MICHAEL DAVID MORRIS

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Noninvasive Raman spectroscopy of rat tibiae: approach to in vivo assessment of bone quality
    Paul I Okagbare
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan
    J Biomed Opt 17:90502-1. 2012
  2. pmc Polymer-capped fiber-optic Raman probe for non-invasive Raman spectroscopy
    Paul I Okagbare
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Analyst 137:77-81. 2012
  3. ncbi request reprint Compatibility of staining protocols for bone tissue with Raman imaging
    M D Morris
    Department of Chemistry, University of Michigan, 930 N University Avenue, Ann Arbor, MI 48109 1055, USA
    Calcif Tissue Int 74:86-94. 2004
  4. pmc Raman assessment of bone quality
    Michael D Morris
    University of Michigan, Ann Arbor, MI, USA
    Clin Orthop Relat Res 469:2160-9. 2011
  5. ncbi request reprint Kerr-gated time-resolved Raman spectroscopy of equine cortical bone tissue
    Michael D Morris
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109, USA
    J Biomed Opt 10:14014. 2005
  6. ncbi request reprint Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro
    D L Lin
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan 48109-0940, USA
    Prostate 47:212-21. 2001
  7. ncbi request reprint Ultrastructural changes accompanying the mechanical deformation of bone tissue: a Raman imaging study
    A Carden
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Calcif Tissue Int 72:166-75. 2003
  8. ncbi request reprint Capillary isotachophoresis with fiber-optic Raman spectroscopic detection. Performance and application to ribonucleotides
    P A Walker
    University of Michigan, Department of Chemistry, Ann Arbor 48109-1055, USA
    J Chromatogr A 805:269-75. 1998
  9. ncbi request reprint Bone chemical structure response to mechanical stress studied by high pressure Raman spectroscopy
    O de Carmejane
    Department of Chemistry, University of Michigan, Ann Arbor, MI, USA
    Calcif Tissue Int 76:207-13. 2005
  10. ncbi request reprint Bone tissue compositional differences in women with and without osteoporotic fracture
    Barbara R McCreadie
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, 2015 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Bone 39:1190-5. 2006

Research Grants

  1. Dynamic Spectroscopic Imaging in Bone Biomechanics
    Michael Morris; Fiscal Year: 2007
  2. Raman Imaging of Bone Tissue Mineralization
    Michael Morris; Fiscal Year: 2006
  3. ELECTRO-OPTIC TECHNIQUES IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1993
  4. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 2001
  5. SPECTROSCOPY OF PROTEIN MEDIATION OF BONE MINERALIZATION
    MICHAEL DAVID MORRIS; Fiscal Year: 2010
  6. Raman Markers of Allograft Osseointegration
    Michael Morris; Fiscal Year: 2009
  7. Real-time Fluorescence Imaging of RNA/Ribosome Dynamics
    Michael Morris; Fiscal Year: 2007
  8. Subdiffraction Fluorescence imaging of Bone Biomechanics
    Michael Morris; Fiscal Year: 2006
  9. ELECTRO-OPTIC MEASUREMENTS IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1991
  10. ELECTRO-OPTIC MEASUREMENTS IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1990

Collaborators

  • Steven Goldstein
  • Pavel Matousek
  • Michael Towrie
  • Edward R C Draper
  • Laurie McCauley
  • Hicham Fenniri
  • Effendi Widjaja
  • Matthew V Schulmerich
  • Paul I Okagbare
  • Kathryn A Dooley
  • Nicole J Crane
  • Ayorinde Awonusi
  • Karen A Dehring
  • Michael A Ignelzi
  • Jacqueline H Cole
  • Subhadra Srinivasan
  • Jaclynn M Kreider
  • Catherine P Tarnowski
  • Blake J Roessler
  • Karen A Esmonde-White
  • Brian W Pogue
  • Thomas M Vanasse
  • Kurtulus Golcuk
  • Barbara R McCreadie
  • Abigail R Smukler
  • William F Finney
  • David H Kohn
  • Glenda J Pettway
  • O de Carmejane
  • Erin E Wilson
  • R M Rajachar
  • Kenneth M Kozloff
  • A Carden
  • Dana Begun
  • D L Lin
  • Mary Tecklenburg
  • Matthew Schulmerich
  • Stephanie V Le Clair
  • Mary M J Tecklenburg
  • Richard A Fredricks
  • Andrew F Callender
  • P A Walker
  • Jonathan B McHugh
  • Victoria Popescu
  • D Sudhaker Rao
  • Gurjit S Mandair
  • Tso Ching Chen
  • Pieter Steenhuis
  • Nadder Sahar
  • L Stixrude
  • M Tecklenburg
  • Abraham Schneider
  • Amy J Koh
  • Mary Mj Tecklenburg
  • Genggeng Yu
  • Jeffrey A Meganck
  • Larry W Beck
  • D H Kohan
  • M K Davis
  • Clemens Bergwitz
  • Wei Wang
  • Antonella Forlino
  • Juan M Taboas
  • Angela Carden
  • Thomas E Uveges
  • Joan C Marini
  • D H Kohn
  • C P Tarnowski
  • A H Patel
  • E T Keller
  • J Dai
  • E Rohn
  • J Zhang

