Research Topics
Genomes and Genes | S L MorganSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
The effect of common artifacts lateral to the spine on bone mineral density in the lumbar spineSarah L Morgan
Department of Nutrition Sciences, UAB Osteoporosis Prevention and Treatment Clinic, Birmingham, AL 35294 1270, USA
J Clin Densitom 11:243-9. 2008..We conclude that artifacts lateral to the spine, particularly in a low BMD spine, can affect the interpretation of L1-L4 BMD using a Hologic Discovery W scanner with 12.7 software in array mode...- Black hole artifacts-a new potential pitfall for DXA accuracy?Sarah L Morgan
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 1270, USA
J Clin Densitom 11:266-75. 2008..Attention should be paid to the possibility of black hole artifacts on DXA scans and the effect they may have on spine results. Viewing scans in the single-energy mode can be used to verify the presence of tantalum clips... 
Medical foods: products for the management of chronic diseasesSarah L Morgan
Department of Nutrition Sciences, School of Health Related Professions, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 1270, USA
Nutr Rev 64:495-501. 2006..Newer medical foods are designed to manage hyperhomocysteinemia, pancreatic exocrine insufficiency, inflammatory conditions, cancer cachexia, and other diseases...- Nonprogression of vertebral area or bone mineral content on DXA does not predict compression fracturesSarah L Morgan
Osteoporosis Prevention and Treatment Clinic, The University of Alabama at Birmingham, 35294 1270, USA
J Clin Densitom 9:261-4. 2006..Thirty percent of subjects had lumbar spine scoliosis. The presence of scoliosis was significantly related to a T-score discrepancy at L1-L4... - Osteoporosis: handy tools for detection, helpful tips for treatmentSarah L Morgan
UAB Osteoporosis Prevention and Treatment Clinic, The University of Alabama at Birmingham, USA
J Fam Pract 57:311-20. 2008 
The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritisSarah L Morgan
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 1270, USA
J Med Food 12:1143-8. 2009..Thus, flavocoxid is safe when used in a population with "below average" to "moderately above average cardiovascular risk" compared to placebo...- Nutrition and bone: it is more than calcium and vitamin DSarah L Morgan
Department of Nutrition Sciences and Department of Medicine, The University of Alabama at Birmingham UAB, The UAB Osteoporosis Prevention and Treatment Clinic and Bone Densitometry Service, 354 Learning Resources Center, 1714 9th Avenue South Birmingham, AL 35294 1270, USA
Womens Health (Lond Engl) 5:727-37. 2009..Future studies should center on whole food and dietary patterns and their relationship to bone metabolism and fracture risk... - The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritisSarah L Morgan
University of Alabama at Birmingham, 35294 1270, USA
Arthritis Rheum 50:3104-11. 2004..AICA and adenosine are markers for MTX interference with purine metabolism... - Effect of methotrexate therapy on bone mineral density and body composition in rat adjuvant arthritisSarah L Morgan
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Rheumatol 31:1693-7. 2004.... - Distribution of Z-scores in a University cohort with an emphasis on "high" bone mineral densitySarah L Morgan
Osteoporosis Prevention and Treatment Clinic and Bone Densitometry Service, University of Alabama at Birmingham, Birmingham, AL 35294 1270, USA
J Clin Densitom 13:385-91. 2010..These data suggest that a high Z-score is common at 1 or more sites. Further research about the criteria for the diagnosis of high BMD is warranted... - Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventionS L Morgan
Department of Nutrition Sciences, School of Medicine, University of Alabama at Birmingham, USA
J Rheumatol 25:441-6. 1998..To determine the effect of longterm methotrexate (MTX) therapy and folic acid supplementation on folate nutriture and homocysteine levels in patients with rheumatoid arthritis... - Calcium and vitamin D in osteoporosisS L Morgan
Division of Clinical Nutrition and Dietetics, Departments of Nutrition Sciences and Medicine, Schools of Medicine, Health Related Professions, and Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA
Rheum Dis Clin North Am 27:101-30. 2001..Calcium and vitamin D supplementation is an important adjunctive therapy to use together with antiresorptive therapies... - Folate supplementation during methotrexate therapy for rheumatoid arthritisS L Morgan
Schools of Health Professions, Medicine, and Dentistry, Birmingham, AL 35294 1270, USA
Clin Exp Rheumatol 28:S102-9. 2010..The cost of FA supplements is substantially less than the cost of FLN supplements. This article reviews clinical trials related to folate supplementation during MTX therapy for RA... - Need for precision studies at individual institutions and assessment of size of regions of interest on serial DXA scansSarah L Morgan
University of Alabama at Birmingham Osteoporosis Prevention and Treatment Clinic, Birmingham, AL 35294 1270, USA
J Clin Densitom 6:97-101. 2003..The trochanter may be less useful in monitoring serial changes if area of the region of interest varies widely... - MTX affects inflammation and tissue destruction differently in the rat AA modelS L Morgan
Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
J Rheumatol 28:1476-81. 2001..To investigate the dose response relationships of methotrexate (MTX) therapy in rat adjuvant arthritis (AA), an animal model of rheumatoid arthritis (RA)... - Association of the presence of bone bars on radiographs and hip fracture in postmenopausal Caucasian womenD B Sarver
University of Alabama School of Medicine, Birmingham, AL, USA
