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Genomes and Genes | Gregory J MortonSummaryAffiliation: University of Washington Country: USA Publications
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Publications
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissueMiles E Matsen
Dept of Medicine, Univ of Washington at South Lake Union, 850 Republican St, N334, Box 358055, Seattle, WA 98195
Am J Physiol Endocrinol Metab 304:E734-46. 2013....
The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signalingGregory J Morton
Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
Am J Physiol Endocrinol Metab 297:E202-10. 2009....- Leptin and the central nervous system control of glucose metabolismGregory J Morton
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Physiol Rev 91:389-411. 2011..Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders... - Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerveJonathan German
Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
Endocrinology 150:4502-11. 2009..We conclude that hypothalamic leptin action increases peripheral insulin sensitivity primarily via effects on the liver and that the mechanism underlying this effect is dependent on the hepatic branch of the vagus nerve... - Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese ratsGregory J Morton
Dept of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Seattle, WA 98109, USA
Am J Physiol Endocrinol Metab 302:E134-44. 2012.... - Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in miceGregory J Morton
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, USA
Am J Physiol Endocrinol Metab 300:E392-401. 2011..Thus, plasma leptin is a physiological regulator of spontaneous physical activity, but the nature of leptin's effect on activity is dependent on food availability... - Hypothalamic leptin regulation of energy homeostasis and glucose metabolismGregory J Morton
Department of Medicine, Harbourview Medical Center, University of Washington, Seattle, WA 98104, USA
J Physiol 583:437-43. 2007.... 
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neuronsGregory J Morton
Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
Cell Metab 2:411-20. 2005..These findings suggest that hypothalamic leptin signaling is an important determinant of glucose metabolism and that the underlying neuronal mechanism involves PI3K...- Leptin deficiency causes insulin resistance induced by uncontrolled diabetesJonathan P German
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 59:1626-34. 2010..This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements induced by uDM... - Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese ratsDavid A Sarruf
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 59:1817-24. 2010..The current studies investigate whether central FGF21 treatment recapitulates these effects... - Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemiaJonathan P German
Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, N334, PO Box 358055, Seattle, Washington 98195, USA
Endocrinology 152:394-404. 2011.... - Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signalingChristopher D Morrison
University of Washington, Harborview Medical Center, Box 359757, 325 Ninth Ave, Seattle, WA 98108, USA
Am J Physiol Endocrinol Metab 289:E1051-7. 2005..In addition, these data suggest that leptin activation of STAT3 is insufficient to inhibit expression of Npy or Agrp in the absence of PI3K signaling... - Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feedingShinsuke Oh-I
UW Medicine at South Lake Union, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
Am J Physiol Endocrinol Metab 299:E47-53. 2010..These observations add to growing evidence linking hypothalamic inflammation to obesity pathogenesis... - Leptin action in the forebrain regulates the hindbrain response to satiety signalsGregory J Morton
Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
J Clin Invest 115:703-10. 2005..These findings demonstrate that forebrain signaling by leptin, a long-term regulator of body adiposity, limits food intake on a meal-to-meal basis by regulating the hindbrain response to short-acting satiety signals... - Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosisHarvey K Chiu
Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
Endocrinology 151:993-1001. 2010..Our results demonstrate that in mice, HL deficiency protects against diet-induced obesity and its hepatic sequelae. Inhibition of HL-activity may therefore have value in the prevention and/or treatment of obesity... - Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasisBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, WA 98104 2499, USA
Am J Physiol Endocrinol Metab 287:E1107-13. 2004..05 vs. vehicle), an effect similar to that of ADX. These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin... - A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrainDenis G Baskin
Office of Research and Development Medical Research Service, Veterans Affairs Puget Sound Health Care System, Department of Veterans Affairs Medical Center, Seattle, Washington 98108, USA
Endocrinology 151:4207-13. 2010.... - Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balanceBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
Brain Res 1144:101-6. 2007.... - Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8James E Blevins
VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009.... - Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistanceFrancis Kim
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
