N A Moran

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc A dual-genome microarray for the pea aphid, Acyrthosiphon pisum, and its obligate bacterial symbiont, Buchnera aphidicola
    Alex C C Wilson
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:50. 2006
  2. ncbi request reprint Intracellular symbionts of sharpshooters (Insecta: Hemiptera: Cicadellinae) form a distinct clade with a small genome
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson 85721, USA
    Environ Microbiol 5:116-26. 2003
  3. pmc A genomic perspective on nutrient provisioning by bacterial symbionts of insects
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:14543-8. 2003
  4. pmc Sexual acquisition of beneficial symbionts in aphids
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 103:12803-6. 2006
  5. ncbi request reprint Microbial minimalism: genome reduction in bacterial pathogens
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Cell 108:583-6. 2002
  6. pmc Evolutionary relationships of three new species of Enterobacteriaceae living as symbionts of aphids and other insects
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 71:3302-10. 2005
  7. pmc Regulation of transcription in a reduced bacterial genome: nutrient-provisioning genes of the obligate symbiont Buchnera aphidicola
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 187:4229-37. 2005
  8. pmc The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genes
    Nancy A Moran
    Departments of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 87521, USA
    Proc Natl Acad Sci U S A 102:16919-26. 2005
  9. ncbi request reprint Bacterial endosymbionts in animals
    N A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, 85721, USA
    Curr Opin Microbiol 3:270-5. 2000
  10. pmc Symbiosis as an adaptive process and source of phenotypic complexity
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 104:8627-33. 2007

Collaborators

Detail Information

Publications74

  1. pmc A dual-genome microarray for the pea aphid, Acyrthosiphon pisum, and its obligate bacterial symbiont, Buchnera aphidicola
    Alex C C Wilson
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 7:50. 2006
    ..Development of this dual-genome array represents a first attempt to characterize gene expression in this emerging model system...
  2. ncbi request reprint Intracellular symbionts of sharpshooters (Insecta: Hemiptera: Cicadellinae) form a distinct clade with a small genome
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson 85721, USA
    Environ Microbiol 5:116-26. 2003
    ..A new genus and species name, 'Candidatus Baumannia cicadellinicola' (sp. nov.) is proposed for this newly characterized clade of symbiotic bacteria...
  3. pmc A genomic perspective on nutrient provisioning by bacterial symbionts of insects
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:14543-8. 2003
    ....
  4. pmc Sexual acquisition of beneficial symbionts in aphids
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 103:12803-6. 2006
    ..Because such transfer can generate coinfections, thereby creating opportunities for symbiont competition and recombination, paternal inheritance has major consequences for expectations regarding symbiont evolution...
  5. ncbi request reprint Microbial minimalism: genome reduction in bacterial pathogens
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Cell 108:583-6. 2002
    ..Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts...
  6. pmc Evolutionary relationships of three new species of Enterobacteriaceae living as symbionts of aphids and other insects
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 71:3302-10. 2005
    ..The other two symbionts, here designated "Candidatus Hamiltonella defensa" and "Candidatus Regiella insecticola," are sister groups to one another and together show a relationship to species of Photorhabdus...
  7. pmc Regulation of transcription in a reduced bacterial genome: nutrient-provisioning genes of the obligate symbiont Buchnera aphidicola
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 187:4229-37. 2005
    ..The irreversible losses of transcriptional regulators constrain ability to alter gene expression in the context of environmental fluctuations affecting the symbiotic partners...
  8. pmc The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genes
    Nancy A Moran
    Departments of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 87521, USA
    Proc Natl Acad Sci U S A 102:16919-26. 2005
    ..defensa life cycle. We propose that, in these mutualistic symbionts, phage-borne toxin genes provide defense to the aphid host and are a basis for the observed protection against eukaryotic parasites...
  9. ncbi request reprint Bacterial endosymbionts in animals
    N A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, 85721, USA
    Curr Opin Microbiol 3:270-5. 2000
    ..Molecular genetic characterization also has revealed adaptive, host-beneficial traits such as amplification of genes underlying nutrient provision...
