Alison Morris

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc HIV and chronic obstructive pulmonary disease: is it worse and why?
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Proc Am Thorac Soc 8:320-5. 2011
  2. pmc Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART era
    M Patricia George
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    PLoS ONE 4:e6328. 2009
  3. pmc Comparison of the respiratory microbiome in healthy nonsmokers and smokers
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:1067-75. 2013
  4. pmc Serum (1→3)-β-D-glucan levels in HIV-infected individuals are associated with immunosuppression, inflammation, and cardiopulmonary function
    Alison Morris
    Departments of Medicin, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Acquir Immune Defic Syndr 61:462-8. 2012
  5. pmc Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era
    Alison Morris
    Department of Medicine, University of Alabama, Birmingham, USA
    AIDS 26:731-40. 2012
  6. pmc Colonization by Pneumocystis jirovecii and its role in disease
    Alison Morris
    Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 25:297-317. 2012
  7. pmc Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients
    Alison Morris
    University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 47:3773-6. 2009
  8. pmc Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease
    Alison Morris
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 47:e64-8. 2008
  9. pmc Pneumocystis: a novel pathogen in chronic obstructive pulmonary disease?
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 5:43-51. 2008
  10. doi request reprint Epidemiology and clinical significance of pneumocystis colonization
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Infect Dis 197:10-7. 2008

