A L Morrow

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence
    A L Morrow
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 37:98-109. 2001
  2. pmc Ethanol Activation of Protein Kinase A Regulates GABAA α1 Receptor Function and Trafficking in Cultured Cerebral Cortical Neurons
    Stephen L Carlson
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599
    J Pharmacol Exp Ther 345:317-25. 2013
  3. pmc The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008
    A Leslie Morrow
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol 43:521-30. 2009
  4. ncbi request reprint Ethanol effects on cell signaling mechanisms
    A Leslie Morrow
    Department of Psychiatry, Center for Alcohol Studies, University of Chapel Hill at North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 28:217-27. 2004
  5. pmc Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Dialogues Clin Neurosci 8:463-77. 2006
  6. pmc Recent developments in the significance and therapeutic relevance of neuroactive steroids--Introduction to the special issue
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC, 27599 7178, USA
    Pharmacol Ther 116:1-6. 2007
  7. ncbi request reprint Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics
    J E Kralic
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Pharmacol Exp Ther 305:600-7. 2003
  8. ncbi request reprint 3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex
    A C Grobin
    Department of Psychiatry, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res Dev Brain Res 131:31-9. 2001
  9. ncbi request reprint GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem
    J E Kralic
    Department of Pharmacology, University of North Carolina at Chapel Hill, 27599, USA
    Neuropharmacology 43:685-94. 2002
  10. ncbi request reprint Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats
    L L Devaud
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Brain Res 796:222-30. 1998

Collaborators

Detail Information

Publications67

  1. ncbi request reprint The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence
    A L Morrow
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 37:98-109. 2001
    ..The identification of neurosteroid intermediaries involved in ethanol action may lead to important advances in the field and the development of novel therapeutics for alcoholism...
  2. pmc Ethanol Activation of Protein Kinase A Regulates GABAA α1 Receptor Function and Trafficking in Cultured Cerebral Cortical Neurons
    Stephen L Carlson
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599
    J Pharmacol Exp Ther 345:317-25. 2013
    ....
  3. pmc The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008
    A Leslie Morrow
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol 43:521-30. 2009
    ..These presentations provide a framework for new theories on the nature of ethanol/stress interactions that may be amenable to therapeutic interventions...
  4. ncbi request reprint Ethanol effects on cell signaling mechanisms
    A Leslie Morrow
    Department of Psychiatry, Center for Alcohol Studies, University of Chapel Hill at North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 28:217-27. 2004
  5. pmc Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Dialogues Clin Neurosci 8:463-77. 2006
    ..Neurosteroids may have therapeutic use in alcohol withdrawal or for relapse prevention...
  6. pmc Recent developments in the significance and therapeutic relevance of neuroactive steroids--Introduction to the special issue
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC, 27599 7178, USA
    Pharmacol Ther 116:1-6. 2007
    ..These studies point to the opportunity for more translational research into potential therapeutic applications and the need for evaluation of potential untoward side effects following long-term treatment...
  7. ncbi request reprint Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics
    J E Kralic
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Pharmacol Exp Ther 305:600-7. 2003
    ..These receptors do not appear to be necessary for most ethanol responses, suggesting involvement of other GABA(A) receptor subtypes or other targets altogether...
  8. ncbi request reprint 3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex
    A C Grobin
    Department of Psychiatry, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res Dev Brain Res 131:31-9. 2001
    ..These data provide a better understanding of potential contributions endogenous GABAergic neurosteroids may make to normal neuronal development...
  9. ncbi request reprint GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem
    J E Kralic
    Department of Pharmacology, University of North Carolina at Chapel Hill, 27599, USA
    Neuropharmacology 43:685-94. 2002
    ..Such adaptations reveal important relationships between subunit expression, receptor function and behavioral responses...
  10. ncbi request reprint Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats
    L L Devaud
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Brain Res 796:222-30. 1998
    ..Taken together, these studies suggest that additional mechanisms, beyond effects on GABAA receptor gene expression are involved in the mediation of ethanol dependence and withdrawal...
  11. ncbi request reprint Chronic ethanol consumption enhances internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex
    S Kumar
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Neurochem 86:700-8. 2003
    ..These results suggest that chronic ethanol consumption selectively increases internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex...
