SEAN MORRISON

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Applying the principles of stem-cell biology to cancer
    Ricardo Pardal
    Howard Hughes Medical Institute, and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, 3215 CCGC, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0934, USA
    Nat Rev Cancer 3:895-902. 2003
  2. ncbi request reprint Cancer stem cells
    Sean J Morrison
    University of Michigan, MI, USA
    Clin Adv Hematol Oncol 3:171-2. 2005
  3. pmc Hirschsprung disease is linked to defects in neural crest stem cell function
    Toshihide Iwashita
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Science 301:972-6. 2003
  4. ncbi request reprint Asymmetric and symmetric stem-cell divisions in development and cancer
    Sean J Morrison
    Howard Hughes Medical Institute and Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:1068-74. 2006
  5. pmc Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress
    Sergei Chuikov
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Nat Cell Biol 12:999-1006. 2010
  6. pmc Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    Daisuke Nakada
    Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 468:653-8. 2010
  7. ncbi request reprint Neuronal potential and lineage determination by neural stem cells
    S J Morrison
    Howard Hughes Medical Institute, Department of Internal Medicine, 3215 CCGC, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Curr Opin Cell Biol 13:666-72. 2001
  8. ncbi request reprint Stem cells and niches: mechanisms that promote stem cell maintenance throughout life
    Sean J Morrison
    Howard Hughes Medical Institute, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI, 48109 2216, USA
    Cell 132:598-611. 2008
  9. pmc DHODH modulates transcriptional elongation in the neural crest and melanoma
    Richard Mark White
    Stem Cell Program and Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:518-22. 2011
  10. ncbi request reprint Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity
    Suzanne Bixby
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:643-56. 2002

Research Grants

Collaborators

  • Michael F Clarke
  • IRVING LERNER WEISSMAN
  • Mark Shackleton
  • Leonard I Zon
  • Grant N Wheeler
  • Yuan Zhu
  • Allan Spradling
  • Wei Guo
  • Eric Fearon
  • Trachette L Jackson
  • MICHAEL SCOTT SABEL
  • S J Conway
  • Rina Ashkenazi
  • NORMAN SHARPLESS
  • Arturo Alvarez-Buylla
  • Omer H Yilmaz
  • Mark J Kiel
  • Nancy M Joseph
  • Toshihide Iwashita
  • Shenghui He
  • Anna V Molofsky
  • Genevieve M Kruger
  • Ricardo Pardal
  • Jack T Mosher
  • In Kyung Park
  • Daisuke Nakada
  • Boaz P Levi
  • Richard Mark White
  • Sergei Chuikov
  • Johanna Buchstaller
  • Jinsuke Nishino
  • Suzanne Bixby
  • Elsa Quintana
  • David J Anderson
  • Manuel Alvarez-Dolado
  • Chris J Kubu
  • Stuart H Orkin
  • Scott Granter
  • Peter B Rahl
  • Matthew L Tomlinson
  • Frank Chen
  • Hannah K Long
  • Erin Langdon
  • Jennifer Cech
  • Jack Mosher
  • Martin Kramer
  • Sumon Datta
  • Sutheera Ratanasirintrawoot
  • Richard A Young
  • Christopher J Burke
  • Charles Y Lin
  • Charles Kaufman
  • Donna Neuberg
  • Thomas L Saunders
  • Michael L Smith
  • Dafydd Thomas
  • Gregg Duester
  • Timothy M Johnson
  • Luis F Parada
  • Megan Lim
  • Kiran Chada
  • Paige Snider
  • Injune Kim
  • Paul E McKeever
  • Douglas R Fullen
  • Jake A Kushner
  • Sara N Gentry
  • Monica Teta
  • Brian K Theisen
  • Riccardo Valdez
  • Hong Wu
  • David O Ferguson
  • Janakiraman Krishnamurthy
  • Shalom G Slutsky
  • Cox Terhorst
  • Osman H Yilmaz
  • Yoh suke Mukouyama
  • Kuo Fen Lee
  • Steven A Crone
  • Dies Meijer
  • Emma Louise Dormand
  • Martine Jaegle
  • Michael W Becker
  • Michael Pihalja
  • Mark Kiel
  • Jose M Garcia-Verdugo
  • John R Fike
  • Hyun O Lee
  • Kelly J Yeager
  • Dalong Qian

