Barbara J Morgan

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Quantifying hypoxia-induced chemoreceptor sensitivity in the awake rodent
    Barbara J Morgan
    Department of Orthopedics and Rehabilitation and the John Rankin Laboratory of Pulmonary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin
    J Appl Physiol (1985) 117:816-24. 2014
  2. pmc Effects of sleep-disordered breathing on cerebrovascular regulation: A population-based study
    Barbara J Morgan
    Department of Orthopedics and Rehabilitation, University of Wisconsin Madison, Middleton Veterans Administration Hospital, USA
    Am J Respir Crit Care Med 182:1445-52. 2010
  3. pmc Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment
    Kevin J Reichmuth
    Departments of Medicine, School of Medicine and Public Health, University of Wisconsin Madison and Middleton Veterans Administration Hospital, Madison, WI, USA
    Am J Respir Crit Care Med 180:1143-50. 2009
  4. pmc Effect of AT1 receptor blockade on intermittent hypoxia-induced endothelial dysfunction
    Noah J Marcus
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, WI 53706 1532, USA
    Respir Physiol Neurobiol 183:67-74. 2012
  5. pmc Influence of cerebral blood flow on breathing stability
    Ailiang Xie
    Departments of Medicin, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 106:850-6. 2009
  6. pmc Cerebrovascular response to arousal from NREM and REM sleep
    Muhammad Fuad Bangash
    Department of Medicine, University of Wisconsin Madison, 53706 1532, USA
    Sleep 31:321-7. 2008
  7. pmc Xanthine oxidase inhibition attenuates endothelial dysfunction caused by chronic intermittent hypoxia in rats
    John M Dopp
    Pharmacy Practice Division, School of Pharmacy, University of Wisconsin, Madison 53705, USA
    Respiration 82:458-67. 2011
  8. pmc Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state
    Jacqueline K Limberg
    Bruno Balke Biodynamics Laboratory, Department of Kinesiology, School of Education, University of Wisconsin, Madison, WI, USA
    Am J Physiol Heart Circ Physiol 304:H1615-23. 2013
  9. pmc Time course of intermittent hypoxia-induced impairments in resistance artery structure and function
    Nathan R Philippi
    John Rankin Laboratory of Pulmonary Medicine, Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, USA
    Respir Physiol Neurobiol 170:157-63. 2010
  10. pmc Impaired hypoxic cerebral vasodilation in younger adults with metabolic syndrome
    John W Harrell
    Department of Kinesiology, University of Wisconsin, Madison, WI 53706, USA
    Diab Vasc Dis Res 10:135-42. 2013

