RALPH CURTIS MORRIS

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications
    R C Morris
    Department of Medicine, The University of California, San Francisco 94143 0126, USA
    Semin Nephrol 19:487-93. 1999
  2. ncbi request reprint Relationship and interaction between sodium and potassium
    R Curtis Morris
    Department of Medicine, University of California at San Francisco, San Francisco, CA 94143 0126, USA
    J Am Coll Nutr 25:262S-270S. 2006
  3. ncbi request reprint Chloride-dominant salt sensitivity in the stroke-prone spontaneously hypertensive rat
    Olga Schmidlin
    Department of Medicine, Division of Nephrology, University of California at San Francisco, CA 94143 0126, USA
    Hypertension 45:867-73. 2005
  4. pmc Sodium-selective salt sensitivity: its occurrence in blacks
    Olga Schmidlin
    Division of Nephrology, Department of Medicine, University of California San Francisco, 1291 Moffitt Hospital, CA 94143 0126, USA
    Hypertension 50:1085-92. 2007
  5. ncbi request reprint Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets
    Lynda A Frassetto
    University of California, San Francisco, California, CA 94143, USA
    J Nutr 138:419S-422S. 2008
  6. ncbi request reprint Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet
    Lynda A Frassetto
    Dept of Medicine and General Clinical Research Center, University of California, San Francisco, CA 94143, USA
    Am J Physiol Renal Physiol 293:F521-5. 2007
  7. pmc What initiates the pressor effect of salt in salt-sensitive humans? Observations in normotensive blacks
    Olga Schmidlin
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94143 0126, USA
    Hypertension 49:1032-9. 2007
  8. pmc Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis
    Olga Schmidlin
    Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, California 94143 0126, USA
    J Hypertens 28:87-94. 2010
  9. ncbi request reprint Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women
    Lynda Frassetto
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Clin Endocrinol Metab 90:831-4. 2005
  10. ncbi request reprint Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors
    Anthony Sebastian
    Department of Medicine and the General Clinical Research Center, University of California, San Francisco, California 94143, USA
    Am J Clin Nutr 76:1308-16. 2002

Research Grants

Detail Information

Publications11

  1. ncbi request reprint Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications
    R C Morris
    Department of Medicine, The University of California, San Francisco 94143 0126, USA
    Semin Nephrol 19:487-93. 1999
    ....
  2. ncbi request reprint Relationship and interaction between sodium and potassium
    R Curtis Morris
    Department of Medicine, University of California at San Francisco, San Francisco, CA 94143 0126, USA
    J Am Coll Nutr 25:262S-270S. 2006
    ....
  3. ncbi request reprint Chloride-dominant salt sensitivity in the stroke-prone spontaneously hypertensive rat
    Olga Schmidlin
    Department of Medicine, Division of Nephrology, University of California at San Francisco, CA 94143 0126, USA
    Hypertension 45:867-73. 2005
    ..We conclude that in the SHRSP, the Cl- component of a dietary NaCl dominantly determines salt sensitivity and thereby phenotypic expression. We suggest that Cl- might do so by inducing renal vasoconstriction...
  4. pmc Sodium-selective salt sensitivity: its occurrence in blacks
    Olga Schmidlin
    Division of Nephrology, Department of Medicine, University of California San Francisco, 1291 Moffitt Hospital, CA 94143 0126, USA
    Hypertension 50:1085-92. 2007
    ....
  5. ncbi request reprint Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets
    Lynda A Frassetto
    University of California, San Francisco, California, CA 94143, USA
    J Nutr 138:419S-422S. 2008
    ..We focus here on the American diet's potential effects on bone through its superphysiologic content of sodium chloride...
  6. ncbi request reprint Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet
    Lynda A Frassetto
    Dept of Medicine and General Clinical Research Center, University of California, San Francisco, CA 94143, USA
    Am J Physiol Renal Physiol 293:F521-5. 2007
    ..Assuming a causal relationship, over their respective ranges of variation, NaCl has approximately 50-100% of the acidosis-producing effect of the diet net acid load...
  7. pmc What initiates the pressor effect of salt in salt-sensitive humans? Observations in normotensive blacks
    Olga Schmidlin
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94143 0126, USA
    Hypertension 49:1032-9. 2007
    ..In SS and SR subjects combined, changes in both MAP and SVR on day 2 strongly predicted changes in MAP on day 7. In many normotensive blacks, vascular dysfunction is critical to the initiation of a pressor response to dietary NaCl...
  8. pmc Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis
    Olga Schmidlin
    Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, California 94143 0126, USA
    J Hypertens 28:87-94. 2010
    ..To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance...
  9. ncbi request reprint Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women
    Lynda Frassetto
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Clin Endocrinol Metab 90:831-4. 2005
    ..Thus, one can preselect postmenopausal women most likely to have the urine calcium-lowering effect of KBC and predict their potential bone calcium increase...
  10. ncbi request reprint Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors
    Anthony Sebastian
    Department of Medicine and the General Clinical Research Center, University of California, San Francisco, California 94143, USA
    Am J Clin Nutr 76:1308-16. 2002
    ..Natural selection has had < 1% of hominid evolutionary time to eliminate the inevitable maladaptations consequent to the profound transformation of the human diet resulting from the inventions of agriculture and animal husbandry...
  11. ncbi request reprint The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes
    Anthony Sebastian
    Department of Medicine, Division of Nephrology, Moffitt Mt Zion General Clinical Research Center, UCSF, San Francisco, CA 94303, USA
    Semin Nephrol 26:447-53. 2006
    ..We discuss the potential implications of our findings in respect to human health and disease...

Research Grants7

  1. RENAL EFFECTS OF DIETARY CHLORIDE IN AFRICAN-AMERICANS
    Ralph Morris; Fiscal Year: 2002
    ..We will interpret such findings as suggesting that the Cl component of KCl can exert a renal vasoconstrictive and potentially renopathic effect despite a concomitant decrease in blood pressure. ..
  2. SELECTIVE SODIUM-SENSITIVITY IN SALT-SENSITIVE BLACKS
    Ralph Morris; Fiscal Year: 2006
    ..5) The acute increases in plasma Na + concentration will predict the extent of acute increases in BP, RVR and TPR. ..