J S Moreb

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay
    Jan S Moreb
    Department of Medicine, Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Cytometry B Clin Cytom 72:281-9. 2007
  2. ncbi request reprint Overcoming immune tolerance against multiple myeloma with lentiviral calnexin-engineered dendritic cells
    Shuhong Han
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610 0266, USA
    Mol Ther 16:269-79. 2008
  3. ncbi request reprint Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro
    J S Moreb
    Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, Florida32610 0277, USA
    J Pharmacol Exp Ther 293:390-6. 2000
  4. ncbi request reprint Aldehyde dehydrogenase as a marker for stem cells
    Jan S Moreb
    Department of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100277, Gainesville, FL 32610, USA
    Curr Stem Cell Res Ther 3:237-46. 2008
  5. pmc ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells
    Jan S Moreb
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Mol Cancer 7:87. 2008
  6. ncbi request reprint RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide
    Jan S Moreb
    Department of Medicine, Division of Hematology Oncology, University of Florida, College of Medicine, 1600 SW Archer Road, Room R4 220, PO Box 100277, Gainesville, FL 32610, USA
    Cancer Chemother Pharmacol 59:127-36. 2007
  7. ncbi request reprint Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde
    Jan S Moreb
    University of Florida, College of Medicine, Department of Medicine, Division of Hematology Oncology, P O Box 100277, 1600 SW Archer Road, Room R4 220, Gainesville, FL 32610 0277, USA
    J Pharmacol Exp Ther 312:339-45. 2005
  8. doi request reprint Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw
    J Katz
    Department of Oral Medicine, College of Dentistry, University of Florida, Gainesville, USA
    Int J Oral Maxillofac Surg 40:605-11. 2011
  9. ncbi request reprint Engraftment syndrome in breast cancer patients after stem cell transplantation is associated with poor long-term survival
    S A Khan
    Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville 32610 0277, USA
    Biol Blood Marrow Transplant 7:433-8. 2001
  10. pmc Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells
    Shuhong Han
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, 32610 USA
    J Immune Based Ther Vaccines 8:8. 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay
    Jan S Moreb
    Department of Medicine, Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Cytometry B Clin Cytom 72:281-9. 2007
    ....
  2. ncbi request reprint Overcoming immune tolerance against multiple myeloma with lentiviral calnexin-engineered dendritic cells
    Shuhong Han
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida 32610 0266, USA
    Mol Ther 16:269-79. 2008
    ..This concept of modulating anticancer immunity by genetically engineering cancer patients' DCs may improve immunotherapeutic regimens in cancer treatment...
  3. ncbi request reprint Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro
    J S Moreb
    Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, Florida32610 0277, USA
    J Pharmacol Exp Ther 293:390-6. 2000
    ..These results indicate that ALDH-1 expression and activity can be specifically and effectively suppressed by AS RNA and lead to increased sensitivity to 4-HC...
  4. ncbi request reprint Aldehyde dehydrogenase as a marker for stem cells
    Jan S Moreb
    Department of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100277, Gainesville, FL 32610, USA
    Curr Stem Cell Res Ther 3:237-46. 2008
    ..We raise questions that need to be investigated before a reasonable therapeutic strategy can be devised that will effectively inhibit ALDH activity...
  5. pmc ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells
    Jan S Moreb
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Mol Cancer 7:87. 2008
    ..Aldehyde dehydrogenase isozymes ALDH1A1 and ALDH3A1 are highly expressed in non small cell lung cancer. Neither the mechanisms nor the biologic significance for such over expression have been studied...
  6. ncbi request reprint RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide
    Jan S Moreb
    Department of Medicine, Division of Hematology Oncology, University of Florida, College of Medicine, 1600 SW Archer Road, Room R4 220, PO Box 100277, Gainesville, FL 32610, USA
    Cancer Chemother Pharmacol 59:127-36. 2007
    ..We have previously reported the downregulation of these enzymes by all-trans retinoic acid (ATRA)...
  7. ncbi request reprint Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde
    Jan S Moreb
    University of Florida, College of Medicine, Department of Medicine, Division of Hematology Oncology, P O Box 100277, 1600 SW Archer Road, Room R4 220, Gainesville, FL 32610 0277, USA
    J Pharmacol Exp Ther 312:339-45. 2005
    ..These results may have clinical implications in regard to the use of retinoids in lung cancer prevention and treatment...