Detail Information

Publications33

  1. pmc Noninvasive Raman spectroscopy of rat tibiae: approach to in vivo assessment of bone quality
    Paul I Okagbare
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan
    J Biomed Opt 17:90502-1. 2012
    ..Our data provide proof of the principle that small changes in bone composition can be monitored through soft tissue at anatomical sites of interest in biomedical studies...
  2. pmc Polymer-capped fiber-optic Raman probe for non-invasive Raman spectroscopy
    Paul I Okagbare
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Analyst 137:77-81. 2012
    ..Ex-vivo Raman spectroscopy of excised rat tibia supports the use of the probe for spectroscopy of various tissues. These results provide proof of principle that the Raman probe can be used in multiple spectroscopic applications...
  3. ncbi request reprint Compatibility of staining protocols for bone tissue with Raman imaging
    M D Morris
    Department of Chemistry, University of Michigan, 930 N University Avenue, Ann Arbor, MI 48109 1055, USA
    Calcif Tissue Int 74:86-94. 2004
    ..Image analysis revealed factors for tissue components and the embedding medium, glycol methacrylate, only. Thus, Raman imaging proved to be compatible with histological stains such as hematoxylin, eosin and toluidine blue...
  4. pmc Raman assessment of bone quality
    Michael D Morris
    University of Michigan, Ann Arbor, MI, USA
    Clin Orthop Relat Res 469:2160-9. 2011
    ..Raman spectroscopy has been used to evaluate alterations to bone composition associated with aging, disease, or injury...
  5. ncbi request reprint Kerr-gated time-resolved Raman spectroscopy of equine cortical bone tissue
    Michael D Morris
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109, USA
    J Biomed Opt 10:14014. 2005
    ..These novel results demonstrate great promise for in vivo applications for studying diseased bone tissue, and ways to optimize the setup are discussed...
  6. ncbi request reprint Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro
    D L Lin
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan 48109-0940, USA
    Prostate 47:212-21. 2001
    ..CONCLUSIONS: These data demonstrate a novel mechanism through which prostate cancer cells may directly contribute to the osteoblastic component that characterize their skeletal metastatic lesions. Prostate 47:212-221, 2001...
  7. ncbi request reprint Ultrastructural changes accompanying the mechanical deformation of bone tissue: a Raman imaging study
    A Carden
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Calcif Tissue Int 72:166-75. 2003
    ..These results give new insight into the mechanisms and causes of bone failure at the ultrastructural level...
  8. ncbi request reprint Capillary isotachophoresis with fiber-optic Raman spectroscopic detection. Performance and application to ribonucleotides
    P A Walker
    University of Michigan, Department of Chemistry, Ann Arbor 48109-1055, USA
    J Chromatogr A 805:269-75. 1998
    ..Raman spectra were excited with a 2W 532 nm NdYVO4, laser as the excitation source, with collection of 1 spectrum per second. Even at 2.10(-5) M initial concentration, Raman spectra were obtained at a good signal-to-noise ratio...
  9. ncbi request reprint Bone chemical structure response to mechanical stress studied by high pressure Raman spectroscopy
    O de Carmejane
    Department of Chemistry, University of Michigan, Ann Arbor, MI, USA
    Calcif Tissue Int 76:207-13. 2005
    ..The use of high pressure Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress and demonstrates that individual mineral and matrix constituents respond differently to pressure...
  10. ncbi request reprint Bone tissue compositional differences in women with and without osteoporotic fracture
    Barbara R McCreadie
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, 2015 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Bone 39:1190-5. 2006
    ..Results suggest that the chemical composition of bone tissue may be an additional risk factor for osteoporotic fracture...
  11. ncbi request reprint Transcutaneous fiber optic Raman spectroscopy of bone using annular illumination and a circular array of collection fibers
    Matthew V Schulmerich
    J Biomed Opt 11:060502. 2006
    ..3% at an integration time of 120 s and within 10% at a 30-s integration time. For chicken tibia 4 mm below the skin surface, the error is less than 8% with a 120-s integration time...
