Diarmuid M Moran
Affiliation: University of Chicago
- Puromycin-based vectors promote a ROS-dependent recruitment of PML to nuclear inclusions enriched with HSP70 and ProteasomesDiarmuid M Moran
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA
BMC Cell Biol 10:32. 2009..Previous studies reported that misfolded proteins or proteins containing polyglutamine tracts form aggregates with PML, chaperones, and components of the proteasome, supporting a role for PML in misfolded protein degradation...
- Nutlin-3a induces cytoskeletal rearrangement and inhibits the migration and invasion capacity of p53 wild-type cancer cellsDiarmuid M Moran
Rush University Medical Center, Department of Anatomy and Cell Biology, 1653 West Congress Parkway, Jelke 1306, Chicago, IL 60612, USA
Mol Cancer Ther 9:895-905. 2010..Mol Cancer Ther; 9(4); 895-905. (c)2010 AACR...
- Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cellsHong Shen
Department of Radiation Oncology, University of Chicago, Chicago, Illinois60637, USA
Cancer Res 68:8260-8. 2008..These findings have important implications regarding the use of Nutlin-3a in cancer therapy..