Philip G Morgan

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans
    Ernst Bernhard Kayser
    Department of Anesthesiology, University of Washington and Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Anesth Analg 112:1321-9. 2011
  2. pmc Novel interactions between mitochondrial superoxide dismutases and the electron transport chain
    Wichit Suthammarak
    Department of Anesthesiology and Pain Medicine, Center for Developmental Therapeutics, University of Washington and Seattle Children s Research Institute, Seattle, WA, USA
    Aging Cell 12:1132-40. 2013
  3. pmc mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome
    Simon C Johnson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 342:1524-8. 2013
  4. pmc Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure
    Georgios Karamanlidis
    Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, 98109, USA
    Cell Metab 18:239-50. 2013
  5. pmc Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans
    Katherine R Gentry
    Department of Anesthesiology and Pain Medicine, Seattle Children s Hospital, M S W 9824, PO Box 5371, Seattle, WA 98105, USA
    Anesth Analg 116:185-9. 2013
  6. doi request reprint Genetics and the evolution of the anesthetic response
    Margaret M Sedensky
    Department of Anesthesiology, University Hospitals and Case School of Medicine, Cleveland, Ohio 44106 5007, USA
    Anesth Analg 107:855-8. 2008

Research Grants

  1. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2006
  2. Anesthetic effects in mitochondrial disease
    Philip Morgan; Fiscal Year: 2006
  3. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2007
  4. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2009
  5. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2009
  6. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2005
  7. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2005
  8. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1993
  9. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1991
  10. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1992

Collaborators

  • Louise M Steele
  • Katherine R Gentry
  • Matt Kaeberlein
  • Margaret M Sedensky
  • Wichit Suthammarak
  • Ernst Bernhard Kayser
  • Georgios Karamanlidis
  • Simon C Johnson
  • Wang Wang
  • Kelly Oh
  • Arni Gagnidze
  • Albert Quintana
  • Lorena Garcia-Menendez
  • Stephen C Kolwicz
  • Jessica Hui
  • Melana E Yanos
  • Brian M Wasko
  • Maya Sangesland
  • Peter S Rabinovitch
  • Benjamin H Somerlot
  • Rong Tian
  • Anthony Castanza
  • Elyce Opheim
  • Fresnida J Ramos
  • Valerie Z Wall
  • Margaret Sedensky
  • Chi Fung Lee
  • Guohua Gong
  • Richard D Palmiter
  • Lauren Uhde

Detail Information

Publications7

  1. pmc Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans
    Ernst Bernhard Kayser
    Department of Anesthesiology, University of Washington and Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Anesth Analg 112:1321-9. 2011
    ..We hypothesized that isoflurane inhibits electron transport by competing with ubiquinone for binding to complex I...
  2. pmc Novel interactions between mitochondrial superoxide dismutases and the electron transport chain
    Wichit Suthammarak
    Department of Anesthesiology and Pain Medicine, Center for Developmental Therapeutics, University of Washington and Seattle Children s Research Institute, Seattle, WA, USA
    Aging Cell 12:1132-40. 2013
    ..The results call for a change in the usual paradigm for the interaction of electron transport chain function, ROS release, scavenging, and compensatory responses. ..
  3. pmc mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome
    Simon C Johnson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 342:1524-8. 2013
    ..This therapeutic strategy may prove relevant for a broad range of mitochondrial diseases. ..
  4. pmc Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure
    Georgios Karamanlidis
    Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, 98109, USA
    Cell Metab 18:239-50. 2013
    ..These findings describe a mechanism connecting mitochondrial dysfunction to the susceptibility to diseases and propose a potential therapeutic target...
  5. pmc Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans
    Katherine R Gentry
    Department of Anesthesiology and Pain Medicine, Seattle Children s Hospital, M S W 9824, PO Box 5371, Seattle, WA 98105, USA
    Anesth Analg 116:185-9. 2013
    ..We hypothesized that exposing the nematode to volatile anesthetics early in life would induce neuron cell death, producing a behavioral defect that would be manifested in adulthood...
  6. doi request reprint Genetics and the evolution of the anesthetic response
    Margaret M Sedensky
    Department of Anesthesiology, University Hospitals and Case School of Medicine, Cleveland, Ohio 44106 5007, USA
    Anesth Analg 107:855-8. 2008

Research Grants22

  1. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2006
    ..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..
  2. Anesthetic effects in mitochondrial disease
    Philip Morgan; Fiscal Year: 2006
    ..These translational studies have important implications for patient safety as well as for the understanding the mechanism of action of volatile anesthetics. . ..
  3. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2007
    ..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..
  4. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2009
    ..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..
  5. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2009
    ..Understanding how these anesthetics function may contribute to improvements in design of anesthetics and in the understanding of consciousness. ..
  6. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2005
    ..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..
  7. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2005
    ..3. To measure the effects of anesthetics on stomatin deficient mice. This approach is the logical extension of the successful use of a model system such as C. elegans to demonstrate its applicability to mammals. ..
  8. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1993
    ..This information will be combined with the data being accumulated by others studying unc-79 and unc-80 in our laboratory...
  9. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1991
    ..This information will be combined with the data being accumulated by others studying unc-79 and unc-80 in our laboratory...
  10. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1992
    ..This information will be combined with the data being accumulated by others studying unc-79 and unc-80 in our laboratory...
  11. MECHANISMS OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 1999
    ....
  12. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2002
    ..3. To measure the effects of anesthetics on stomatin deficient mice. This approach is the logical extension of the successful use of a model system such as C. elegans to demonstrate its applicability to mammals. ..
  13. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2002
    ..3. To measure the effects of anesthetics on stomatin deficient mice. This approach is the logical extension of the successful use of a model system such as C. elegans to demonstrate its applicability to mammals. ..
  14. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2003
    ..3. To measure the effects of anesthetics on stomatin deficient mice. This approach is the logical extension of the successful use of a model system such as C. elegans to demonstrate its applicability to mammals. ..
  15. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip Morgan; Fiscal Year: 2004
    ..3. To measure the effects of anesthetics on stomatin deficient mice. This approach is the logical extension of the successful use of a model system such as C. elegans to demonstrate its applicability to mammals. ..
  16. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip G Morgan; Fiscal Year: 2010
    ..Understanding how these anesthetics function may contribute to improvements in design of anesthetics and in the understanding of consciousness. ..