L Morel

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi Epistatic modifiers of autoimmunity in a murine model of lupus nephritis
    L Morel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    Immunity 11:131-9. 1999
  2. ncbi Polygenic control of susceptibility to murine systemic lupus erythematosus
    L Morel
    Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610
    Immunity 1:219-29. 1994
  3. ncbi Functional dissection of systemic lupus erythematosus using congenic mouse strains
    L Morel
    Center for Mammalian Genetics and Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    J Immunol 158:6019-28. 1997
  4. pmc Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes
    C Mohan
    Center for Mammalian Genetics, and Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0275, USA
    J Clin Invest 101:1362-72. 1998
  5. ncbi Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity
    C Mohan
    Center for Mammalian Genetics and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    J Immunol 159:454-65. 1997
  6. pmc Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
    L Morel
    Departments of Medicine and Pathology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 97:6670-5. 2000
  7. ncbi Multiplex inheritance of component phenotypes in a murine model of lupus
    L Morel
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida 32610 USA
    Mamm Genome 10:176-81. 1999
  8. ncbi Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells
    E S Sobel
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610, USA
    J Immunol 162:2415-21. 1999
  9. ncbi Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat
    H C Jones
    Department of Pharmacology, University of Florida, Gainesville 32610, USA
    Mamm Genome 12:22-6. 2001
  10. pmc The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
    L Morel
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 98:1787-92. 2001

Collaborators

Detail Information

Publications20

  1. ncbi Epistatic modifiers of autoimmunity in a murine model of lupus nephritis
    L Morel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    Immunity 11:131-9. 1999
    ..Moreover, Sles1 was sufficient to completely suppress autoimmunity initiated by Sle1 in B6.NZMc1 x NZW hybrids. These results demonstrate the complex epistatic interactions of loci augmenting and suppressing systemic autoimmunity...
  2. ncbi Polygenic control of susceptibility to murine systemic lupus erythematosus
    L Morel
    Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610
    Immunity 1:219-29. 1994
    ..Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system...
  3. ncbi Functional dissection of systemic lupus erythematosus using congenic mouse strains
    L Morel
    Center for Mammalian Genetics and Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    J Immunol 158:6019-28. 1997
    ..Therefore, our results show that three defined genomic intervals from the NZM2410 SLE-prone strain each contribute specific component phenotypes that have been associated with SLE, which in combination can mediate severe disease...
  4. pmc Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes
    C Mohan
    Center for Mammalian Genetics, and Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0275, USA
    J Clin Invest 101:1362-72. 1998
    ..We hypothesize that Sle1 may lead to the presentation of chromatin in an immunogenic fashion, or directly impact tolerance of chromatin-specific B cells...
  5. ncbi Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity
    C Mohan
    Center for Mammalian Genetics and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    J Immunol 159:454-65. 1997
    ..However, Sle2 by itself on the normal B6 background is insufficient to generate IgG antinuclear Abs (ANA) or nephritis. By reducing the B cell signaling threshold, Sle2 might serve to amplify an ongoing autoimmune response...
  6. pmc Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
    L Morel
    Departments of Medicine and Pathology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 97:6670-5. 2000
    ....
  7. ncbi Multiplex inheritance of component phenotypes in a murine model of lupus
    L Morel
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida 32610 USA
    Mamm Genome 10:176-81. 1999
    ..Each of NZM2410 susceptibility loci can be aligned with a specific genetic pathways contributing to SLE pathogenesis on the basis of the spectrum of component phenotypes expressed...
  8. ncbi Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells
    E S Sobel
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610, USA
    J Immunol 162:2415-21. 1999
    ..These findings indicate that the expression of Sle1 in B cells is essential for the development of autoimmunity...
  9. ncbi Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat
    H C Jones
    Department of Pharmacology, University of Florida, Gainesville 32610, USA
    Mamm Genome 12:22-6. 2001
    ..5% of the total variance. It is concluded that hydrocephalus in the H-Tx rat is associated with two, possibly four genetic loci, but that there may be additional undefined genetic and environmental influences...
  10. pmc The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
    L Morel
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 98:1787-92. 2001
    ..This level of genetic complexity, combined with similar findings in other systems, supports the possibility that many complex trait loci reflect the impact of polymorphisms in linked clusters of genes with related functions...
  11. ncbi Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus
    B P Croker
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Genes Immun 4:575-85. 2003
    ..Our results illustrate the complexity of interactions between susceptibility loci in polygenic diseases such as lupus and may explain the clinical heterogeneity of the disease...
  12. ncbi The expression of inherited hydrocephalus in H-Tx rats
    H C Jones
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville 32610, USA
    Childs Nerv Syst 16:578-84. 2000
    ..The aims of this study were to characterize the expression of hydrocephalus in the H-Tx rat colony, to perform within-strain and between-strain DNA analysis and to examine hydrocephalus expression in specific breeding experiments...
  13. ncbi Lessons from the NZM2410 model and related strains
    L Morel
    Department of Medicine, University of Florida, Gainesville 32610 0275, USA
    Int Rev Immunol 19:423-46. 2000
    ....
  14. ncbi Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
    L Morel
    Department of Pathology, University of Florida, Gainesville, 32610, USA
    Mamm Genome 7:335-9. 1996
    ..They will also be instrumental to the positional cloning and identification of the genes responsible for SLE susceptibility, via the production of congenic recombinants...
  15. pmc Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes
    L Zeumer
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Genes Immun 12:199-207. 2011
    ..This constitutes an important step toward the identification of novel genes that have a critical role in B-cell tolerance...
  16. pmc Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells
    C M Cuda
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, 32610 0275, USA
    Genes Immun 11:542-53. 2010
    ..These results also show that the Sle1 locus is an excellent model for the genetic architecture of lupus, in which a major obligate phenotype results from the coexpression of multiple genetic variants with individual weak effects...
  17. pmc The combination of two Sle2 lupus-susceptibility loci and Cdkn2c deficiency leads to T-cell-mediated pathology in B6.Fas(lpr) mice
    Z Xu
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Genes Immun 14:373-9. 2013
    ....
  18. pmc The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator
    M Sengupta
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA
    Genes Immun 13:653-7. 2012
    ..These results constitute a first step towards the understanding on how Pbx1-d contributes to systemic autoimmunity in the NZM2410 mouse model as well as in lupus patients...
  19. ncbi Speed congenics: a classic technique in the fast lane (relatively speaking)
    E Wakeland
    Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610 0275, USA
    Immunol Today 18:472-7. 1997
    ..Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits...
  20. ncbi Chromosomal linkage associated with disease severity in the hydrocephalic H-Tx rat
    H C Jones
    Department of Pharmacology, University of Florida, Gainesville 32610, USA
    Behav Genet 31:101-11. 2001
    ..The number of hydrocephalus-associated loci carried by each rat correlated with the severity of disease. It is concluded that the severity of hydrocephalus in H-Tx is influenced by different genetic loci...