  12. ncbi request reprint Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone
    Glenda J Pettway
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Bone 36:959-70. 2005
    ..These data indicate that anabolic actions of PTH in ectopic ossicles are temporally dependent on the BMSC implanted and suggest that cell implantation strategies are particularly responsive to PTH...
  13. ncbi request reprint Is photobleaching necessary for Raman imaging of bone tissue using a green laser?
    Kurtulus Golcuk
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Biochim Biophys Acta 1758:868-73. 2006
    ..The use of electron multiplying couple charge detector (EMCCD) enables to acquire Raman spectra of bone tissues within 1-5 s range and to obtain Raman images less than in 10 min...
  14. ncbi request reprint Carbonate assignment and calibration in the Raman spectrum of apatite
    Ayorinde Awonusi
    Department of Chemistry, Central Michigan University, Mt Pleasant, MI 48859, USA
    Calcif Tissue Int 81:46-52. 2007
    ..The carbonate content of apatite was calibrated to a carbonate Raman band, and the method was used to determine the carbonate content of a sample of bovine cortical bone, 7.7 +/- 0.4%...
  15. ncbi request reprint Subsurface and transcutaneous Raman spectroscopy and mapping using concentric illumination rings and collection with a circular fiber-optic array
    Matthew V Schulmerich
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109 1055, USA
    Appl Spectrosc 61:671-8. 2007
    ..5 mm below the Teflon surface. The same protocols were used to recover canine bone spectra transcutaneously at depths up to 5 mm below the skin's surface. The recovered bone spectra were validated by exposed bone measurements...
  16. pmc Noninvasive Raman tomographic imaging of canine bone tissue
    Matthew V Schulmerich
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109 1055, USA
    J Biomed Opt 13:020506. 2008
    ..Diffuse emission tomography reconstruction was used, and the location that was recovered has been confirmed by micro-computed tomography (micro-CT) images...
  17. pmc Optical clearing in transcutaneous Raman spectroscopy of murine cortical bone tissue
    Matthew V Schulmerich
    University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109, USA
    J Biomed Opt 13:021108. 2008
    ..Glycerol reduces the noise in the raw spectra (p=0.0037) and significantly improves the cross-correlation between the recovered bone factor and the exposed bone measurement in a low signal-to-noise region of the bone spectra (p=0.0245)...
  18. pmc Effect of conformation and drop properties on surface-enhanced Raman spectroscopy of dried biopolymer drops
    Karen A Esmonde-White
    Department of Biomedical Engineering, University of Michigan, 930 N University Ave, Ann Arbor, Michigan 48109, USA
    Appl Spectrosc 62:503-11. 2008
    ..These data suggest an approach to elucidate the effects of biopolymers and dehydrated biofluids on SERS analysis...
  19. pmc Image-guided Raman spectroscopic recovery of canine cortical bone contrast in situ
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    Opt Express 16:12190-200. 2008
    ..Considerably less contrast was found without the CT image to guide recovery. This study presents the first known IG-RS results from tissue and indicates that intrinsically high contrasts (on the order of a hundred fold) are available...
  20. ncbi request reprint Band-target entropy minimization (BTEM) applied to hyperspectral Raman image data
    Effendi Widjaja
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Appl Spectrosc 57:1353-62. 2003
    ..An improvement in signal/noise ratio of the recovered spectra is also obtained...
  21. ncbi request reprint Mineralization of developing mouse calvaria as revealed by Raman microspectroscopy
    Catherine P Tarnowski
    Department of Chemistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Bone Miner Res 17:1118-26. 2002
    ..Insights into the chemical species, the degree of mineralization, and the multiple mineral environments that are present in normal calvarial tissue will enable us to better understand both normal and abnormal mineralization processes...
  22. ncbi request reprint Identifying chemical changes in subchondral bone taken from murine knee joints using Raman spectroscopy
    Karen A Dehring
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Appl Spectrosc 60:1134-41. 2006
