Kari M Morrissey

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Renal transporters in drug development
    Kari M Morrissey
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Annu Rev Pharmacol Toxicol 53:503-29. 2013
  2. ncbi request reprint OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143 2911 Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China
    Proc Natl Acad Sci U S A 111:9983-8. 2014
  3. pmc Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
    Matthias B Wittwer
    University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences RH 581, 1550 Fourth Street, San Francisco, California 94158, USA
    J Med Chem 56:781-95. 2013

Collaborators

  • Yan Shu
  • Yong Huang
  • Ligong Chen
  • Kathleen M Giacomini
  • Arik A Zur
  • Matthias B Wittwer
  • Huan Chieh Chien
  • Eugene C Chen
  • Michael J Lin
  • Lu Xu
  • Kaveh Ashrafi
  • Sook Wah Yee
  • John Kurhanewicz
  • Jason Liu
  • Shuanglian Li
  • Kevan M Shokat
  • Jonathan Ostrem
  • Noah S Younger
  • Kayvan R Keshari
  • Youcai Zhang
  • Xiaomin Liang
  • Andrej Sali
  • Xuexiang Zhang
  • Natalia Khuri
  • Alan Kosaka
  • Yasuto Kido

Detail Information

Publications3

  1. doi request reprint Renal transporters in drug development
    Kari M Morrissey
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Annu Rev Pharmacol Toxicol 53:503-29. 2013
    ..Renal drug elimination in special populations and transporter splicing variants are also described...
  2. ncbi request reprint OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143 2911 Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China
    Proc Natl Acad Sci U S A 111:9983-8. 2014
    ..The studies implicate OCT1 as well as metformin in thiamine disposition, suggesting an intriguing and parallel mechanism for metformin and its major hepatic transporter in metabolic function. ..
  3. pmc Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
    Matthias B Wittwer
    University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences RH 581, 1550 Fourth Street, San Francisco, California 94158, USA
    J Med Chem 56:781-95. 2013
    ..In parallel, a QSAR model identified distinct molecular properties of MATE1 versus OCT2 inhibitors and was used to screen the DrugBank in silico library for new hits in a larger chemical space...