Collaborators

Detail Information

Publications40

  1. pmc HIV and chronic obstructive pulmonary disease: is it worse and why?
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Proc Am Thorac Soc 8:320-5. 2011
    ....
  2. pmc Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART era
    M Patricia George
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    PLoS ONE 4:e6328. 2009
    ..We evaluated respiratory symptoms and measured airway obstruction to identify the impact of HAART and other risk factors on respiratory symptoms and pulmonary function...
  3. pmc Comparison of the respiratory microbiome in healthy nonsmokers and smokers
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:1067-75. 2013
    ..Results from 16S rDNA-encoding gene sequence-based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome...
  4. pmc Serum (1→3)-β-D-glucan levels in HIV-infected individuals are associated with immunosuppression, inflammation, and cardiopulmonary function
    Alison Morris
    Departments of Medicin, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Acquir Immune Defic Syndr 61:462-8. 2012
    ..HIV-infected individuals are also susceptible to fungal infection and colonization, but whether fungal translocation occurs and influences HIV progression or comorbidities is unknown...
  5. pmc Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era
    Alison Morris
    Department of Medicine, University of Alabama, Birmingham, USA
    AIDS 26:731-40. 2012
    ..To determine relationship of echocardiographic measures of pulmonary hypertension to lung function and inflammatory biomarkers in HIV-infected individuals...
  6. pmc Colonization by Pneumocystis jirovecii and its role in disease
    Alison Morris
    Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 25:297-317. 2012
    ..In this review, we discuss current clinical and research topics in the study of Pneumocystis and highlight areas for future research...
  7. pmc Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients
    Alison Morris
    University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 47:3773-6. 2009
    ..Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease...
  8. pmc Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease
    Alison Morris
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 47:e64-8. 2008
    ..Undetectable anti-Pneumocystis antibody titer was an independent predictor of more-severe airway obstruction, although use of inhaled corticosteroids is a possible confounder of this effect...
  9. pmc Pneumocystis: a novel pathogen in chronic obstructive pulmonary disease?
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 5:43-51. 2008
    ..Additional studies are needed to confirm the role of Pneumocystis in the pathogenesis of COPD, given that this agent might be a treatable co-factor in disease progression...
  10. doi request reprint Epidemiology and clinical significance of pneumocystis colonization
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Infect Dis 197:10-7. 2008
    ..We also evaluate the clinical significance of Pneumocystis colonization and its relationship to lung disease...
  11. pmc Persistent pneumocystis colonization leads to the development of chronic obstructive pulmonary disease in a nonhuman primate model of AIDS
    Timothy W Shipley
    Department of Immunology, Division of Pulmonary, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Infect Dis 202:302-12. 2010
    ..Furthermore, this model allows examination of early host responses important to disease progression, thus identifying potential therapeutic targets for COPD...
  12. pmc Asthma diagnosis and airway bronchodilator response in HIV-infected patients
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 129:708-714.e8. 2012
    ....
  13. pmc Trimethoprim-sulfamethoxazole treatment does not reverse obstructive pulmonary changes in pneumocystis-colonized nonhuman primates with SHIV infection
    Heather M Kling
    Departments of Immunology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
    J Acquir Immune Defic Syndr 65:381-9. 2014
    ..In the present study, we examined kinetics of COPD development in non-human primate and tested the effect of Pc burden reduction on pulmonary function by TMP-SMX treatment...
  14. pmc Pulmonary function abnormalities in HIV-infected patients during the current antiretroviral therapy era
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 182:790-6. 2010
    ..The prevalence and exact phenotype of pulmonary abnormalities in the current era are unknown. In addition, these abnormalities may be underdiagnosed...
  15. pmc HIV infection is associated with reduced pulmonary diffusing capacity
    Kristina Crothers
    Department of Medicine, University of Washington, Seattle, WA Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Medicine, University of California, Los Angeles, Los Angeles, CA Department of Medicine, Atlanta Veterans Affairs Medical Center VAMC and Emory University, Atlanta, GA Department of Medicine, West Los Angeles VAMC and David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA Department of Medicine, James J Peters Bronx VAMC, Bronx, NY Department of Medicine, Michael E DeBakey Houston VAMC and Baylor College of Medicine, Houston, TX Department of Medicine, University of California, San Francisco, San Francisco, CA Department of Medicine, Clinical Trials and Survey Corporation, Owings Mills, MD Department of Medicine, Ohio State University Medical Center, Columbus, OH Department of Medicine, Johns Hopkins University, Baltimore, MD Department of Medicine, New York University School of Medicine, New York, NY Departments of Infectious Diseases and Microbiology and Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA and Departments of Medicine and Immunology, University of Pittsburgh, Pittsburgh, PA
    J Acquir Immune Defic Syndr 64:271-8. 2013
    ..Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited...
  16. pmc Relationship of Pneumocystis jiroveci humoral immunity to prevention of colonization and chronic obstructive pulmonary disease in a primate model of HIV infection
    Heather M Kling
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Infect Immun 78:4320-30. 2010
    ..In addition, these results indicate that an effective Pneumocystis-specific memory B-cell response is maintained despite progressive loss of CD4(+) T cells during SHIV infection...
  17. pmc Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension
    M Patricia George
    Department of Immunology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261
    Am J Respir Cell Mol Biol 48:374-81. 2013
    ..These studies establish an important nonhuman primate model of HIV-associated PAH that will be useful in studies of disease pathogenesis and the efficacy of interventions...
  18. pmc Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003
    Saba Radhi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, CA, USA
    BMC Infect Dis 8:118. 2008
    ..Epidemiology of PCP in the recent era of highly active antiretroviral therapy (HAART) is not well known and the impact of HAART on outcome of PCP has been debated...
  19. pmc HIV infection is associated with diffusing capacity impairment in women
    Meghan E Fitzpatrick
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA Departments of Medicine Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA and Department of Immunology, University of Pittsburgh, Pittsburgh, PA
    J Acquir Immune Defic Syndr 64:284-8. 2013
    ..Providers should be aware that DL(CO) impairment is common in HIV infection, and that either DL(CO) impairment or airflow obstruction may cause respiratory symptoms in this population...
  20. ncbi request reprint Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men
    Alison Morris
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    AIDS 18:793-8. 2004
    ..The epidemiology and transmission of Pneumocystis are poorly understood. The incidence of colonization, or detection of organisms without signs of disease, has been debated, and risk factors for colonization are largely unknown...
  21. pmc Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques
    M Patricia George
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    AIDS Res Hum Retroviruses 27:103-11. 2011
    ..This SHIV-env model provides a new means to investigate HIV-PAH...
  22. pmc Pneumocystis colonization in immunocompetent and simian immunodeficiency virus-infected cynomolgus macaques