    ..The effect of the cartilage layer on collection of spectra is discussed. The technique proposed is capable of providing insight into the chemical changes that occur in subchondral bone on a molecular level...
  23. ncbi request reprint Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength
    Kenneth M Kozloff
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan 48109 0486, USA
    J Bone Miner Res 19:614-22. 2004
    ..This adaptation is accomplished without a corresponding improvement in geometric resistance to bending, suggesting an improvement in matrix material properties...
  24. ncbi request reprint Highly ordered interstitial water observed in bone by nuclear magnetic resonance
    Erin E Wilson
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Bone Miner Res 20:625-34. 2005
    ..Distance measurements show that the first water layer at the surface of the mineral in cortical bone is structured. This water may serve to couple the mineral to the organic matrix and may play a role in deformation...
  25. ncbi request reprint Bone tissue ultrastructural response to elastic deformation probed by Raman spectroscopy
    Michael D Morris
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Faraday Discuss 126:159-68; discussion 169-83. 2004
    ..The mineral active response to loading may function as a local energy storage and dissipation mechanism, thus helping to protect tissue from catastrophic damage...
  26. ncbi request reprint Infrared and Raman spectroscopy
    Michael D Morris
    J Biomed Opt 10:031101. 2005
  27. ncbi request reprint Raman imaging demonstrates FGF2-induced craniosynostosis in mouse calvaria
    Nicole J Crane
    The University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109 1055, USA
    J Biomed Opt 10:031119. 2005
    ..In addition, FGF2-treated mouse sutures show a marked increase in mineral-to-matrix ratios compared to control mouse sutures, typical of increased mineralization...
  28. ncbi request reprint Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy
    Edward R C Draper
    Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom
    J Bone Miner Res 20:1968-72. 2005
    ..We recorded Raman spectra of both the mineral and organic phases of bone transcutaneously, a technology with potential to enhance bone quality and fracture risk assessment...
  29. ncbi request reprint Earliest mineral and matrix changes in force-induced musculoskeletal disease as revealed by Raman microspectroscopic imaging
    Catherine P Tarnowski
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA
    J Bone Miner Res 19:64-71. 2004
    ..Raman imaging revealed decreased relative mineral content in skulls undergoing craniosynostosis compared with unloaded specimens...
  30. ncbi request reprint Subsurface Raman spectroscopy and mapping using a globally illuminated non-confocal fiber-optic array probe in the presence of Raman photon migration
    Matthew V Schulmerich
    Department of Chemistry, University of Michigan, Ann Arbor, 48109 1055, USA
    Appl Spectrosc 60:109-14. 2006
    ....
  31. ncbi request reprint Correlating changes in collagen secondary structure with aging and defective type II collagen by Raman spectroscopy
    Karen A Dehring
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Appl Spectrosc 60:366-72. 2006
    ..These preliminary results suggest that Raman is capable of recognizing and measuring abnormality in eye collagen and may have potential as a diagnostic tool for ocular collagen damage...
  32. ncbi request reprint Raman spectroscopic evidence for octacalcium phosphate and other transient mineral species deposited during intramembranous mineralization
    Nicole J Crane
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 1055, USA
    Bone 39:434-42. 2006
    ..We detected increased levels of a transient phase resembling octacalcium phosphate in sutures undergoing premature suture closure...
  33. ncbi request reprint Classification of spectroscopically encoded resins by Raman mapping and infrared hyperspectral imaging
    Hicham Fenniri
    National Institute of Nanotechnology, National Research Council NINT NRC and Department of Chemistry, University of Alberta, ECERF 9107 116 Street, Edmonton, Alberta T6G 2V4, Canada
    J Comb Chem 8:192-8. 2006
    ..We have also established that reliable single-bead Raman spectra can be recorded in 10 ms, thus confirming that Raman mapping, in particular, could be a very fast method to classify the BCRs...

