JOSE ANTONIO MORCUENDE

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Swarm rat chondrosarcoma cells as an in vivo model: lung colonization and effects of tissue environment on tumor growth
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation University of Iowa 200 Hawkins Drive, Iowa City, IA 52242, USA
    Iowa Orthop J 32:46-53. 2012
  2. pmc Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype
    Tracy L McGregor
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Med Genet 12:92. 2011
  3. pmc Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
    Christopher A Hamm
    Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA
    BMC Cancer 10:471. 2010
  4. pmc Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis
    William Shyy
    Departments of Orthopaedic Surgery and Rehabilitation, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    J Pediatr Orthop 30:539-43. 2010
  5. pmc Results of the Ponseti method in patients with clubfoot associated with arthrogryposis
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, Iowa 52242, USA
    Iowa Orthop J 28:22-6. 2008
  6. pmc Diabetic muscle infarction
    J A Morcuende
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Iowa Orthop J 20:65-74. 2000
  7. ncbi request reprint Congenital idiopathic clubfoot: prevention of late deformity and disability by conservative treatment with the Ponseti technique
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, Iowa, USA
    Pediatr Ann 35:128-30, 132-6. 2006
  8. ncbi request reprint Results of an accelerated Ponseti protocol for clubfoot
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Pediatr Orthop 25:623-6. 2005
  9. pmc Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2
    Jose A Morcuende
    Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Iowa Orthop J 24:36-42. 2004
  10. pmc Identification and initial characterization of 6,000 expressed sequenced tags (ESTs) from rat normal-growing cartilage and swarm rat chondrosarcoma cDNA libraries
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    Iowa Orthop J 22:28-34. 2002

Research Grants

  1. Genetic Mapping of Familial Idiopathic Scoliosis
    Jose Morcuende; Fiscal Year: 2007
  2. Intrnational Clubfoot Symposium
    Jose Morcuende; Fiscal Year: 2007

