J A Mortimer

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study
    J A Mortimer
    Institute on Aging, University of South Florida, Tampa FL 33612 3805, USA
    Neurology 62:428-32. 2004
  2. ncbi request reprint Head circumference, education and risk of dementia: findings from the Nun Study
    James A Mortimer
    Institute on Aging, University of South Florida, Tampa, FL 33612 3899, USA
    J Clin Exp Neuropsychol 25:671-9. 2003
  3. pmc Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression
    James A Mortimer
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612 3899, USA
    J Geriatr Psychiatry Neurol 18:218-23. 2005
  4. ncbi request reprint Tools of the epidemiologist
    James A Mortimer
    Department of Epidemiology and Biostatistics, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Alzheimer Dis Assoc Disord 20:S35-41. 2006
  5. ncbi request reprint Hippocampal volume as an index of Alzheimer neuropathology: findings from the Nun Study
    K M Gosche
    Institute on Aging, University of South Florida, Tampa 33612 3899, USA
    Neurology 58:1476-82. 2002
  6. ncbi request reprint Is APOE--epsilon4 a risk factor for cognitive impairment in normal aging?
    B J Small
    Department of Gerontology, University of South Florida, Tampa 33620, USA
    Neurology 54:2082-8. 2000
  7. ncbi request reprint An automated technique for measuring hippocampal volumes from MR imaging studies
    K M Gosche
    Institute on Aging, University of South Florida, Tampa 33612-3899, USA
    AJNR Am J Neuroradiol 22:1686-9. 2001
  8. ncbi request reprint Elderly norms for the Hopkins Verbal Learning Test-Revised
    R D Vanderploeg
    Departments of Psychology and Neurology, James A Haley VA Medical Center, and University of South Florida, Tampa, USA
    Clin Neuropsychol 14:318-24. 2000
  9. ncbi request reprint Determinants of a sense of mastery in African American and White older adults
    Yuri Jang
    Institute on Aging, University of South Florida, Tampa, USA
    J Gerontol B Psychol Sci Soc Sci 58:S221-4. 2003
  10. ncbi request reprint Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam
    A R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612 3805, USA
    Neurology 68:1764-71. 2007

Detail Information

Publications44

  1. ncbi request reprint Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study
    J A Mortimer
    Institute on Aging, University of South Florida, Tampa FL 33612 3805, USA
    Neurology 62:428-32. 2004
    ..To examine the associations of hippocampal volume and the severity of neurofibrillary lesions determined at autopsy with delayed verbal recall performance evaluated an average of 1 year prior to death...
  2. ncbi request reprint Head circumference, education and risk of dementia: findings from the Nun Study
    James A Mortimer
    Institute on Aging, University of South Florida, Tampa, FL 33612 3899, USA
    J Clin Exp Neuropsychol 25:671-9. 2003
    ..The findings suggest that higher education and larger head size, alone or in combination, may reduce the risk of expressing dementia in late life...
  3. pmc Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression
    James A Mortimer
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612 3899, USA
    J Geriatr Psychiatry Neurol 18:218-23. 2005
    ..Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology...
  4. ncbi request reprint Tools of the epidemiologist
    James A Mortimer
    Department of Epidemiology and Biostatistics, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Alzheimer Dis Assoc Disord 20:S35-41. 2006
    ..Over the past 60 years, the epidemiologic study of dementia has evolved from basic descriptive studies of prevalence and incidence to case-control and cohort studies and finally to the first clinical trials to prevent AD...
  5. ncbi request reprint Hippocampal volume as an index of Alzheimer neuropathology: findings from the Nun Study
    K M Gosche
    Institute on Aging, University of South Florida, Tampa 33612 3899, USA
    Neurology 58:1476-82. 2002
    ..To determine whether hippocampal volume is a sensitive and specific indicator of Alzheimer neuropathology, regardless of the presence or absence of cognitive and memory impairment...
  6. ncbi request reprint Is APOE--epsilon4 a risk factor for cognitive impairment in normal aging?
    B J Small
    Department of Gerontology, University of South Florida, Tampa 33620, USA
    Neurology 54:2082-8. 2000
    ....
