John B Morris

Summary

Affiliation: University of Connecticut
Country: USA

Publications

  1. doi request reprint A review of whole animal bioassays of the carcinogenic potential of naphthalene
    D Warner North
    NorthWorks, Inc, 1002 Misty Lane, Belmont, CA 94002 3651, USA
    Regul Toxicol Pharmacol 51:S6-14. 2008
  2. doi request reprint Nasal dosimetry of inspired naphthalene vapor in the male and female B6C3F1 mouse
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269, USA
    Toxicology 309:66-72. 2013
  3. doi request reprint Biologically-based modeling insights in inhaled vapor absorption and dosimetry
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, USA
    Pharmacol Ther 136:401-13. 2012
  4. pmc Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 108:173-83. 2009
  5. ncbi request reprint Nasal NPSH depletion and propylene oxide uptake in the upper respiratory tract of the mouse
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269 3092, USA
    Toxicol Sci 92:228-34. 2006
  6. doi request reprint Upper respiratory tract uptake of naphthalene
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
    Toxicol Sci 111:383-91. 2009
  7. ncbi request reprint Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice
    John B Morris
    University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, Storrs, Connecticut 06269, USA
    J Appl Physiol (1985) 94:1563-71. 2003
  8. pmc Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene
    Michael J Lanosa
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 115:589-95. 2010
  9. ncbi request reprint Uptake of inspired propylene oxide in the upper respiratory tract of the f344 rat
    John B Morris
    Department of Pharmaceutical Sciences, School of Pharmacy, 372 Fairfield Rd, Box U 2092, University of Connecticut, Storrs 06269 2092, USA
    Toxicol Sci 81:216-24. 2004
  10. doi request reprint Sulfur-containing malodorant vapors enhance responsiveness to the sensory irritant capsaicin
    Christopher R Desesa
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 104:198-209. 2008

