ANTOINETTE M MORAN

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth
    Antoinette Moran
    Deprtment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 28:1763-8. 2005
  2. doi request reprint Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55454, USA
    Circulation 117:2361-8. 2008
  3. pmc Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 32:1626-31. 2009
  4. pmc Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial
    Antoinette Moran
    University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 32:1783-8. 2009
  5. ncbi request reprint Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 87:4817-20. 2002
  6. ncbi request reprint Relation of leptin to insulin resistance syndrome in children
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical School, University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, USA
    Obes Res 11:1124-30. 2003
  7. ncbi request reprint Abnormal lipid concentrations in cystic fibrosis
    Veronica Figueroa
    Divisions of Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Am J Clin Nutr 75:1005-11. 2002
  8. ncbi request reprint Relation of birth weight to fasting insulin, insulin resistance, and body size in adolescence
    Maureen A Murtaugh
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 26:187-92. 2003
  9. pmc Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults
    Erin R Rademacher
    Department of Pediatrics, University of Rochester, New York 14642, USA
    J Hypertens 27:1766-74. 2009
  10. pmc Influence of waist on adiponectin and insulin sensitivity in adolescence
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 17:156-61. 2009

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth
    Antoinette Moran
    Deprtment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 28:1763-8. 2005
    ..Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth...
  2. doi request reprint Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55454, USA
    Circulation 117:2361-8. 2008
    ..Developmental changes in insulin resistance and cardiovascular risk were studied in youths 11 to 19 years of age...
  3. pmc Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 32:1626-31. 2009
    ..Current trends in CFRD prevalence, incidence, and mortality were determined from a comprehensive clinical database...
  4. pmc Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial
    Antoinette Moran
    University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 32:1783-8. 2009
    ..The Cystic Fibrosis Related Diabetes Therapy (CFRDT) Trial sought to determine whether diabetes therapy improves BMI in these patients...
  5. ncbi request reprint Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 87:4817-20. 2002
    ..04), whereas IGFBP-3 correlated positively with insulin resistance in boys (P = 0.0004) but not girls (P = 0.85). These data suggest that the GH/IGF-I axis is an important contributor to the insulin resistance of puberty...
  6. ncbi request reprint Relation of leptin to insulin resistance syndrome in children
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical School, University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, USA
    Obes Res 11:1124-30. 2003
    ..To examine the relation of leptin to insulin resistance, as measured by euglycemic insulin clamp, and insulin resistance syndrome factors in thin and heavy children...
  7. ncbi request reprint Abnormal lipid concentrations in cystic fibrosis
    Veronica Figueroa
    Divisions of Endocrinology, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Am J Clin Nutr 75:1005-11. 2002
    ..Concentrations of cholesterol and triacylglycerol are commonly believed to be low in persons with cystic fibrosis and thus not of concern...
  8. ncbi request reprint Relation of birth weight to fasting insulin, insulin resistance, and body size in adolescence
    Maureen A Murtaugh
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 26:187-92. 2003
    ..A relationship between birth weight and the insulin resistance syndrome has been reported in adults but has not been defined in adolescents...
  9. pmc Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults
    Erin R Rademacher
    Department of Pediatrics, University of Rochester, New York 14642, USA
    J Hypertens 27:1766-74. 2009
    ..Although childhood BMI and blood pressure (BP) track into adulthood, how they influence adult cardiovascular risk independent of each other is not well defined...
  10. pmc Influence of waist on adiponectin and insulin sensitivity in adolescence
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 17:156-61. 2009
    ..These results support the hypothesis that adiponectin may contribute to the association of waist and insulin sensitivity...
  11. doi request reprint Gender differences in vascular function and insulin sensitivity in young adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 120:153-60. 2011
    ..However, the lower EID observed in males could not be explained by artery diameter. Future studies need to continue to examine influence of gender on EID and other measures of vascular function...
  12. pmc Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents
    Erica M Holt
    Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, USA
    J Am Diet Assoc 109:414-21. 2009
    ..Markers of inflammation and oxidative stress are predictors of coronary heart disease risk; however, it is unknown whether these markers are related to dietary flavonoid and antioxidant intake in youth...
  13. doi request reprint Measurement of insulin sensitivity in children: comparison between the euglycemic-hyperinsulinemic clamp and surrogate measures
    Betsy Schwartz
    Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Diabetes Care 31:783-8. 2008
    ..e., homeostasis model assessment [HOMA], quantitative insulin sensitivity check index [QUICKI], and fasting glucose-to-insulin ratio [FGIR]) or triglycerides to the insulin clamp in a cohort of children/adolescents...