Collaborators

Detail Information

Publications25

  1. pmc Quantifying hypoxia-induced chemoreceptor sensitivity in the awake rodent
    Barbara J Morgan
    Department of Orthopedics and Rehabilitation and the John Rankin Laboratory of Pulmonary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin
    J Appl Physiol (1985) 117:816-24. 2014
    ..Because of the somewhat curvilinear nature of these responses, exposure to multiple levels of graded hypoxia provides the most complete characterization of hypoxic chemosensitivity. ..
  2. pmc Effects of sleep-disordered breathing on cerebrovascular regulation: A population-based study
    Barbara J Morgan
    Department of Orthopedics and Rehabilitation, University of Wisconsin Madison, Middleton Veterans Administration Hospital, USA
    Am J Respir Crit Care Med 182:1445-52. 2010
    ..Cerebrovascular regulation is impaired in patients with moderate to severe obstructive sleep apnea; however, it is unknown whether this impairment exists in individuals with less severe sleep-disordered breathing...
  3. pmc Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment
    Kevin J Reichmuth
    Departments of Medicine, School of Medicine and Public Health, University of Wisconsin Madison and Middleton Veterans Administration Hospital, Madison, WI, USA
    Am J Respir Crit Care Med 180:1143-50. 2009
    ..Impaired endothelium-dependent vasodilation has been documented in patients with sleep apnea. This impairment may result in blood flow dysregulation during apnea-induced fluctuations in arterial blood gases...
  4. pmc Effect of AT1 receptor blockade on intermittent hypoxia-induced endothelial dysfunction
    Noah J Marcus
    John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, WI 53706 1532, USA
    Respir Physiol Neurobiol 183:67-74. 2012
    ..NORM, but this was unaffected by Los. These results indicate that the blood pressure elevation and endothelial dysfunction associated with CIH is dependent, at least in part, on RAS signaling...
  5. pmc Influence of cerebral blood flow on breathing stability
    Ailiang Xie
    Departments of Medicin, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol (1985) 106:850-6. 2009
    ..06 +/- 0.10 vs. 1.61 +/- 0.27 l x min(-1) x mmHg(-1), P < 0.05). We conclude that reductions in the normal cerebral vascular response to hypocapnia will increase the susceptibility to apneas and breathing instability during sleep...
  6. pmc Cerebrovascular response to arousal from NREM and REM sleep
    Muhammad Fuad Bangash
    Department of Medicine, University of Wisconsin Madison, 53706 1532, USA
    Sleep 31:321-7. 2008
    ..To determine the effect of arousal from sleep on cerebral blood flow velocity (CBFV) in relation to associated ventilatory and systemic hemodynamic changes...
  7. pmc Xanthine oxidase inhibition attenuates endothelial dysfunction caused by chronic intermittent hypoxia in rats
    John M Dopp
    Pharmacy Practice Division, School of Pharmacy, University of Wisconsin, Madison 53705, USA
    Respiration 82:458-67. 2011
    ..Xanthine oxidase is a major source of superoxide in the vascular endothelium. Previous work in humans demonstrated improved conduit artery function following xanthine oxidase inhibition in patients with obstructive sleep apnea...
  8. pmc Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state
    Jacqueline K Limberg
    Bruno Balke Biodynamics Laboratory, Department of Kinesiology, School of Education, University of Wisconsin, Madison, WI, USA
    Am J Physiol Heart Circ Physiol 304:H1615-23. 2013
    ..those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow...
  9. pmc Time course of intermittent hypoxia-induced impairments in resistance artery structure and function
    Nathan R Philippi
    John Rankin Laboratory of Pulmonary Medicine, Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, USA
    Respir Physiol Neurobiol 170:157-63. 2010
    ..Exposure to CIH produces functional and structural deficits in skeletal muscle resistance arteries. These impairments develop within 2 weeks after initiation of exposure and they are accompanied by systemic evidence of oxidant stress...
  10. pmc Impaired hypoxic cerebral vasodilation in younger adults with metabolic syndrome
    John W Harrell
    Department of Kinesiology, University of Wisconsin, Madison, WI 53706, USA
    Diab Vasc Dis Res 10:135-42. 2013
    ..These findings provide novel insight into cerebrovascular disease onset in MetSyn adults...
  11. ncbi request reprint Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans
    Rami N Khayat
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Appl Physiol 97:635-40. 2004
    ..In contrast, vagal afferent input elicited by hyperventilation-induced lung stretch plays an important role in the profound, rapid sympathetic inhibition that occurs after resumption of breathing after apnea...
  12. ncbi request reprint Association of blood and hair mercury with blood pressure and vascular reactivity
    Leonelo E Bautista
    University of Wisconsin School of Medicine and Population Health, Department of Population Health Sciences, 610 Walnut St, 703 WARF, Madison, WI 53726 2397, USA
    WMJ 108:250-2. 2009
