G R Morrow

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..A more thorough evaluation of the various therapeutic options is required to better define their efficacy and safety profiles in this patient population...

..The possible role of this reduction in cortisol is discussed in relation to induction of chemotherapy-induced nausea and vomiting...

..This paper introduces four plausible hypotheses for the development of fatigue. Evidence available to support a role for anemia, adenosine triphosphate, vagal afferents, and the interaction of the HPA/cytokines and 5HT is discussed...

..This paper draws on both physiological and psychological origins of NV to begin the development of a biobehavioral model of development that integrates features of both approaches...

..Further investigation of ANS involvement in chemotherapy-induced nausea could increase understanding of nausea etiology and potentially lead to the prediction of susceptible patients...

..An increase in parasympathetic activity seems to set the stage for the expression of nausea but an additional stimulus is apparently needed to finally trigger the event...

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..A better understanding of chemotherapy side effect mechanisms is likely to result in less polypharmacy and more effective individualized treatment for cancer patients...

..1 for all). Study results do not support the hypothesis that acustimulation bands are efficacious as an adjunct to pharmacological antiemetics for control of chemotherapy-related nausea in female breast cancer patients...

..052). Expected efficacy of the bands was related to outcomes for the acupressure but not the acustimulation conditions...

..Explanations for these findings include the possibility that the expectancy manipulation was not strong enough, and the possibility that changing nausea expectancies does not change occurrence of nausea...

..15; P < 0.001). Results support a role for cognitive factors in the development of chemotherapy side effects and suggest testing psychologic interventions to modify patients' expectations...

..Although studies have consistently linked active smoking to various pregnancy outcomes, results from the few studies examining SHS exposure and pregnancy difficulties have been inconsistent...

..Secondary osteoporosis is usually a result of a disease, such as cystic fibrosis, or medical treatment, such as corticosteroids or cancer treatment...

..This article will provide a description of-the NCI CCOP, its functions, and a brief overview of ongoing research on CRF both at our institution and other locations across the United States...

..Disclosure of potential conflicts of interest is found at the end of this article...

..Disclosure of potential conflicts of interest is found at the end of this article...

..Disclosure of potential conflicts of interest is found at the end of this article...

..An understanding of relevant mechanisms may offer potential routes for its prevention and treatment in patients with cancer.Disclosure of potential conflicts of interest is found at the end of this article...

..Strategies to facilitate reliable assessment of CRF are also discussed. Disclosure of potential conflicts of interest is found at the end of this article...

..This pilot study compared the influence of TCC with that of standard support therapy (ST; exercise control) on BL biomarkers among breast cancer survivors...

..Our goal was to assess primary care physicians' use of the 5A model in discussions with underserved populations about physical activity...

..The aims of this study were to determine the effect of accounting for secondhand smoke (SHS) exposure on the association between smoking and colorectal cancer and to determine the association between SHS and colorectal cancer...

..Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation...

..Sleep disruption is prevalent in patients with cancer and survivors, but the prevalence of insomnia, a distressing sleep disorder, in these populations has yet to be determined in large-scale studies...

..Results of this pilot study provide positive preliminary evidence that exercise during radiation may be beneficial for cancer patients...

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..To identify risk factors for chemotherapy-related nausea...

..This study aimed to examine colorectal cancer risk by smoking exposure using data collected in the late-1950s and early-1960s...

..Few studies have evaluated the independent effect of a cancer diagnosis on vulnerability and frailty, which have been associated with adverse health outcomes in older adults...

..An attempt to boost the efficacy of the acupressure bands by providing positive information was not successful...

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..It commonly co-exists with depression in patients undergoing chemotherapy, suggesting that administration of an antidepressant that alleviates symptoms of depression could also reduce fatigue...

..Patients often describe fatigue as the most distressing of the symptoms they experienced during their cancer treatment. Fatigue may increase from initial levels experienced during cancer treatment with the addition of radiotherapy (RT)...