Collaborators

Detail Information

Publications35

  1. pmc Swarm rat chondrosarcoma cells as an in vivo model: lung colonization and effects of tissue environment on tumor growth
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation University of Iowa 200 Hawkins Drive, Iowa City, IA 52242, USA
    Iowa Orthop J 32:46-53. 2012
    ..Identifying these interactions will lead to further understanding of chondrosarcoma and contribute to therapeutic targets in the future...
  2. pmc Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype
    Tracy L McGregor
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Med Genet 12:92. 2011
    ..We hypothesized that common polymorphisms in the five human lysyl oxidase genes (LOX, LOXL1, LOXL2, LOXL3, and LOXL4) may be associated with the phenotype of adolescent idiopathic scoliosis...
  3. pmc Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
    Christopher A Hamm
    Interdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA
    BMC Cancer 10:471. 2010
    ..Previous studies with this model revealed that tumor microenvironment could significantly influence chondrosarcoma malignancy...
  4. pmc Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis
    William Shyy
    Departments of Orthopaedic Surgery and Rehabilitation, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    J Pediatr Orthop 30:539-43. 2010
    ....
  5. pmc Results of the Ponseti method in patients with clubfoot associated with arthrogryposis
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, Iowa 52242, USA
    Iowa Orthop J 28:22-6. 2008
    ..Although this deformity is more rigid than in idiopathic clubfoot, many cases can be corrected when started in the first few weeks after birth...
  6. pmc Diabetic muscle infarction
    J A Morcuende
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Iowa Orthop J 20:65-74. 2000
    ..Recurrences in the same or opposite limb are common. Although the short-term prognosis is very good and the majority of cases resolve spontaneously, the long-term survival is uncertain in this patient population...
  7. ncbi request reprint Congenital idiopathic clubfoot: prevention of late deformity and disability by conservative treatment with the Ponseti technique
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, Iowa, USA
    Pediatr Ann 35:128-30, 132-6. 2006
    ..Awareness of the excellent results provided by the Ponseti method is essential for counseling and providing treatment advice to the families of children born with this deformity...
  8. ncbi request reprint Results of an accelerated Ponseti protocol for clubfoot
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Pediatr Orthop 25:623-6. 2005
    ..001). Three patients (1.3%) required corrective surgery and there were 36 relapses (P = 0.4). In conclusion, the Ponseti method is very effective and the deformity can be corrected in a relatively short time...
  9. pmc Effect of chemotherapy on segmental bone healing enhanced by rhBMP-2
    Jose A Morcuende
    Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Iowa Orthop J 24:36-42. 2004
    ..These results suggest that the effect of chemotherapy on bone formation could be related to inhibition in a specific pathway stimulated by the rhBMP-2...
  10. pmc Identification and initial characterization of 6,000 expressed sequenced tags (ESTs) from rat normal-growing cartilage and swarm rat chondrosarcoma cDNA libraries
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    Iowa Orthop J 22:28-34. 2002
    ..It suggests that the biochemical characterization of growing cartilage and chondrosarcoma reported to date has only begun to describe the complexity of these tissues...
  11. ncbi request reprint Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, Iowa, USA
    Spine (Phila Pa 1976) 28:2025-8; discussion 2029. 2003
    ..A genetic study of patients with familial adolescent idiopathic scoliosis...
  12. ncbi request reprint Radical reduction in the rate of extensive corrective surgery for clubfoot using the Ponseti method
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, Iowa, USA
    Pediatrics 113:376-80. 2004
    ..The purpose of this study was to evaluate the efficacy of the Ponseti method in reducing extensive corrective surgery rates for congenital idiopathic clubfoot...
  13. ncbi request reprint Developmental skeletal anomalies
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Birth Defects Res C Embryo Today 69:197-207. 2003
    ..Unraveling these mysteries and defining them in molecular and cellular terms will be the challenges for the near future...
  14. pmc The effect of the internet in the treatment of congenital idiopathic clubfoot
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA 52242, USA
    Iowa Orthop J 23:83-6. 2003
    ..This sharing of information is affecting how parents make their treatment choices and also has the potential to induce unexpected changes in clinical orthopaedic practice...
  15. ncbi request reprint Radiographic measurements in developmental dysplasia of the hip: reliability and validity of a digitizing program
    Douglas R Pedersen
    Department of Biomedical Engineering, College of Engineering, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    J Pediatr Orthop 24:156-60. 2004
    ..If this program is added to a software reporting system, measurements can be done on a real-time basis and can be included in the patient's medical record...
  16. doi request reprint Adolescent idiopathic scoliosis
    Stuart L Weinstein
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, Iowa, IA 52242, USA
    Lancet 371:1527-37. 2008
    ..However, we do not have long-term results of these changing surgical treatments. Much has yet to be learned about the general health, quality of life, and self-image of both treated and untreated patients with AIS...
  17. pmc Ethanol as a local adjuvant for giant cell tumor of bone
    Kevin B Jones
    Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01051 John Pappajohn Pavilion, Iowa City, IA 52242, USA
    Iowa Orthop J 26:69-76. 2006
    ..Until such evidence becomes available, the use of adjuvant ethanol offers a compromise between higher toxicity adjuvants and no chemical adjuvant at all...
  18. pmc Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot
    William Shyy
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, 200 Hawkins Drive, 01023 JPP, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 467:1201-5. 2009