  10. pmc Symbiosis as an adaptive process and source of phenotypic complexity
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 104:8627-33. 2007
    ..Multiple symbionts often coexist in the same host, resulting in coadaptation among several phylogenetically distant genomes...
  11. pmc Symbiosis and insect diversification: an ancient symbiont of sap-feeding insects from the bacterial phylum Bacteroidetes
    Nancy A Moran
    Biological Sciences West 310, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Appl Environ Microbiol 71:8802-10. 2005
    ..Candidatus Sulcia muelleri" is proposed as the name of the new symbiont...
  12. ncbi request reprint Functional genomics of Buchnera and the ecology of aphid hosts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Mol Ecol 15:1251-61. 2006
    ..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera...
  13. pmc Intraspecific phylogenetic congruence among multiple symbiont genomes
    D J Funk
    Department of Ecology and Evolutionary Biology, and Center for Insect Science, University of Arizona, Tucson 85721, USA
    Proc Biol Sci 267:2517-21. 2000
    ..These results may reflect the obligate nature of this intimate mutualism and indicate opportunities for adaptive coevolution among linked symbiont genomes...
  14. ncbi request reprint Independent origins and horizontal transfer of bacterial symbionts of aphids
    J P Sandström
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Mol Ecol 10:217-28. 2001
    ..pisum and U. ambrosiae containing secondary symbionts. Electron microscopy of R-type and T-type bacteria in A. pisum and in U. ambrosiae revealed rod-shaped organisms that attain extremely high densities within a few bacteriocytes...
  15. pmc The process of genome shrinkage in the obligate symbiont Buchnera aphidicola
    N A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genome Biol 2:RESEARCH0054. 2001
    ....
  16. ncbi request reprint Phylogenetics and the cohesion of bacterial genomes
    Vincent Daubin
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ, 85721, USA
    Science 301:829-32. 2003
    ..Although comparisons of complete gene inventories indicate appreciable gain and loss of genes, orthologs available for phylogenetic reconstruction are consistent with a single tree...
  17. pmc From gene trees to organismal phylogeny in prokaryotes: the case of the gamma-Proteobacteria
    Emmanuelle Lerat
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, USA
    PLoS Biol 1:E19. 2003
    ....
  18. pmc Intraspecific variation in symbiont genomes: bottlenecks and the aphid-buchnera association
    D J Funk
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genetics 157:477-89. 2001
    ..However, our study cannot rule out the possibility that mechanisms other than bottlenecks also contribute to reduced N(e) at aphid and endosymbiont loci...
  19. ncbi request reprint Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein-coding genes
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 16:83-97. 1999
    ..Combined, these results suggest a decreased effectiveness of purifying selection in purging endosymbiont populations of slightly deleterious mutations, particularly those affecting codon usage and amino acid identity...
  20. ncbi request reprint Genes lost and genes found: evolution of bacterial pathogenesis and symbiosis
    H Ochman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85718, USA
    Science 292:1096-9. 2001
    ..Furthermore, pathogens and symbionts depend on similar mechanisms for interacting with hosts and show parallel trends in genome evolution...
  21. pmc Decoupling of genome size and sequence divergence in a symbiotic bacterium
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 182:3867-9. 2000
    ..This exceptional size conservation may reflect the inability of this obligate mutualist to acquire foreign DNA and reduced selection for genetic novelty within a static intracellular environment...
  22. pmc Decay of mutualistic potential in aphid endosymbionts through silencing of biosynthetic loci: Buchnera of Diuraphis
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, Center for Insect Science, University of Arizona, Tucson 85721, USA
    Proc Biol Sci 267:1423-31. 2000
    ....
  23. ncbi request reprint Side-stepping secondary symbionts: widespread horizontal transfer across and beyond the Aphidoidea
    J A Russell
    University of Arizona, Department of Ecology and Evolutionary Biology, Biological Sciences West, Tucson, Arizona 85721, USA
    Mol Ecol 12:1061-75. 2003
    ..Our findings on the prevalence of these symbionts within many aphid taxa, along with published observations concerning their effects on host fitness, imply a significant role of facultative symbiosis in aphid ecology and evolution...