    Heather M Kling
    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Infect Dis 199:89-96. 2009
    ..These results demonstrate the usefulness of recombinant KEX1 in serologic studies of Pc colonization and will improve the understanding of Pc transmission and clinical consequences of Pc colonization in HIV-infected patients...
  23. pmc Isolated right ventricular dysfunction in patients with human immunodeficiency virus
    Marc A Simon
    Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    J Card Fail 20:414-21. 2014
    ..Right ventricular (RV) dysfunction is associated with worse outcomes in these conditions, yet its prevalence is poorly defined in HIV. We sought to determine the prevalence of RV dysfunction in an outpatient HIV cohort...
  24. pmc Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts
    Matthew R Gingo
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Pulm Med 14:75. 2014
    ..The objective of the study is to determine the impact of HIV on prevalence and incidence of respiratory disease in the current era of effective antiretroviral treatment...
  25. pmc Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease
    Meghan E Fitzpatrick
    Department of Medicine, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, Pennsylvania, 15213, USA
    Microbiol Immunol 58:202-11. 2014
    ..The finding of upregulation of these inflammatory genes in the setting of Pneumocystis colonization sheds light on infectious-immune relationships in COPD. ..
  26. pmc Human immunodeficiency virus-associated obstructive lung diseases
    Matthew R Gingo
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Chest Med 34:273-82. 2013
    ..This article reviews the evidence linking HIV infection to obstructive lung disease, and discusses management issues related to the treatment of obstructive lung disease in HIV-infected patients...
  27. pmc Serologic responses to pneumocystis proteins in HIV patients with and without Pneumocystis jirovecii pneumonia
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 57:190-6. 2011
    ..Immune responses to Pneumocystis jirovecii are not well understood in HIV infection, but antibody responses to proteins may be useful as a marker of Pneumocystis risk or presence of Pneumocystis pneumonia (PcP)...
  28. pmc Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease
    Karen A Norris
    Department of Immunology, University of Pittsburgh School of Medicine, E 1057 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Immunol Res 50:175-80. 2011
    ..These findings support the hypothesis that immunity to KEX1 may be critical to controlling Pc colonization and preventing or slowing development of COPD...
  29. ncbi request reprint Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumonia
    Alison Morris
    Department of Medicine, San Francisco General Hospital, San Francisco, California, USA
    AIDS 17:73-80. 2003
    ..Highly active antiretroviral therapy (HAART) might alter the course of PCP either via effects on the immune system or through anti- actions; however, HAART has not been studied in patients acutely ill with PCP...
  30. ncbi request reprint Current issues in critical care of the human immunodeficiency virus-infected patient
    Alison Morris
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Crit Care Med 34:42-9. 2006
    ....
  31. pmc Contributors to diffusion impairment in HIV-infected persons
    Matthew R Gingo
    University of Pittsburgh, Pittsburgh, PA
    Eur Respir J 43:195-203. 2014
    ..Never-smokers may have a unique phenotype of diffusing capacity impairment. The interaction of multiple factors may account for the pervasive nature of diffusing capacity impairment in HIV infection...
  32. pmc Future directions: lung aging, inflammation, and human immunodeficiency virus
    Meghan Fitzpatrick
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Chest Med 34:325-31. 2013
    ..This article describes how HIV-associated COPD and PH may fit into a paradigm of immunosenescence, and outlines the hypothesized associations among chronic HIV infection, immune dysfunction and senescence, and cardiopulmonary outcomes...
  33. pmc STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina
    Riley C Myers
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:6287-94. 2013
    ..Collectively, our data suggest that robust local and systemic Th2-mediated responses are critical for immunity to Pneumocystis...
  34. pmc Pathogenesis of HIV and the lung
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Curr HIV/AIDS Rep 10:42-50. 2013
    ..The effect of HIV infection on lung-specific immune responses is being elucidated to help develop better prevention and treatment strategies in HIV-infected persons...
  35. ncbi request reprint Pneumocystis colonization, airway inflammation, and pulmonary function decline in acquired immunodeficiency syndrome
    Karen A Norris
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Immunol Res 36:175-87. 2006
    ..Information gained from these studies will lead to the development of interventions to prevent lung injury associated with Pc colonization and the development of HIV-associated COPD...
  36. pmc The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts
    Matthew R Gingo
    Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e58812. 2013
    ..To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART)...
  37. ncbi request reprint Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapy
    Alison Morris
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Am J Respir Crit Care Med 166:262-7. 2002
    ..These patients may have an improved survival because of effects of therapy on variables such as likelihood of non-AIDS-associated admission diagnoses and serum albumin levels...
  38. pmc Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production
    Michael P Nelson
    Dept of Medicine, Univ of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Lung Cell Mol Physiol 303:L469-75. 2012
    ..murina. Collectively, our data indicate that MMP12 induction is a component of the P. murina-induced M2 response and thus provides insight into the link between Pneumocystis colonization/infection and exacerbations in COPD...
  39. pmc Distribution of Pneumocystis jirovecii in lungs from colonized COPD patients
    Sheila Sivam
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Diagn Microbiol Infect Dis 71:24-8. 2011
    ....
  40. ncbi request reprint Update on the epidemiology and transmission of Pneumocystis carinii
    Alison Morris
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Microbes Infect 4:95-103. 2002
    ..This review summarizes the current state of knowledge about the epidemiology and transmission of P. carinii and reports on evolving techniques that may improve our understanding of this organism in the future...

Research Grants13

  1. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2005
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  2. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2009
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  3. Prevalence & Pathogenesis of Pulmonary Disease in a Large Multicenter HIV Cohort
    Alison Morris; Fiscal Year: 2009
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from emphysema. ..
  4. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2009
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  5. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2006
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  6. Prevalence & Pathogenesis of Pulmonary Disease in a Large Multicenter HIV Cohort
    Alison Morris; Fiscal Year: 2007
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from emphysema. ..
  7. Epidemiology and Significance of P carinii Colonization
    Alison Morris; Fiscal Year: 2006
    ..In addition, greater insight into the epidemiology of colonization may aid in understanding the transmission and prevention of P. carinii. ..
  8. Epidemiology and Significance of P carinii Colonization
    Alison Morris; Fiscal Year: 2007
    ..In addition, greater insight into the epidemiology of colonization may aid in understanding the transmission and prevention of P. carinii. ..
  9. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2007
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  10. Prevalence & Pathogenesis of Pulmonary Disease in a Large Multicenter HIV Cohort
    Alison Morris; Fiscal Year: 2010
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from emphysema. ..