Gregory J Morton

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling
    Gregory J Morton
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
    Am J Physiol Endocrinol Metab 297:E202-10. 2009
  2. pmc Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    Jonathan German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
    Endocrinology 150:4502-11. 2009
  3. pmc Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
    Gregory J Morton
    Department of Medicine, Harbourview Medical Center, University of Washington, Seattle, WA 98104, USA
    J Physiol 583:437-43. 2007
  4. pmc Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
    Gregory J Morton
    Dept of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 302:E134-44. 2012
  5. pmc Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice
    Gregory J Morton
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 300:E392-401. 2011
  6. pmc Leptin and the central nervous system control of glucose metabolism
    Gregory J Morton
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Physiol Rev 91:389-411. 2011
  7. ncbi request reprint Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
    Cell Metab 2:411-20. 2005
  8. pmc Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, University of Washington at South Lake Union, 850 Republican Street, N334, Box 358055, Seattle, Washington 98195, USA
    Endocrinology 154:3067-76. 2013
  9. pmc Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    Jonathan P German
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1626-34. 2010
  10. pmc BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 62:1512-8. 2013

Collaborators

Detail Information

Publications42

  1. pmc The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling
    Gregory J Morton
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
    Am J Physiol Endocrinol Metab 297:E202-10. 2009
    ....
  2. pmc Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    Jonathan German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
    Endocrinology 150:4502-11. 2009
    ..We conclude that hypothalamic leptin action increases peripheral insulin sensitivity primarily via effects on the liver and that the mechanism underlying this effect is dependent on the hepatic branch of the vagus nerve...
  3. pmc Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
    Gregory J Morton
    Department of Medicine, Harbourview Medical Center, University of Washington, Seattle, WA 98104, USA
    J Physiol 583:437-43. 2007
    ....
  4. pmc Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
    Gregory J Morton
    Dept of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 302:E134-44. 2012
    ....
  5. pmc Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice
    Gregory J Morton
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 300:E392-401. 2011
    ..Thus, plasma leptin is a physiological regulator of spontaneous physical activity, but the nature of leptin's effect on activity is dependent on food availability...
  6. pmc Leptin and the central nervous system control of glucose metabolism
    Gregory J Morton
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Physiol Rev 91:389-411. 2011
    ..Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders...
  7. ncbi request reprint Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
    Cell Metab 2:411-20. 2005
    ..These findings suggest that hypothalamic leptin signaling is an important determinant of glucose metabolism and that the underlying neuronal mechanism involves PI3K...
  8. pmc Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, University of Washington at South Lake Union, 850 Republican Street, N334, Box 358055, Seattle, Washington 98195, USA
    Endocrinology 154:3067-76. 2013
    ..Leptin action within a distributed neuronal network may mediate its effects on glucose homeostasis. ..
  9. pmc Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    Jonathan P German
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1626-34. 2010
    ..This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements induced by uDM...
  10. pmc BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 62:1512-8. 2013
    ..This action of BDNF likely involves the VMN and is associated with inhibition of glucagon secretion and a decrease in the rate of HGP...
  11. pmc Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia
    Jonathan P German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, N334, PO Box 358055, Seattle, Washington 98195, USA
    Endocrinology 152:394-404. 2011
    ....
  12. pmc In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
    Miles E Matsen
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Endocrinol Metab 304:E734-46. 2013
    ....
  13. pmc Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
    David A Sarruf
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1817-24. 2010
    ..The current studies investigate whether central FGF21 treatment recapitulates these effects...
  14. pmc Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding
    Shinsuke Oh-I
    UW Medicine at South Lake Union, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 299:E47-53. 2010
    ..These observations add to growing evidence linking hypothalamic inflammation to obesity pathogenesis...
  15. ncbi request reprint Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
    Christopher D Morrison
    University of Washington, Harborview Medical Center, Box 359757, 325 Ninth Ave, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 289:E1051-7. 2005
    ..In addition, these data suggest that leptin activation of STAT3 is insufficient to inhibit expression of Npy or Agrp in the absence of PI3K signaling...
  16. pmc Leptin action in the forebrain regulates the hindbrain response to satiety signals
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 115:703-10. 2005
    ..These findings demonstrate that forebrain signaling by leptin, a long-term regulator of body adiposity, limits food intake on a meal-to-meal basis by regulating the hindbrain response to short-acting satiety signals...
  17. ncbi request reprint Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, WA 98104 2499, USA
    Am J Physiol Endocrinol Metab 287:E1107-13. 2004
    ..05 vs. vehicle), an effect similar to that of ADX. These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin...
  18. pmc Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis
    Harvey K Chiu
    Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Endocrinology 151:993-1001. 2010
    ..Our results demonstrate that in mice, HL deficiency protects against diet-induced obesity and its hepatic sequelae. Inhibition of HL-activity may therefore have value in the prevention and/or treatment of obesity...
  19. pmc A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain
    Denis G Baskin
    Office of Research and Development Medical Research Service, Veterans Affairs Puget Sound Health Care System, Department of Veterans Affairs Medical Center, Seattle, Washington 98108, USA
    Endocrinology 151:4207-13. 2010
    ....
  20. doi request reprint Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