Clin Radiol 67:840-2. 2012..To determine whether the presence of bone bars (BB) identified on anteroposterior hip radiographs are more prevalent in patients that have had a hip fracture as compared to patients without a fracture... - Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritisL B Hughes
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 415 Lyons Harrison Research Building, Birmingham, AL 35294 0007, USA
Ann Rheum Dis 65:1213-8. 2006..The anti-folate drug methotrexate (MTX) is commonly used to treat rheumatoid arthritis... - Homocysteine, B vitamins, and vascular-access thrombosis in patients treated with hemodialysisT Tamura
Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 3360, USA
Am J Kidney Dis 32:475-81. 1998..All three white patients had Ala/Ala genotype, and 3 in 45 black patients (6.7%) were heterozygotes (Val/Ala)... - Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolismJoseph E Baggott
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 1270, USA
Eur J Pharm Sci 31:95-101. 2007..Also adenosine accumulation and blockage of adenosine deaminase (i.e., by EHNA) appear to be less critical to MTX efficacy. Increased levels of AICA metabolites may suppress the immune response in rat AA... - Cofactor role for 10-formyldihydrofolic acidJ E Baggott
Department of Nutrition Sciences, University of Alabama, Birmingham 35294, USA
Biochem J 308:1031-6. 1995..1.2.2). The existence in vivo of 10-HCO-H2folate is suggested in mammals by several reports of detectable amounts of radiolabelled 10-HCO-folate in bile and urine after administration of radiolabelled folic acid... - Not just calcium and vitamin D: other nutritional considerations in osteoporosisBeth Kitchin
School of Health Professions and UAB Osteoporosis Prevention and Treatment Clinic, The University of Alabama at Birmingham, 354 LRC, 1714 9th Avenue South, Birmingham, AL 35294 1270, USA
Curr Rheumatol Rep 9:85-92. 2007..Diets high in fruits and vegetables contribute nutrients such as magnesium associated with bone health and may also produce an alkaline environment, reducing calcium excretion and thus improving bone density... - Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementationJoseph E Baggott
University of Alabama at Birmingham, Birmingham, AL 35294 1270, USA
Arthritis Rheum 60:2257-61. 2009..To assess the catabolism of methotrexate (MTX) to 7-hydroxy-MTX (7-OH-MTX) in patients with rheumatoid arthritis as well as the effect of folic acid and folinic acid on this catabolism... - The energy cost of adjuvant-induced arthritis in ratsTara Goodson
The University of Alabama at Birmingham, USA
Arthritis Rheum 48:2979-82. 2003..During the active phase of the disease (i.e., clinical inflammation), this value increased to 18% of total calories... - Zinc status of women with low bone mineral density who receive calcium supplementsSarah L Morgan
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biol Trace Elem Res 110:211-22. 2006..Although limited by the small sample size and short study duration, our data suggest that a daily calcium dose of 1200 mg had no effect on the zinc status of our subjects... - Measurement of erythrocyte methotrexate polyglutamate levels: ready for clinical use in rheumatoid arthritis?Maria I Danila
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1530 3rd Avenue South, 178 SHEL, Birmingham, AL 35294 2182, USA
Curr Rheumatol Rep 12:342-7. 2010.... - The effect of peritoneal dialysate on DXA bone densitometry results in patients with end-stage renal diseaseMerry Lynn Mann
University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
J Clin Densitom 11:532-6. 2008..We recommend that peritoneal dialyzate be removed prior to scanning patients on PD and that densitometry technologists should be observant about the presence of peritoneal dialysate... - Evidence for two phenotypes in the metabolism of methotrexate to 7-hydroxymethotrexate in patients with rheumatoid arthritisJoseph E Baggott
University of Alabama at Birmingham, Birmingham, AL, USA
Arthritis Rheum 52:356-8. 2005 - 13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in manJoseph E Baggott
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biochem Biophys Res Commun 361:307-10. 2007..10-HCO-H(2)folate may function in vivo as the predominant substrate for AICAR transformylase in humans... - Effect of folic acid supplementation on the efficacy of methotrexate treatment in rheumatoid arthritis: comment on the article by Khanna et alSarah L Morgan
Arthritis Rheum 54:1708-9; author reply 1709-10. 2006 - Folic acid supplements are good (not bad) for rheumatoid arthritis patients treated with low-dose methotrexateJoseph E Baggott
Am J Clin Nutr 88:479-80; author reply 480. 2008 - Comparing BMD results between two similar DXA systems using the generalized least significant changeJohn A Shepherd
Department of Radiology, University of California at San Francisco, San Francisco, CA 94143 0946, USA
J Clin Densitom 11:237-42. 2008..A revision of the International Society for Clinical Densitometry's policies for comparing scans from systems of the same technology may be appropriate... - Folic acid and folinic acid supplementation during low-dose methotrexate therapy for rheumatoid arthritis: comment on the article by van Ede et alSarah L Morgan
Arthritis Rheum 46:1413-4. 2002 - Vitamin K and the prevention of fracturesTsunenobu Tamura
Arch Intern Med 167:94; author reply 94-5. 2007
Research Grants
- Flavocoxid: A Medical Food Therapy for OsteoarthritisSarah Morgan; Fiscal Year: 2004..This innovative compound has commercial potential with its expected efficacy comparable to or exceeding the currently marketed COX inhibitors but with fewer side effects and at a significantly lower cost. ..