  24. pmc The consequences of genetic drift for bacterial genome complexity
    Chih Horng Kuo
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genome Res 19:1450-4. 2009
    ..This ratio, which reflects the action of purifying selection across the entire genome, shows a strong inverse relationship with genome size, indicating that drift promotes genome reduction in bacteria...
  25. ncbi request reprint Deletional bias and the evolution of bacterial genomes
    A Mira
    Dept of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Trends Genet 17:589-96. 2001
    ..Here we discuss the evidence showing that deletional bias is a major force that shapes bacterial genomes...
  26. pmc Vertical transmission of biosynthetic plasmids in aphid endosymbionts (Buchnera)
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 183:785-90. 2001
    ..Synonymous divergences indicate elevated mutation on plasmids relative to chromosomal genes...
  27. ncbi request reprint Extremely low levels of genetic polymorphism in endosymbionts (Buchnera) of aphids (Pemphigus)
    P Abbot
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Mol Ecol 11:2649-60. 2002
    ..These results support the generality of small effective population size in Buchnera and their aphid hosts...
  28. doi request reprint Multiple introductions of the Spiroplasma bacterial endosymbiont into Drosophila
    Tamara S Haselkorn
    Department of Ecology and Evolutionary Biology Biosciences, University of Arizona, Tucson, 85721 0088, USA
    Mol Ecol 18:1294-305. 2009
    ..Patterns of variation in Drosophila mitochondrial haplotypes in Spiroplasma-infected and uninfected flies imply imperfect vertical transmission in host populations and possible horizontal transmission...
  29. pmc Extracting single genomes from heterogenous DNA samples: a test case with Carsonella ruddii, the bacterial symbiont of psyllids (Insecta)
    Colin Dale
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    J Insect Sci 5:3. 2005
    ..The resulting libraries were highly enriched in bacterial sequences. Through the use of alternate enzymes and partial digests, this technique can be adapted to yield virtually pure DNA libraries for individual bacterial species...
  30. pmc Type III secretion systems and the evolution of mutualistic endosymbiosis
    Colin Dale
    Department of Ecology and Evolutionary Biology, Center for Insect Science, and Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721
    Proc Natl Acad Sci U S A 99:12397-402. 2002
    ..The function of inv/spa genes in maintaining symbiosis is demonstrated by the up-regulation of their expression under both in vivo and in vitro conditions that coincide with host cell invasion...
  31. pmc Chromosome stability and gene loss in cockroach endosymbionts
    Zakee L Sabree
    Center for Insect Science, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 76:4076-9. 2010
    ..We speculate that distant homologs may replace the functions of some eliminated genes through broadened substrate specificity...
  32. pmc Evolutionary origins of genomic repertoires in bacteria
    Emmanuelle Lerat
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA
    PLoS Biol 3:e130. 2005
    ..Although our analyses are limited to the gamma-Proteobacteria, these results resolve a long-standing paradox-i.e., the ability to make robust phylogenetic inferences in light of substantial LGT...
  33. ncbi request reprint Estimating population size and transmission bottlenecks in maternally transmitted endosymbiotic bacteria
    A Mira
    Department of Ecology and Evolutionary Biology, University of Arizona, PO Box 210088, Tucson, AZ 85721 0088, USA
    Microb Ecol 44:137-43. 2002
    ..Secondary symbionts were arranged both extracellularly and in clusters of 2000-8000 bacteria inside bacteriocytes. These numbers are consistent with the few previous estimates of symbiont population sizes based on counts of gene copies...
  34. doi request reprint The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Science 323:379-82. 2009
    ..Although purifying selection eliminates many mutations, some persist, resulting in ongoing loss of genes and DNA from this already tiny genome. Our results provide a general model for the stepwise process leading to genome reduction...
  35. doi request reprint Genomics and evolution of heritable bacterial symbionts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Genet 42:165-90. 2008
    ..In addition, insect symbionts provide some of the extremes of cellular genomes, including the smallest and the fastest evolving, raising new questions about the limits of evolution of life...