    ..Based on these results it is unlikely CAND2 and WNT7a are the major genes that causes clubfoot, however WNT7a might be one of many genes that could increase susceptibility to develop clubfoot but do not directly cause it...
  19. pmc Cytogenetics of swarm rat chondrosarcoma
    Jeff W Stevens
    Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Iowa Orthop J 25:135-40. 2005
    ....
  20. pmc A historical and economic perspective on Sir John Charnley, Chas F. Thackray Limited, and the early arthoplasty industry
    Pablo F Gomez
    Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Iowa Orthop J 25:30-7. 2005
    ..Thackray Limited, now a subsidiary of DePuy Orthopaedics, a Johnson and Johnson Company. We review here that relationship, in light of the complex relationships today that exist among industry, researchers, surgeons, and the public...
  21. pmc Early attempts at hip arthroplasty--1700s to 1950s
    Pablo F Gomez
    Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Iowa Orthop J 25:25-9. 2005
    ....
  22. pmc Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot
    William Shyy
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA, USA
    J Pediatr Orthop 30:231-4. 2010
    ..In this study, we hypothesized that a mutation in an embryonic or perinatal myosin gene could be associated with congenital idiopathic clubfoot...
  23. pmc Effect of cast removal timing in the correction of idiopathic clubfoot by the Ponseti method
    Gaston Terrazas-Lafargue
    The Ponseti Clubfoot Treatment Center, University of Iowa, Iowa City, Iowa, USA
    Iowa Orthop J 27:24-7. 2007
    ..42). In conclusion, removing the cast just before the new cast is applied significantly decreases the number of casts required for correction and shortens the length of treatment...
  24. pmc Neuromuscular disease as the cause of late clubfoot relapses: report of 4 cases
    Matthew E Lovell
    The Ponseti Center for Clubfoot Treatment, Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, Iowa 52242, USA
    Iowa Orthop J 27:82-4. 2007
    ..In conclusion, late relapses in patients with idiopathic clubfoot may represent the onset of a previously undiagnosed neuromuscular disease, and should be thoroughly evaluated...
  25. ncbi request reprint Treatment of the complex idiopathic clubfoot
    Ignacio V Ponseti
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, IA, USA
    Clin Orthop Relat Res 451:171-6. 2006
    ..There were seven relapses that responded to casting. Three patients had a second tenotomy. Modifying the treatment protocol for complex clubfeet successfully corrected the deformity without the need for extensive corrective surgery...
  26. pmc Natural history of type III growth disturbance after treatment of developmental dislocation of the hip
    Claudio A Fernandez
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, Iowa 52242 1088, USA
    Iowa Orthop J 28:27-35. 2008
    ..This study evaluated the long-term outcomes of patients treated for DDH who developed a T3GD hip compared to those who didn't, with an emphasis on possible risk factors...
  27. ncbi request reprint Early results of a new method of treatment for idiopathic congenital vertical talus. Surgical technique
    Matthew B Dobbs
    Department of Orthopaedic Surgery, Washington University School of Medicine, One Children s Place, Suite 4S20, St Louis, MO 63110, USA
    J Bone Joint Surg Am 89:111-21. 2007
    ....
  28. ncbi request reprint Early results of a new method of treatment for idiopathic congenital vertical talus
    Matthew B Dobbs
    Department of Orthopaedic Surgery, Washington University School of Medicine, One Children s Place, Suite 4S20, St Louis, MO 63110, USA
    J Bone Joint Surg Am 88:1192-200. 2006
    ....
  29. ncbi request reprint The prevalence of hereditary neuropathy with liability to pressure palsies in patients with multiple surgically treated entrapment neuropathies
    Michael D Sander
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Hand Surg Am 30:1236-41. 2005
    ..We hypothesized that some of these patients have an underlying hereditary neuropathy. The purpose of this study was to determine the prevalence of HNPP in patients with multiple surgically treated upper-extremity entrapment neuropathies...
  30. pmc Patient location strategies for pediatric long-term follow-up studies
    Matthew E Lovell
    The Ponseti Center for Clubfoot Treatment, The University of Iowa, Iowa City, Iowa, USA
    Iowa Orthop J 26:91-5. 2006
    ..The purpose of this study is to test an algorithm proposed by King et al., as well as other search methods, using a cohort of patients treated for clubfoot in childhood..
  31. pmc Of hedgehogs and hereditary bone tumors: re-examination of the pathogenesis of osteochondromas
    Kevin B Jones
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA 52242, USA
    Iowa Orthop J 23:87-95. 2003
    ....
  32. doi request reprint Epidemiology of congenital idiopathic talipes equinovarus in Iowa, 1997-2005
    Vijaya Kancherla
    Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 152:1695-700. 2010
    ..More detailed, longitudinal studies of isolated ITEV are recommended...
  33. ncbi request reprint Prevalence of neural axis abnormalities in patients with infantile idiopathic scoliosis
    Matthew B Dobbs
    Department of Orthopaedic Surgery, Washington University School of Medicine, Saint Luis, Missouri 63110, USA
    J Bone Joint Surg Am 84:2230-4. 2002
    ..In two previous studies involving a total of only ten patients with infantile idiopathic scoliosis, five patients were noted to have a neural axis abnormality on magnetic resonance images...
  34. pmc Bone and brain: a review of neural, hormonal, and musculoskeletal connections
    Kevin B Jones
    Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Iowa Orthop J 24:123-32. 2004
    ....
  35. pmc Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes
    George S Oji
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    Iowa Orthop J 27:9-16. 2007
    ..Understanding the underlying mechanisms may provide a target for future therapy for chondrosarcoma...

Research Grants3

  1. Genetic Mapping of Familial Idiopathic Scoliosis
    Jose Morcuende; Fiscal Year: 2007
    ..Together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  2. Intrnational Clubfoot Symposium
    Jose Morcuende; Fiscal Year: 2007
    ....