  14. ncbi request reprint Insulin regulation of free fatty acid kinetics in adult cystic fibrosis patients with impaired glucose tolerance
    Antoinette Moran
    Division of Endocrinology, Department of Pediatrics, University of Minnesota, MN 55455, USA
    Metabolism 53:1467-72. 2004
    ..This quantitative difference in lipolysis may account for inadequate insulin-induced suppression of hepatic glucose production in CF, and may be a metabolic adaptation to increased energy needs...
  15. ncbi request reprint Whole grain intake is associated with lower body mass and greater insulin sensitivity among adolescents
    Lyn M Steffen
    Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis 55454, USA
    Am J Epidemiol 158:243-50. 2003
    ..02). This relation was stronger among adolescents with higher BMIs (p = 0.001). Whole grain intake was associated with greater insulin sensitivity and lower BMI in adolescents, especially among the heaviest persons...
  16. ncbi request reprint Diagnosis, screening, and management of cystic fibrosis-related diabetes
    Antoinette Moran
    Department of Pediatrics MMC 404, University of Minnesota, 516 Delaware Street, Minneapolis, MN 55455, USA
    Curr Diab Rep 2:111-5. 2002
    ..This article reviews those recommendations, and presents a practical approach to the management of CFRD...
  17. ncbi request reprint Relation of insulin resistance and body composition to left ventricular mass in children
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical School, MMC 94, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Cardiol 90:1177-80. 2002
  18. ncbi request reprint Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence
    Alan R Sinaiko
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Box 491 UMHC, Minneapolis, MN 55455, USA
    Circulation 111:1985-91. 2005
    ..This study assessed the relation of fatness and insulin resistance and their interaction with cardiovascular risk factors, inflammatory factors, and oxidative stress in thin and heavy adolescents...
  19. ncbi request reprint Relation of insulin resistance to blood pressure in childhood
    Alan R Sinaiko
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Hypertens 20:509-17. 2002
    ..To determine the relation between blood pressure and insulin resistance in children and the differences between fasting insulin and the insulin clamp in that relation...
  20. doi request reprint Predicting islet yield in pediatric patients undergoing pancreatectomy and autoislet transplantation for chronic pancreatitis
    Melena D Bellin
    Department of Pediatrics, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
    Pediatr Diabetes 11:227-34. 2010
    ..Currently there is no known method to predict islet yield in a given patient. We assessed the ability of preoperative metabolic tests to predict islet yields in 10 children undergoing TP/IAT...
  21. doi request reprint Recent trends in cystic fibrosis-related diabetes
    Brandon M Nathan
    Divisions of Pediatric Endocrinology, University of Minnesota, Minneapolis, Minnesota, USA
    Curr Opin Endocrinol Diabetes Obes 17:335-41. 2010
    ..To provide an updated literature review highlighting important aspects of cystic fibrosis-related diabetes (CFRD) including epidemiology, pathogenesis, complications, screening, and management...
  22. pmc Circulating activated endothelial cells in pediatric obesity
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Pediatr 157:547-51. 2010
    ..We characterized the state of the vascular endothelium in pediatric obesity by comparing circulating endothelial cell (CEC) number and activation phenotype in severely obese children to that of normal weight, overweight, and obese children...
  23. ncbi request reprint Glargine versus NPH insulin in cystic fibrosis related diabetes
    Patricia Grover
    Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, MN 55454, United States
    J Cyst Fibros 7:134-6. 2008
    ..We hypothesized that insulin glargine would improve blood glucose control and weight in patients with CFRD without causing hypoglycemia...
  24. pmc The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Suite 300, Minneapolis, MN 55454 1015, USA
    Hum Genet 125:21-8. 2009
    ..There are several other variants in ADIPOQ, ADIPOR1, and ADIPOR2 that may influence insulin sensitivity and these variants should be further investigated in other populations...
  25. doi request reprint Outcome after pancreatectomy and islet autotransplantation in a pediatric population
    Melena D Bellin
    Department of Pediatrics, Division of Endocrinology, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55455, USA
    J Pediatr Gastroenterol Nutr 47:37-44. 2008
    ..In this study, we document pain control and metabolic course after this procedure in a pediatric population...
  26. ncbi request reprint Diabetes is associated with dramatically decreased survival in female but not male subjects with cystic fibrosis
    Carlos E Milla
    Department of Pediatrics, MMC 742, Minnesota Cystic Fibrosis Center, University of Minnesota, 420 Delaware St WE, Minneapolis, Minnesota 55455, USA
    Diabetes Care 28:2141-4. 2005
    ..Survival analysis was performed on a prospectively followed cohort of patients with cystic fibrosis (CF) to determine the impact of the development of diabetes on survival...
  27. ncbi request reprint Relation of increase in adiposity to increase in left ventricular mass from childhood to young adulthood
    Shanthi Sivanandam
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Am J Cardiol 98:411-5. 2006
    ....