  7. ncbi request reprint An automated technique for measuring hippocampal volumes from MR imaging studies
    K M Gosche
    Institute on Aging, University of South Florida, Tampa 33612-3899, USA
    AJNR Am J Neuroradiol 22:1686-9. 2001
    ..KGMAP provides a rapid and accurate estimate of hippocampal volume that is suitable for use in clinical practice...
  8. ncbi request reprint Elderly norms for the Hopkins Verbal Learning Test-Revised
    R D Vanderploeg
    Departments of Psychology and Neurology, James A Haley VA Medical Center, and University of South Florida, Tampa, USA
    Clin Neuropsychol 14:318-24. 2000
    ..These subjects did not differ in overall performance from our entire sample. Therefore, the normative data provided in this paper can be considered to be census-comparable for age, education, and gender...
  9. ncbi request reprint Determinants of a sense of mastery in African American and White older adults
    Yuri Jang
    Institute on Aging, University of South Florida, Tampa, USA
    J Gerontol B Psychol Sci Soc Sci 58:S221-4. 2003
    ..This study compares determinants of a sense of mastery in African American and White older adults...
  10. ncbi request reprint Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam
    A R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612 3805, USA
    Neurology 68:1764-71. 2007
    ..To study cycad-derived products as possible risk factors for dementia, mild cognitive impairment (MCI), and parkinsonism-dementia complex (PDC) on Guam...
  11. pmc Effects of apolipoprotein E-epsilon4 and -epsilon2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P
    Amy R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA
    Am J Alzheimers Dis Other Demen 25:233-8. 2010
    ..To determine apolipoprotein E (APOE)-epsilon4 and -epsilon2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China...
  12. ncbi request reprint Developmental and vascular risk factors for Alzheimer's disease
    Amy R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL 33612 3805, USA
    Neurobiol Aging 26:325-34. 2005
    ..7-15.5; HR 3.3, 95% CI 1.4-8.1)). These findings indicate that clinical AD is a result of early life as well as later life risk factors, and that genetic predisposition to the disease may modify the constellation of predictors...
  13. ncbi request reprint Florida Cognitive Activities Scale: initial development and validation
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL 33612, USA
    J Int Neuropsychol Soc 11:108-16. 2005
    ..7). Further cross-validation studies in minority groups and groups of varying socioeconomic status will be critical in establishing the research and clinical value of the scale and subscales...
  14. pmc The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology
    James A Mortimer
    Department of Epidemiology and Biostatistics, University of South Florida, 13201 Bruce B Downs Boulevard, MDC 56, Tampa, FL 33612 3805, USA
    Alzheimer Dis Assoc Disord 23:152-7. 2009
    ..The findings suggest that the effect of epsilon4 on dementia is mediated by the severity of AD pathology. Although infarcts and atherosclerosis contribute to the occurrence of dementia, this contribution seems unrelated to APOE genotype...
  15. ncbi request reprint The association between social resources and cognitive change in older adults: evidence from the Charlotte County Healthy Aging Study
    Tiffany F Hughes
    School of Aging Studies, University of South Florida, 4202 East Fowler Avenue, MHC 1300, Tampa, FL 33620, USA
    J Gerontol B Psychol Sci Soc Sci 63:P241-P244. 2008
    ..The results suggest that social resources may be differentially important for cognitive change but that different cognitive domains respond in a similar pattern to social resources...
  16. ncbi request reprint Depressive symptoms among African American and white older adults
    Yuri Jang
    Department of Aging and Mental Health, Florida Mental Health Institute, University of South Florida, MHC 1439, Tampa, Florida 33612, USA
    J Gerontol B Psychol Sci Soc Sci 60:P313-P319. 2005
    ..In addition, we obtained significant interactions among predictor variables in each group, identifying risk-reducing and risk-enhancing factors within each group...
  17. doi request reprint Small head circumference is associated with less education in persons at risk for Alzheimer disease in later life
    James A Mortimer
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612 3805, USA
    Alzheimer Dis Assoc Disord 22:249-54. 2008
    ..These findings suggest that small HC limits educational attainment only among individuals who have greater risk of AD owing to their APOE genotype or who are destined to develop this illness later in life...
  18. ncbi request reprint Confirmatory factor analysis of the PTSD checklist in the elderly
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL 33612, USA
    J Trauma Stress 20:281-9. 2007
    ..Future studies will be facilitated by the knowledge that the PCL-C 4-factor model appears to apply across the adult age range and a variety of posttraumatic stress disorder-producing conditions...