    James E Blevins
    VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009
    ....
  21. pmc Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Brain Res 1144:101-6. 2007
    ....
  22. pmc Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
    Francis Kim
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
    Arterioscler Thromb Vasc Biol 28:1982-8. 2008
    ....
  23. pmc A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients
    Christian L Roth
    Division of Endocrinology, Seattle Children s Research Institute, University of Washington, Seattle, Washington 98101, USA
    Pediatr Res 69:230-6. 2011
    ....
  24. pmc Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice
    Richard W Gelling
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Endocrinology 149:6053-64. 2008
    ..These findings collectively identify a novel and potentially important role for TACE in energy homeostasis...
  25. pmc Identification of body fat mass as a major determinant of metabolic rate in mice
    Karl J Kaiyala
    Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, Washington, USA
    Diabetes 59:1657-66. 2010
    ....
  26. pmc Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding
    Sanshiro Tateya
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 60:2792-801. 2011
    ....
  27. ncbi request reprint Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
    Endocrinology 144:2016-24. 2003
    ..Adenoviral gene therapy is thus a viable strategy with which to study the physiological importance of specific molecules acting in discrete brain areas...
  28. pmc Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice
    Karl J Kaiyala
    Department of Dentistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e41473. 2012
    ..51, p<0.01). We conclude that acutely decreased energy expenditure decreases food intake suggesting that energy intake is regulated by metabolic signals that respond rapidly and accurately to reduced energy expenditure...
  29. doi request reprint Cooperation between brain and islet in glucose homeostasis and diabetes
    Michael W Schwartz
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 503:59-66. 2013
    ..Consequently, therapies that target the BCGS in addition to conventional approaches based on enhancing insulin effects may have the potential to induce diabetes remission, whereas targeting just one typically does not. ..
  30. doi request reprint Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation
    Christian L Roth
    Division of Endocrinology, Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
    Hepatology 55:1103-11. 2012
    ..In addition it causes IR, higher hepatic resistin gene expression, and up-regulation of hepatic inflammatory and oxidative stress genes...
  31. pmc Obesity is associated with hypothalamic injury in rodents and humans
    Joshua P Thaler
    Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington 98109, USA
    J Clin Invest 122:153-62. 2012
    ..These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control...
  32. ncbi request reprint Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding
    Richard W Gelling
    Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359657, Seattle, Washington 98104, USA
    Endocrinology 145:4575-82. 2004
    ..Although plasma ghrelin levels fall in response to hyperphagic feeding, these findings support the hypothesis that increased ghrelin signaling contributes to the pathogenesis of diabetic hyperphagia...
  33. doi request reprint Carbohydrate Feeding Dissociates the Postprandial FGF19 Response From Circulating Bile Acid Levels in Humans
    Gregory J Morton
    Department of Medicine G J M, K E F S, D E C, M W S and Department of Dental Public Health Sciences K J K, School of Dentistry, University of Washington, Seattle, Washington 98195 and Veterans Affairs Puget Sound Health Care System K E F S, D E C, Seattle, Washington 98108
    J Clin Endocrinol Metab 99:E241-5. 2014
    ..Conclusions: A bile acid-independent mechanism is implicated in the effect of meals to raise plasma FGF19 concentrations. ..
  34. ncbi request reprint Increased hypothalamic melanin concentrating hormone gene expression during energy restriction involves a melanocortin-independent, estrogen-sensitive mechanism
    Gregory J Morton
    Department of Medicine, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Box 359757, Seattle, WA 98104, USA
    Peptides 25:667-74. 2004
    ..These findings suggest that while both energy restriction and reduced melanocortin signaling stimulate hypothalamic Mch gene expression, they do so via distinct mechanisms...
  35. ncbi request reprint Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia
    Dana K Sindelar
    Department of Medicine, Harborview Medical Centr, Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Endocrinology 145:3363-8. 2004
    ..We conclude that NPY signaling is required for hyperphagic feeding, but not neuroendocrine responses to moderate hypoglycemia...
  36. pmc Leptin, diabetes, and the brain
    Thomas H Meek
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, WA, USA
    Indian J Endocrinol Metab 16:S534-42. 2012
    ....
  37. ncbi request reprint Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration
    Patrick Weydt
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Cell Metab 4:349-62. 2006
    ..Finally, HD striatal neurons expressing exogenous PGC-1alpha were resistant to 3-nitropropionic acid treatment. Altered PGC-1alpha function may thus link transcription dysregulation and mitochondrial dysfunction in HD...
  38. ncbi request reprint Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid
    Christopher B Kaelin
    Department of Genetics and Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Endocrinol 20:2591-602. 2006
    ....
  39. pmc Effects of hypothalamic neurodegeneration on energy balance
    Allison Wanting Xu
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 3:e415. 2005
    ..These findings provide new insight into the roles of hypothalamic neurons in energy balance regulation, and provide a model for understanding defects in human energy balance associated with neurodegeneration and aging...
  40. pmc Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
    Lijie Gong
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 550 East Canfield, Detroit, MI 48201, USA
    Endocrinology 149:3346-54. 2008
    ..We conclude that Stat3 in Agrp/Npy neurons is required for normal energy homeostasis, but Stat3 signaling in other brain areas also contributes to the regulation of energy homeostasis...
  41. ncbi request reprint Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance
    James Trevaskis
    Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Geelong 3217, Victoria, Australia
    Endocrinology 146:3757-64. 2005
    ..Together these data suggest that SGIP1 is an important and novel member of the group of neuronal molecules required for the regulation of energy homeostasis...
  42. ncbi request reprint Obesity: keeping hunger at bay
    Michael W Schwartz
    Nature 418:595-7. 2002