  8. doi request reprint Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw
    J Katz
    Department of Oral Medicine, College of Dentistry, University of Florida, Gainesville, USA
    Int J Oral Maxillofac Surg 40:605-11. 2011
    ..2 (95% confidence interval of 1.8-69.9; p value 0.0097). Smoking, type of BP and combined genotype score of COL1A1, RANK, MMP2, OPG and OPN were significantly associated with BONJ in MM patients undergoing BP therapy...
  9. ncbi request reprint Engraftment syndrome in breast cancer patients after stem cell transplantation is associated with poor long-term survival
    S A Khan
    Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville 32610 0277, USA
    Biol Blood Marrow Transplant 7:433-8. 2001
    ..Thus, patients with ES should be considered for close follow-up and further therapy posttransplantation...
  10. pmc Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells
    Shuhong Han
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, 32610 USA
    J Immune Based Ther Vaccines 8:8. 2010
    ....
  11. pmc Aldehyde dehydrogenase activity as a functional marker for lung cancer
    Deniz Ucar
    Department of Medicine, University of Florida, Gainesville, FL, USA
    Chem Biol Interact 178:48-55. 2009
    ..These observations and the known role of ALDH in drug resistance may have significant therapeutic implications in the treatment of lung cancer...
  12. ncbi request reprint ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors
    Miten Patel
    Department of Medicine, University of Florida, FL, USA
    Lung Cancer 59:340-9. 2008
    ....
  13. ncbi request reprint Late onset of invasive aspergillus infection in bone marrow transplant patients at a university hospital
    W B Grow
    University of Florida College of Medicine, Shands Hospital, Gainesville, FL 32610 0277, USA
    Bone Marrow Transplant 29:15-9. 2002
    ..These data have important implications in an era of alternate donor transplants and more intense immunosuppression. Established strategies implementing newer, less toxic antifungal agents as prophylaxis in high-risk patients are needed...
  14. ncbi request reprint Six cases of permanent alopecia after various conditioning regimens commonly used in hematopoietic stem cell transplantation
    M Machado
    Department of Medicine, University of Florida, Gainesville Florida, FL 32610, USA
    Bone Marrow Transplant 40:979-82. 2007
    ..Our findings may also have medico legal and psychosocial implications that need to be taken into consideration when consenting patients for HSCT...
  15. ncbi request reprint Correlation of early lymphocyte recovery and progression-free survival after autologous stem-cell transplant in patients with Hodgkin's and non-Hodgkin's Lymphoma
    L N Gordan
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Bone Marrow Transplant 31:1009-13. 2003
    ....
  16. ncbi request reprint Poor mobilization of peripheral blood stem cells is a risk factor for worse outcome in lymphoma patients undergoing autologous stem cell transplantation
    L N Gordan
    Department of Medicine, Division of Hematology Oncology, College of Medicine, University of Florida, P O Box 100277, Gainesville, FL 32610, USA
    Leuk Lymphoma 44:815-20. 2003
    ....
  17. pmc Diverse T-cell differentiation potentials of human fetal thymus, fetal liver, cord blood and adult bone marrow CD34 cells on lentiviral Delta-like-1-modified mouse stromal cells
    Ekta Patel
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610 0266, USA
    Immunology 128:e497-505. 2009
    ..However, further modification of this in vitro T-cell development system is necessary to attain fully functional T cells...
  18. ncbi request reprint Diagnosis of an early precursor-B-ALL presenting with hypereosinophilia using FISH on immunomagnetically selected CD19+ cells
    Karl T Hagler
    Division of Hematology Oncology, University of Florida, Gainesville, FL 32610, USA
    Clin Adv Hematol Oncol 3:62-4. 2005
  19. ncbi request reprint Busulfan, cyclophosphamide, and etoposide as conditioning for autologous stem cell transplantation in multiple myeloma
    Christopher R Cogle
    University of Florida, Division of Hematology Oncology, Gainesville, Florida 32610, USA
    Am J Hematol 73:169-75. 2003
    ....