Arterioscler Thromb Vasc Biol 28:1982-8. 2008.... - Identification of body fat mass as a major determinant of metabolic rate in miceKarl J Kaiyala
Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, Washington, USA
Diabetes 59:1657-66. 2010.... - A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patientsChristian L Roth
Division of Endocrinology, Seattle Children s Research Institute, University of Washington, Seattle, Washington 98101, USA
Pediatr Res 69:230-6. 2011.... - Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in miceRichard W Gelling
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Endocrinology 149:6053-64. 2008..These findings collectively identify a novel and potentially important role for TACE in energy homeostasis... - Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feedingSanshiro Tateya
Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 60:2792-801. 2011.... - Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) ratsGregory J Morton
Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
Endocrinology 144:2016-24. 2003..Adenoviral gene therapy is thus a viable strategy with which to study the physiological importance of specific molecules acting in discrete brain areas... - Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in miceKarl J Kaiyala
Department of Dentistry, University of Washington, Seattle, Washington, United States of America
PLoS ONE 7:e41473. 2012..51, p<0.01). We conclude that acutely decreased energy expenditure decreases food intake suggesting that energy intake is regulated by metabolic signals that respond rapidly and accurately to reduced energy expenditure... - BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose ProductionThomas H Meek
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington
Diabetes 62:1512-8. 2013..This action of BDNF likely involves the VMN and is associated with inhibition of glucagon secretion and a decrease in the rate of HGP... - Obesity is associated with hypothalamic injury in rodents and humansJoshua P Thaler
Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington 98109, USA
J Clin Invest 122:153-62. 2012..These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control... - Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activationChristian L Roth
Division of Endocrinology, Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
Hepatology 55:1103-11. 2012..In addition it causes IR, higher hepatic resistin gene expression, and up-regulation of hepatic inflammatory and oxidative stress genes... - Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feedingRichard W Gelling
Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359657, Seattle, Washington 98104, USA
Endocrinology 145:4575-82. 2004..Although plasma ghrelin levels fall in response to hyperphagic feeding, these findings support the hypothesis that increased ghrelin signaling contributes to the pathogenesis of diabetic hyperphagia... - Increased hypothalamic melanin concentrating hormone gene expression during energy restriction involves a melanocortin-independent, estrogen-sensitive mechanismGregory J Morton
Department of Medicine, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Box 359757, Seattle, WA 98104, USA
Peptides 25:667-74. 2004..These findings suggest that while both energy restriction and reduced melanocortin signaling stimulate hypothalamic Mch gene expression, they do so via distinct mechanisms... - Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopeniaDana K Sindelar
Department of Medicine, Harborview Medical Centr, Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
Endocrinology 145:3363-8. 2004..We conclude that NPY signaling is required for hyperphagic feeding, but not neuroendocrine responses to moderate hypoglycemia... - Leptin, diabetes, and the brainThomas H Meek
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA, USA
Indian J Endocrinol Metab 16:S534-42. 2012.... - Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegenerationPatrick Weydt
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
Cell Metab 4:349-62. 2006..Finally, HD striatal neurons expressing exogenous PGC-1alpha were resistant to 3-nitropropionic acid treatment. Altered PGC-1alpha function may thus link transcription dysregulation and mitochondrial dysfunction in HD... - Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasisLijie Gong
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 550 East Canfield, Detroit, MI 48201, USA
Endocrinology 149:3346-54. 2008..We conclude that Stat3 in Agrp/Npy neurons is required for normal energy homeostasis, but Stat3 signaling in other brain areas also contributes to the regulation of energy homeostasis... - Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acidChristopher B Kaelin
Department of Genetics and Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
Mol Endocrinol 20:2591-602. 2006.... - Effects of hypothalamic neurodegeneration on energy balanceAllison Wanting Xu
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 3:e415. 2005..These findings provide new insight into the roles of hypothalamic neurons in energy balance regulation, and provide a model for understanding defects in human energy balance associated with neurodegeneration and aging... - Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balanceJames Trevaskis
Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Geelong 3217, Victoria, Australia
Endocrinology 146:3757-64. 2005..Together these data suggest that SGIP1 is an important and novel member of the group of neuronal molecules required for the regulation of energy homeostasis... - Obesity: keeping hunger at bayMichael W Schwartz
Nature 418:595-7. 2002