DAVID OWEN MORGAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Sequential primed kinases create a damage-responsive phosphodegron on Eco1
    Nicholas A Lyons
    Department of Physiology, University of California, San Francisco, San Francisco, California, USA
    Nat Struct Mol Biol 20:194-201. 2013
  2. pmc The D box meets its match
    David O Morgan
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    Mol Cell 50:609-10. 2013
  3. pmc Mechanisms of ubiquitin transfer by the anaphase-promoting complex
    Mary E Matyskiela
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    J Biol 8:92. 2009
  4. ncbi request reprint The hidden rhythms of the dividing cell
    David O Morgan
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Cell 141:224-6. 2010

Research Grants

  1. Cell Cycle control by cyclin-dependent kinases
    David Morgan; Fiscal Year: 2007
  2. Cell Cycle control by cyclin-dependent kinases
    DAVID OWEN MORGAN; Fiscal Year: 2010
  3. STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    David Morgan; Fiscal Year: 1999
  4. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2004
  5. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2002
  6. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2000
  7. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2001
  8. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2007
  9. Regulation of Chromosome Segregation
    DAVID OWEN MORGAN; Fiscal Year: 2010
  10. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2009

Collaborators

  • Nicholas A Lyons
  • Mary E Matyskiela
  • John R Yates
  • Bryan R Fonslow
  • Jolene K Diedrich
  • Monica C Rodrigo-Brenni

Detail Information

Publications4

  1. pmc Sequential primed kinases create a damage-responsive phosphodegron on Eco1
    Nicholas A Lyons
    Department of Physiology, University of California, San Francisco, San Francisco, California, USA
    Nat Struct Mol Biol 20:194-201. 2013
    ..This elaborate regulatory system, involving three independent kinases and stringent substrate selection by a ubiquitin ligase, enables robust control of cohesion establishment during normal growth and after stress...
  2. pmc The D box meets its match
    David O Morgan
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    Mol Cell 50:609-10. 2013
    ..In this issue of Molecular Cell, He and colleagues (2013) unveil a high-resolution structure of a key regulatory interface in cell-cycle control: the destruction box sequence bound to the anaphase-promoting complex...
  3. pmc Mechanisms of ubiquitin transfer by the anaphase-promoting complex
    Mary E Matyskiela
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    J Biol 8:92. 2009
    ....
  4. ncbi request reprint The hidden rhythms of the dividing cell
    David O Morgan
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Cell 141:224-6. 2010
    ..Lu and Cross (2010) now propose that cell-cycle events are ordered by a regulatory system in which a master oscillator, based on cyclin-dependent kinases, entrains a series of peripheral oscillators controlling individual events...

Research Grants34

  1. Cell Cycle control by cyclin-dependent kinases
    David Morgan; Fiscal Year: 2007
    ..Such insights are an important step toward a better understanding of the chromosome segregation defects and other cell-cycle defects that characterize the cancer cell. ..
  2. Cell Cycle control by cyclin-dependent kinases
    DAVID OWEN MORGAN; Fiscal Year: 2010
    ..These studies will lead to a better understanding of how errors in cell division and chromosome segregation can arise in human disease. ..
  3. STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    David Morgan; Fiscal Year: 1999
    ..The goal in this work will be to achieve a detailed biochemical understanding of the mechanisms by which this complex enzyme is assembled and regulated during mitosis. ..
  4. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2004
    ..Such knowledge is an essential prerequisite for an understanding of the segregation errors that often contribute to developmental defects or cancer progression. ..
  5. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2002
    ..In addition, the long term goal in these studies is to complete our understanding of APC regulation by reconstituting the APC from individual recombinant subunits. ..
  6. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2000
    ..In addition, the long term goal in these studies is to complete our understanding of APC regulation by reconstituting the APC from individual recombinant subunits. ..
  7. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2001
    ..In addition, the long term goal in these studies is to complete our understanding of APC regulation by reconstituting the APC from individual recombinant subunits. ..
  8. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2007
    ..These studies are also likely to illuminate general mechanisms of protein ubiquitination, a regulatory modification of importance throughout cell biology and human disease. ..
  9. Regulation of Chromosome Segregation
    DAVID OWEN MORGAN; Fiscal Year: 2010
    ..These studies will lead to a better understanding of how errors in chromosome segregation can arise in human disease. ..
  10. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2009
    ..These studies are also likely to illuminate general mechanisms of protein ubiquitination, a regulatory modification of importance throughout cell biology and human disease. ..
  11. MOLECULAR CONTROL OF CELL PROLIFERATION
    DAVID OWEN MORGAN; Fiscal Year: 2010
    ..These studies are also likely to illuminate general mechanisms of protein ubiquitination, a regulatory modification of importance throughout cell biology and human disease. ..
  12. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2005
    ..Such knowledge is an essential prerequisite for an understanding of the segregation errors that often contribute to developmental defects or cancer progression. ..
  13. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2003
    ..Such knowledge is an essential prerequisite for an understanding of the segregation errors that often contribute to developmental defects or cancer progression. ..
  14. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2006
    ..Such knowledge is an essential prerequisite for an understanding of the segregation errors that often contribute to developmental defects or cancer progression. ..
  15. STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    David Morgan; Fiscal Year: 2002
    ..The goal in this work will be to achieve a detailed biochemical understanding of the mechanisms by which this complex enzyme is assembled and regulated during mitosis. ..
  16. Cell Cycle control by cyclin-dependent kinases
    David Morgan; Fiscal Year: 2009
    ..These studies will lead to a better understanding of how errors in cell division and chromosome segregation can arise in human disease. ..
  17. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 1999
    ..In addition, the long term goal in these studies is to complete our understanding of APC regulation by reconstituting the APC from individual recombinant subunits. ..
  18. Cell Cycle control by cyclin-dependent kinases
    David Morgan; Fiscal Year: 2006
    ..Such insights are an important step toward a better understanding of the chromosome segregation defects and other cell-cycle defects that characterize the cancer cell. ..
  19. MOLECULAR CONTROL OF CELL PROLIFERATION
    David Morgan; Fiscal Year: 2009
    ..These studies are also likely to illuminate general mechanisms of protein ubiquitination, a regulatory modification of importance throughout cell biology and human disease. ..
  20. STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    David Morgan; Fiscal Year: 2001
    ..The goal in this work will be to achieve a detailed biochemical understanding of the mechanisms by which this complex enzyme is assembled and regulated during mitosis. ..
  21. STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    David Morgan; Fiscal Year: 2000
    ..The goal in this work will be to achieve a detailed biochemical understanding of the mechanisms by which this complex enzyme is assembled and regulated during mitosis. ..