  36. doi request reprint A simple and distinctive microbiota associated with honey bees and bumble bees
    Vincent G Martinson
    Center for Insect Science, University of Arizona, 1007 East Lowell Street, Tucson, AZ 85721 0088, USA
    Mol Ecol 20:619-28. 2011
    ..Phylogenetic analyses provide a more refined taxonomic placement of the A. mellifera symbionts...
  37. doi request reprint Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophage
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
    Mol Ecol 17:916-29. 2008
    ..pisum, one subclade of H. defensa appears to be universal within a subclade of the aphid genus Uroleucon, suggesting a transition from facultative, horizontal transmission to strictly vertical inheritance...
  38. pmc Parallel genomic evolution and metabolic interdependence in an ancient symbiosis
    John P McCutcheon
    Center for Insect Science and Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Proc Natl Acad Sci U S A 104:19392-7. 2007
    ..Analysis of the coding capacities of Sulcia and Baumannia reveals striking complementarity in metabolic capabilities...
  39. pmc Population dynamics of defensive symbionts in aphids
    Kerry M Oliver
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Biol Sci 275:293-9. 2008
    ..The declining frequencies of Hamiltonella-infected aphids in population cages in the absence of parasitism indicate a probable cost to infection and may explain why Hamiltonella remains at intermediate frequencies in natural populations...
  40. pmc Diverse phage-encoded toxins in a protective insect endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Appl Environ Microbiol 74:6782-91. 2008
    ..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts...
  41. pmc Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Arizona Genomics Institute, University of Arizona, Tucson, AZ 85721 USA
    Proc Natl Acad Sci U S A 106:9063-8. 2009
    ..The genome is also littered with mobile DNA, including phage-derived genes, plasmids, and insertion-sequence elements, highlighting its dynamic nature and the continued role horizontal gene transfer plays in shaping it...
  42. doi request reprint Lateral transfer of genes from fungi underlies carotenoid production in aphids
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, 1041 East Lowell Street, University of Arizona, Tucson, AZ 85721, USA
    Science 328:624-7. 2010
    ..A mutation causing an amino acid replacement in this desaturase results in loss of torulene and of red body color. Thus, aphids are animals that make their own carotenoids...
  43. pmc Sources of variation in dietary requirements in an obligate nutritional symbiosis
    Kevin J Vogel
    Department of Ecology and Evolutionary Biology, The University of Arizona, Tucson, AZ 85721, USA
    Proc Biol Sci 278:115-21. 2011
    ..Our results indicate that variation among pea aphids in dependence on dietary amino acids can result from Buchnera mutation as well as variation in the host genotype...
  44. pmc Evolution and diversity of facultative symbionts from the aphid subfamily Lachninae
    Gaelen R Burke
    Department of Ecology and Evolutionary Biology, University of Arizona, 1041 East Lowell Street, Tucson, Arizona 85721 0088, USA
    Appl Environ Microbiol 75:5328-35. 2009
    ..Serratia symbiotica" with Cinara subgenus Cinara species and weigh against an obligate nutritional role. Finally, we show that species belonging to the subfamily Lachninae have a high incidence of facultative symbiont infection...
  45. pmc Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ, USA
    PLoS Genet 5:e1000565. 2009
    ..Although it is not clear why this tiny genome lacks the low GC content typical of other small bacterial genomes, these observations support a role of genome reduction rather than base composition as a driver of codon reassignment...
  46. pmc Convergent evolution of metabolic roles in bacterial co-symbionts of insects
    John P McCutcheon
    Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 106:15394-9. 2009
    ....
  47. pmc Dynamics of a recurrent Buchnera mutation that affects thermal tolerance of pea aphid hosts
    Gaelen R Burke
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 186:367-72. 2010
    ..This single base polymorphism in Buchnera has the potential to allow aphid populations to adapt quickly to prevailing conditions...
  48. pmc Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont
    Zakee L Sabree
    Department of Ecology and Evolutionary Biology, University of Arizona, Center for Insect Science, Tucson, AZ 85721 0088, USA
    Proc Natl Acad Sci U S A 106:19521-6. 2009
    ....
  49. pmc Aphid thermal tolerance is governed by a point mutation in bacterial symbionts
    Helen E Dunbar
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Biol 5:e96. 2007
    ..Other cases in which symbiont microevolution has a major effect on host ecological tolerance are likely to be widespread because of the high mutation rates of symbiotic bacteria and their crucial roles in host metabolism and development...