Research Grants37

  1. Dynamic Spectroscopic Imaging in Bone Biomechanics
    Michael Morris; Fiscal Year: 2007
    ..Both univariate and multivariate methods will be used for data reduction. Systematic studies of age effects will be performed on murine tissue with exploratory work on human tissue at age extremes. ..
  2. Raman Imaging of Bone Tissue Mineralization
    Michael Morris; Fiscal Year: 2006
    ..Correlative immunohistological staining and Raman imaging will be used to understand the effects of bone sialoprotein and osteocalcin on the course of mineralization. ..
  3. ELECTRO-OPTIC TECHNIQUES IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1993
    ..Raman microspectrometry will be used to investigate structural changes in polyacrylamide and other gels in capillaries, to determine the factors governing capillary life times...
  4. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 2001
    ..abstract_text> ..
  5. SPECTROSCOPY OF PROTEIN MEDIATION OF BONE MINERALIZATION
    MICHAEL DAVID MORRIS; Fiscal Year: 2010
    ..The information gained in this project will help in the design of new therapeutic agents for some of these diseases. ..
  6. Raman Markers of Allograft Osseointegration
    Michael Morris; Fiscal Year: 2009
    ....
  7. Real-time Fluorescence Imaging of RNA/Ribosome Dynamics
    Michael Morris; Fiscal Year: 2007
    ..With the multiple probe technology we will study the effect of mRNA secondary and tertiary structure on ribosome processivity and translation kinetics. ..
  8. Subdiffraction Fluorescence imaging of Bone Biomechanics
    Michael Morris; Fiscal Year: 2006
    ..With success of this phase of the project, extension to labeling cytoskeletal elements will be undertaken. ..
  9. ELECTRO-OPTIC MEASUREMENTS IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1991
    ..The modulated signal will be insensitive to heating, capillary movement and certain detector response fluctuations. Greatly improved detection limits are expected...
  10. ELECTRO-OPTIC MEASUREMENTS IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1990
    ..The modulated signal will be insensitive to heating, capillary movement and certain detector response fluctuations. Greatly improved detection limits are expected...
  11. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 1999
    ..The concept will be tested on model protein separations, such as the serum proteins or commercial size standards. ..
  12. ELECTRO-OPTIC TECHNIQUES IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1992
    ..Raman microspectrometry will be used to investigate structural changes in polyacrylamide and other gels in capillaries, to determine the factors governing capillary life times...
  13. Raman Tomography of Musculoskeletal Tissue
    MICHAEL DAVID MORRIS; Fiscal Year: 2010
    ..The technology is also readily adapted to measurement of other important health indicators, including presence and extent of atherosclerotic plaque and levels of serum cholesterol. ..
  14. Real-time Fluorescence Imaging of RNA/Ribosome Dynamics
    Michael Morris; Fiscal Year: 2009
    ..With the multiple probe technology we will study the effect of mRNA secondary and tertiary structure on ribosome processivity and translation kinetics. ..
  15. SPECTROSCOPY OF PROTEIN MEDIATION OF BONE MINERALIZATION
    Michael Morris; Fiscal Year: 2009
    ..The information gained in this project will help in the design of new therapeutic agents for some of these diseases. ..
  16. Raman Tomography of Musculoskeletal Tissue
    Michael Morris; Fiscal Year: 2009
    ..The technology is also readily adapted to measurement of other important health indicators, including presence and extent of atherosclerotic plaque and levels of serum cholesterol. ..
  17. Chemical Structure Effects on Bone Response to Mechanical Load
    MICHAEL DAVID MORRIS; Fiscal Year: 2010
    ....
  18. Raman Tomography of Musculoskeletal Tissue
    Michael Morris; Fiscal Year: 2007
    ..The technology is also readily adapted to measurement of other important health indicators, including presence and extent of atherosclerotic plaque and levels of serum cholesterol. ..
  19. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 2000
    ..The concept will be tested on model protein separations, such as the serum proteins or commercial size standards. ..
  20. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 2002
    ..abstract_text> ..
  21. Raman Imaging of Bone Tissue Mineralization
    Michael Morris; Fiscal Year: 2003
    ..Correlative immunohistological staining and Raman imaging will be used to understand the effects of bone sialoprotein and osteocalcin on the course of mineralization. ..
  22. Dynamic Spectroscopic Imaging in Bone Biomechanics
    Michael Morris; Fiscal Year: 2006
    ..Both univariate and multivariate methods will be used for data reduction. Systematic studies of age effects will be performed on murine tissue with exploratory work on human tissue at age extremes. ..
  23. Real-time Fluorescence Imaging of RNA/Ribosome Dynamics
    Michael Morris; Fiscal Year: 2006
    ..With the multiple probe technology we will study the effect of mRNA secondary and tertiary structure on ribosome processivity and translation kinetics. ..
  24. Raman Markers of Allograft Osseointegration
    MICHAEL DAVID MORRIS; Fiscal Year: 2010
    ....