Detail Information

Publications37

  1. ncbi request reprint Applying the principles of stem-cell biology to cancer
    Ricardo Pardal
    Howard Hughes Medical Institute, and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, 3215 CCGC, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0934, USA
    Nat Rev Cancer 3:895-902. 2003
  2. ncbi request reprint Cancer stem cells
    Sean J Morrison
    University of Michigan, MI, USA
    Clin Adv Hematol Oncol 3:171-2. 2005
  3. pmc Hirschsprung disease is linked to defects in neural crest stem cell function
    Toshihide Iwashita
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Science 301:972-6. 2003
    ..Gene expression profiling, combined with reverse genetics and analyses of stem cell function, suggests that Hirschsprung disease is caused by defects in neural crest stem cell function...
  4. ncbi request reprint Asymmetric and symmetric stem-cell divisions in development and cancer
    Sean J Morrison
    Howard Hughes Medical Institute and Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:1068-74. 2006
    ..The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity...
  5. pmc Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress
    Sergei Chuikov
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Nat Cell Biol 12:999-1006. 2010
    ..Prdm16 therefore promotes stem cell maintenance in multiple tissues, partly by modulating oxidative stress...
  6. pmc Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    Daisuke Nakada
    Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 468:653-8. 2010
    ..Lkb1 is therefore required for HSC maintenance through AMPK-dependent and AMPK-independent mechanisms, revealing differences in metabolic and cell-cycle regulation between HSCs and some other haematopoietic progenitors...
  7. ncbi request reprint Neuronal potential and lineage determination by neural stem cells
    S J Morrison
    Howard Hughes Medical Institute, Department of Internal Medicine, 3215 CCGC, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Curr Opin Cell Biol 13:666-72. 2001
    ....
  8. ncbi request reprint Stem cells and niches: mechanisms that promote stem cell maintenance throughout life
    Sean J Morrison
    Howard Hughes Medical Institute, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI, 48109 2216, USA
    Cell 132:598-611. 2008
    ..Mechanisms of stem cell maintenance are key to the regulation of homeostasis and likely contribute to aging and tumorigenesis when altered during adulthood...
  9. pmc DHODH modulates transcriptional elongation in the neural crest and melanoma
    Richard Mark White
    Stem Cell Program and Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:518-22. 2011
    ..Taken together, these studies highlight developmental pathways in neural crest cells that have a direct bearing on melanoma formation...
  10. ncbi request reprint Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity
    Suzanne Bixby
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:643-56. 2002
    ..Upon transplantation of uncultured NCSCs into developing peripheral nerves in vivo, sciatic nerve NCSCs gave rise only to glia, while gut NCSCs gave rise primarily to neurons. Thus, cell fate in the nerve was stem cell determined...
  11. pmc Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    Anna V Molofsky
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 443:448-52. 2006
    ..Declining subventricular zone progenitor function and olfactory bulb neurogenesis during ageing are thus caused partly by increasing p16INK4a expression...
  12. pmc Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness
    Genevieve M Kruger
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:657-69. 2002
    ..The persistence of NCSCs in the adult PNS opens up new possibilities for regeneration after injury or disease...
  13. pmc The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells
    Nancy M Joseph
    Center for Stem Cell Biology, Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cancer Cell 13:129-40. 2008
    ..Tumors appeared to arise from differentiated glia, not NCSCs...
  14. pmc Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression
    Jinsuke Nishino
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cell 135:227-39. 2008
    ..Hmga2 thus promotes fetal and young-adult stem cell self-renewal by decreasing p16(Ink4a)/p19(Arf) expression. Changes in let-7 and Hmga2 expression during aging contribute to the decline in neural stem cell function...
  15. pmc Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems
    Boaz P Levi
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Blood 113:1670-80. 2009
    ..Finally, Aldh1a1 deficiency did not affect the function of stem cells from the adult central or peripheral nervous systems. Aldh1a1 is not a critical regulator of adult stem cell function or Aldefluor staining in mice...
  16. pmc Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    Anna V Molofsky
    Howard Hughes Medical Institute, and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 0934, USA
    Nature 425:962-7. 2003
    ..Restricted neural progenitors from the gut and forebrain proliferate normally in the absence of Bmi-1. Thus, Bmi-1 dependence distinguishes stem cell self-renewal from restricted progenitor proliferation in these tissues...
  17. doi request reprint Mechanisms of stem cell self-renewal
    Shenghui He
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Annu Rev Cell Dev Biol 25:377-406. 2009
    ..Reduced stem cell function and tissue regenerative capacity during aging are caused by changes in self-renewal programs that augment tumor suppression. Cancer arises from mutations that inappropriately activate self-renewal programs...
  18. doi request reprint Heterogeneity in cancer: cancer stem cells versus clonal evolution
    Mark Shackleton
    Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 138:822-9. 2009