  28. ncbi request reprint Influence of insulin resistance and body mass index at age 13 on systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19
    Alan R Sinaiko
    Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minn 55455, USA
    Hypertension 48:730-6. 2006
    ..These results show an effect for insulin resistance that is independent of BMI, consistent with the hypothesis that reducing insulin resistance, in addition to weight, may be needed to reduce the prevalence of cardiovascular risk...
  29. ncbi request reprint Microvascular complications in cystic fibrosis-related diabetes
    Sarah Jane Schwarzenberg
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 30:1056-61. 2007
    ..The incidence of cystic fibrosis-related diabetes (CFRD) and the prevalence of diabetic microvascular complications were determined at the University of Minnesota...
  30. doi request reprint Metabolic complications of obesity in childhood and adolescence: more than just diabetes
    Brandon M Nathan
    Division of Pediatric Endocrinology, University of Minnesota, Minneapolis 55455, USA
    Curr Opin Endocrinol Diabetes Obes 15:21-9. 2008
    ..This review summarizes recent literature on detection, pathophysiology, and potential intervention strategies for the metabolic derangements encountered in the overweight pediatric population...
  31. ncbi request reprint Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome
    James S Pankow
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 27:775-80. 2004
    ..To evaluate whether children of parents with the insulin resistance syndrome (IRS) themselves have greater insulin resistance and unfavorable patterns of cardiovascular disease (CVD) risk factors...
  32. doi request reprint Similar islet function in islet allotransplant and autotransplant recipients, despite lower islet mass in autotransplants
    Melena D Bellin
    Division of Endocrinology and Diabetes, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 91:367-72. 2011
    ..In contrast, islet autografts, infused at the time of pancreatectomy for chronic pancreatitis, are not subject to these variables. Islet function was compared in autograft and allograft recipients...
  33. pmc Relation of circulating oxidized LDL to obesity and insulin resistance in children
    Aaron S Kelly
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Pediatr Diabetes 11:552-5. 2010
    ..The purpose of this study was to assess the relation of oxidative stress, measured by circulating oxidized LDL, with measures of adiposity and insulin resistance in children...
  34. pmc First phase insulin release and glucose tolerance in children with Fanconi anemia after hematopoietic cell transplantation
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 53:191-6. 2009
    ..Fanconi anemia (FA) is an autosomal and X-linked recessive disease of chromosomal instability, which results in bone marrow failure. Children with FA have been shown to have an increased risk of diabetes mellitus (DM)...
  35. doi request reprint Correlation of pancreatic histopathologic findings and islet yield in children with chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation
    Takashi Kobayashi
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Pancreas 39:57-63. 2010
    ..Our goal was to correlate the islet yield with the histopathologic findings and the clinical parameters in pediatric (age, <19 years) CP patients undergoing TP-IAT...
  36. ncbi request reprint Insulin glargine improves hemoglobin A1c in children and adolescents with poorly controlled type 1 diabetes
    Anne Jackson
    Department of Pediatrics, University of Minnesota, 516 Delaware St SE, Mpls, MN 55455, USA
    Pediatr Diabetes 4:64-9. 2003
    ..0% to insulin glargine in an effort to improve glycemic control. Retrospective chart analysis was performed on 37 patients 6 months after the switch to insulin glargine therapy...
  37. ncbi request reprint Endocrine complications of cystic fibrosis
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
    Adolesc Med 13:145-59, vii-viii. 2002
    ..This chapter discusses pathophysiology, screening, and treatment of endocrine complications of CF...
  38. pmc Impaired fasting glucose in cystic fibrosis
    Brigitte I Frohnert
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 33:2660-4. 2010
    ..While glucose tolerance abnormalities are common in cystic fibrosis (CF), impaired fasting glucose (IFG) has scarcely been explored. No studies have examined the relation between IFG and clinical status...
  39. pmc Microalbuminuria in patients with cystic fibrosis
    Melanie Lind-Ayres
    Department of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Diabetes Care 34:1526-8. 2011
    ..We investigated transient (TMA) and persistent (PMA) microalbuminuria in CF patients to resolve these contradictory findings...

Research Grants8

  1. Diabetes Therapy to Improve BMI and Lung Function in CF
    Antoinette Moran; Fiscal Year: 2005
    ..The question of whether these patients should receive diabetes therapy was given the highest priority for future research funding at a national consensus conference on CFRD ..
  2. Pre-Faculty Research Training in Pediatric Endocrinology
    Antoinette Moran; Fiscal Year: 2007
    ..The historic strengths of this institution and its programs afford trainees an exceptionally diverse and high quality educational experience ..
  3. Type 1 Diabetes-A Proposal for Prevention & Intervention
    Antoinette Moran; Fiscal Year: 2007
    ..abstract_text> ..