James H Morrissey

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. doi request reprint Low-carb tissue factor?
    J H Morrissey
    Department of Biochemistry, College of Medicine, University of Illinois, Urbana, IL 61801, USA
    J Thromb Haemost 9:1508-10. 2011
  2. pmc Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
    James H Morrissey
    Biochemistry Department, University of Illinois, 506 S Mathews Ave, Urbana, IL 61801, USA
    Blood 119:5972-9. 2012
  3. pmc Tissue factor/factor VIIa complex: role of the membrane surface
    James H Morrissey
    Department of Biochemistry, Chemistry, and Pharmacology, University of Illinois, Urbana, IL 61801, USA
    Thromb Res 129:S8-10. 2012
  4. pmc Polyphosphate: a link between platelets, coagulation and inflammation
    James H Morrissey
    Department of Biochemistry, University of Illinois, 417 Med Sci Bldg MC 714, 506 S Mathews Ave, Urbana, IL 61801, USA
    Int J Hematol 95:346-52. 2012
  5. pmc Protein-membrane interactions: blood clotting on nanoscale bilayers
    J H Morrissey
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Thromb Haemost 7:169-72. 2009
  6. pmc Nanoscale studies of protein-membrane interactions in blood clotting
    J H Morrissey
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Thromb Haemost 9:162-7. 2011
  7. pmc Protein-phospholipid interactions in blood clotting
    James H Morrissey
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews Ave, Urbana, IL, USA
    Thromb Res 125:S23-5. 2010
  8. pmc Blood clotting reactions on nanoscale phospholipid bilayers
    James H Morrissey
    Departments of Biochemistry, Chemistry and Pharmacology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 1217263, USA
    Thromb Res 122:S23-6. 2008
  9. pmc Factor VII and protein C are phosphatidic acid-binding proteins
    Narjes Tavoosi
    Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA
    Biochemistry 52:5545-52. 2013
  10. pmc Polyphosphate is a cofactor for the activation of factor XI by thrombin
    Sharon H Choi
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 61801, USA
    Blood 118:6963-70. 2011