    ....
  19. pmc Efficient tumour formation by single human melanoma cells
    Elsa Quintana
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 456:593-8. 2008
    ..Modifications to xenotransplantation assays can therefore dramatically increase the detectable frequency of tumorigenic cells, demonstrating that they are common in some human cancers...
  20. pmc Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo
    Shenghui He
    Howard Hughes Medical Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, 5435 Life Sciences Institute, 210 Washtenaw Ave, Ann Arbor, MI 48109 2216, USA
    Dev Biol 328:257-72. 2009
    ..Bmi-1 over-expression therefore has more pronounced effects in culture and does not appear to be sufficient to induce tumorigenesis in vivo...
  21. pmc The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells
    Omer H Yilmaz
    Howard Hughes Medical Institute, Department of Internal Medicine, and Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 2216, USA
    Blood Cells Mol Dis 41:73-6. 2008
    ..This raises the possibility that drugs targeting this pathway could be more effective at eliminating cancer stem cells while being less toxic against normal stem cells...
  22. pmc Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
    Mark J Kiel
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Centre for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 449:238-42. 2007
    ..Thus, HSCs cannot be identified on the basis of BrdU-label retention and do not retain older DNA strands during division, indicating that these are not general properties of stem cells...
  23. ncbi request reprint Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  24. ncbi request reprint Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    Omer H Yilmaz
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:475-82. 2006
    ..Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to deplete cancer stem cells without damaging normal stem cells...
  25. ncbi request reprint Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells
    Genevieve M Kruger
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Neuron 40:917-29. 2003
    ..This migratory defect could be bypassed by transplanting wild-type NCSCs directly into the aganglionic region of the Ednrb(sl/sl) gut, where they engrafted and formed neurons as efficiently as in the wild-type gut...
  26. pmc Bmi1, stem cells, and senescence regulation
    In Kyung Park
    Department of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, 48109, USA
    J Clin Invest 113:175-9. 2004
    ..Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death...
  27. pmc Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells
    Nancy M Joseph
    Department of Internal Medicine, 1500 East Medical Center Drive, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Development 131:5599-612. 2004
    ..Nerve development is thus more complex than was previously thought, involving NCSC self-renewal, lineage commitment and multilineage differentiation...
  28. ncbi request reprint Diverse mechanisms regulate stem cell self-renewal
    Anna V Molofsky
    Howard Hughes Medical Institute, and Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, 3215 CCGC, Ann Arbor, Michigan 48109 0934, USA
    Curr Opin Cell Biol 16:700-7. 2004
    ..By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells...
  29. ncbi request reprint Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells
    Mark J Kiel
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109 0934, USA
    Dev Biol 283:29-39. 2005
    ....
  30. ncbi request reprint SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  31. ncbi request reprint Brain repair by endogenous progenitors
    Genevieve M Kruger
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Cell 110:399-402. 2002
    ..Coupled with recent insights into the mechanism by which Nogo inhibits axonal regeneration, this discovery may inspire new treatments for central nervous system injuries and neurodegenerative diseases...
  32. pmc SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity
    Omer H Yilmaz
    Howard Hughes Medical Institute, Department of Internal Medicine, Ann Arbor, MI, USA
    Blood 107:924-30. 2006
    ..SLAM family receptor expression is conserved among HSCs from diverse contexts, and HSCs from old, reconstituted, and mobilized mice engraft relatively efficiently after transplantation when contaminating cells are eliminated...
  33. ncbi request reprint Toward an understanding of the physiological function of Mammalian stem cells
    Nancy M Joseph
    Howard Hughes Medical Institute and Department of Internal Medicine, 1500 East Medical Center Drive, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 9:173-83. 2005
    ..However, to understand tissue development/maintenance or the role of stem cells in disease, it is important to characterize progenitor function in vivo to evaluate physiological significance...
  34. ncbi request reprint Stem-cell competition
    Stuart H Orkin
    Nature 418:25-7. 2002
  35. ncbi request reprint Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Nature 425:968-73. 2003
    ..These observations provide the first in vivo evidence for cell fusion of BMDCs with neurons and cardiomyocytes, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types...
  36. ncbi request reprint Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells
    Chris J Kubu
    Laboratory of Neural Stem Cell Biology, John P Robarts Research Institute, 100 Perth Drive, London Ontario, N6A5K8, Canada
    Dev Biol 244:199-214. 2002
    ..Thus, Delta-mediated feedback interactions between NCSCs, coupled with positive feedback control of Notch sensitivity within individual cells, may underlie developmental changes in the ligand-sensitivity of these cells...
  37. ncbi request reprint Pten-uating neural growth
    Sean J Morrison
    Nat Med 8:16-8. 2002