  50. ncbi request reprint Symbiosis
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Curr Biol 16:R866-71. 2006
  51. ncbi request reprint Genomic changes following host restriction in bacteria
    Nancy A Moran
    Department of Ecology and Evolutionary Biology and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Curr Opin Genet Dev 14:627-33. 2004
    ..Considerable variation also exists, however, in part reflecting unstudied aspects of the population structure and ecology of host-restricted bacterial lineages...
  52. pmc Variation in resistance to parasitism in aphids is due to symbionts not host genotype
    Kerry M Oliver
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 102:12795-800. 2005
    ..Thus, acquisition of a heritable symbiont appears to be a major mode of adaptation to natural enemy pressure in these insects...
  53. ncbi request reprint The evolutionary history of quorum-sensing systems in bacteria
    Emmanuelle Lerat
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    Mol Biol Evol 21:903-13. 2004
    ..Gene phylogenies for the main LuxI/R family in Pseudomonas species imply a complex history of lateral transfer, ancestral duplication, and gene loss within the genus...
  54. ncbi request reprint Tracing the evolution of gene loss in obligate bacterial symbionts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Curr Opin Microbiol 6:512-8. 2003
    ..This pattern appears to be characteristic of symbiont evolution...
  55. ncbi request reprint Comment on "The origins of genome complexity"
    Vincent Daubin
    Department of Biochemistry and Molecular Biophysics, University of Arizona Tuscon, AZ 85721, USA
    Science 306:978; author reply 978. 2004
  56. pmc Costs and benefits of symbiont infection in aphids: variation among symbionts and across temperatures
    Jacob A Russell
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    Proc Biol Sci 273:603-10. 2006
    ..insecticola under these same conditions. These findings reveal a role for heritable symbionts in the adaptation of aphids to their abiotic environments and add to an expanding body of knowledge on the adaptive significance of symbiosis...
  57. pmc Costs and benefits of a superinfection of facultative symbionts in aphids
    Kerry M Oliver
    Department of Entomology, University of Arizona, 410 Forbes Building, Tucson, AZ 85721, USA
    Proc Biol Sci 273:1273-80. 2006
    ..Our results indicate that in addition to host-symbiont interactions, interactions among the symbionts themselves probably play a critical role in determining the distributions of symbionts in natural populations...
  58. ncbi request reprint Consequences of reductive evolution for gene expression in an obligate endosymbiont
    Jennifer L Wilcox
    Department of Ecology and Evolutionary Biology, University of Arizona, BioSciences West Rm 310, Tucson 85721, USA
    Mol Microbiol 48:1491-500. 2003
    ..aphidicola. Our demonstration of a diminished stress response validates reports of temperature sensitivity in B. aphidicola and suggests that this reduced bacterial genome exhibits transcriptional inflexibility...
  59. ncbi request reprint Low and homogeneous copy number of plasmid-borne symbiont genes affecting host nutrition in Buchnera aphidicola of the aphid Uroleucon ambrosiae
    Gordon R Plague
    Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Mol Ecol 12:1095-100. 2003
    ..Consequently, the plasmid location of trpEG combined with Buchnera's chromosomal polyploidy may functionally limit, rather than increase, tryptophan production within Uroleucon ambrosiae...
  60. ncbi request reprint The 160-kilobase genome of the bacterial endosymbiont Carsonella
    Atsushi Nakabachi
    Environmental Molecular Biology Laboratory, RIKEN, Wako, Saitama 351 0198, Japan
    Science 314:267. 2006
    ..Genes for translation and amino acid biosynthesis are relatively well represented, but numerous genes considered essential for life are missing, suggesting that Carsonella may have achieved organelle-like status...
  61. pmc Genetic conflict and conditional altruism in social aphid colonies
    P Abbot
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 98:12068-71. 2001
    ..This conditionality in the social life of P. obesinymphae reveals complex dynamics and a degree of behavioral plasticity not previously known in aphid societies...
