Leonid Moroz

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica
    Sami H Jezzini
    The Whitney Laboratory and Department of Neuroscience, University of Florida, 9505 Ocean Shore Blvd St Augustine, FL 32080, USA
    Brain Res Mol Brain Res 127:27-38. 2004
  2. ncbi request reprint Molecular characterization and expression of a two-pore domain potassium channel in the CNS of Aplysia californica
    Sami H Jezzini
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
    Brain Res 1094:47-56. 2006
  3. ncbi request reprint Phylogenomics meets neuroscience: how many times might complex brains have evolved?
    L L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd St Augustine Florida 32080, USA
    Acta Biol Hung 63:3-19. 2012
  4. pmc Computational workflow for analysis of gain and loss of genes in distantly related genomes
    Andrey Ptitsyn
    Whitney Laboratory for Marine Biosciences, University of Florida 9505 Ocean Shore Blvd, Saint Augustine, FL 32080, USA
    BMC Bioinformatics 13:S5. 2012
  5. pmc Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia
    Scott F Cummins
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    BMC Biol 7:28. 2009
  6. pmc On the independent origins of complex brains and neurons
    Leonid L Moroz
    Department of Neuroscience and McKnight Brain Institute, Gainesville, Fla, USA
    Brain Behav Evol 74:177-90. 2009
  7. ncbi request reprint Parallel evolution of nitric oxide signaling: diversity of synthesis and memory pathways
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080 8623, USA
    Front Biosci (Landmark Ed) 16:2008-51. 2011
  8. ncbi request reprint Neuronal transcriptome of Aplysia: neuronal compartments and circuitry
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
    Cell 127:1453-67. 2006
  9. ncbi request reprint Localization of putative nitrergic neurons in peripheral chemosensory areas and the central nervous system of Aplysia californica
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience and Department of Neuroscience, University of Florida, St Augustine, Florida 32080, USA
    J Comp Neurol 495:10-20. 2006
  10. ncbi request reprint Single-cell analyses of nitrergic neurons in simple nervous systems
    L L Moroz
    Department of Chemistry and Beckman Institute, Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    J Exp Biol 202:333-41. 1999

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica
    Sami H Jezzini
    The Whitney Laboratory and Department of Neuroscience, University of Florida, 9505 Ocean Shore Blvd St Augustine, FL 32080, USA
    Brain Res Mol Brain Res 127:27-38. 2004
    ....
  2. ncbi request reprint Molecular characterization and expression of a two-pore domain potassium channel in the CNS of Aplysia californica
    Sami H Jezzini
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
    Brain Res 1094:47-56. 2006
    ..The neuron-specific expression pattern seen for this channel is consistent with data from a variety of organisms that implicate K2p channels as determinants of neuronal phenotype and function...
  3. ncbi request reprint Phylogenomics meets neuroscience: how many times might complex brains have evolved?
    L L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd St Augustine Florida 32080, USA
    Acta Biol Hung 63:3-19. 2012
    ..To further reconstruct the parallel evolution of nervous systems genomic approaches are essential to probe enigmatic neurons of basal metazoans, selected lophotrochozoans (e.g. phoronids, brachiopods) and deuterostomes...
  4. pmc Computational workflow for analysis of gain and loss of genes in distantly related genomes
    Andrey Ptitsyn
    Whitney Laboratory for Marine Biosciences, University of Florida 9505 Ocean Shore Blvd, Saint Augustine, FL 32080, USA
    BMC Bioinformatics 13:S5. 2012
    ..Here, we present a simple but efficient workflow for elucidation of gene gain and gene loss within major branches of the animal kingdom...
  5. pmc Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia
    Scott F Cummins
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    BMC Biol 7:28. 2009
    ..The expression of G protein and phospholipase C signaling molecules in this organ is consistent with chemosensory detection being via a G-protein-coupled signaling mechanism...
  6. pmc On the independent origins of complex brains and neurons
    Leonid L Moroz
    Department of Neuroscience and McKnight Brain Institute, Gainesville, Fla, USA
    Brain Behav Evol 74:177-90. 2009
    ....