  12. ncbi request reprint Differential effects of systemic ethanol administration on protein kinase cepsilon, gamma, and beta isoform expression, membrane translocation, and target phosphorylation: reversal by chronic ethanol exposure
    S Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 319:1366-75. 2006
    ..Furthermore, chronic ethanol administration prevents ethanol-induced alterations in PKC expression in the P2 fraction, where PKC interacts with ethanol-responsive ion channels...
  13. ncbi request reprint Chronic ethanol consumption alters recovery of spontaneously active medial septal/diagonal band of broca neurons from GABA-microiontophoresis
    D B Matthews
    Skipper Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Alcohol Clin Exp Res 24:1427-32. 2000
    ..However, it is unknown if chronic ethanol consumption produces alterations in GABA-mediated inhibition in the MS/DB in a manner similar to that found in the cerebral cortex...
  14. pmc Basis of the gabamimetic profile of ethanol
    G R Breese
    Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 30:731-44. 2006
    ..Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABA(A) receptors...
  15. ncbi request reprint Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels
    D B Matthews
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7178, USA
    Pharmacol Biochem Behav 68:13-21. 2001
    ..These results indicate that sucrose can significantly alter blood ethanol levels and that chronic self-administration of a sweetened ethanol solution for 6 weeks does not produce ethanol dependence...
  16. ncbi request reprint Chronic ethanol consumption differentially alters GABA(A) receptor alpha1 and alpha4 subunit peptide expression and GABA(A) receptor-mediated 36 Cl(-) uptake in mesocorticolimbic regions of rat brain
    S Papadeas
    Bowles Center for Alcohol Studies and the Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7178, USA
    Alcohol Clin Exp Res 25:1270-5. 2001
    ..Decreased expression of alpha4 subunits is associated with increases in GABA(A) receptor function in the AMG, but not the NAC. These changes may contribute to alcohol drinking behavior and the development of ethanol dependence...
  17. ncbi request reprint Perinatal allopregnanolone influences prefrontal cortex structure, connectivity and behavior in adult rats
    A C Grobin
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, 27599 7160, USA
    Neuroscience 138:809-19. 2006
    ..If neurosteroids play a role in normal development of prefrontal/medial dorsal patency as suggested by these studies, then alterations in neurosteroid levels may contribute to abnormal neurodevelopment...
  18. ncbi request reprint Effects of acute and chronic ethanol exposure on spatial cognitive processing and hippocampal function in the rat
    D B Matthews
    Skipper Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Hippocampus 10:122-30. 2000
    ..Finally, several unanswered questions concerning the interaction between ethanol and spatial cognitive processing will be identified...
  19. pmc The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons
    Rebekah L Fleming
    Curriculum in Neurobiology, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Alcohol 43:603-18. 2009
    ....
  20. ncbi request reprint Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption
    Sandeep Kumar
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Neurochem 82:110-7. 2002
    ..These results suggest that PKCgamma may be involved in GABA(A) receptor adaptations following chronic ethanol consumption...
  21. ncbi request reprint 3alpha-hydroxy-5alpha-pregnan-20-one exposure reduces GABA(A) receptor alpha4 subunit mRNA levels
    A C Grobin
    Department of Psychiatry, Pharmacology and Bowles Center for Alcohol Studies, CB 7178, University of North Carolina at Chapel Hill, NC 27599 7178, USA
    Eur J Pharmacol 409:R1-2. 2000
    ..These data suggest that variations in neurosteroid levels regulate the pattern of GABA(A) receptor subunit expression and may alter the trophic effects of GABA...
  22. ncbi request reprint Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia
    C E Marx
    Department of Psychiatry, Campus Box 7160, University of North Carolina, 27599 7160, Chapel Hill, NC, USA
    Brain Res 871:104-12. 2000
    ..DHEA and DHEAS modulation of anoxia in embryonic neurons may be relevant to disorders of neurodevelopment involving this insult...