  19. ncbi request reprint Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians
    Amy R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, MDC 56, University of South Florida, 13201 Bruce B Downs Boulevard, Tampa, FL 33612 3805, USA
    Ethn Dis 16:9-15. 2006
    ..Among Caucasians, APOE-epsilon4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-epsilon4 allele in our African-American sample compared to other US-based studies...
  20. pmc High normal fasting blood glucose is associated with dementia in Chinese elderly
    James A Mortimer
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA
    Alzheimers Dement 6:440-7. 2010
    ..Diabetes is a risk factor for mild cognitive impairment (MCI) and dementia. However, the association between high normal fasting blood glucose (FBG) and dementia has not been studied...
  21. ncbi request reprint Early-life risk factors for Alzheimer disease
    Amy R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA
    Alzheimer Dis Assoc Disord 20:63-72. 2006
    ..Enhancement or preservation of brain or cognitive reserve could delay the onset of Alzheimer disease and in some cases prevent the disease from occurring altogether...
  22. ncbi request reprint The role of mastery and social resources in the associations between disability and depression in later life
    Yuri Jang
    Institute on Aging, University of South Florida, Tampa, FL, USA
    Gerontologist 42:807-13. 2002
    ..The present study assessed the impacts of mastery and social resources (social network, social support, and satisfaction with support) on depression and, in particular, whether they modify the link between disability and depression...
  23. ncbi request reprint Nonauditory determinants of self-perceived hearing problems among older adults: the role of stressful life conditions, neuroticism, and social resources
    Yuri Jang
    Institute on Aging, University of South Florida, Tampa 33612, USA
    J Gerontol A Biol Sci Med Sci 57:M466-9. 2002
    ....
  24. ncbi request reprint Effects of the use of alcohol and cigarettes on cognition in elderly adults
    John A Schinka
    James A Haley VA Medical Center, and Department of Psychiatry, University of South Florida, Tampa 33612, USA
    J Int Neuropsychol Soc 8:811-8. 2002
    ..No detrimental effect of smoking was found in any analysis; nor was there any evidence of an interaction between alcohol and cigarette use on any cognitive measure...
  25. ncbi request reprint Effects of the use of alcohol and cigarettes on cognition in elderly African American adults
    John A Schinka
    James A Haley VA Medical Center, Tampa, Florida 33612, USA
    J Int Neuropsychol Soc 9:690-7. 2003
    ..Specifically, moderate users performed at a lower level than abstainers or heavy users, who did not differ from each other...
  26. ncbi request reprint Head circumference and incident Alzheimer's disease: modification by apolipoprotein E
    A Borenstein Graves
    Department of Epidemiology and Biostatistics, University of South Florida, Tampa, 33612 3805, USA
    Neurology 57:1453-60. 2001
    ..The association between head circumference (HC), a measure of brain reserve, and the incidence of probable AD was examined in a large nondemented cohort that has been followed since 1992 and its modification by APOE epsilon 4 genotype...
  27. doi request reprint Characteristics of the Florida cognitive activities scale in older African Americans
    Vonetta M Dotson
    James A Haley VA Medical Center, University of Florida, Tampa, FL 33612, USA
    Assessment 15:72-7. 2008
    ....
  28. doi request reprint Health-related quality of life in community-dwelling older Whites and African Americans
    Yuri Jang
    University of South Florida, Tampa, USA
    J Aging Health 21:336-49. 2009
    ..They hypothesized that the general well-being factor would be a mediator between physical and mental health in both groups...
  29. ncbi request reprint Hopkins Verbal Learning Test-Revised: norms for elderly African Americans
    Melissa A Friedman
    James A Haley VA Medical Center, Tampa, FL, USA
    Clin Neuropsychol 16:356-72. 2002
    ..Age, gender, and education accounted for moderate amounts of variance in HVLT-R performance. Based on these results, normative tables for HVLT-R scores, stratified by age and with score adjustments for education and gender, are provided...
  30. ncbi request reprint Five-factor personality dimensions, mood states, and cognitive performance in older adults
    Jane E Booth
    James A Haley Veterans Hospital, Tampa, FL 33612, USA
    J Clin Exp Neuropsychol 28:676-83. 2006
    ..State anxiety and depression variables were found to play a very small part, however, in contributing to cognitive function...