  7. ncbi request reprint Parallel evolution of nitric oxide signaling: diversity of synthesis and memory pathways
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080 8623, USA
    Front Biosci (Landmark Ed) 16:2008-51. 2011
    ..Giant uniquely identified cells from Aplysia and related species precent unuque opportunities for integrative analysis of NO signaling at the single cell level...
  8. ncbi request reprint Neuronal transcriptome of Aplysia: neuronal compartments and circuitry
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
    Cell 127:1453-67. 2006
    ....
  9. ncbi request reprint Localization of putative nitrergic neurons in peripheral chemosensory areas and the central nervous system of Aplysia californica
    Leonid L Moroz
    The Whitney Laboratory for Marine Bioscience and Department of Neuroscience, University of Florida, St Augustine, Florida 32080, USA
    J Comp Neurol 495:10-20. 2006
    ..The highly selective NADPH-d labeling revealed here suggests the presence of NOS in sensory areas both in the CNS and the peripheral organs of Aplysia and implies a role for NO as a modulator of chemosensory processing...
  10. ncbi request reprint Single-cell analyses of nitrergic neurons in simple nervous systems
    L L Moroz
    Department of Chemistry and Beckman Institute, Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    J Exp Biol 202:333-41. 1999
    ..The methodologies and instrumentation developed and tested using the convenient molluscan cell model can be adapted to the smaller and more delicate neurons of other invertebrates and chordates...
  11. ncbi request reprint Direct single cell determination of nitric oxide synthase related metabolites in identified nitrergic neurons
    Leonid L Moroz
    Department of Neuroscience, Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    J Inorg Biochem 99:929-39. 2005
    ..On the contrary, we found that absolute concentrations of other NOS related metabolites including nitrates are not reliable markers of NOS activity and demonstrate the need for multiple assays for NOS activity...
  12. ncbi request reprint Non-enzymatic production of nitric oxide (NO) from NO synthase inhibitors
    L L Moroz
    Department of Neuroscience, The Whitney Laboratory, University of Florida, St Augustine 32086 8623, USA
    Biochem Biophys Res Commun 253:571-6. 1998
    ..These results have important implications for therapeutic regulation of NO homeostasis...
  13. ncbi request reprint Giant identified NO-releasing neurons and comparative histochemistry of putative nitrergic systems in gastropod molluscs
    L L Moroz
    The Whitney Laboratory and Department of Neuroscience, University of Florida, St Augustine, Florida 32086, USA
    Microsc Res Tech 49:557-69. 2000
    ....
  14. ncbi request reprint Nitric oxide regulates swimming in the jellyfish Aglantha digitale
    Leonid L Moroz
    The Whitney Laboratory and Department of Neuroscience, University of Florida, St Augustine, Florida 32080, USA
    J Comp Neurol 471:26-36. 2004
    ..We suggest that an NO/cGMP signaling pathway modulates the rhythmic swimming associated with feeding in Aglantha, possibly by means of putative nitrergic sensory neurons in its tentacles...
  15. ncbi request reprint Distribution of NADPH-diaphorase reactivity and effects of nitric oxide on feeding and locomotory circuitry in the pteropod mollusc, Clione limacina
    L L Moroz
    The Whitney Laboratory, Department of Neuroscience, University of Florida, St Augustine, Florida 32080 8623, USA
    J Comp Neurol 427:274-84. 2000
    ..The cGMP analog, 8-Br-cGMP, mimicked the effects of NO on neurons. We suggest that NO is an endogenous neuromodulator involved in the control of some aspects of feeding and locomotor behavior of Clione...
  16. ncbi request reprint Molecular beacons for bioanalytical applications
    Li Tan
    Center for Research at the Bio Nano Interface, Department of Chemistry and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611 7200, USA
    Analyst 130:1002-5. 2005
    ..These important applications have shown that MBs hold great potential in genomics and proteomics where real-time molecular recognition with high sensitivity and excellent specificity is critical...
  17. ncbi request reprint Endogenous thyroid hormone synthesis in facultative planktotrophic larvae of the sand dollar Clypeaster rosaceus: implications for the evolutionary loss of larval feeding
    Andreas Heyland
    The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, FL 32080, USA
    Evol Dev 8:568-79. 2006
    ..We conclude that upregulation of endogenous hormone synthesis might have been associated with the evolution of nonfeeding development, subsequently leading to morphological changes characteristic of nonfeeding development...