  62. pmc Calibrating bacterial evolution
    H Ochman
    Department of Ecology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 96:12638-43. 1999
    ..However, there is evidence that bacteria have a constant genome-wide mutation rate on an evolutionary time scale but that this rate differs dramatically from the rate estimated by experimental methods...
  63. pmc Facultative bacterial symbionts in aphids confer resistance to parasitic wasps
    Kerry M Oliver
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:1803-7. 2003
    ..This strong interaction between a symbiotic bacterium and a host natural enemy provides a mechanism for the persistence and spread of symbiotic bacteria...
  64. doi request reprint Responses of the pea aphid transcriptome to infection by facultative symbionts
    G R Burke
    Department of Ecology and Evolutionary Biology, The University of Arizona, Tucson, AZ, USA
    Insect Mol Biol 20:357-65. 2011
    ..Although S. symbiotica has a major influence on its host's metabolome and resistance to heat, it induces little change in gene expression in its host...
  65. pmc Heritable endosymbionts of Drosophila
    Mariana Mateos
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 174:363-76. 2006
    ..Several new strains of Wolbachia and Spiroplasma were discovered, including ones divergent from any reported to date. The phylogenetic distribution of Wolbachia and Spiroplasma in Drosophila is discussed...
  66. pmc Variable incidence of Spiroplasma infections in natural populations of Drosophila species
    Thomas Watts
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 4:e5703. 2009
    ..These findings suggest that Spiroplasma has other effects on hosts that allow it to persist, and that environmental or host variation affects transmission or persistence leading to differences among populations in infection frequencies...
  67. pmc Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters
    Dongying Wu
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Biol 4:e188. 2006
    ..coagulata and other sharpshooters serve as vectors of transmission...
  68. ncbi request reprint Molecular interactions between bacterial symbionts and their hosts
    Colin Dale
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Cell 126:453-65. 2006
    ..Furthermore, some symbionts use many of the same mechanisms as pathogens to infect hosts and evade immune responses. Here we discuss what is currently known about the interactions between bacterial symbionts and their hosts...
  69. pmc Horizontal transfer of bacterial symbionts: heritability and fitness effects in a novel aphid host
    Jacob A Russell
    Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology Labs, Harvard University, 26 Oxford St, Cambridge, MA 02138, USA
    Appl Environ Microbiol 71:7987-94. 2005
    ....
  70. ncbi request reprint 50 million years of genomic stasis in endosymbiotic bacteria
    Ivica Tamas
    Department of Molecular Evolution, Evolutionary Biology Center, University of Uppsala, Uppsala, Sweden
    Science 296:2376-9. 2002
    ..The genomic stasis of B. aphidicola, likely attributable to the loss of phages, repeated sequences, and recA, indicates that B. aphidicola is no longer a source of ecological innovation for its hosts...
  71. pmc Extensive proliferation of transposable elements in heritable bacterial symbionts
    Gordon R Plague
    Louis Calder Center, Fordham University, P O Box 887, Armonk, NY 10504, USA
    J Bacteriol 190:777-9. 2008
    ..Because multicopy elements can facilitate genomic recombination and deletion, this IS expansion may represent an early stage in the genomic reduction that is common in most ancient endosymbionts...
  72. ncbi request reprint A metagenomic survey of microbes in honey bee colony collapse disorder
    Diana L Cox-Foster
    Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA
    Science 318:283-7. 2007
    ..One organism, Israeli acute paralysis virus of bees, was strongly correlated with CCD...
  73. ncbi request reprint Co-cladogenesis spanning three phyla: leafhoppers (Insecta: Hemiptera: Cicadellidae) and their dual bacterial symbionts
    Daniela M Takiya
    Center for Biodiversity, Illinois Natural History Survey, 1816 S Oak Street, Champaign, IL 61820, USA
    Mol Ecol 15:4175-91. 2006
    ..Sulcia shows a fivefold lower rate of 16S rDNA sequence divergence than does Baumannia for the same host pairs. The term 'coprimary' symbiont is proposed for such cases...
  74. pmc Profile of Nancy A. Moran
    Nick Zagorski
    Proc Natl Acad Sci U S A 102:16916-8. 2005