  31. ncbi request reprint The role of neuroticism in the association between performance-based and self-reported measures of mobility
    Yuri Jang
    University of South Florida, USA
    J Aging Health 14:495-508. 2002
    ..The present study examined the role of neuroticism in older individuals' self-reports of mobility. The authors hypothesized that neuroticism would modify the association between performance-based and self-reported measures of mobility...
  32. ncbi request reprint Negative life events and cognitive performance in a population of older adults
    Christopher B Rosnick
    University of South Florida, Tampa, FL, USA and Brandeis University, Department of Psychology MS 062, 415 South Street, Waltham, MA 02454 USA
    J Aging Health 19:612-29. 2007
    ..This study examined the association between negative life events in the past year and cognitive performance in a population of older adults...
  33. ncbi request reprint A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances
    J A Schinka
    The Roskamp Institute, University of South Florida, Tampa, FL 33620, USA
    Mol Psychiatry 7:224-8. 2002
    ..The contribution of the gene to risk for substance dependence is small, and is detected most easily in studies that use control samples that are screened for all forms of substance dependence...
  34. ncbi request reprint Normative data for elderly African Americans for the Stroop Color and Word Test
    Robert G Moering
    James A Haley VA Medical Center, Tampa, FL 33612, USA
    Arch Clin Neuropsychol 19:61-71. 2004
    ..Based on these results, normative tables for Stroop Color and Word Test scores, stratified by age and with score adjustments for education and gender, are provided...
  35. ncbi request reprint 3MS normative data for elderly African Americans
    Lisa M Brown
    James A Haley VA Medical Center, Tampa, FL 33612, USA
    J Clin Exp Neuropsychol 25:234-41. 2003
    ..Age, gender, and education accounted for moderate amounts of variance in 3MS performance. Based on these results, normative tables for 3MS scores, stratified by age and with score adjustments for education and gender, are provided...
  36. ncbi request reprint Telephone screening to identify potential dementia cases in a population-based sample of older adults
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
    Int Psychogeriatr 14:273-89. 2002
    ..One recommendation based on our experience is that longitudinal studies should include a telephone interview component for anyone who drops out of the study, to enable characterizing the cognitive status of dropouts...
  37. ncbi request reprint Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
    ..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset...
  38. ncbi request reprint Similarities and differences in attitudes toward long-term care between Japanese Americans and Caucasian Americans
    Wayne C McCormick
    Harborview Medical Center, University of Washington, 325 9th Avenue, Mail Stop 359755, Seattle, WA 98104, USA
    J Am Geriatr Soc 50:1149-55. 2002
    ....
  39. ncbi request reprint Non-familial Alzheimer's disease is mainly due to genetic factors
    J Wesson Ashford
    Department of Psychiatry, Sanders Brown Center on Aging, University of Kentucky, Veterans Affairs Medical Center, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 4:169-77. 2002
    ..This paper further reviews the mechanisms associated with AD causation for APOE and other candidate genes and implications for the development of prevention strategies...
  40. pmc Accounting for the relationship between low education and dementia: a twin study
    Margaret Gatz
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Physiol Behav 92:232-7. 2007
    ..Low education is confirmed as a risk factor for dementia. Findings from three different analytic approaches showed that genetic influences did not explain this association...
  41. ncbi request reprint Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    ..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)...
  42. ncbi request reprint Normal pressure hydrocephalus and large head size
    Thomas A Krefft
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Alzheimer Dis Assoc Disord 18:35-7. 2004
    ..To determine if patients with normal pressure hydrocephalus (NPH) have larger head size than normal controls...
  43. pmc Children of persons with Alzheimer disease: what does the future hold?
    Lissy Jarvik
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 22:6-20. 2008
    ..We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring...
  44. ncbi request reprint Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    Chris Zarow
    Department of Neurology, University of Southern California, Los Angeles, CA, USA
    Arch Neurol 60:337-41. 2003
    ..Alzheimer disease (AD) and Parkinson disease (PD) are associated with neuronal degeneration in major subcortical nuclei, but few studies have examined the neuronal degeneration in these nuclei concurrently...