    Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
    Trends Biochem Sci 32:95-100. 2007
  3. pmc Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    EMBO J 23:4595-605. 2004
  4. ncbi request reprint The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Dev Cell 6:303-9. 2004
  5. pmc Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo
    Jun Qi Yang
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 106:1099-104. 2009
  6. pmc Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo
    Anita S Galvez
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267, USA
    Mol Cell Biol 29:104-15. 2009
  7. pmc Regulation of mature T lymphocyte proliferation and differentiation by Par-4
    Maria Jose Lafuente
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:4689-98. 2003
  8. pmc NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
    Jun Qi Yang
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    EMBO J 29:3421-33. 2010
  9. pmc PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
    Sang Jun Lee
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cell Metab 12:65-77. 2010
  10. pmc Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
    Jayashree Joshi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    EMBO J 27:2181-93. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Cell signaling and function organized by PB1 domain interactions
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    Mol Cell 23:631-40. 2006
    ..Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions...
  2. ncbi request reprint Signal integration and diversification through the p62 scaffold protein
    Jorge Moscat
    Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
    Trends Biochem Sci 32:95-100. 2007
    ..The availability of mice in which p62 has been genetically inactivated is providing new insight into the mechanism and function of p62 at a whole-organism level...
  3. pmc Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    EMBO J 23:4595-605. 2004
    ..In contrast, Par-4-/- mice have increased sensitivity to ConA-induced liver damage and IL-4 signaling. This unveils a novel and critical involvement of PKCzeta in the IL-4/Stat6 signaling pathway in vitro and in vivo...
  4. ncbi request reprint The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Dev Cell 6:303-9. 2004
    ..These observations demonstrate that p62 is an important mediator during osteoclastogenesis and induced bone remodeling...
  5. pmc Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo
    Jun Qi Yang
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 106:1099-104. 2009
    ..Therefore PKC lambda/iota emerges as a critical regulator of Th 2 activation...
  6. pmc Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo
    Anita S Galvez
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267, USA
    Mol Cell Biol 29:104-15. 2009
    ..We also show that PKCzeta represses histone acetylation at the C/EBPbeta element in the IL-6 promoter. Therefore, PKCzeta, by controlling the production of IL-6, is a critical signaling molecule in tumorigenesis...
  7. pmc Regulation of mature T lymphocyte proliferation and differentiation by Par-4
    Maria Jose Lafuente
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:4689-98. 2003
    ..This is compelling evidence that Par-4 is a novel modulator of the immune response through its ability to impact aPKC activity, which translates into lower JNK signaling...
  8. pmc NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
    Jun Qi Yang
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    EMBO J 29:3421-33. 2010
    ..These results establish NBR1 as a novel PB1 adapter in Th2 differentiation and asthma...
  9. pmc PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
    Sang Jun Lee
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cell Metab 12:65-77. 2010
    ..These results establish PKCzeta as a critical negative regulator of IL-6 in the control of obesity-induced inflammation in adipocytes...
  10. pmc Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
    Jayashree Joshi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    EMBO J 27:2181-93. 2008
    ....
  11. doi request reprint A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis
    Sang Jun Lee
    Department of Cancer and Cell Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    EMBO Rep 11:226-32. 2010
    ..These results establish genetically that p62 is a crucial regulator of ERK1 in metabolism...
  12. pmc Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation
    Amitava Sengupta
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:9957-62. 2011
    ....
  13. ncbi request reprint Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
    Angelina Rodriguez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Cell Metab 3:211-22. 2006
    ..We propose that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity...
  14. pmc Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts
    Carlota García-Hoz
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, 28049 Madrid, Universidad Autonoma de Madrid, Spain
    J Biol Chem 287:7792-802. 2012
    ..Taken together, our results show that PKCζ is essential for Gq-dependent ERK5 activation in cardiomyocytes and cardiac fibroblasts and indicate a key cardiac physiological role for the Gα(q)/PKCζ/ERK5 signaling axis...
  15. doi request reprint The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis
    Angeles Duran
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Cell 13:343-54. 2008
    ....
  16. pmc Control of T helper 2 cell function and allergic airway inflammation by PKCzeta
    Pilar Martin
    Centro de Biología Molecular Severo Ochoa and Departamento de Inmunologia y Oncologia Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 102:9866-71. 2005
    ..Moreover, PKCzeta-/- mice display dramatic inhibition of ovalbumin-induced allergic airway disease, strongly suggesting that PKCzeta can be a therapeutic target in asthma...
  17. pmc Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:3910-8. 2003
    ..These results demonstrate the mechanism whereby zetaPKC regulates NF-kappaB activation in vivo...
  18. pmc NF-kappaB activation by protein kinase C isoforms and B-cell function
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, Spain
    EMBO Rep 4:31-6. 2003
    ..These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB...
  19. pmc The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation
    Pilar Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    EMBO J 25:3524-33. 2006
    ....
  20. pmc DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Univerisidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Cell Biol 166:549-57. 2004
    ..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC...
  21. pmc The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway
    Antonia Avila
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Mol Cell Biol 22:8787-95. 2002
    ..Collectively, these results demonstrate the conservation of the p62-aPKC complex for the control of innate immunity signal transduction in Drosophila melanogaster...
  22. pmc Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation
    Juan F Linares
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Mol Cell Biol 31:105-17. 2011
    ..Therefore, p62 emerges as a node for the control of not only cell survival but also cell transit through mitosis...
  23. pmc G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR)
    Carlota García-Hoz
    Departamento de Biologia Molecular, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Biol Chem 285:13480-9. 2010
    ..These data put forward a novel function of G alpha(q) as a scaffold protein involved in the modulation of the ERK5 cascade by GPCR that could be relevant in G(q)-mediated physiological functions...
  24. pmc Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38
    Isabel Garcia-Cao
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO Rep 4:307-12. 2003
    ..Higher levels of an anti-apoptotic JNK-inhibitor protein, X-chromosome-linked inhibitor of apoptosis, in Par4(-/-) EFs might explain the inhibition of JNK activation in these cells...
  25. ncbi request reprint Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4
    Maria T Diaz-Meco
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Cell Cycle 7:2817-20. 2008
    ....
  26. ncbi request reprint The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Adv Enzyme Regul 42:173-9. 2002
  27. doi request reprint p62 at the crossroads of autophagy, apoptosis, and cancer
    Jorge Moscat
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cell 137:1001-4. 2009
    ..2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival...
  28. ncbi request reprint Par-4 keeps the atypical PKCs at bay
    Jorge Moscat
    Centre de Biología Molecular Severe Ochoa, Consejo Superior de Investigations Cientílicos, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    Cell Cycle 2:71-2. 2003
  29. pmc Role of zeta PKC in B-cell signaling and function
    Pilar Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, E 28049 Madrid, Spain
    EMBO J 21:4049-57. 2002
    ..Furthermore, zeta PKC-/- mice are unable to mount an optimal T-cell-dependent immune response. Collectively, these results genetically establish a critical role for zeta PKC in B-cell function in vitro and in vivo...
  30. doi request reprint Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 283:6783-9. 2008
    ..Thus, p62 has a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to balance the turnover of Lys63-polyubiquitinated proteins such as TrkA...
  31. ncbi request reprint The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway...
  32. ncbi request reprint OPR, PC and AID: all in the PB1 family
    Chris P Ponting
    Trends Biochem Sci 27:10. 2002
  33. pmc The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling
    Carme Sole
    Group Cell Signalling and Apoptosis, Department of Basic Medical Sciences, Universitat de Lleida, 25008 Lleida, Spain
    J Cell Biol 167:479-92. 2004
    ..These results reveal a new function of FAIM in promoting neurite outgrowth by a mechanism involving activation of the Ras-ERK pathway and NF-kappa B...
  34. pmc Tumour-suppression activity of the proapoptotic regulator Par4
    Isabel Garcia-Cao
    Spanish National Cancer Center CNIO, 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
    EMBO Rep 6:577-83. 2005
    ..These data show that Par4 has an important role in tumour suppression, with a particular relevance in the endometrium and prostate...
  35. doi request reprint Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
    J Ramesh Babu
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Neurochem 106:107-20. 2008
    ..Thus, these findings provide new insight into manifestation of sporadic Alzheimer disease and the impact of obesity...

Research Grants6

  1. Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lung
    Jorge Moscat; Fiscal Year: 2009
    ..It is expected that the knowledge gained through this work will contribute to the development of new, more specific and, thus, more effective drug therapies for this type of cancer. ..
  2. Obesity-induced inflammation and insulin resistance by the p62/PKCzeta signaling
    Jorge Moscat; Fiscal Year: 2010
    ....
  3. The p62/atypical PKC signaling complex in Th2 differentiation and asthma
    Jorge Moscat; Fiscal Year: 2010
    ....
  4. Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lung
    Jorge Moscat; Fiscal Year: 2010
    ..It is expected that the knowledge gained through this work will contribute to the development of new, more specific and, thus, more effective drug therapies for this type of cancer. ..