GERARDO ANDRES MORFINI

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C
    G Morfini
    Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:2442-7. 2007
  2. ncbi Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
    Gerardo A Morfini
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, USA
    Nat Neurosci 12:864-71. 2009
  3. ncbi Axonal transport defects in neurodegenerative diseases
    Gerardo A Morfini
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 29:12776-86. 2009
  4. ncbi Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta
    G Pigino
    Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 106:5907-12. 2009
  5. ncbi Regulation of kinesin: implications for neuronal development
    G Morfini
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
    Dev Neurosci 23:364-76. 2001

Research Grants

  1. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2010

Collaborators

Detail Information

Publications5

  1. ncbi 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C
    G Morfini
    Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:2442-7. 2007
    ....
  2. ncbi Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
    Gerardo A Morfini
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, USA
    Nat Neurosci 12:864-71. 2009
    ..These data identify JNK3 as a critical mediator of polyQ-Htt toxicity and provide a molecular basis for polyQ-Htt-induced inhibition of FAT...
  3. ncbi Axonal transport defects in neurodegenerative diseases
    Gerardo A Morfini
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 29:12776-86. 2009
    ..Illumination of such mechanisms provides a framework for the development of novel therapeutic strategies aimed to prevent axonal and synaptic dysfunction in several major AONDs...
  4. ncbi Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta
    G Pigino
    Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 106:5907-12. 2009
    ..Therefore pharmacological modulation of CK2 activity may represent a promising target for therapeutic intervention in AD...
  5. ncbi Regulation of kinesin: implications for neuronal development
    G Morfini
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
    Dev Neurosci 23:364-76. 2001
    ..Since kinesin is a phosphoprotein in vivo, we evaluated the correlation between kinesin phosphorylation and its membrane association and identified a number of kinases which phosphorylate kinesin and alter its function...

Research Grants1

  1. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2010
    ..The ultimate goal of this project is to define disease mechanisms and identify novel therapeutic targets in HSP. ..