Research Grants

  1. Mechanisms of Clotting Factor Assembly
    James H Morrissey; Fiscal Year: 2010
  2. Mechanisms of Clotting Factor Assembly
    James Morrissey; Fiscal Year: 2009
  3. Mechanisms of Clotting Factor Assembly
    James Morrissey; Fiscal Year: 2007
  4. MECHANISMS OF TISSUE FACTOR/FACTOR VII ASSEMBLY
    James Morrissey; Fiscal Year: 2004
  5. MECHANISMS OF TISSUE FACTOR/FACTOR VII ASSEMBLY
    James Morrissey; Fiscal Year: 2000
  6. Structure and Function of Protein-Membrane Interactions in Blood Clotting
    Chad M Rienstra; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. doi request reprint Low-carb tissue factor?
    J H Morrissey
    Department of Biochemistry, College of Medicine, University of Illinois, Urbana, IL 61801, USA
    J Thromb Haemost 9:1508-10. 2011
  2. pmc Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
    James H Morrissey
    Biochemistry Department, University of Illinois, 506 S Mathews Ave, Urbana, IL 61801, USA
    Blood 119:5972-9. 2012
    ..The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated...
  3. pmc Tissue factor/factor VIIa complex: role of the membrane surface
    James H Morrissey
    Department of Biochemistry, Chemistry, and Pharmacology, University of Illinois, Urbana, IL 61801, USA
    Thromb Res 129:S8-10. 2012
    ....
  4. pmc Polyphosphate: a link between platelets, coagulation and inflammation
    James H Morrissey
    Department of Biochemistry, University of Illinois, 417 Med Sci Bldg MC 714, 506 S Mathews Ave, Urbana, IL 61801, USA
    Int J Hematol 95:346-52. 2012
    ..The detailed molecular mechanisms by which polyP modulates blood clotting reactions still remain to be elucidated...
  5. pmc Protein-membrane interactions: blood clotting on nanoscale bilayers
    J H Morrissey
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Thromb Haemost 7:169-72. 2009
    ..Furthermore, exciting new progress in solid-state NMR and large-scale molecular dynamics simulations allow structural insights into interactions between proteins and membrane surfaces with atomic resolution...
  6. pmc Nanoscale studies of protein-membrane interactions in blood clotting
    J H Morrissey
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Thromb Haemost 9:162-7. 2011
    ..Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces...
  7. pmc Protein-phospholipid interactions in blood clotting
    James H Morrissey
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews Ave, Urbana, IL, USA
    Thromb Res 125:S23-5. 2010
    ..These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions...
  8. pmc Blood clotting reactions on nanoscale phospholipid bilayers
    James H Morrissey
    Departments of Biochemistry, Chemistry and Pharmacology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 1217263, USA
    Thromb Res 122:S23-6. 2008
    ..We have also used detailed molecular-dynamics simulations of nanoscale bilayers to provide atomic-scale predictions of how the membrane-binding domain of factor VIIa interacts with PS in membranes...
  9. pmc Factor VII and protein C are phosphatidic acid-binding proteins
    Narjes Tavoosi
    Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA
    Biochemistry 52:5545-52. 2013
    ..We conclude that factor VII and protein C bind preferentially to monoester phosphates, which may have implications for the function of these proteases in vivo. ..
  10. pmc Polyphosphate is a cofactor for the activation of factor XI by thrombin
    Sharon H Choi
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 61801, USA
    Blood 118:6963-70. 2011
    ..We therefore propose that polyphosphate is a natural cofactor for factor XI activation in plasma that may help explain the role of factor XI in hemostasis and thrombosis...
  11. ncbi request reprint The local phospholipid environment modulates the activation of blood clotting
    Andrew W Shaw
    Department of Chemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 282:6556-63. 2007
    ..tissue factor complex requires extremely high local concentrations of anionic phospholipids and further that a large pool of membrane-bound factor X is not required to support sustained catalysis...
  12. pmc Polyphosphate exerts differential effects on blood clotting, depending on polymer size
    Stephanie A Smith
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Blood 116:4353-9. 2010
    ..Microbial polyphosphate, which is highly procoagulant, may function in host responses to pathogens...
  13. pmc Molecular determinants of phospholipid synergy in blood clotting
    Narjes Tavoosi
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 286:23247-53. 2011
    ..Following cell damage or activation, exposed PS and phosphatidylethanolamine collaborate to bind GLA domains by providing phospho-L-serine-specific and phosphate-specific interactions, respectively...
  14. pmc Atomic view of calcium-induced clustering of phosphatidylserine in mixed lipid bilayers
    John M Boettcher
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    Biochemistry 50:2264-73. 2011
    ..The results of MD simulations performed on PS lipid bilayers in the presence or absence of Ca(2+) provide an atomic view of the conformational effects underlying the observed spectra...
  15. pmc Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation
    Stephanie A Smith
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Blood 120:5103-10. 2012
    ..This study provides proof of principle for polyphosphate inhibitors as antithrombotic/anti-inflammatory agents in vitro and in vivo, with a novel mode of action compared with conventional anticoagulants...
  16. pmc Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activities
    Sharon H Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    Biochemistry 49:9935-41. 2010
    ..Our findings open up essentially the entire armamentarium of protein chemistry to modifying polyphosphate, which should greatly facilitate studies of its biological roles...
  17. ncbi request reprint Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation
    Emily K Waters
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 281:26062-8. 2006
    ..These studies indicate that proper positioning of the factor VII/VIIa binding site on tissue factor above the membrane surface is important for efficient rates of activation of factor X by this membrane-bound enzyme/cofactor complex...
  18. pmc Polyphosphate modulates blood coagulation and fibrinolysis
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 103:903-8. 2006
    ....
  19. pmc Polyphosphate enhances fibrin clot structure
    Stephanie A Smith
    Departments of Internal Medicine and Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, USA
    Blood 112:2810-6. 2008
    ..Polyphosphate may also be useful in enhancing the structure of surgical fibrin sealants...
  20. pmc Polyphosphate and omptins: novel bacterial procoagulant agents
    Thomas H Yun
    Biochemistry Department, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Mol Med 13:4146-53. 2009
    ..However, since the rate of TFPI inactivation is much higher than the rate of plasminogen activation, we suggest that Pla may have a dual function in supporting the bubonic form of plague which is unique to Yersinia pestis...
  21. pmc Restoring full biological activity to the isolated ectodomain of an integral membrane protein
    Emily K Waters
    Department of Biochemistry, College of Medicine, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 45:3769-74. 2006
    ..Applications include high-throughput screening of mutants or drugs, flow reactors, clinical assays, and point-of-care instrumentation...
  22. pmc Backbone 1H, 13C and 15N resonance assignments of the extracellular domain of tissue factor
    John M Boettcher
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 S Mathews Ave, Box 50 6, Urbana, IL 61801, USA
    Biomol NMR Assign 4:183-5. 2010
    ..Tissue factor is the integral membrane protein that initiates blood coagulation through the formation an enzymatic complex with the plasma serine protease, factor VIIa...
  23. ncbi request reprint Tissue factor: a key molecule in hemostatic and nonhemostatic systems
    James H Morrissey
    Biochemistry Department, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Int J Hematol 79:103-8. 2004
    ....
  24. ncbi request reprint Sensitive fluorescence detection of polyphosphate in polyacrylamide gels using 4',6-diamidino-2-phenylindol
    Stephanie A Smith
    Department of Internal Medicine, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews, Urbana, IL 61801, USA
    Electrophoresis 28:3461-5. 2007
    ..The lower LOD using DAPI negative staining was 4 pmol (0.3 ng) phosphate per band, compared to conventional toluidine blue staining with a lower LOD of 250 pmol per band...
  25. pmc Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins
    Thomas H Yun
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, IL 61801, USA
    Blood 113:1139-48. 2009
    ..This may contribute to the hemostatic imbalance in disseminated intravascular coagulation and other coagulopathies accompanying severe sepsis...
  26. ncbi request reprint Tissue factor alters the pK(a) values of catalytically important factor VIIa residues
    Pierre F Neuenschwander
    Department of Biochemistry, Biomedical Research Lab C7, The University of Texas Health Center at Tyler, 11937 U S Highway 271, Tyler, TX 75708, USA
    Biochemistry 41:3364-71. 2002
    ....

