Research Topics
| CHET T contact MORITZSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Direct control of paralysed muscles by cortical neuronsChet T Moritz
Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
Nature 456:639-42. 2008..These results are the first demonstration that direct artificial connections between cortical cells and muscles can compensate for interrupted physiological pathways and restore volitional control of movement to paralysed limbs...- Human hoppers compensate for simultaneous changes in surface compression and dampingChet T Moritz
Locomotion Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
J Biomech 39:1030-8. 2006..Runners may use similar strategies on natural energy-dissipating surfaces such as sand, mud and snow... - Human hopping on very soft elastic surfaces: implications for muscle pre-stretch and elastic energy storage in locomotionChet T Moritz
Locomotion Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
J Exp Biol 208:939-49. 2005..Thus, the extreme adjustment to leg mechanics for very soft surfaces helps maintain normal center of mass dynamics but requires high muscle activation levels due to the loss of the normal extensor muscle stretch-shorten cycle... - Coherence at 16-32 Hz can be caused by short-term synchrony of motor unitsChet T Moritz
Department of Integrative Physiology, University of Colorado, Boulder, USA
J Neurophysiol 94:105-18. 2005..Although the in vivo processes that adjust the timing of motor-unit discharges are not fully understood, these results suggest that they may not depend entirely on an oscillatory drive by the CNS... - Discharge rate variability influences the variation in force fluctuations across the working range of a hand muscleChet T Moritz
Department of Physiology and Biophysics, Box 357290, University of Colorado, Boulder, USA
J Neurophysiol 93:2449-59. 2005..22) at all force levels. These results support the hypothesis that discharge rate variability is a major determinant of the trends in isometric force variability across the working range of a muscle... - Forelimb movements and muscle responses evoked by microstimulation of cervical spinal cord in sedated monkeysChet T Moritz
Department of Physiology and Biophysics, Box 357290, University of Washington School of Medicine, Seattle, WA 98195 7290, USA
J Neurophysiol 97:110-20. 2007..The absence of a clear somatotopic map of output sites is probably a result of the stimulation of complex mixtures of fibers and cells... - Passive dynamics change leg mechanics for an unexpected surface during human hoppingChet T Moritz
Dept of Integrative Physiology, 354 UCB, Boulder, CO 80309 0354, USA
J Appl Physiol 97:1313-22. 2004..These results show that passive mechanisms alter leg stiffness for unexpected surface changes before muscle EMG changes and may be critical for adjustments to variable terrain encountered during locomotion in the natural world... - Prolonged muscle vibration increases stretch reflex amplitude, motor unit discharge rate, and force fluctuations in a hand muscleMinoru Shinohara
Dept of Integrative Physiology, Univ of Colorado, Boulder, CO 80309 0354, USA
J Appl Physiol 99:1835-42. 2005..These adjustments were necessary to achieve the target force due to the vibration-induced decrease in the force capacity of the muscle... - The Neurochip BCI: towards a neural prosthesis for upper limb functionAndrew Jackson
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
IEEE Trans Neural Syst Rehabil Eng 14:187-90. 2006..These observations suggest that spinal microstimulation controlled by cortical neurons could help compensate for damaged corticospinal projections... - Neuromuscular changes for hopping on a range of damped surfacesChet T Moritz
Locomotion Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
J Appl Physiol 96:1996-2004. 2004..Our findings, and those of previous studies of hopping on elastic surfaces, show that the ankle joint is the key determinant of both springlike and actuator-like leg mechanics during hopping in place... - Human hopping on damped surfaces: strategies for adjusting leg mechanicsChet T Moritz
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
Proc Biol Sci 270:1741-6. 2003..Conserving the trajectory of the centre of mass by maintaining spring-like mechanics of the leg-surface combination may be an important control strategy for fast-legged locomotion on variable terrain...
Research Grants
- Cortical signals restore functional muscle activationCHET MORITZ; Fiscal Year: 2007..The long-term goal of the proposed research is to develop an implantable brain-computer interface capable of bypassing spinal cord lesions and restoring movement to spinal cord injured patients. ..
- Combined stem cell transplantation and targeted microstimulation to direct the foCHET T contact MORITZ; Fiscal Year: 2010..Targeted electrical microstimulation will be applied across the injury in order to guide implanted stem cells to make appropriate connections and restore function following injury. ..
- Combined stem cell transplantation and targeted microstimulation to direct the foCHET T contact MORITZ; Fiscal Year: 2010..Targeted electrical microstimulation will be applied across the injury in order to guide implanted stem cells to make appropriate connections and restore function following injury. ..