Research Topics
| Richard MorrisonSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neuronsS Ghatan
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
J Cell Biol 150:335-47. 2000..These results demonstrate that p38 MAP kinase activity plays a critical role in NO-mediated cell death in neurons by stimulating Bax translocation to the mitochondria, thereby activating the cell death pathway...
Proteomic analysis in the neurosciencesRichard S Morrison
Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
Mol Cell Proteomics 1:553-60. 2002..These advances have significant implications for understanding the multitude of pathways that govern behavior and cognition and the response of the nervous system to injury and disease...- p53-dependent cell death signaling in neuronsRichard S Morrison
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
Neurochem Res 28:15-27. 2003.... - The multiple roles of p53 in the pathogenesis of HIV associated dementiaGwenn A Garden
Department of Neurology, University of Washington, Seattle, WA, USA
Biochem Biophys Res Commun 331:799-809. 2005.... - The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genesSuman Jayadev
Department of Neurology, University of Washington, Seattle, WA, USA
J Neuroimmune Pharmacol 2:359-70. 2007..Activation of p53 mediated pathways in the glia of HAD patients may contribute to the neuroinflammatory processes that promote neurodegeneration by inhibiting glial proliferation and/or promoting glial cell dysfunction... - HIV associated neurodegeneration requires p53 in neurons and microgliaGwenn A Garden
Department of Neurology, Box 356465, University of Washington, Seattle, WA 98195, USA
FASEB J 18:1141-3. 2004.... - Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometryMark D Johnson
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195-6470, USA
J Biol Chem 279:26685-97. 2004..These data demonstrate the power of high throughput mass spectrometry for quantitative analysis of the neuronal proteome... - Proteome analysis of camptothecin-treated cortical neurons using isotope-coded affinity tagsLi-Rong Yu
Pacific Northwest National Laboratory, Richland, WA, USA
Electrophoresis 23:1591-8. 2002..While proteins from most functional classes of proteins were identified, a particularly large percentage of the enzymes involved in glycolysis and the tricarboxylic acid cycle were observed... - Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal deathMark D Johnson
Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
J Biol Chem 277:23000-7. 2002..These findings implicate Peg3/Pw1 as a mediator between p53 and Bax in a neuronal cell death pathway activated by DNA damage... - Proteomics in the postgenomic ageRichard S Morrison
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195, USA
Adv Protein Chem 65:1-23. 2003..These advances have significant implications for understanding how cellular proteomes are regulated in health and disease... - Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neuronsTakuma Uo
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
J Neurosci 27:12198-210. 2007..The uniqueness of p53-mediated apoptotic signaling in postnatal cortical neurons was further illustrated by the dispensable function of the proline-rich domain of p53... - Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosisChristina Tun
Department of Neurology, The University of Washington, Seattle, Washington 98195, USA
J Neurochem 102:1206-19. 2007..These findings suggest that p53 regulates neuronal apoptosis, in part, by suppressing the anti-apoptotic protein XIAP via transcriptional activation of Omi/HtrA2... - Potential applications and limitations of proteomics in the study of neurological diseaseYoshito Kinoshita
Department of Neurological Surgery and Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA
Arch Neurol 63:1692-6. 2006 - Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cellsEric M Sikorski
Division of Nephrology, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 281:24423-30. 2006..The findings demonstrate the important and previously unrecognized role of pescadillo as a DNA-binding protein interacting specifically with the cadmium response element of the human heme oxygenase-1 gene... - TWIST is expressed in human gliomas and promotes invasionMaria C Elias
Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
Neoplasia 7:824-37. 2005..TWIST was also expressed in embryonic and fetal human brain, and in neurons, but not glia, of mature brain, indicating that, in gliomas, TWIST may promote the functions also critical for CNS development or normal neuronal physiology... - The proteomics of neurodegenerationMark D Johnson
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195-6470, USA
Am J Pharmacogenomics 5:259-70. 2005.... - The power of the dark side: Huntington's disease protein and p53 form a deadly allianceAlbert R La Spada
Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
Neuron 47:1-3. 2005..In this issue of Neuron, Bae et al. present data implicating p53 in HD pathogenesis. This intriguing study may thus provide a link between nuclear transcription dysregulation and mitochondrial abnormalities in HD... - Biomarkers: mining the biofluid proteomeTimothy D Veenstra
Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
Mol Cell Proteomics 4:409-18. 2005.... - Evaluation of the acid-cleavable isotope-coded affinity tag reagents: application to camptothecin-treated cortical neuronsLi-Rong Yu
Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute at Frederick, P.O. Box B, Frederick, Maryland 21702-1201, USA
J Proteome Res 3:469-77. 2004..The new ICAT reagents were then applied to the analysis of a cortical neuron proteome sample to identify proteins regulated by the antitumor drug, camptothecin... - Global analysis of the cortical neuron proteomeLi-Rong Yu
Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702-1201, USA
Mol Cell Proteomics 3:896-907. 2004..The results presented here provide the broadest proteome coverage for a mammalian cell to date and show that MS-based proteomics has the potential to provide high coverage of the proteins expressed within a cell... - Neuronal survival and cell death signaling pathwaysRichard S Morrison
Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195-6470, USA
Adv Exp Med Biol 513:41-86. 2002..In this review we examine recent evidence pertaining to the presence and activation of anti- and pro-cell death regulatory pathways in nervous system injury and degeneration... - Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosisTakuma Uo
Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
J Biol Chem 280:9065-73. 2005..The absence of full-length Bak expression explains the near exclusive requirement for Bax in neuronal apoptosis...
Research Grants
- Proteome analysis of malignant astrocytesRichard Morrison; Fiscal Year: 2006....
- REGULATION OF NEURONAL SURVIVALRichard Morrison; Fiscal Year: 2007..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
- REGULATION OF NEURONAL SURVIVALRichard Morrison; Fiscal Year: 2009..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
- Mechanisms of Neuroprotection by Histone Deacetylase InhibitionRichard Morrison; Fiscal Year: 2009..We propose to determine how histone deacetylase inhibitors block neuronal cell death which could lead to the development of new therapeutic agents for treating neurological diseases and nervous system injury. ..
- REGULATION OF NEURONAL SURVIVALRichard S Morrison; Fiscal Year: 2010..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
- Proteome-Wide Characterization of PhosphoproteinsRichard Morrison; Fiscal Year: 2004..abstract_text> ..
- REGULATION OF NEURONAL SURVIVALRichard Morrison; Fiscal Year: 2000..Elucidating the function of p53 in the nervous system may shed light on the regulation of neuronal survival in response to injury in neurologic disease. ..
- REGULATION OF NEURONAL SURVIVALRichard Morrison; Fiscal Year: 2004..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
- Regulation of Astrocytoma GrowthRichard Morrison; Fiscal Year: 2004..abstract_text> ..
- Mechanisms of Neuroprotection by Histone Deacetylase InhibitionRichard S Morrison; Fiscal Year: 2010..We propose to determine how histone deacetylase inhibitors block neuronal cell death which could lead to the development of new therapeutic agents for treating neurological diseases and nervous system injury. ..