  23. ncbi request reprint Action of zolpidem on responses to GABA in relation to mRNAs for GABA(A) receptor alpha subunits within single cells: evidence for multiple functional GABA(A) isoreceptors on individual neurons
    H E Criswell
    UNC Neuroscience Center, University of North Carolina, School of Medicine, Chapel Hill 27599, USA
    Neuropharmacology 36:1641-52. 1997
    ..Thus, the present investigation emphasizes the importance of characterizing the relationship between endogenous GABA(A) receptor function and the presence of specific structural components forming GABA(A) receptor subtypes on neurons...
  24. pmc Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis
    Kevin N Boyd
    Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurochem 112:784-96. 2010
    ..As GABAergic steroids contribute to ethanol actions and ethanol sensitivity, the mechanisms of this effect of ethanol may be important factors that contribute to the behavioral actions of ethanol and risk for alcohol abuse disorders...
  25. ncbi request reprint Perinatal flunitrazepam exposure causes persistent alteration of parvalbumin-immunoreactive interneuron localization in rat prefrontal cortex
    A Chistina Grobin
    Department of Psychiatry, Pharmacology and Bowles Center for Alcohol Studies, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Neurosci Lett 359:9-12. 2004
    ..These data are consistent with altered distribution of a subset of interneurons after benzodiazepine exposure and suggest a role for GABAA receptor modulation in normal development of GABAergic systems in PFC...
  26. ncbi request reprint NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists
    David H Overstreet
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 75:619-25. 2003
    ..A reduction in [3H]flunitrazepam binding was also seen at this concentration. These findings are consistent with NPI-031G being a weak benzodiazepine site antagonist...
  27. ncbi request reprint Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine
    A Chistina Grobin
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 179:544-50. 2005
    ..Thus, it is possible that enhanced allopregnanolone levels are involved in the effects of abused drugs...
  28. ncbi request reprint Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  29. ncbi request reprint Perinatal neurosteroid levels influence GABAergic interneuron localization in adult rat prefrontal cortex
    A Chistina Grobin
    Department of Psychiatry, and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 23:1832-9. 2003
    ..These data are consistent with a change in the distribution of a subset of interneurons in response to neurosteroid exposure and suggest that GABAergic neurosteroids are critical for normal development of GABAergic systems in the PFC...
  30. ncbi request reprint Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder
    S S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599, USA
    Biol Psychiatry 49:788-97. 2001
    ..CONCLUSIONS: These results suggest dysregulation of allopregnanolone mechanisms in PMDD and that continued investigations into a potential pathophysiologic role of allopregnanolone in PMDD are warranted...
  31. ncbi request reprint GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Neuropsychopharmacology 30:1193-203. 2005
    ..The effects of finasteride provide indirect evidence for a mediating role of neuroactive steroids in some of the subjective effects of alcohol...
  32. pmc The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress
    Sandeep Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 205:529-64. 2009
    ....
  33. pmc Ethanol reduces GABAA alpha1 subunit receptor surface expression by a protein kinase Cgamma-dependent mechanism in cultured cerebral cortical neurons
    Sandeep Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Pharmacol 77:793-803. 2010
    ..These findings suggest that ethanol exposure selectively alters PKCgamma translocation to GABA(A) receptors and PKCgamma regulates GABA(A) alpha1 receptor trafficking after ethanol exposure...
  34. pmc Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: mechanisms and reversal by exogenous ACTH
    Kevin N Boyd
    Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 115:142-52. 2010
    ..Loss of the ethanol-induced increases in neuroactive steroids may contribute to behavioral tolerance to ethanol and influence the progression towards alcoholism...
  35. ncbi request reprint Neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats
    Rahul T Khisti
    Departments of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Brain Res 980:255-65. 2003
    ..Ethanol-induced increases in neurosteroids could be pertinent to the etiology of sleep-related disorders associated with alcoholism...
  36. ncbi request reprint Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms
    Sandeep Kumar
    Department of Psychiatry, Center for Alcohol Studies, University of Chapel Hill at North Carolina, CB 7178, Chapel Hill, NC 27599, USA
    Pharmacol Ther 101:211-26. 2004
    ..In this review, we provide an overview of recent data pertaining to mechanisms that could be responsible for altered properties and expression of GABA(A) receptors following chronic ethanol administration...
