D O Morgan

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The dynamics of cyclin dependent kinase structure
    D O Morgan
    Department of Physiology, Box 0444, University of California, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 8:767-72. 1996
  2. ncbi request reprint Cyclin-dependent kinases: engines, clocks, and microprocessors
    D O Morgan
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Annu Rev Cell Dev Biol 13:261-91. 1997
  3. pmc Cak1 is required for Kin28 phosphorylation and activation in vivo
    F H Espinoza
    Departments of Physiology and Biochemistry and Biophysics, University of California, San Francisco, California 94143 0444, USA
    Mol Cell Biol 18:6365-73. 1998
  4. pmc A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae
    S L Jaspersen
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Mol Biol Cell 9:2803-17. 1998
  5. ncbi request reprint Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
    S L Jaspersen
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Curr Biol 9:227-36. 1999
  6. ncbi request reprint Cdc14 activates cdc15 to promote mitotic exit in budding yeast
    S L Jaspersen
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Curr Biol 10:615-8. 2000
  7. pmc Cdc37 promotes the stability of protein kinases Cdc28 and Cak1
    A Farrell
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Mol Cell Biol 20:749-54. 2000
  8. ncbi request reprint A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK
    F H Espinoza
    Department of Physiology, University of California, San Francisco, 94143 0444, USA
    Science 273:1714-7. 1996
  9. ncbi request reprint Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
    N S Gray
    Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Science 281:533-8. 1998
  10. pmc Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
    P Jin
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Cell Biol 141:875-85. 1998

