TRUDY MORRISON

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi request reprint Subunit and virus-like particle vaccine approaches for respiratory syncytial virus
    Trudy G Morrison
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Curr Top Microbiol Immunol 372:285-306. 2013
  2. ncbi request reprint The three faces of paramyxovirus attachment proteins
    T G Morrison
    Dept of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Trends Microbiol 9:103-5. 2001
  3. pmc Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:2894-903. 2006
  4. ncbi request reprint Mutational analysis of the membrane proximal heptad repeat of the newcastle disease virus fusion protein
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01532, USA
    Virology 289:343-52. 2001
  5. pmc Role of the cytoplasmic domain of the Newcastle disease virus fusion protein in association with lipid rafts
    V Dolganiuc
    Department of Molecular Genetics and Microbiology Department of Cell Biology Program in Virology and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Virol 77:12968-79. 2003
  6. pmc The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein
    Kathryn A Gravel
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 85:3486-97. 2011
  7. pmc Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins
    Lori W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:366-77. 2011
  8. pmc Mutations in the fusion peptide and adjacent heptad repeat inhibit folding or activity of the Newcastle disease virus fusion protein
    T A Sergel
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Virol 75:7934-43. 2001
  9. pmc Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB/c mice, with no evidence of immunopathology
    Matthew R Murawski
    Department of Molecular Genetics, University of Massachusetts Medical School, Rm S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 84:1110-23. 2010

Research Grants

  1. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2003
  2. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2002
  3. MUTATIONAL ANALYSIS OF THE NDV FUSION GLYCOPROTEIN
    TRUDY MORRISON; Fiscal Year: 1993
  4. MUTATIONAL ANALYSIS OF THE NDV FUSION GLYCOPROTEIN
    TRUDY MORRISON; Fiscal Year: 1992
  5. MUTATIONAL ANALYSIS OF THE NDV FUSION GLYCOPROTEIN
    TRUDY MORRISON; Fiscal Year: 1991
  6. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 1999
  7. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2000
  8. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2004
  9. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2005

Collaborators

  • Edward E Walsh
  • Lori W McGinnes
  • L W McGinnes
  • Kathryn A Gravel
  • Gale Smith
  • Michael J Massare
  • Evelyn A Kurt-Jones
  • Robert W Finberg
  • Matthew R Murawski
  • V Dolganiuc
  • T A Sergel
  • Julie Reitter
  • Madelyn R Schmidt
  • Armando E Fraire
  • Penny M Heaton
  • L McGinnes
  • E J Luna
  • L Hamo
  • D Li
  • H Chen
  • T Sergel
  • S Schwertz

Detail Information

Publications9

  1. doi request reprint Subunit and virus-like particle vaccine approaches for respiratory syncytial virus
    Trudy G Morrison
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Curr Top Microbiol Immunol 372:285-306. 2013
    ..Rather, efforts have focused on development of other approaches. In this chapter, we review the history and status of purified proteins, peptides, virus-like particles, virosomes, and nanoparticles and discuss their future potential. ..
  2. ncbi request reprint The three faces of paramyxovirus attachment proteins
    T G Morrison
    Dept of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Trends Microbiol 9:103-5. 2001
    ..The recent report of the structure of a paramyxovirus attachment protein should clarify the mechanism of cell entry by these viruses...
  3. pmc Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
    J Virol 80:2894-903. 2006
    ..Furthermore, the results show that not only receptor binding but also F protein cleavage are necessary for disassociation of the HN and F protein-containing complexes...
  4. ncbi request reprint Mutational analysis of the membrane proximal heptad repeat of the newcastle disease virus fusion protein
    L W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01532, USA
    Virology 289:343-52. 2001
    ..These results also suggest that the HR2 domain, particularly the carboxyl-terminal region, plays an additional role in fusion, a role related to content mixing and syncytia formation...
  5. pmc Role of the cytoplasmic domain of the Newcastle disease virus fusion protein in association with lipid rafts
    V Dolganiuc
    Department of Molecular Genetics and Microbiology Department of Cell Biology Program in Virology and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Virol 77:12968-79. 2003
    ..The results presented here raise the possibility that the cytoplasmic domain is important in virus assembly at least in part because it directs the protein to cholesterol-rich membrane domains...
  6. pmc The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein
    Kathryn A Gravel
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Virol 85:3486-97. 2011
    ..These results show that the specific sequence of the TM domain of the NDV F protein is important for the conformation of the preactivation form of the ectodomain, the interactions of the protein with HN protein, and fusion activity...
  7. pmc Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins
    Lori W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:366-77. 2011
    ..These results suggest that these VLPs are effective RSV vaccines in mice, in contrast to other nonreplicating RSV vaccine candidates...
  8. pmc Mutations in the fusion peptide and adjacent heptad repeat inhibit folding or activity of the Newcastle disease virus fusion protein
    T A Sergel
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Virol 75:7934-43. 2001
    ..We also found that mutations within the fusion peptide, at residue 128, can interfere with folding of the protein, implicating this region in folding of the molecule. No characterized mutation enhanced fusion...
  9. pmc Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB/c mice, with no evidence of immunopathology
    Matthew R Murawski
    Department of Molecular Genetics, University of Massachusetts Medical School, Rm S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 84:1110-23. 2010
    ..These data support further development of virus-like particle vaccine candidates for protection against RSV...

Research Grants14

  1. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2003
    ..4) explore the role of attachment in initiation of fusion. ..
  2. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2002
    ..4) explore the role of attachment in initiation of fusion. ..
  3. MUTATIONAL ANALYSIS OF THE NDV FUSION GLYCOPROTEIN
    TRUDY MORRISON; Fiscal Year: 1993
  4. MUTATIONAL ANALYSIS OF THE NDV FUSION GLYCOPROTEIN
    TRUDY MORRISON; Fiscal Year: 1992
  5. MUTATIONAL ANALYSIS OF THE NDV FUSION GLYCOPROTEIN
    TRUDY MORRISON; Fiscal Year: 1991
  6. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 1999
    ..To define how the fusion protein directs the fusion between the attack and the target membranes. 2. To test the hypothesis that the HN protein functions to activate the fusion protein and to define the mechanisms involved in activation. ..
  7. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2000
    ..To define how the fusion protein directs the fusion between the attack and the target membranes. 2. To test the hypothesis that the HN protein functions to activate the fusion protein and to define the mechanisms involved in activation. ..
  8. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2004
    ..4) explore the role of attachment in initiation of fusion. ..
  9. PARAMYXOVIRUS MEMBRANE FUSION
    TRUDY MORRISON; Fiscal Year: 2005
    ..4) explore the role of attachment in initiation of fusion. ..