Research Topics
Species | John B MorrisSummaryAffiliation: University of Connecticut Country: USA Publications
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Detail Information
Publications
A review of whole animal bioassays of the carcinogenic potential of naphthaleneD Warner North
NorthWorks, Inc, 1002 Misty Lane, Belmont, CA 94002 3651, USA
Regul Toxicol Pharmacol 51:S6-14. 2008....- Biologically-based modeling insights in inhaled vapor absorption and dosimetryJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, USA Electronic address
Pharmacol Ther 136:401-13. 2012.... - Upper respiratory tract uptake of naphthaleneJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
Toxicol Sci 111:383-91. 2009..These results provide evidence that nasal CYP metabolism of naphthalene contributes to URT scrubbing of this vapor and is also involved in the concentration dependence of uptake that is observed... 
Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vaporsJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
Toxicol Sci 108:173-83. 2009..Butyric acid may modulate diacetyl toxicity by inhibiting its metabolism and/or altering its inhalation dosimetric patterns...
Nasal NPSH depletion and propylene oxide uptake in the upper respiratory tract of the mouseJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269 3092, USA
Toxicol Sci 92:228-34. 2006..Similar levels of NPSH depletion were observed in both nasal respiratory and olfactory mucosa. These data from mouse show some key differences when compared with those reported for the rat...- Immediate sensory nerve-mediated respiratory responses to irritants in healthy and allergic airway-diseased miceJohn B Morris
University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, Storrs, Connecticut 06269, USA
J Appl Physiol 94:1563-71. 2003.... - Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthaleneMichael J Lanosa
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
Toxicol Sci 115:589-95. 2010..Thus, these results support the hypothesis that styrene and naphthalene vapors initiate the sensory irritation response through TRPA1 detection of their CYP450 metabolites... - Sulfur-containing malodorant vapors enhance responsiveness to the sensory irritant capsaicinChristopher R Desesa
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
Toxicol Sci 104:198-209. 2008..05 compared with capsaicin alone). These results suggest trigeminal nerve responsiveness is enhanced by exposure to malodorants through a theophylline-sensitive paracrine signaling pathway between olfactory and trigeminal nerves... - Uptake of inspired propylene oxide in the upper respiratory tract of the f344 ratJohn B Morris
Department of Pharmaceutical Sciences, School of Pharmacy, 372 Fairfield Rd, Box U 2092, University of Connecticut, Storrs 06269 2092, USA
Toxicol Sci 81:216-24. 2004..Olfactory mucosal NPSH levels also generally decreased at 300 or 500 ppm propylene oxide, but did not demonstrate statistically significant, consistent changes after propylene oxide exposure... - A validated hybrid computational fluid dynamics-physiologically based pharmacokinetic model for respiratory tract vapor absorption in the human and rat and its application to inhalation dosimetry of diacetylEric Gloede
Department of Pharmaceutical Sciences, Toxicology Program, University of Connecticut, Storrs, Connecticut 06269 3092, USA
Toxicol Sci 123:231-46. 2011..Bronchiolar tissue concentrations of diacetyl in the human are estimated to exceed those in the rat by 40-fold. These inhalation dosimetric differences may contribute to the human-rat differences in diacetyl-induced airway injury... - Adenosine sensory transduction pathways contribute to activation of the sensory irritation response to inspired irritant vaporsRyan P Vaughan
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269-3092, USA
Toxicol Sci 93:411-21. 2006..If sensory nerves are activated by mediators that are released from injured airway mucosal cells, then nasal sensory nerve activation may be a reflection of irritant-induced alterations in airway cell integrity... - Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritantsDaniel N Willis
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
FASEB J 25:4434-44. 2011..Through suppression of respiratory irritation, menthol may facilitate smoke inhalation and promote nicotine addiction and smoking-related morbidities... - Lack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mousePeter T Symanowicz
University of Connecticut Pulmonary Research Consortium, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269 2092, USA
Neurosci Lett 362:150-3. 2004..Thus, in the C57Bl/6J mouse the TRPV1 receptor does not appear to play a major role in the stimulation of nasal trigeminal central reflex responses by these irritant air pollutants... - Regional distribution and kinetics of vinyl acetate hydrolysis in the oral cavity of the rat and mouseJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Box U 2092, Storrs, CT 06269, USA
Toxicol Lett 126:31-9. 2002..Acetaldehyde was detected in these solutions providing evidence that metabolism of this ester occurs in vivo in oral tissues... - Modulation of sensory irritation responsiveness by adenosine and malodorantsDaniel N Willis
Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
Chem Senses 38:91-100. 2013..These results highlight that trigeminal chemosensory responsiveness is not static, but can be quickly modulated by adenosine and select odors resulting in hyperresponsive states... - In situ measurement of vapor uptake in the rodent upper respiratory tractJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA
Curr Protoc Toxicol . 2013..These data have been instrumental not only in understanding the regional airway toxicity of inspired vapors, but also for developing mathematical models to describe inhaled vapor dosimetry... - Effect of nitrogen dioxide on ovalbumin-induced allergic airway disease in a murine modelAndrea K Hubbard
Department of Pharmaceutical Sciences, University of Connecticut, Storrs 06269, USA
J Toxicol Environ Health A 65:1999-2005. 2002..Contrary to expectations, exposure to NO(2) during the aerosol challenge to OVA dramatically diminished the outcome of allergic disease in lungs as measured by airway cellular inflammation... - Sensory nerve-mediated nasal vasodilatory response to inspired ethyl acrylateJohn B Morris
Toxicology Program, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269 3092, USA
Inhal Toxicol 14:585-97. 2002.... - Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vaporsClay B Frederick
Toxicology Department, Rohm and Haas Company, Spring House, Pennsylvania 19477, USA
Toxicol Appl Pharmacol 183:23-40. 2002.... - Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of actionKenneth T Bogen
Exponent Health and Environmental, 500 12th Street, Suite 220, Oakland, CA 94607, USA
Regul Toxicol Pharmacol 51:S27-36. 2008....
Research Grants
- Nasal dosimetry of diacetyl and butyric acid vaporsJohn Morris; Fiscal Year: 2005....