  18. ncbi request reprint Molecular characterization of NMDA-like receptors in Aplysia and Lymnaea: relevance to memory mechanisms
    Thomas J Ha
    The Whitney Laboratory for Marine Bioscience, Evelyn F and William McKnight Brain Institute of the University of Florida, Florida 32080, USA
    Biol Bull 210:255-70. 2006
    ..The widespread distribution of AcNR1 and LsNR1 transcripts also implies diverse functions, including their involvement in the organization of feeding, locomotory, and defensive behaviors...
  19. ncbi request reprint Developmental transcriptome of Aplysia californica
    Andreas Heyland
    Integrative Biology, University of Guelph, Ontario, Canada
    J Exp Zool B Mol Dev Evol 316:113-34. 2011
    ....
  20. ncbi request reprint Thyroid hormone metabolism and peroxidase function in two non-chordate animals
    Andreas Heyland
    The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, FL 32080, USA
    J Exp Zool B Mol Dev Evol 306:551-66. 2006
    ..We discuss our new findings in the context of evolution of TH synthesis and TH signaling in non-chordate animals...
  21. ncbi request reprint High-resolution microanalysis of nitrite and nitrate in neuronal tissues by capillary electrophoresis with conductivity detection
    Dmitri Y Boudko
    The Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 774:97-104. 2002
    ..In rat dorsal root ganglia, endogenous levels of nitrate (231+/-29 microM; n=6) and nitrite (24-96 microM) were found. These concentrations exceeded those previously found in neuronal tissue homogenates using different techniques...
  22. ncbi request reprint Cross-kingdom hormonal signaling: an insight from thyroid hormone functions in marine larvae
    Andreas Heyland
    The Whitney Laboratory for Marine Bioscience and Department of Neuroscience, University of Florida, FL 32080, USA
    J Exp Biol 208:4355-61. 2005
    ....
  23. ncbi request reprint Calcium/calmodulin-dependent nitric oxide synthase activity in the CNS of Aplysia californica: biochemical characterization and link to cGMP pathways
    Michaela Bodnarova
    Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    J Inorg Biochem 99:922-8. 2005
    ..This confirms that NO may indeed function as a messenger in the molluscan CNS, and that cGMP acts as one of its effectors...
  24. ncbi request reprint Single cell glutamate analysis in Aplysia sensory neurons
    Timothy J Drake
    Department of Chemistry, University of Florida, Box 100072, Gainesville, FL 32611, USA
    J Neurosci Methods 144:73-7. 2005
    ..L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons. Proc Natl Acad Sci USA 1993;90:7163-7.], suggesting that glutamate plays a role as neurotransmitter in these cells...
  25. ncbi request reprint Nitric oxide potentiates cAMP-gated cation current in feeding neurons of Pleurobranchaea californica independent of cAMP and cGMP signaling pathways
    Nathan G Hatcher
    Deprtment of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 414 Burrill Hall, 407 S Goodwin Ave, Urbana, IL 61801, USA
    J Neurophysiol 95:3219-27. 2006
    ....
  26. ncbi request reprint Schistosoma mansoni: use of a fluorescent indicator to detect nitric oxide and related species in living parasites
    Andrea B Kohn
    Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, 32080, USA
    Exp Parasitol 113:130-3. 2006
    ....
  27. ncbi request reprint Ascorbic acid assays of individual neurons and neuronal tissues using capillary electrophoresis with laser-induced fluorescence detection
    Won Suk Kim
    Department of Chemistry and the Beckman Institute, University of Illinois, Urbana 61801, USA
    Anal Chem 74:5614-20. 2002
    ....
  28. ncbi request reprint Two-color in situ hybridization in the CNS of Aplysia californica
    Sami H Jezzini
    The Whitney Laboratory for Marine Bioscience and Department of Neuroscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    J Neurosci Methods 149:15-25. 2005
    ..The sensitive detection of mRNA and great preservation of CNS morphology makes this method a useful tool for analyzing expression patterns of neuron specific genes in Aplysia...
