Dave Morgan

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
  2. ncbi request reprint Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology and Molecular Therapeutics, University of South Florida, MDC Box 9, Tampa, FL 33612, United States
    Neurochem Int 49:190-4. 2006
  3. ncbi request reprint Immunotherapy for Alzheimer's disease
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology and Molecular Therapeutics, University of South Florida, Tampa, FL 33612, USA
    J Alzheimers Dis 9:425-32. 2006
  4. ncbi request reprint Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics
    Dave Morgan
    Department of Pharmacology, University of South Florida, Tampa, 33612, USA
    J Neuropathol Exp Neurol 64:743-53. 2005
  5. ncbi request reprint Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease
    Dave Morgan
    Department of Pharmacology, University of South Florida, 12901 Downs Blvd, MDC Box 9, Tampa, FL 33612 4799, USA
    Neurobiol Aging 25:605-8. 2004
  6. ncbi request reprint Antibody therapy for Alzheimer's disease
    Dave Morgan
    Dept of Pharmacology, University of South Florida, Tampa, FC 33612 4799, USA
    Expert Rev Vaccines 2:53-9. 2003
  7. ncbi request reprint Learning and memory deficits in APP transgenic mouse models of amyloid deposition
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, Florida 33612, USA
    Neurochem Res 28:1029-34. 2003
  8. ncbi request reprint Mechanisms of A beta plaque clearance following passive A beta immunization
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology, College of Medicine, University of South Florida, Tampa, FL 33612 4799, USA
    Neurodegener Dis 2:261-6. 2005
  9. pmc Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33612 4799, USA
    J Alzheimers Dis 15:605-14. 2008
  10. ncbi request reprint What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer's disease
    Dave Morgan
    Department of Pharmacology and Biochemistry, University of South Florida College of Medicine, Tampa FL 33612 4799, USA
    J Alzheimers Dis 4:257-60. 2002

Collaborators

Detail Information

Publications51

  1. ncbi request reprint A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
    ..The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia...
  2. ncbi request reprint Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology and Molecular Therapeutics, University of South Florida, MDC Box 9, Tampa, FL 33612, United States
    Neurochem Int 49:190-4. 2006
    ....
  3. ncbi request reprint Immunotherapy for Alzheimer's disease
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology and Molecular Therapeutics, University of South Florida, Tampa, FL 33612, USA
    J Alzheimers Dis 9:425-32. 2006
    ..At this time, anti-amyloid immunotherapy stands poised to be the first test of the amyloid hypothesis in the treatment of Alzheimer disease...
  4. ncbi request reprint Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics
    Dave Morgan
    Department of Pharmacology, University of South Florida, Tampa, 33612, USA
    J Neuropathol Exp Neurol 64:743-53. 2005
    ..Several markers are identified from studies outside the brain that neuroscientists might consider evaluating when attempting to more definitively describe the activation state of the monocyte-derived cells in the brain...
  5. ncbi request reprint Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease
    Dave Morgan
    Department of Pharmacology, University of South Florida, 12901 Downs Blvd, MDC Box 9, Tampa, FL 33612 4799, USA
    Neurobiol Aging 25:605-8. 2004
    ..This supports the continued cautious testing of passive immunization and, possibly even active immunization against the Abeta peptide using preparations less likely to cause autoimmune reactions in the central nervous system...
  6. ncbi request reprint Antibody therapy for Alzheimer's disease
    Dave Morgan
    Dept of Pharmacology, University of South Florida, Tampa, FC 33612 4799, USA
    Expert Rev Vaccines 2:53-9. 2003
    ..This review summarizes the rationale, progress and setbacks regarding the use of antibody-based therapies to treat Alzheimer's disease and discusses future directions for this approach in Alzheimer's and other disorders...
  7. ncbi request reprint Learning and memory deficits in APP transgenic mouse models of amyloid deposition
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, Florida 33612, USA
    Neurochem Res 28:1029-34. 2003
    ....
  8. ncbi request reprint Mechanisms of A beta plaque clearance following passive A beta immunization
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology, College of Medicine, University of South Florida, Tampa, FL 33612 4799, USA
    Neurodegener Dis 2:261-6. 2005
    ..Thus, although we favor continued testing of the immunotherapy to treat Alzheimer's disease, we believe caution should be taken to minimize the risk of vascular leakage...
