SIDNEY MACHEN MORRIS

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Arginases and arginine deficiency syndromes
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 15:64-70. 2012
  2. ncbi request reprint Application of branched-chain amino acids in experimental animals: discussion of session 2
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Nutr 136:254S-5S. 2006
  3. ncbi request reprint Arginine: beyond protein
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 83:508S-512S. 2006
  4. ncbi request reprint Arginine metabolism: boundaries of our knowledge
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Nutr 137:1602S-1609S. 2007
  5. pmc Recent advances in arginine metabolism: roles and regulation of the arginases
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Br J Pharmacol 157:922-30. 2009
  6. ncbi request reprint Enzymes of arginine metabolism
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Nutr 134:2743S-2747S; discussion 2765S-2767S. 2004
  7. ncbi request reprint Arginine metabolism in vascular biology and disease
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA
    Vasc Med 10:S83-7. 2005
  8. ncbi request reprint Recent advances in arginine metabolism
    Sidney M Morris
    Department of Molecular Genetcs and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Philadelphia 15261, USA
    Curr Opin Clin Nutr Metab Care 7:45-51. 2004
  9. ncbi request reprint Vertebrate agmatinases: what role do they play in agmatine catabolism?
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Ann N Y Acad Sci 1009:30-3. 2003
  10. ncbi request reprint Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, W1255 Biomedical Science Tower, PA 15206, USA
    Biochem Biophys Res Commun 294:749-52. 2002

Research Grants

  1. ARGINASE AND INFLAMMATION AND TRAUMA
    Sidney Morris; Fiscal Year: 2001
  2. Role of Arginase in Inflammation and Trauma
    SIDNEY MACHEN MORRIS; Fiscal Year: 2010
  3. Regulation of Arginase Genes in Sepsis and Trauma
    Sidney Morris; Fiscal Year: 2005
  4. Role of Arginase in Inflammation and Trauma
    Sidney Morris; Fiscal Year: 2005
  5. Role of Arginase in Inflammation and Trauma
    SIDNEY MACHEN MORRIS; Fiscal Year: 2011