Research Grants10

  1. Mechanisms of Clotting Factor Assembly
    James H Morrissey; Fiscal Year: 2010
    ..These studies are aimed at understanding how newly discovered modulators of the blood clotting system contribute to normal hemostasis and to the activation of the blood clotting system in human disease. ..
  2. Mechanisms of Clotting Factor Assembly
    James Morrissey; Fiscal Year: 2009
    ..These studies are aimed at understanding how newly discovered modulators of the blood clotting system contribute to normal hemostasis and to the activation of the blood clotting system in human disease. ..
  3. Mechanisms of Clotting Factor Assembly
    James Morrissey; Fiscal Year: 2007
    ..These studies are aimed at understanding how newly discovered modulators of the blood clotting system contribute to normal hemostasis and to the activation of the blood clotting system in human disease. ..
  4. MECHANISMS OF TISSUE FACTOR/FACTOR VII ASSEMBLY
    James Morrissey; Fiscal Year: 2004
    ..These studies are designed to provide new insights in the process by which the blood clotting system is triggered in thrombotic disease, the major cause of disability and death in the United States. ..
  5. MECHANISMS OF TISSUE FACTOR/FACTOR VII ASSEMBLY
    James Morrissey; Fiscal Year: 2000
    ..Such knowledge will ultimately be useful in designing and applying novel antithrombotic agents targeted at the initiation phase of the clotting system. ..
  6. Structure and Function of Protein-Membrane Interactions in Blood Clotting
    Chad M Rienstra; Fiscal Year: 2010
    ..These studies will shed new light on the regulation of the blood clotting system, with a particular focus on achieving a detailed understanding of how and why blood clotting reactions occur on membrane surfaces. ..