  9. pmc Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice
    Dave Morgan
    Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33612 4799, USA
    J Alzheimers Dis 15:605-14. 2008
    ..In conclusion, it seems that the modest tau overexpression or the presence of mutant tau in the JNPL3 tau mice may provide some benefit with respect to motor and cognitive performance before the onset of paralysis...
  10. ncbi request reprint What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer's disease
    Dave Morgan
    Department of Pharmacology and Biochemistry, University of South Florida College of Medicine, Tampa FL 33612 4799, USA
    J Alzheimers Dis 4:257-60. 2002
  11. ncbi request reprint Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    Donna M Wilcock
    Department of Pharmacology and Molecular Therapeutics, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 26:5340-6. 2006
    ....
  12. pmc Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
    Maj Linda B Selenica
    Department of Molecular Pharmacology and Physiology, Byrd Alzheimer Institute, University of South Florida, Tampa, FL, USA
    J Neuroinflammation 10:86. 2013
    ..The chemokine (C-C motif) ligand 2 (CCL2) is a monocyte chemoattractant protein that mediates macrophage recruitment and migration during peripheral and central nervous system (CNS) inflammation...
  13. ncbi request reprint Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    Paul T Jantzen
    Department of Pharmacology, Alzheimer s Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 22:2246-54. 2002
    ..In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia...
  14. ncbi request reprint Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice
    Donna L Herber
    Alzheimer Research Laboratory, Department of Pharmacology and Therapeutics, University of South Florida, Tampa, FL 33612 4799, USA
    Exp Neurol 190:245-53. 2004
    ..These results indicate that activation of brain glia can rapidly and transiently clear diffuse Abeta deposits but has no effect on compacted fibrillar amyloid...
  15. ncbi request reprint Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
    Donna M Wilcock
    Department of Pharmacology, Alzheimer s Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 23:3745-51. 2003
    ..The results are discussed in the context of other studies identifying coincident microglial activation and amyloid removal in APP transgenic animals...
  16. ncbi request reprint Deglycosylated anti-Abeta antibody dose-response effects on pathology and memory in APP transgenic mice
    Rachel A Karlnoski
    School of Basic Biomedical Sciences, Department of Molecular Pharmacology and Physiology, Alzheimer s Research Laboratory, University of South Florida, 12901 Bruce B Downs Blvd, MDC Box 8, Tampa, FL 33612 4799, USA
    J Neuroimmune Pharmacol 3:187-97. 2008
    ..These data suggest that excess antibody unbound to antigen can interfere with antibody-mediated Abeta clearance, possibly by saturating the FcRn antibody transporter...
  17. ncbi request reprint Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
    Donna M Wilcock
    Department of Pharmacology, Alzheimer s Research Laboratory, University of South Florida, Tampa, FL 33612, USA
    Neurobiol Dis 15:11-20. 2004
    ..These data suggest that microglial activation is necessary for efficient removal of compact amyloid deposits with immunotherapy. Inhibition of this activation may result in an impaired clinical response to vaccination against Abeta...
  18. ncbi request reprint Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
    Donna M Wilcock
    Alzheimer s Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 24:6144-51. 2004
    ..Together with our earlier work, our data argue that all proposed mechanisms of anti-Abeta antibody-mediated amyloid removal can be simultaneously active...
  19. doi request reprint Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load
    Qingyou Li
    USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neuroimmune Pharmacol 7:202-14. 2012
    ..We conclude that preclinical studies should be conducted in aged animal models as well as young mice to better prepare for unintended consequences in the human trial...
  20. ncbi request reprint Diverse microglial responses after intrahippocampal administration of lipopolysaccharide
    Donna L Herber
    Department of Pharmacology and Therapeutics, Alzheimer Research Laboratory, University of South Florida, Tampa, USA
    Glia 53:382-91. 2006
    ..These findings indicate a multivariate response to LPS, and evaluation of microglial phenotypes may lead to a better understanding of neuroinflammatory diseases...
  21. pmc LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
    Daniel C Lee
    Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 7:56. 2010
    ....
  22. doi request reprint Virus-like peptide vaccines against Abeta N-terminal or C-terminal domains reduce amyloid deposition in APP transgenic mice without addition of adjuvant
    Qing You Li
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA
    J Neuroimmune Pharmacol 5:133-42. 2010
    ..These data demonstrate that (a) C-terminal specific vaccines can effectively lower Abeta and (b) IgM antibodies against Abeta may be capable of lowering Abeta, possibly through action in the brain rather than the periphery...
