Barbara J Morgan
Affiliation: University of Wisconsin
- Effects of sleep-disordered breathing on cerebrovascular regulation: A population-based studyBarbara J Morgan
Department of Orthopedics and Rehabilitation, University of Wisconsin Madison, Middleton Veterans Administration Hospital, USA
Am J Respir Crit Care Med 182:1445-52. 2010..Cerebrovascular regulation is impaired in patients with moderate to severe obstructive sleep apnea; however, it is unknown whether this impairment exists in individuals with less severe sleep-disordered breathing...
- Cerebrovascular response to arousal from NREM and REM sleepMuhammad Fuad Bangash
Department of Medicine, University of Wisconsin Madison, 53706 1532, USA
Sleep 31:321-7. 2008..To determine the effect of arousal from sleep on cerebral blood flow velocity (CBFV) in relation to associated ventilatory and systemic hemodynamic changes...
- Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humansRami N Khayat
Department of Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
J Appl Physiol 97:635-40. 2004..In contrast, vagal afferent input elicited by hyperventilation-induced lung stretch plays an important role in the profound, rapid sympathetic inhibition that occurs after resumption of breathing after apnea...
- Respiratory influences on sympathetic vasomotor outflow in humansJerome A Dempsey
John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, 504 N Walnut Street, Madison, WI 53706, USA
Respir Physiol Neurobiol 130:3-20. 2002..Recent evidence suggests that these respiratory influences contribute significantly to sympathetic vasomotor outflow and to the distribution of systemic vascular conductances and blood flow in the exercising human...
- Pharmacologic approaches for the management of symptoms and cardiovascular consequences of obstructive sleep apnea in adultsJohn M Dopp
Pharmacy Practice Division, School of Pharmacy, University of Wisconsin, Madison, WI, USA
Sleep Breath 14:307-15. 2010..As a result, complementary pharmacologic therapies that can be used with CPAP therapy have the potential to reduce symptoms and consequences of OSA...
- Pathophysiology of sleep apneaJerome A Dempsey
The John Rankin Laboratory of Pulmonary Medicine, Departments of Population Health Sciences and of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
Physiol Rev 90:47-112. 2010..We discuss future research into understanding the pathophysiology of sleep apnea as a basis for uncovering newer forms of treatment of both the ventilatory disorder and its multiple sequelae...
- Influence of cerebral blood flow on breathing stabilityAiliang Xie
Departments of Medicin, University of Wisconsin, Madison, Wisconsin 53705, USA
J Appl Physiol (1985) 106:850-6. 2009..06 +/- 0.10 vs. 1.61 +/- 0.27 l x min(-1) x mmHg(-1), P < 0.05). We conclude that reductions in the normal cerebral vascular response to hypocapnia will increase the susceptibility to apneas and breathing instability during sleep...
- Time-dependent adaptation in the hemodynamic response to hypoxiaNoah J Marcus
John Rankin Laboratory of Pulmonary Medicine, Department of Kinesiology, Respiratory Neurobiology Training Program, University of Wisconsin, Madison, WI, USA
Respir Physiol Neurobiol 165:90-6. 2009..The observed time-dependent modulation of the acute hemodynamic responses to hypoxia may reflect important changes in neurocirculatory regulation that contribute to CIH-induced hypertension...
- Vascular consequences of intermittent hypoxiaBarbara J Morgan
Department of Orthopedics and Rehabilitation, University of Wisconsin Madison, Madison, Wisconsin, USA
Adv Exp Med Biol 618:69-84. 2007..Such research has relevance not only to hypertension, but also to atherosclerosis and other important cardiovascular sequelae of OSA...
- Time course of intermittent hypoxia-induced impairments in resistance artery structure and functionNathan R Philippi
John Rankin Laboratory of Pulmonary Medicine, Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, USA
Respir Physiol Neurobiol 170:157-63. 2010..Exposure to CIH produces functional and structural deficits in skeletal muscle resistance arteries. These impairments develop within 2 weeks after initiation of exposure and they are accompanied by systemic evidence of oxidant stress...
- Altered neurovascular control of the resting circulation in human metabolic syndromeJacqueline K Limberg
School of Education, Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53076, USA
J Physiol 590:6109-19. 2012....
- Sleep-disordered breathing and obesity: pathophysiology, complications, and treatmentCorey J Leinum
Pharmacy Practice Division, School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA
Nutr Clin Pract 24:675-87. 2009..Large randomized trials are required to determine the utility of these strategies as long-term approaches to improving SDB and reducing associated complications...
- Obstructive sleep apnea and hypertension: mechanisms, evaluation, and managementJohn M Dopp
Department of Orthopedics and Rehabilitation, Madison, WI 53706, USA
Curr Hypertens Rep 9:529-34. 2007..Because even small decreases in arterial pressure can contribute to reducing cardiovascular risk, screening for OSA is an essential element of evaluating patients with hypertension...
- Mechanisms of the cerebrovascular response to apnoea in humansTadeusz Przybyłowski
Department of Population Health Sciences, University of Wisconsin Madison, The John Rankin Laboratory of Pulmonary Medicine, and the Middleton Veterans Administration Hospital, 53705, USA
J Physiol 548:323-32. 2003....