  37. ncbi request reprint GABAergic neurosteroid modulation of ethanol actions
    Rahul T Khisti
    Departments of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, CB 7178, 3027 Thurston Bowles Bldg, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    World J Biol Psychiatry 3:87-95. 2002
    ..The development of new therapeutic strategies for alcoholism may arise based on the novel interaction between ethanol and neurosteroids in the brain...
  38. ncbi request reprint Neonatal neurosteroid administration alters parvalbumin expression and neuron number in medial dorsal thalamus of adult rats
    Samantha S Gizerian
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Brain Res 1012:66-74. 2004
    ....
  39. ncbi request reprint Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice
    J E Kralic
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    J Pharmacol Exp Ther 302:1037-45. 2002
    ..These data emphasize the significance of alpha1 subunit expression and its involvement in the regulation of CNS excitability...
  40. pmc The relationship of allopregnanolone immunoreactivity and HPA-axis measures to experimental pain sensitivity: Evidence for ethnic differences
    Beth Mechlin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Pain 131:142-52. 2007
    ..These results suggest that lower ALLO-ir concentrations are associated with decreased pain sensitivity in humans, especially in non-Hispanic Whites, and that this relationship may be mediated by HPA-axis function...
  41. pmc Role of acetaldehyde in ethanol-induced elevation of the neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one in rats
    Kevin N Boyd
    Curriculum in Toxicology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, USA
    Alcohol Clin Exp Res 32:1774-81. 2008
    ..We investigated the role of acetaldehyde in ethanol-induced elevations of 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) levels in cerebral cortex...
  42. pmc Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Steroids 74:463-73. 2009
    ..This method can be used to investigate the physiological and pathological role of neuroactive steroids and to develop biomarkers and new therapeutics for neurological and psychiatric disorders...
  43. pmc Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:450-9. 2009
    ..The authors assessed the expression of GABA(A) receptor alpha4 and delta subunits, which coassemble to form receptors mediating tonic inhibition, in schizophrenia...
  44. ncbi request reprint Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response
    Rahul T Khisti
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1049:104-11. 2005
    ..These findings suggest that acute ethanol increases DOC levels in ethanol naïve rats and chronic ethanol consumption induces tolerance to ethanol-induced increases in DOC levels...
  45. ncbi request reprint Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  46. ncbi request reprint Ethanol rapidly induces steroidogenic acute regulatory protein expression and translocation in rat adrenal gland
    Rahul T Khisti
    Departments of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Eur J Pharmacol 473:225-7. 2003
    ..The rapid synthesis and translocation of StAR protein in adrenals likely represent the mechanism of ethanol-induced increases in neuroactive steroids...
  47. ncbi request reprint Regulation of native GABAA receptors by PKC and protein phosphatase activity
    Sandeep Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 183:241-7. 2005
    ....
  48. pmc Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice
    Jason E Kralic
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    J Clin Invest 115:774-9. 2005
    ..This genetic animal model elucidates a mechanism of GABAergic dysfunction in the major motor pathway and potential targets for pharmacotherapy of essential tremor...
  49. ncbi request reprint 3alpha,5beta-Reduced cortisol exhibits antagonist properties on cerebral cortical GABA(A) receptors
    Shannon N Penland
    Department of Pharmacology, Bowles Center for Alcohol Studies, CB No 7178, 3027 Thurston Bowles Building, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Eur J Pharmacol 506:129-32. 2004
    ..We conclude that cortisol metabolism may produce antagonistic GABAergic activity...
  50. ncbi request reprint Ethanol-induced elevation of 3 alpha-hydroxy-5 alpha-pregnan-20-one does not modulate motor incoordination in rats
    Rahul T Khisti
    Departments of Psychiatry and Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 28:1249-56. 2004
    ..In the present study, we investigated whether such elevation of GABAergic neuroactive steroids contributes to the motor incoordinating effects of ethanol...
  51. pmc Acute ethanol administration rapidly increases phosphorylation of conventional protein kinase C in specific mammalian brain regions in vivo
    Mary Beth Wilkie
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 31:1259-67. 2007
    ....
  52. ncbi request reprint Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 71:2-11. 2006
    ....