  23. pmc Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    Lori Lebson
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 30:9651-8. 2010
    ..Moreover, these data support the results from bone marrow grafts that circulating CD11b+ cells can enter the CNS without requiring the use of lethal irradiation...
  24. ncbi request reprint Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice
    Donna L Herber
    Alzheimer Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612 4799, USA
    J Neuroimmune Pharmacol 2:222-31. 2007
    ..Nonetheless, microglial activation was necessary to remove Abeta in this model of neuroinflammation...
  25. pmc Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
    Maj Linda B Selenica
    Department of Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, FL 33613, USA
    Neurodegener Dis 11:165-81. 2013
    ..We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau phosphorylation...
  26. pmc Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice
    Nikisha Carty
    University of South Florida College of Medicine, Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, Tampa, Florida, United States of America
    PLoS ONE 8:e59626. 2013
    ..As such, they may be considered reasonable candidates for gene therapy trials in AD...
  27. pmc Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, USA
    BMC Neurosci 6:7. 2005
    ....
  28. pmc Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw
    Joanne M Ajmo
    Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, USA
    J Neurochem 113:784-95. 2010
    ..As proteoglycans stabilize synaptic structure and inhibit molecular plasticity, defective brevican processing observed in Abeta-bearing mice and potentially end-stage human AD, may contribute to deficient neural plasticity...
  29. pmc Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology
    Milene L Brownlow
    Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States of America USF Health Byrd Alzheimer s Institute, Tampa, Florida, United States of America
    PLoS ONE 8:e75713. 2013
    ..These data suggest that ketogenic diets may play an important role in enhancing motor performance in mice, but have minimal impact on the phenotype of murine models of amyloid or tau deposition. ..
  30. ncbi request reprint Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse
    Marcia N Gordon
    Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, Florida 33612 4799, USA
    Exp Neurol 173:183-95. 2002
    ....
  31. ncbi request reprint Increased fibrillar beta-amyloid in response to human clq injections into hippocampus and cortex of APP+PS1 transgenic mice
    Kristal W Boyett
    Alzheimer s Research Laboratory, Department of Pharmacology and Therapeutics, Tampa, Florida 33612, USA
    Neurochem Res 28:83-93. 2003
    ..In conclusion, complement protein C1q, believed to be involved in the pathogenesis of Alzheimer's disease in humans, can cause increased fibrillogenesis in the APP+PS1 mouse model of amyloid deposition...
  32. ncbi request reprint Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    J Neurochem 88:434-42. 2004
    ..Presumably, pharmacological agents blocking the Abeta-related inhibition of gene expression will have benefit in AD...
  33. pmc Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection
    Rachel Karlnoski
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, 12901 Bruce B Downs Boulevard, MDC Box 9, Tampa, FL 33612, USA
    Neurobiol Dis 25:179-88. 2007
    ..The inactive mutant bak BH3 peptide did not cause degeneration in any mice. These data demonstrate that the increased Bcl-2 expression in brain regions containing Abeta deposits is associated with neuroprotection...
  34. pmc Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies
    Qingyou Li
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612 4799, USA
    BMC Neurosci 8:22. 2007
    ..In addition, we examined use of a less stringent low pH procedure at pH 3.5, to ascertain if it had the same effects as the pH 2.5 procedure...
  35. ncbi request reprint Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition
    Qingyou Li
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612 4799, USA
    Cell Transplant 17:397-408. 2008
    ..These data emphasize the need for evaluating potential Abeta aggregation inhibitors with in vivo models of amyloid deposition before assuming they will have benefit in treating Alzheimer's disease patients...
  36. pmc Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice
    Niki C Carty
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Mol Ther 16:1580-6. 2008
    ..These results indicate that increasing the expression of beta-amyloid degrading enzymes through gene therapy is a promising approach to the treatment of AD...
  37. pmc Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology
    Yuyan Zhu
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, College of Medicine, University of South Florida, Tampa, FL 33613, USA
    J Cell Mol Med 15:327-38. 2011
    ..These data show that haematopoietic cells bearing the mhPS1 transgene exacerbate AD-like pathology, suggesting a novel therapeutic strategy for AD based on targeting PS1 in peripheral immune cells...
