Richard Morrison

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons
    S Ghatan
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Cell Biol 150:335-47. 2000
  2. ncbi request reprint Proteomic analysis in the neurosciences
    Richard S Morrison
    Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Mol Cell Proteomics 1:553-60. 2002
  3. ncbi request reprint p53-dependent cell death signaling in neurons
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Neurochem Res 28:15-27. 2003
  4. ncbi request reprint The multiple roles of p53 in the pathogenesis of HIV associated dementia
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, WA, USA
    Biochem Biophys Res Commun 331:799-809. 2005
  5. ncbi request reprint The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Neuroimmune Pharmacol 2:359-70. 2007
  6. ncbi request reprint HIV associated neurodegeneration requires p53 in neurons and microglia
    Gwenn A Garden
    Department of Neurology, Box 356465, University of Washington, Seattle, WA 98195, USA
    FASEB J 18:1141-3. 2004
  7. ncbi request reprint Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometry
    Mark D Johnson
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Biol Chem 279:26685-97. 2004
  8. ncbi request reprint Proteome analysis of camptothecin-treated cortical neurons using isotope-coded affinity tags
    Li Rong Yu
    Pacific Northwest National Laboratory, Richland, WA, USA
    Electrophoresis 23:1591-8. 2002
  9. ncbi request reprint Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death
    Mark D Johnson
    Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
    J Biol Chem 277:23000-7. 2002
  10. ncbi request reprint Proteomics in the postgenomic age
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Adv Protein Chem 65:1-23. 2003

Research Grants

  1. Proteome analysis of malignant astrocytes
    Richard Morrison; Fiscal Year: 2006
  2. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2007
  3. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2009
  4. Mechanisms of Neuroprotection by Histone Deacetylase Inhibition
    Richard Morrison; Fiscal Year: 2009
  5. REGULATION OF NEURONAL SURVIVAL
    Richard S Morrison; Fiscal Year: 2010
  6. Proteome-Wide Characterization of Phosphoproteins
    Richard Morrison; Fiscal Year: 2004
  7. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2000
  8. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2004
  9. Regulation of Astrocytoma Growth
    Richard Morrison; Fiscal Year: 2004
  10. Mechanisms of Neuroprotection by Histone Deacetylase Inhibition
    Richard S Morrison; Fiscal Year: 2010