    ..Some studies suggest that high levels of blood and hair mercury (Hg) increase the risk of atherothrombotic diseases, an effect that may be explained by oxidative damage to the vascular endothelium...
  13. pmc Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor
    Noah J Marcus
    Department of Kinesiology, University of Wisconsin, Madison, WI 53706, USA
    Respir Physiol Neurobiol 171:36-45. 2010
    ..None of these differences were evident in animals treated with losartan. CIH-induced augmentation of chemoreflex sensitivity occurs, at least in part, via the renin-angiotensin system...
  14. pmc Neural control of blood flow during exercise in human metabolic syndrome
    Jacqueline K Limberg
    School of Education, Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53706, USA
    Exp Physiol 99:1191-202. 2014
    ..These results suggest that adults with MetSyn exhibit compensatory vascular control mechanisms capable of preserving blood flow responses to exercise in the face of augmented sympathetic adrenergic activity. ..
  15. pmc Sleep-disordered breathing and obesity: pathophysiology, complications, and treatment
    Corey J Leinum
    Pharmacy Practice Division, School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA
    Nutr Clin Pract 24:675-87. 2009
    ..Large randomized trials are required to determine the utility of these strategies as long-term approaches to improving SDB and reducing associated complications...
  16. pmc Mechanisms of the cerebrovascular response to apnoea in humans
    Tadeusz PrzybyƂowski
    Department of Population Health Sciences, University of Wisconsin Madison, The John Rankin Laboratory of Pulmonary Medicine, and the Middleton Veterans Administration Hospital, 53705, USA
    J Physiol 548:323-32. 2003
    ....
  17. ncbi request reprint Vascular consequences of intermittent hypoxia
    Barbara J Morgan
    Department of Orthopedics and Rehabilitation, University of Wisconsin Madison, Madison, Wisconsin, USA
    Adv Exp Med Biol 618:69-84. 2007
    ..Such research has relevance not only to hypertension, but also to atherosclerosis and other important cardiovascular sequelae of OSA...
  18. doi request reprint Pharmacologic approaches for the management of symptoms and cardiovascular consequences of obstructive sleep apnea in adults
    John M Dopp
    Pharmacy Practice Division, School of Pharmacy, University of Wisconsin, Madison, WI, USA
    Sleep Breath 14:307-15. 2010
    ..As a result, complementary pharmacologic therapies that can be used with CPAP therapy have the potential to reduce symptoms and consequences of OSA...
  19. ncbi request reprint Respiratory influences on sympathetic vasomotor outflow in humans
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, 504 N Walnut Street, Madison, WI 53706, USA
    Respir Physiol Neurobiol 130:3-20. 2002
    ..Recent evidence suggests that these respiratory influences contribute significantly to sympathetic vasomotor outflow and to the distribution of systemic vascular conductances and blood flow in the exercising human...
  20. ncbi request reprint Obstructive sleep apnea and hypertension: mechanisms, evaluation, and management
    John M Dopp
    Department of Orthopedics and Rehabilitation, Madison, WI 53706, USA
    Curr Hypertens Rep 9:529-34. 2007
    ..Because even small decreases in arterial pressure can contribute to reducing cardiovascular risk, screening for OSA is an essential element of evaluating patients with hypertension...
  21. pmc Altered neurovascular control of the resting circulation in human metabolic syndrome
    Jacqueline K Limberg
    School of Education, Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53076, USA
    J Physiol 590:6109-19. 2012
    ....
  22. pmc Pathophysiology of sleep apnea
    Jerome A Dempsey
    The John Rankin Laboratory of Pulmonary Medicine, Departments of Population Health Sciences and of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Rev 90:47-112. 2010
    ..We discuss future research into understanding the pathophysiology of sleep apnea as a basis for uncovering newer forms of treatment of both the ventilatory disorder and its multiple sequelae...
  23. pmc Time-dependent adaptation in the hemodynamic response to hypoxia
    Noah J Marcus
    John Rankin Laboratory of Pulmonary Medicine, Department of Kinesiology, Respiratory Neurobiology Training Program, University of Wisconsin, Madison, WI, USA
    Respir Physiol Neurobiol 165:90-6. 2009
    ..The observed time-dependent modulation of the acute hemodynamic responses to hypoxia may reflect important changes in neurocirculatory regulation that contribute to CIH-induced hypertension...
  24. ncbi request reprint Effects of expiratory muscle work on muscle sympathetic nerve activity
    P Alexander Derchak
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol 92:1539-52. 2002
    ..The evidence suggests that these effects are mediated primarily via a muscle metaboreflex with a minor, variable contribution from augmented central expiratory motor output...
  25. ncbi request reprint Cardiovascular consequences of sleep-disordered breathing
    John M Dopp
    Pharmacy Practice Division, School of Pharmacy, University of Wisconsin, Madison, 53706, USA
    J Cardiopulm Rehabil 26:123-30. 2006