..04; FSCL r=-0.30; P=0.04; CES-D r=-0.39; P=0.008; HDI r=-0.34; P=0.03; POMS r=-0.40; P=.007). These findings provide evidence that circadian rhythm disruption is involved in the experience of fatigue and depression in cancer patients...

..To assess complementary and alternative medicine (CAM) therapies being utilized by cancer patients during treatment and communication about CAM usage between the patient and physician...

..The findings from a pilot study examining the efficacy of the complementary and alternative practice of Polarity Therapy (PT) in reducing CRF and improving HRQL are reported...

..This study summarized the frequency, timing, and intensity of postchemotherapy nausea for patients receiving doxorubicin, cisplatin, or carboplatin...

..This review focuses on both physiological and psychological origins of nausea and vomiting as side effects of chemotherapy...

..These findings provide ample justification for further study of acustimulation in clinical oncology...

..However, to the authors' knowledge, less is known regarding what patients expect to experience regarding these side effects and how patient characteristics are related to these expectations...

..We undertook a randomised, double-blind, placebo-controlled, multi-institutional trial to assess the efficacy of gabapentin in controlling hot flashes in women with breast cancer...

..We aimed to assess whether a 5-HT-receptor antagonist was more effective than was prochlorperazine for control of delayed nausea and delayed vomiting caused by doxorubicin...

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..Two additional patients did not provide complete data. Gabapentin is a promising new agent in the treatment of tamoxifen induced hot flashes, and should be studied further...

..Similarities between the experience of anticipatory nausea and vomiting and morning sickness suggest that the conditioning model may be relevant to understanding the development of pregnancy-related nausea...

..The results suggest that patients could benefit from increased knowledge about what to expect during their radiation treatments...

..There remains a need for more research in several methodologic aspects of design, analysis, and interpretation of symptom management trials...

..Improved understanding about the time course and dose response of radiation-induced toxicity will permit more accurate presentation of side effect risk at the time patient consent is obtained...

..Finally, ethically acceptable interventions that are designed to reduce patients' nausea expectancies or increase their expectancies of nausea control should be developed and studied...

..Our results suggest that symptom management for post-treatment skin reactions in cancer patients receiving radiation treatment could differ depending on their racial background...

..Behavioral interventions, especially progressive muscle relaxation training and systematic desensitization, should be considered important methods for preventing and treating ANV...

..This paper examines the prevalence of CRF and explores the impact of this distressing symptom on patients' functioning and QoL. Disclosure of potential conflicts of interest is found at the end of this article...

..The results from this study highlight the importance of reevaluating patients' preferences for involvement in medical decision making throughout the course of cancer therapy, as such preferences are likely to change...

..In conclusion, these data suggest that IL1B plays a critical role in radiation-induced fibrosis and that the increased MMPs fail to block the IL1-related collagen accumulation...

..These findings suggest that intervention programs to help reduce family conflict may be especially beneficial for younger adult and female patients...

..05). These patient characteristics identify women with primary breast cancer who are likely to experience difficulty in their interactions with nurses and physicians and to be less satisfied with their physicians...

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..CONCLUSION The Update Committee recommends that clinicians administer antiemetics while considering patients' emetic risk categories and other characteristics...

..The findings suggest that helping patients and their families communicate in more satisfactory and supportive ways and maintain an organized family system might be beneficial in reducing the symptoms of chemotherapy-related nausea...

..The relationship between cancer related fatigue, age and coping styles requires further exploration within longitudinal studies...

..Significantly more information was desired regarding the long-term implications of treatment and disease...

..Furthermore, these results suggest women at greatest risk are those who are younger, who receive postsurgical cancer treatment, who are low in emotional self-efficacy and whose lives are most affected by having cancer...

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..A rigorous evaluation plan will closely track the performance of each trainee and assess the program's success in preparing its graduates for careers in cancer control intervention research. ..

..During this renewal period, we added five new CCOPs for a total of 18 regular and two minority-based CCOPs within the URCC network. ..

..During this renewal period, we added five new CCOPs for a total of 18 regular and two minority-based CCOPs within the URCC network. ..