Collaborators

Detail Information

Publications21

  1. pmc Arginases and arginine deficiency syndromes
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 15:64-70. 2012
    ..This review will emphasize recent findings regarding effects of plasma arginase and arginine deficiencies in disease...
  2. ncbi request reprint Application of branched-chain amino acids in experimental animals: discussion of session 2
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Nutr 136:254S-5S. 2006
  3. ncbi request reprint Arginine: beyond protein
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 83:508S-512S. 2006
    ..This overview highlights selected aspects of arginine metabolism, including areas in which our knowledge remains fragmentary and incomplete...
  4. ncbi request reprint Arginine metabolism: boundaries of our knowledge
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Nutr 137:1602S-1609S. 2007
    ..It has become clear that a more complete understanding of arginine metabolism will require integration of information obtained from multiple approaches, including genomics, proteomics, and metabolomics...
  5. pmc Recent advances in arginine metabolism: roles and regulation of the arginases
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Br J Pharmacol 157:922-30. 2009
    ....
  6. ncbi request reprint Enzymes of arginine metabolism
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Nutr 134:2743S-2747S; discussion 2765S-2767S. 2004
    ..This overview highlights key features of the arginine metabolic enzymes and their interactions...
  7. ncbi request reprint Arginine metabolism in vascular biology and disease
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA
    Vasc Med 10:S83-7. 2005
    ..This review will highlight recent findings in this area that may suggest additional avenues of investigation that will allow a fuller understanding of cardiovascular physiology in health and disease...
  8. ncbi request reprint Recent advances in arginine metabolism
    Sidney M Morris
    Department of Molecular Genetcs and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Philadelphia 15261, USA
    Curr Opin Clin Nutr Metab Care 7:45-51. 2004
    ..The purpose of this review is to highlight recent studies on the urea cycle, agmatine metabolism, and the arginases...
  9. ncbi request reprint Vertebrate agmatinases: what role do they play in agmatine catabolism?
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Ann N Y Acad Sci 1009:30-3. 2003
    ....
  10. ncbi request reprint Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, W1255 Biomedical Science Tower, PA 15206, USA
    Biochem Biophys Res Commun 294:749-52. 2002
    ..Thus, hormonal regulation of ORNT1 mRNA in hepatocytes is coordinated with that of mRNAs encoding the urea cycle enzymes...
  11. ncbi request reprint Regulation of enzymes of the urea cycle and arginine metabolism
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Nutr 22:87-105. 2002
    ..Regulation of these enzymes is largely transcriptional in virtually all cell types. This review emphasizes recent information regarding roles and regulation of urea cycle and arginine metabolic enzymes in liver and other cell types...
  12. doi request reprint Arginine: master and commander in innate immune responses
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Sci Signal 3:pe27. 2010
    ..These findings illustrate the growing complexity of the roles of arginine as an enzyme substrate and also as a regulatory molecule in signal transduction pathways in immune cells...
  13. ncbi request reprint Biochemical responses of healthy subjects during dietary supplementation with L-arginine
    Rhobert W Evans
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Nutr Biochem 15:534-9. 2004
    ..However, subjects varied widely in their responses, indicating that L-arginine supplementation needs to be tailored to individuals...
  14. ncbi request reprint Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus
    Sanjay K Mistry
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Physiol Gastrointest Liver Physiol 282:G375-81. 2002
    ..Its expression in human liver is induced during hepatitis B virus infection, suggesting that agmatinase may play a role in the pathophysiology of this disease...
  15. pmc Nitric oxide-mediated suppression of detrusor overactivity by arginase inhibitor in rats with chronic spinal cord injury
    Kurumi Sasatomi
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Urology 72:696-700. 2008
    ..We investigated the effects of an arginase inhibitor on bladder overactivity and measured bladder arginase I and II mRNA levels in rats with chronic spinal cord injury (SCI)...
  16. ncbi request reprint Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta
    Michael J Gray
    Department of Molecular Genetics and Biochemistry, W1255 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene 353:98-106. 2005
    ..Elucidation of the mechanisms involved in regulation of arginase I transcription may provide a basis for developing strategies to modulate arginase expression in Th2 cytokine-predominant diseases...
  17. pmc Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation
    Mirjana Poljakovic
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Toxicol Environ Health A 70:118-27. 2007
    ....
  18. ncbi request reprint Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection
    Scott A Shell
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15221, USA
    J Biol Chem 280:39950-61. 2005
    ....
  19. doi request reprint Determination of mammalian arginase activity
    Diane Kepka-Lenhart
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Methods Enzymol 440:221-30. 2008
    ..No activity assay currently available is capable of distinguishing the arginase isozymes...
  20. pmc The 'intestinal-renal' arginine biosynthetic axis in the aging rat
    Sanjay K Mistry
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA15261, USA
    Mech Ageing Dev 123:1159-65. 2002
    ..Therefore, the reduced NO generating capacity that occurs in aging must be due to downstream changes in the NO biosynthesis pathway, such as reduced abundance of NO biosynthetic enzymes...
  21. ncbi request reprint Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages
    Aaron Erdely
    Dept of Molecular Genetics and Biochemistry, W1255 Biomedical Science Tower, Univ of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Physiol Lung Cell Mol Physiol 290:L534-9. 2006
    ..Therefore, consequences of increased arginase expression should be evaluated whenever PDE inhibitors are proposed for treatment of inflammatory disorders in which IL-4 and/or TGF-beta predominate...

Research Grants15

  1. ARGINASE AND INFLAMMATION AND TRAUMA
    Sidney Morris; Fiscal Year: 2001
    ..The third aim is to elucidate the physiologic roles of Arg II in vivo. The investigator will apply tools of modern molecular biology and genetics to address these questions. ..
  2. Role of Arginase in Inflammation and Trauma
    SIDNEY MACHEN MORRIS; Fiscal Year: 2010
    ..Results of these studies will provide a basis for rational development of new and more effective therapeutic strategies and for monitoring efficacy of treatment in inflammatory diseases. ..
  3. Regulation of Arginase Genes in Sepsis and Trauma
    Sidney Morris; Fiscal Year: 2005
    ..abstract_text> ..
  4. Role of Arginase in Inflammation and Trauma
    Sidney Morris; Fiscal Year: 2005
    ..abstract_text> ..
  5. Role of Arginase in Inflammation and Trauma
    SIDNEY MACHEN MORRIS; Fiscal Year: 2011
    ..Results of these studies will provide a basis for rational development of new and more effective therapeutic strategies and for monitoring efficacy of treatment in inflammatory diseases. ..