  29. ncbi request reprint Electroporation of neurons and growth cones in Aplysia californica
    Peter Lovell
    The Whitney Laboratory for Marine Bioscience, University of Florida, 9005 Ocean Shore Blvd, St Augustine, FL 32080, USA
    J Neurosci Methods 151:114-20. 2006
    ..The protocol can be easily applied to a variety of models in neuroscience including accessible nervous systems of invertebrate animals...
  30. ncbi request reprint Complete DNA sequence of the mitochondrial genome of the sea-slug, Aplysia californica: conservation of the gene order in Euthyneura
    Bjarne Knudsen
    Department of Zoology, University of Florida, 223 Bartram Hall, Gainesville, 32611, USA
    Mol Phylogenet Evol 38:459-69. 2006
    ..The Aplysia mitochondrial genome sequenced here will serve as an important platform in both comparative and neurobiological studies using this model organism...
  31. ncbi request reprint Interfering with nitric oxide measurements. 4,5-diaminofluorescein reacts with dehydroascorbic acid and ascorbic acid
    Xin Zhang
    Department of Chemistry and the Beckman Institute, University of Illinois, Urbana 61801, USA
    J Biol Chem 277:48472-8. 2002
    ....
  32. ncbi request reprint Analysis of nitric oxide-cyclic guanosine monophosphate signaling during metamorphosis of the nudibranch Phestilla sibogae Bergh (Gastropoda: Opisthobranchia)
    Cory D Bishop
    Kewalo Marine Laboratories, 41 Ahui St, Honolulu, HA 96822, USA
    Evol Dev 10:288-99. 2008
    ..These results suggest that endogenous NO and cGMP are involved in modulating responses of P. sibogae to a natural settlement cue. We discuss these results with respect to habitat selection and larval ecology...
  33. ncbi request reprint Monitoring real-time release of ATP from the molluscan central nervous system
    Jason A Gruenhagen
    Ames Laboratory USDOE, Department of Chemistry, Iowa State University, Ames, IA 50011, USA
    J Neurosci Methods 139:145-52. 2004
    ..Release of ATP from Lymnaea ganglia varied among the different ganglia as well as within individual ganglia. Furthermore, the magnitude of ATP release varied following the stimulation of neurons with common neurotransmitters...
  34. ncbi request reprint Somatotopic organization and functional properties of mechanosensory neurons expressing sensorin-A mRNA in Aplysia californica
    Edgar T Walters
    Department of Integrative Biology and Pharmacology, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Comp Neurol 471:219-40. 2004
    ..Interesting questions arise from observations that mRNA for sensorin-A is present not only in the somata but also in synaptic regions, connectives, and peripheral fibers...
  35. pmc Simple cDNA normalization using kamchatka crab duplex-specific nuclease
    Pavel A Zhulidov
    Shemiakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho Maklaya 16 10, 117871 Moscow, Russia
    Nucleic Acids Res 32:e37. 2004
    ..We also employed DSN normalization to normalize cDNA from nervous tissues of the marine mollusc Aplysia californica (a popular model organism in neuroscience) to illustrate further the efficiency of the normalization technique...
  36. ncbi request reprint Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida
    Sarah J Bourlat
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Nature 444:85-8. 2006
    ..As such, Xenoturbella is shown to be an independent phylum, Xenoturbellida, bringing the number of living deuterostome phyla to four...
  37. ncbi request reprint Role of nitric oxide in classical conditioning of siphon withdrawal in Aplysia
    Igor Antonov
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 27:10993-1002. 2007
    ..In addition, they suggest that NO does not come from either the sensory or motor neurons but rather comes from another source, perhaps the L29 interneurons...
  38. pmc Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes
    Yuri Panchin
    Institute for Information Transmission Problems, Russian Academy of Science, 127994 Moscow, Russia
    Biochem Biophys Res Commun 369:818-23. 2008
    ..This refines the "RAG transposon" hypothesis and allows us to propose a scenario for V(D)J recombination machinery evolution from a relic transposon related to the existing mobile elements N-RAG-TP, Chapaev, and Transib...

Research Grants4

  1. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 1999
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  2. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2000
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  3. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2001
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  4. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..