Collaborators

Detail Information

Publications22

  1. pmc p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons
    S Ghatan
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Cell Biol 150:335-47. 2000
    ..These results demonstrate that p38 MAP kinase activity plays a critical role in NO-mediated cell death in neurons by stimulating Bax translocation to the mitochondria, thereby activating the cell death pathway...
  2. ncbi request reprint Proteomic analysis in the neurosciences
    Richard S Morrison
    Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Mol Cell Proteomics 1:553-60. 2002
    ..These advances have significant implications for understanding the multitude of pathways that govern behavior and cognition and the response of the nervous system to injury and disease...
  3. ncbi request reprint p53-dependent cell death signaling in neurons
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Neurochem Res 28:15-27. 2003
    ....
  4. ncbi request reprint The multiple roles of p53 in the pathogenesis of HIV associated dementia
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, WA, USA
    Biochem Biophys Res Commun 331:799-809. 2005
    ....
  5. ncbi request reprint The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Neuroimmune Pharmacol 2:359-70. 2007
    ..Activation of p53 mediated pathways in the glia of HAD patients may contribute to the neuroinflammatory processes that promote neurodegeneration by inhibiting glial proliferation and/or promoting glial cell dysfunction...
  6. ncbi request reprint HIV associated neurodegeneration requires p53 in neurons and microglia
    Gwenn A Garden
    Department of Neurology, Box 356465, University of Washington, Seattle, WA 98195, USA
    FASEB J 18:1141-3. 2004
    ....
  7. ncbi request reprint Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometry
    Mark D Johnson
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Biol Chem 279:26685-97. 2004
    ..These data demonstrate the power of high throughput mass spectrometry for quantitative analysis of the neuronal proteome...
  8. ncbi request reprint Proteome analysis of camptothecin-treated cortical neurons using isotope-coded affinity tags
    Li Rong Yu
    Pacific Northwest National Laboratory, Richland, WA, USA
    Electrophoresis 23:1591-8. 2002
    ..While proteins from most functional classes of proteins were identified, a particularly large percentage of the enzymes involved in glycolysis and the tricarboxylic acid cycle were observed...
  9. ncbi request reprint Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death
    Mark D Johnson
    Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
    J Biol Chem 277:23000-7. 2002
    ..These findings implicate Peg3/Pw1 as a mediator between p53 and Bax in a neuronal cell death pathway activated by DNA damage...
  10. ncbi request reprint Proteomics in the postgenomic age
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Adv Protein Chem 65:1-23. 2003
    ..These advances have significant implications for understanding how cellular proteomes are regulated in health and disease...
  11. ncbi request reprint Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons
    Takuma Uo
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Neurosci 27:12198-210. 2007
    ..The uniqueness of p53-mediated apoptotic signaling in postnatal cortical neurons was further illustrated by the dispensable function of the proline-rich domain of p53...
  12. ncbi request reprint Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis
    Christina Tun
    Department of Neurology, The University of Washington, Seattle, Washington 98195, USA
    J Neurochem 102:1206-19. 2007
    ..These findings suggest that p53 regulates neuronal apoptosis, in part, by suppressing the anti-apoptotic protein XIAP via transcriptional activation of Omi/HtrA2...
  13. ncbi request reprint Potential applications and limitations of proteomics in the study of neurological disease
    Yoshito Kinoshita
    Department of Neurological Surgery and Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Arch Neurol 63:1692-6. 2006
  14. ncbi request reprint Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cells
    Eric M Sikorski
    Division of Nephrology, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 281:24423-30. 2006
    ..The findings demonstrate the important and previously unrecognized role of pescadillo as a DNA-binding protein interacting specifically with the cadmium response element of the human heme oxygenase-1 gene...
  15. pmc TWIST is expressed in human gliomas and promotes invasion
    Maria C Elias
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Neoplasia 7:824-37. 2005
    ..TWIST was also expressed in embryonic and fetal human brain, and in neurons, but not glia, of mature brain, indicating that, in gliomas, TWIST may promote the functions also critical for CNS development or normal neuronal physiology...
  16. ncbi request reprint The proteomics of neurodegeneration
    Mark D Johnson
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Am J Pharmacogenomics 5:259-70. 2005
    ....
  17. ncbi request reprint The power of the dark side: Huntington's disease protein and p53 form a deadly alliance
    Albert R La Spada
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Neuron 47:1-3. 2005
    ..In this issue of Neuron, Bae et al. present data implicating p53 in HD pathogenesis. This intriguing study may thus provide a link between nuclear transcription dysregulation and mitochondrial abnormalities in HD...
  18. ncbi request reprint Biomarkers: mining the biofluid proteome
    Timothy D Veenstra
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Mol Cell Proteomics 4:409-18. 2005
    ....
  19. ncbi request reprint Evaluation of the acid-cleavable isotope-coded affinity tag reagents: application to camptothecin-treated cortical neurons
    Li Rong Yu
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, National Cancer Institute at Frederick, P O Box B, Frederick, Maryland 21702 1201, USA
    J Proteome Res 3:469-77. 2004
    ..The new ICAT reagents were then applied to the analysis of a cortical neuron proteome sample to identify proteins regulated by the antitumor drug, camptothecin...
  20. ncbi request reprint Global analysis of the cortical neuron proteome
    Li Rong Yu
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, National Cancer Institute at Frederick, P O Box B, Frederick, MD 21702 1201, USA
    Mol Cell Proteomics 3:896-907. 2004
    ..The results presented here provide the broadest proteome coverage for a mammalian cell to date and show that MS-based proteomics has the potential to provide high coverage of the proteins expressed within a cell...
  21. ncbi request reprint Neuronal survival and cell death signaling pathways
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
    Adv Exp Med Biol 513:41-86. 2002
    ..In this review we examine recent evidence pertaining to the presence and activation of anti- and pro-cell death regulatory pathways in nervous system injury and degeneration...
  22. ncbi request reprint Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis
    Takuma Uo
    Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
    J Biol Chem 280:9065-73. 2005
    ..The absence of full-length Bak expression explains the near exclusive requirement for Bax in neuronal apoptosis...

Research Grants23

  1. Proteome analysis of malignant astrocytes
    Richard Morrison; Fiscal Year: 2006
    ....
  2. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2007
    ..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
  3. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2009
    ..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
  4. Mechanisms of Neuroprotection by Histone Deacetylase Inhibition
    Richard Morrison; Fiscal Year: 2009
    ..We propose to determine how histone deacetylase inhibitors block neuronal cell death which could lead to the development of new therapeutic agents for treating neurological diseases and nervous system injury. ..
  5. REGULATION OF NEURONAL SURVIVAL
    Richard S Morrison; Fiscal Year: 2010
    ..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
  6. Proteome-Wide Characterization of Phosphoproteins
    Richard Morrison; Fiscal Year: 2004
    ..abstract_text> ..
  7. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2000
    ..Elucidating the function of p53 in the nervous system may shed light on the regulation of neuronal survival in response to injury in neurologic disease. ..
  8. REGULATION OF NEURONAL SURVIVAL
    Richard Morrison; Fiscal Year: 2004
    ..These studies will help elucidate the mechanism by which p53 regulates neuronal survival and activity in response to injury and neurologic disease. ..
  9. Regulation of Astrocytoma Growth
    Richard Morrison; Fiscal Year: 2004
    ..abstract_text> ..
  10. Mechanisms of Neuroprotection by Histone Deacetylase Inhibition
    Richard S Morrison; Fiscal Year: 2010
    ..We propose to determine how histone deacetylase inhibitors block neuronal cell death which could lead to the development of new therapeutic agents for treating neurological diseases and nervous system injury. ..