Collaborators

Detail Information

Publications23

  1. ncbi request reprint The dynamics of cyclin dependent kinase structure
    D O Morgan
    Department of Physiology, Box 0444, University of California, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 8:767-72. 1996
    ....
  2. ncbi request reprint Cyclin-dependent kinases: engines, clocks, and microprocessors
    D O Morgan
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Annu Rev Cell Dev Biol 13:261-91. 1997
    ..In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division...
  3. pmc Cak1 is required for Kin28 phosphorylation and activation in vivo
    F H Espinoza
    Departments of Physiology and Biochemistry and Biophysics, University of California, San Francisco, California 94143 0444, USA
    Mol Cell Biol 18:6365-73. 1998
    ..We conclude that Cak1 is required for the activating phosphorylation of Kin28 as well as that of Cdc28...
  4. pmc A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae
    S L Jaspersen
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Mol Biol Cell 9:2803-17. 1998
    ..Mutant cells arrested in G1 contain normal APC activity. We conclude that Cdc15, Cdc5, Cdc14, Dbf2, and Tem1 cooperate in the activation of the APC in late mitosis but are not required for maintenance of that activity in G1...
  5. ncbi request reprint Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
    S L Jaspersen
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Curr Biol 9:227-36. 1999
    ..Here, we explore the molecular function and regulation of the APC regulatory subunit Hct1 in Saccharomyces cerevisiae...
  6. ncbi request reprint Cdc14 activates cdc15 to promote mitotic exit in budding yeast
    S L Jaspersen
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Curr Biol 10:615-8. 2000
    ..Instead, Cdc15 dephosphorylation may promote some additional function of Cdc15 that is independent of its effects on Cdc14 activation...
  7. pmc Cdc37 promotes the stability of protein kinases Cdc28 and Cak1
    A Farrell
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Mol Cell Biol 20:749-54. 2000
    ..We conclude that budding yeast Cdc37, like its higher eukaryotic homologs, promotes the physical integrity of multiple protein kinases, perhaps by virtue of a cotranslational role in protein folding...
  8. ncbi request reprint A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK
    F H Espinoza
    Department of Physiology, University of California, San Francisco, 94143 0444, USA
    Science 273:1714-7. 1996
    ..The CAK1 gene was essential for cell viability. Thus, the major CAK in S. cerevisiae is distinct from the vertebrate enzyme, suggesting that budding yeast and vertebrates may have evolved different mechanisms of CDK activation...
  9. ncbi request reprint Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
    N S Gray
    Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Science 281:533-8. 1998
    ..Purine libraries could provide useful tools for analyzing a variety of signaling and regulatory pathways and may lead to the development of new therapeutics...
  10. pmc Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
    P Jin
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Cell Biol 141:875-85. 1998
    ..Thus, nuclear targeting of cyclin B1 and dephosphorylation of Cdc2 both contribute to the control of mitotic entry and exit in human cells...
  11. pmc Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta
    C G Takizawa
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 96:7938-43. 1999
    ..We conclude that cyclin B1 import is mediated by an unusual importin beta-dependent mechanism that does not require Ran...
  12. ncbi request reprint A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
    R P Fisher
    Department of Physiology, University of California, San Francisco 94143 0444
    Cell 78:713-24. 1994
    ..Thus, CAK is a CDK-cyclin complex implicated in the control of multiple cell cycle transitions...
  13. pmc Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2
    D Desai
    Department of Physiology, University of California, San Francisco 94143 0444
    Mol Cell Biol 15:345-50. 1995
    ..CDC2 does not bind with high affinity to cyclin E in vitro, even after phosphorylation of the CDC2 subunit. Thus, phosphorylation is of varying importance in the formation of high-affinity CDK-cyclin complexes...
  14. ncbi request reprint Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase
    K K Kim
    Department of Chemistry, University of California, Berkeley 94720, USA
    Nat Struct Biol 3:849-55. 1996
    ..Outside of the core domains, the N- and C-terminal regions of the three structures are completely different. The conformational differences between cyclin H and A structures may reflect functional differences between the two cyclins...
  15. ncbi request reprint Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85
    F H Espinoza
    Department of Physiology, University of California, San Francisco 94143
    Science 266:1388-91. 1994
    ..HCS26 does not associate with CDC28, but instead associates with PHO85, a closely related protein kinase. Thus, budding yeast, like higher eukaryotes, use multiple cdk's in the regulation of cell cycle progression...
  16. ncbi request reprint The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
    J F Charles
    Department of Physiology, University of California San Francisco, California, 94143, USA
    Curr Biol 8:497-507. 1998
    ..The Polo-related protein kinase Cdc5 in Saccharomyces cerevisiae might encode a regulator of the APC, because cdc5 mutant cells arrest with a late mitotic phenotype similar to that observed in cells with defective cyclin destruction...
  17. ncbi request reprint Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C
    C G Takizawa
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Curr Opin Cell Biol 12:658-65. 2000
    ..Phosphorylation-dependent changes in the rate of nuclear import and export of these proteins help to control the onset of mitosis both in normal cells and in cells delayed before mitosis by DNA damage...
  18. ncbi request reprint Regulation of the APC and the exit from mitosis
    D O Morgan
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Nat Cell Biol 1:E47-53. 1999
    ..An intricate regulatory network governs APC activity and helps to ensure that late mitotic events are properly timed and coordinated...
  19. pmc Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases
    A G Polson
    Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Virol 75:3175-84. 2001
    ..These studies indicate that K-bZIP is a substrate for CDKs and should inform further functional analyses of the protein...
  20. pmc Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins
    M R Gerber
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Proc Natl Acad Sci U S A 92:4651-5. 1995
    ..cdc37-1 mutants also exhibit a defect in the binding and activation of Cdc28 by the mitotic cyclin Clb2. Thus Cdc37 may be a regulator that is required for the association of Cdc28 with multiple cyclins...
  21. ncbi request reprint Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase
    R P Fisher
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Cell 83:47-57. 1995
    ..Thus, CDK7-cyclin H complex formation can be achieved by multiple mechanisms...
  22. ncbi request reprint Principles of CDK regulation
    D O Morgan
    Department of Physiology, University of California, San Francisco 94143 0444
    Nature 374:131-4. 1995
    ..The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy...
  23. pmc Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
    Y Gu
    Department of Physiology, University of California, San Francisco 94143 0444
    EMBO J 11:3995-4005. 1992
    ..Phosphorylation on the inhibitory sites T14 and Y15 is also maximal during S phase and G2. Thus, the activity of a subpopulation of CDK2 molecules is inhibited at a time in the cell cycle when overall CDK2 activity is increased...