  53. ncbi request reprint Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, and Department of Psychiatry and Behavioral Sciences, Durham VA Medical Center, NC 27705, USA
    Psychopharmacology (Berl) 186:451-61. 2006
    ..This study examined the effects of alcohol on plasma steroid hormone concentrations on the hypothesis that the endocrine effects mediate some of the subjective effects of alcohol...
  54. ncbi request reprint Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one-like immunoreactivity in healthy men and women
    Louis Holdstock
    Department of Psychiatry, The University of Chicago, MC3077, 5841 S Maryland Avenue, 60637, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 186:442-50. 2006
    ..Humans synthesize 3alpha,5alpha-THP, but its role in response to systemic administration of ethanol is unclear...
  55. ncbi request reprint Associations of histories of depression and PMDD diagnosis with allopregnanolone concentrations following the oral administration of micronized progesterone
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Psychoneuroendocrinology 31:1208-19. 2006
    ....
  56. pmc Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon
    Clyde W Hodge
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
    J Clin Invest 110:1003-10. 2002
    ..The findings also suggest PKCepsilon as a possible therapeutic target for development of anxiolytics...
  57. ncbi request reprint Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task
    Douglas B Matthews
    Department of Psychology, The University of Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 26:1747-51. 2002
    ..Given that ethanol and allopregnanolone are both gamma-aminobutyric acid type A receptor modulators, both drugs should produce similar degradations in spatial learning and memory...
  58. ncbi request reprint Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Neuropsychopharmacology 28:1-13. 2003
    ..Alterations in this neuroactive steroid may result in the modulation of GABAergic and dopaminergic neurotransmission, potentially contributing to antipsychotic efficacy...
  59. ncbi request reprint Chronic intermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance
    Janelle M Silvers
    Department of Psychology, University of Memphis, Memphis, TN 38152, USA
    Alcohol 39:151-8. 2006
    ..Furthermore, cognitive tolerance is reversible and time dependent, but the reversal of cognitive tolerance is not correlated with normalization of hippocampal allopregnanolone levels...
  60. pmc Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors
    Chunsheng Wang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, NC 27705, USA
    Neurosci Lett 415:118-23. 2007
    ..These ALLO effects on GABAergic transmission in the central amygdala may play a role in mediating its anxiolytic actions...
  61. pmc Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear
    James M Sonner
    Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
    Mol Pharmacol 68:61-8. 2005
    ..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane...
  62. pmc Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, TN, USA
    Alcohol 42:469-76. 2008
    ..These data demonstrate that mild footshock stress is a suboptimal method of modeling the stress-induced increases in ethanol consumption often reported by humans...
  63. ncbi request reprint Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity
    Sayaka Tokunaga
    Department of Psychology, The University of Memphis, TN 38152, USA
    Brain Res 967:273-80. 2003
    ..The results further demonstrate similar effects of allopregnanolone and ethanol on hippocampal neurophysiology and that allopregnanolone plays a key role in producing ethanol-induced inhibition of hippocampal neural activity...
  64. ncbi request reprint Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions
    Christine E Marx
    Duke University Medical Center, Durham NC, New York, NY, USA
    Pharmacol Biochem Behav 84:609-17. 2006
    ..Since pregnenolone decreases have been linked to depression, it is possible that olanzapine- and fluoxetine-induced pregnenolone elevations may contribute to the antidepressant actions of these agents...
  65. ncbi request reprint Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?
    Christine E Marx
    Duke University Medical Center, Durham NC, USA
    Pharmacol Biochem Behav 84:598-608. 2006
    ..987). Olanzapine also elevates pregnenolone levels, but to a lesser degree than clozapine. Pregnenolone induction may contribute to the clinical actions of clozapine and olanzapine...
  66. ncbi request reprint Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuropsychopharmacology 31:1249-63. 2006
    ..Neuroactive steroids may therefore be candidate modulators of the pathophysiology of schizophrenia and bipolar disorder, and relevant to the treatment of these disorders...
  67. ncbi request reprint Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice
    Jason E Kralic
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    J Comp Neurol 495:408-21. 2006
    ..In addition, clustering of gephyrin at synaptic sites in cerebellum and thalamus appears to be dependent on expression of a GABA(A) receptor subtype localized postsynaptically...