Research Grants21

  1. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    Sean J Morrison; Fiscal Year: 2010
    ..By better understanding these mechanisms we will gain new insights into how the PNS forms and what goes wrong in the context of disease. ..
  2. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2001
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  3. ASCB Summer Meeting- Stem Cell Niches
    SEAN MORRISON; Fiscal Year: 2006
    ....
  4. Genetic analysis of stem cell maintenance in vivo
    SEAN MORRISON; Fiscal Year: 2009
    ..Such information is critical to understand how blood cell formation is regulated and how stem cells are sustained in this tissue throughout life. ..
  5. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2006
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  6. Genetic analysis of stem cell maintenance in vivo
    Sean J Morrison; Fiscal Year: 2010
    ..Such information is critical to understand how blood cell formation is regulated and how stem cells are sustained in this tissue throughout life. ..
  7. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2004
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  8. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
  9. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2002
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  10. The Regulation of Stem Cell Aging
    SEAN MORRISON; Fiscal Year: 2007
    ..Answers to these questions would have fundamental implications for understanding the regulation of stem cell aging, and for generating new strategies for treating age-related morbidity. ..
  11. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    Sean J Morrison; Fiscal Year: 2010
    ..By better understanding these mechanisms we will gain new insights into how the PNS forms and what goes wrong in the context of disease. ..
  12. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    SEAN MORRISON; Fiscal Year: 2009
    ..These studies will test whether NCSCs with specific regional characteristics can be derived from hES cells and whether these cells engraft in the gut of an animal model of Hirschsprung disease. ..
  13. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2009
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  14. The Regulation of Stem Cell Aging
    SEAN MORRISON; Fiscal Year: 2006
    ..Answers to these questions would have fundamental implications for understanding the regulation of stem cell aging, and for generating new strategies for treating age-related morbidity. ..
  15. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2007
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  16. The Regulation of Stem Cell Aging
    SEAN MORRISON; Fiscal Year: 2006
    ..Answers to these questions would have fundamental implications for understanding the regulation of stem cell aging, and for generating new strategies for treating age-related morbidity. ..
  17. The Regulation of Stem Cell Aging
    SEAN MORRISON; Fiscal Year: 2005
    ..Answers to these questions would have fundamental implications for understanding the regulation of stem cell aging, and for generating new strategies for treating age-related morbidity. ..
  18. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2005
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..
  19. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    SEAN MORRISON; Fiscal Year: 2003
    ..The discovery of NCSCs in postnatal tissues might fundamentally alter approaches to regeneration in the PNS. Answers to these questions could change the way we think about PNS development, injury, and disease. ..