  38. ncbi request reprint Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
    Jennifer Alamed
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Tampa, Florida 33612, USA
    Nat Protoc 1:1671-9. 2006
    ..With two sessions each day, 16 mice can be tested over 2 days...
  39. pmc Aging enhances classical activation but mitigates alternative activation in the central nervous system
    Daniel C Lee
    Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA
    Neurobiol Aging 34:1610-20. 2013
    ..Importantly, selective transcripts were induced at all ages by CKT-1, whereas selective gene transcripts induced by CKT-2 decreased with age suggesting an age-related reduction in the IL-4/ IL-13 signaling pathway...
  40. pmc Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice
    Qingyou Li
    Department of Pharmacology University of South Florida, Tampa FL 33612 4799, USA
    BMC Neurosci 5:21. 2004
    ....
  41. pmc Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain
    Nikisha Carty
    Byrd Alzheimer s Institute and Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, FL 33613, USA
    J Neurosci Methods 194:144-53. 2010
    ..These data suggest that combining advanced injection techniques with newer rAAV serotypes greatly improves viral vector distribution, which could have significant benefits for implementation of gene therapy strategies...
  42. pmc Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage
    William V Nikolic
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Proc Natl Acad Sci U S A 104:2507-12. 2007
    ..Together, these data suggest that t.c. immunization constitutes an effective and potentially safe treatment strategy for AD...
  43. ncbi request reprint Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    J Neurosci 23:5219-26. 2003
    ..This suggests that the memory loss in APP+PS1 transgenic mice may model the early memory dysfunction in AD before the degeneration of synapses and neurons...
  44. ncbi request reprint Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue
    Donna L Herber
    Department of Pharmacology and Therapeutics, University of South Florida, 12901 Bruce B Downs Blvd, MDC Box 9, Tampa, FL 33612 4799, USA
    J Histochem Cytochem 52:1367-76. 2004
    ..These findings suggest caution in interpreting results when using several commercially available alpha7 nicotinic receptor antibodies...
  45. ncbi request reprint Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain
    Donna M Wilcock
    Alzheimer s Research Laboratory, School of Basic Biomedical Sciences, College of Medicine, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    Nat Protoc 1:1591-5. 2006
    ..Time required for image analysis depends greatly on the number of samples being analyzed and the software being used. In our hands, 30 images can be collected per hour and quantified in a further 2 h...
  46. ncbi request reprint The role of microglia in antibody-mediated clearance of amyloid-beta from the brain
    Dave Morgan
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
    CNS Neurol Disord Drug Targets 8:7-15. 2009
    ....
  47. ncbi request reprint Amyloid, memory and neurogenesis
    Dave Morgan
    Alzheimer Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, 12901 BB Downs Blvd MDC Box 9, University of South Florida, Tampa, FL 33612, USA
    Exp Neurol 205:330-5. 2007
    ..The possible relationship to memory loss in Alzheimer's dementia is also discussed...
  48. pmc Akt and CHIP coregulate tau degradation through coordinated interactions
    Chad A Dickey
    Department of Molecular Pharmacology and Physiology and H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Proc Natl Acad Sci U S A 105:3622-7. 2008
    ..Hence, Akt serves as a major regulator of tau biology by manipulating both tau kinases and protein quality control, providing a link to several common pathways that have demonstrated dysfunction in Alzheimer's disease...
  49. ncbi request reprint Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, Tampa, FL 12901 Bruce B Downs Boulevard, MDC 9, Tampa, FL 33612, USA
    Neurosci Lett 366:10-4. 2004
    ..These findings provide an in vitro model in which to test other agents that might modulate the induction of memory-associated genes...
  50. pmc Amyloid, hyperactivity, and metabolism: theoretical comment on Vloeberghs et al. (2008)
    Dave Morgan
    Alzheimer Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida, USA
    Behav Neurosci 122:730-2. 2008
    ..If amyloid were found to induce a hypermetabolic state, this would suggest an alternative mechanism for the pathology found in the disease and provide opportunities for therapeutic strategies not yet considered...
  51. doi request reprint The promise and perils of an Alzheimer disease vaccine: a video debate
    Dave Morgan
    Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroimmune Pharmacol 4:1-3. 2009
    ..This video article takes the form of a debate between Dr. Morgan and Dr. Landreth on the merits and drawbacks of an Alzheimer's disease vaccine. Click on Supplemental Material to watch the streaming video...