Research Grants

Collaborators

Detail Information

Publications23

  1. doi request reprint A review of whole animal bioassays of the carcinogenic potential of naphthalene
    D Warner North
    NorthWorks, Inc, 1002 Misty Lane, Belmont, CA 94002 3651, USA
    Regul Toxicol Pharmacol 51:S6-14. 2008
    ....
  2. doi request reprint Nasal dosimetry of inspired naphthalene vapor in the male and female B6C3F1 mouse
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269, USA
    Toxicology 309:66-72. 2013
    ..Overall, the high URT uptake efficiency of naphthalene in the mouse nose indicates the absence of a tumorigenic response is not attributable to low delivered dose rates in this species...
  3. doi request reprint Biologically-based modeling insights in inhaled vapor absorption and dosimetry
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, USA
    Pharmacol Ther 136:401-13. 2012
    ....
  4. pmc Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 108:173-83. 2009
    ..Butyric acid may modulate diacetyl toxicity by inhibiting its metabolism and/or altering its inhalation dosimetric patterns...
  5. ncbi request reprint Nasal NPSH depletion and propylene oxide uptake in the upper respiratory tract of the mouse
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269 3092, USA
    Toxicol Sci 92:228-34. 2006
    ..Similar levels of NPSH depletion were observed in both nasal respiratory and olfactory mucosa. These data from mouse show some key differences when compared with those reported for the rat...
  6. doi request reprint Upper respiratory tract uptake of naphthalene
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
    Toxicol Sci 111:383-91. 2009
    ..These results provide evidence that nasal CYP metabolism of naphthalene contributes to URT scrubbing of this vapor and is also involved in the concentration dependence of uptake that is observed...
  7. ncbi request reprint Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased mice
    John B Morris
    University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, Storrs, Connecticut 06269, USA
    J Appl Physiol (1985) 94:1563-71. 2003
    ....
  8. pmc Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene
    Michael J Lanosa
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 115:589-95. 2010
    ..Thus, these results support the hypothesis that styrene and naphthalene vapors initiate the sensory irritation response through TRPA1 detection of their CYP450 metabolites...
  9. ncbi request reprint Uptake of inspired propylene oxide in the upper respiratory tract of the f344 rat
    John B Morris
    Department of Pharmaceutical Sciences, School of Pharmacy, 372 Fairfield Rd, Box U 2092, University of Connecticut, Storrs 06269 2092, USA
    Toxicol Sci 81:216-24. 2004
    ..Olfactory mucosal NPSH levels also generally decreased at 300 or 500 ppm propylene oxide, but did not demonstrate statistically significant, consistent changes after propylene oxide exposure...
  10. doi request reprint Sulfur-containing malodorant vapors enhance responsiveness to the sensory irritant capsaicin
    Christopher R Desesa
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 104:198-209. 2008
    ..05 compared with capsaicin alone). These results suggest trigeminal nerve responsiveness is enhanced by exposure to malodorants through a theophylline-sensitive paracrine signaling pathway between olfactory and trigeminal nerves...
  11. doi request reprint In situ measurement of vapor uptake in the rodent upper respiratory tract
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
    Curr Protoc Toxicol . 2013
    ..These data have been instrumental not only in understanding the regional airway toxicity of inspired vapors, but also for developing mathematical models to describe inhaled vapor dosimetry...
  12. doi request reprint Modulation of sensory irritation responsiveness by adenosine and malodorants
    Daniel N Willis
    Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
    Chem Senses 38:91-100. 2013
    ..These results highlight that trigeminal chemosensory responsiveness is not static, but can be quickly modulated by adenosine and select odors resulting in hyperresponsive states...
  13. doi request reprint A validated hybrid computational fluid dynamics-physiologically based pharmacokinetic model for respiratory tract vapor absorption in the human and rat and its application to inhalation dosimetry of diacetyl
    Eric Gloede
    Department of Pharmaceutical Sciences, Toxicology Program, University of Connecticut, Storrs, Connecticut 06269 3092, USA
    Toxicol Sci 123:231-46. 2011
    ..Bronchiolar tissue concentrations of diacetyl in the human are estimated to exceed those in the rat by 40-fold. These inhalation dosimetric differences may contribute to the human-rat differences in diacetyl-induced airway injury...
  14. pmc TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain
    Boyi Liu
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Pain 154:2169-77. 2013
    ..Our data show that TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. In contrast to menthol, selective TRPM8 agonists may produce analgesia more effectively, with diminished side effects. ..
  15. ncbi request reprint Adenosine sensory transduction pathways contribute to activation of the sensory irritation response to inspired irritant vapors
    Ryan P Vaughan
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269 3092, USA
    Toxicol Sci 93:411-21. 2006
    ..If sensory nerves are activated by mediators that are released from injured airway mucosal cells, then nasal sensory nerve activation may be a reflection of irritant-induced alterations in airway cell integrity...
  16. pmc Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
    Daniel N Willis
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
    FASEB J 25:4434-44. 2011
    ..Through suppression of respiratory irritation, menthol may facilitate smoke inhalation and promote nicotine addiction and smoking-related morbidities...
  17. ncbi request reprint Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mouse
    Peter T Symanowicz
    University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269 2092, USA
    Neurosci Lett 362:150-3. 2004
    ..Thus, in the C57Bl/6J mouse the TRPV1 receptor does not appear to play a major role in the stimulation of nasal trigeminal central reflex responses by these irritant air pollutants...
  18. ncbi request reprint Regional distribution and kinetics of vinyl acetate hydrolysis in the oral cavity of the rat and mouse
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Box U 2092, Storrs, CT 06269, USA
    Toxicol Lett 126:31-9. 2002
    ..Acetaldehyde was detected in these solutions providing evidence that metabolism of this ester occurs in vivo in oral tissues...
  19. ncbi request reprint Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene
    Joseph A Cichocki
    University of Connecticut, Department of Pharmaceutical Sciences, Toxicology Program, Storrs, Connecticut, 06269
    Toxicol Sci 139:234-44. 2014
    ....
  20. ncbi request reprint Effect of nitrogen dioxide on ovalbumin-induced allergic airway disease in a murine model
    Andrea K Hubbard
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269, USA
    J Toxicol Environ Health A 65:1999-2005. 2002
    ..Contrary to expectations, exposure to NO(2) during the aerosol challenge to OVA dramatically diminished the outcome of allergic disease in lungs as measured by airway cellular inflammation...
  21. ncbi request reprint Sensory nerve-mediated nasal vasodilatory response to inspired ethyl acrylate
    John B Morris
    Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269 3092, USA
    Inhal Toxicol 14:585-97. 2002
    ....
  22. ncbi request reprint Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors
    Clay B Frederick
    Toxicology Department, Rohm and Haas Company, Spring House, Pennsylvania 19477, USA
    Toxicol Appl Pharmacol 183:23-40. 2002
    ....
  23. pmc Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action
    Kenneth T Bogen
    Exponent Health and Environmental, 500 12th Street, Suite 220, Oakland, CA 94607, USA
    Regul Toxicol Pharmacol 51:S27-36. 2008
    ....

Research Grants1

  1. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ....