David A Morilak

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Role of brain norepinephrine in the behavioral response to stress
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1214-24. 2005
  2. ncbi request reprint Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Int J Neuropsychopharmacol 7:193-218. 2004
  3. ncbi request reprint Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, MC 7764, 7703 Floyd Curl Drive, 78229 3900, USA
    Life Sci 73:715-26. 2003
  4. ncbi request reprint Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals
    Gabe Barrera
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, 78229, USA
    Synapse 59:27-40. 2006
  5. ncbi request reprint Regulation of the norepinephrine transporter by chronic administration of antidepressants
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biol Psychiatry 55:313-6. 2004
  6. ncbi request reprint Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment
    Corina O Bondi
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 33:320-31. 2008
  7. ncbi request reprint Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 28:1633-41. 2003
  8. ncbi request reprint Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine
    Corina O Bondi
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:482-95. 2007
  9. ncbi request reprint Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment
    April S Garcia
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 91:683-93. 2004
  10. ncbi request reprint Chronic treatment with desipramine improves cognitive performance of rats in an attentional set-shifting test
    M Danet S Lapiz
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 32:1000-10. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Role of brain norepinephrine in the behavioral response to stress
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1214-24. 2005
    ....
  2. ncbi request reprint Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Int J Neuropsychopharmacol 7:193-218. 2004
    ....
  3. ncbi request reprint Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress
    David A Morilak
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, MC 7764, 7703 Floyd Curl Drive, 78229 3900, USA
    Life Sci 73:715-26. 2003
    ..Thus, the interaction of galanin and norepinephrine may be a viable target for the future development of novel therapeutic strategies for treating behavioral disorders related to stress or drug abuse...
  4. ncbi request reprint Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals
    Gabe Barrera
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, 78229, USA
    Synapse 59:27-40. 2006
    ....
  5. ncbi request reprint Regulation of the norepinephrine transporter by chronic administration of antidepressants
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biol Psychiatry 55:313-6. 2004
    ..This study investigated if chronic treatment of rats with selective NRIs or SSRIs also affected the norepinephrine transporter (NET)...
  6. ncbi request reprint Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment
    Corina O Bondi
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 33:320-31. 2008
    ..These effects were prevented by chronic treatment with antidepressant drugs, consistent also with clinical evidence that relapse of depressive episodes can be prevented by antidepressant drug treatment...
  7. ncbi request reprint Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems
    Georgianna G Gould
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 28:1633-41. 2003
    ..Thus, pretreatment of rats with PRX actually enhanced at least one regulatory effect of RBX treatment on the noradrenergic system, and did not interfere with any other pharmacological effect caused by RBX treatment...
  8. ncbi request reprint Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine
    Corina O Bondi
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:482-95. 2007
    ....
  9. ncbi request reprint Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment
    April S Garcia
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 91:683-93. 2004
    ..Together, these data suggest that endogenous activation of alpha(2)-autoreceptors persists in restraining NA neurotransmission in the face of tonically elevated basal NA levels following chronic reuptake blockade...
  10. ncbi request reprint Chronic treatment with desipramine improves cognitive performance of rats in an attentional set-shifting test
    M Danet S Lapiz
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 32:1000-10. 2007
    ....
  11. pmc Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats
    M Danet S Lapiz-Bluhm
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 202:329-41. 2009
    ..Orbitofrontal cortex (OFC) has been implicated specifically in reversal learning, a form of cognitive flexibility modulated by 5-HT...
  12. ncbi request reprint Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress
    Habibeh Khoshbouei
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neuropsychopharmacology 27:25-34. 2002
    ..These results suggest that during stress, the neuropeptide galanin exerts a modulatory effect in the BSTL, facilitating behavioral and neuroendocrine components of the acute stress response...
  13. ncbi request reprint Blockade of autoreceptor-mediated inhibition of norepinephrine release by atipamezole is maintained after chronic reuptake inhibition
    M Danet Lapiz
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX 778229 3900, USA
    Int J Neuropsychopharmacol 10:827-33. 2007
    ....
  14. ncbi request reprint Administration of the galanin antagonist M40 into lateral septum attenuates shock probe defensive burying behavior in rats
    David J Echevarria
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
    Neuropeptides 39:445-51. 2005
    ..These results highlight the fact that, rather than a unified system-like role in modulating anxiety, the effects of GAL can be either facilitating or attenuating, and are region-specific, context-specific and response-specific...
  15. doi request reprint A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex
    Jennifer J Donegan
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, and Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Neurosci 34:953-62. 2014
    ....
  16. pmc Too much of a good thing: blocking noradrenergic facilitation in medial prefrontal cortex prevents the detrimental effects of chronic stress on cognition
    Julianne D Jett
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 38:585-95. 2013
    ....
  17. pmc A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment
    M Danet
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 13:997-1009. 2010
    ....
  18. ncbi request reprint Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala
    Habibeh Khoshbouei
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Pharmacol Biochem Behav 71:407-17. 2002
    ..The balance between noradrenergic and peptidergic neurotransmission may be modified by prior stress, drug treatment or genetic variability, and may represent a novel target for treatment of stress-related neuropsychiatric disorders...
  19. ncbi request reprint One for all or one for one: does co-transmission unify the concept of a brain galanin "system" or clarify any consistent role in anxiety?
    Gabe Barrera
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, MC 7764, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neuropeptides 39:289-92. 2005
    ....
  20. doi request reprint Effects of milnacipran on cognitive flexibility following chronic stress in rats
    Kale J Naegeli
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Eur J Pharmacol 703:62-6. 2013
    ....
  21. ncbi request reprint Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter
    Saloua Benmansour
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 22:6766-72. 2002
    ..SERT binding sites decreases are not a consequence of reduced SERT gene expression, as revealed by in situ hybridization measurements. SSRI-induced downregulation of the SERT may be a key component for the clinical response to SSRIs...
  22. ncbi request reprint Chronic cold stress sensitizes brain noradrenergic reactivity and noradrenergic facilitation of the HPA stress response in Wistar Kyoto rats
    Marie Christine Pardon
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Brain Res 971:55-65. 2003
    ....
  23. pmc Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity
    Megan K Roth
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neuropharmacology 63:1118-26. 2012
    ....
  24. ncbi request reprint What should animal models of depression model?
    Alan Frazer
    Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neurosci Biobehav Rev 29:515-23. 2005
    ..Such models may then provide access not only to the neural regulatory mechanisms underlying effective antidepressant treatment, but may also provide clues to the processes underlying the development and manifestation of depression...
  25. ncbi request reprint Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior
    Brian C Bingham
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Psychoneuroendocrinology 38:2746-57. 2013
    ..The data further suggest that adverse prenatal environments constitute a risk factor for PTSD-like symptomatology, especially when combined with chronic stressors later in life...
  26. pmc Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress
    Milena Girotti
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
    Psychoneuroendocrinology 38:1158-69. 2013
    ....
  27. ncbi request reprint Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress
    Marco Cecchi
    The University of Michigan, Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuropharmacology 43:1139-47. 2002
    ....

Research Grants18

  1. Interaction of Brain Norepinephrine/Galanin in Stress
    David Morilak; Fiscal Year: 2001
    ..abstract_text> ..
  2. Noradrenergic mechanisms in antidepressant drug effects
    David A Morilak; Fiscal Year: 2010
    ....
  3. Brain Norepinephrine and Stress Reactivity
    David Morilak; Fiscal Year: 2009
    ....
  4. Noradrenergic mechanisms in antidepressant drug effects
    David Morilak; Fiscal Year: 2009
    ....
  5. Noradrenergic mechanisms in antidepressant drug effects
    David Morilak; Fiscal Year: 2007
    ....
  6. Brain Norepinephrine and Stress Reactivity
    David Morilak; Fiscal Year: 2006
    ..By comparing neurobiological differences between these strains, before and after sensitization, we hope to understand better the link between stress and disease states in vulnerable individuals ..
  7. Noradrenergic mechanisms in antidepressant drug effects
    David Morilak; Fiscal Year: 2006
    ....
  8. Interaction of Brain Norepinephrine/Galanin in Stress
    David Morilak; Fiscal Year: 2005
    ..abstract_text> ..
  9. Interaction of Brain Norepinephrine/Galanin in Stress
    David Morilak; Fiscal Year: 2004
    ..abstract_text> ..
  10. Interaction of Brain Norepinephrine/Galanin in Stress
    David Morilak; Fiscal Year: 2003
    ..abstract_text> ..
  11. Interaction of Brain Norepinephrine/Galanin in Stress
    David Morilak; Fiscal Year: 2002
    ..abstract_text> ..
  12. Brain Norepinephrine and Stress Reactivity
    David Morilak; Fiscal Year: 2002
    ..By comparing neurobiological differences between these strains, before and after sensitization, we hope to understand better the link between stress and disease states in vulnerable individuals ..
  13. Brain Norepinephrine and Stress Reactivity
    David A Morilak; Fiscal Year: 2010
    ....