Janet Moradian-Oldak

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Assembly of amelogenin proteolytic products and control of octacalcium phosphate crystal morphology
    J Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Connect Tissue Res 44:58-64. 2003
  2. ncbi request reprint Amelogenin supra-molecular assembly in vitro compared with the architecture of the forming enamel matrix
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, Calif 90033, USA
    Cells Tissues Organs 181:202-18. 2005
  3. ncbi request reprint On the formation of amelogenin microribbons
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Eur J Oral Sci 114:289-96; discussion 327-9, 382. 2006
  4. pmc Protein-mediated enamel mineralization
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Front Biosci 17:1996-2023. 2012
  5. ncbi request reprint The emergence of "nanospheres" as basic structural components adopted by amelogenin
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA Room 103, Los Angeles, CA 90033, USA
    J Dent Res 86:487-90. 2007
  6. pmc Amelogenin-enamelin association in phosphate-buffered saline
    Xiudong Yang
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Eur J Oral Sci 119:351-6. 2011
  7. ncbi request reprint Supramolecular assembly of amelogenin nanospheres into birefringent microribbons
    Chang Du
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Science 307:1450-4. 2005
  8. ncbi request reprint In vitro study on the interaction between the 32 kDa enamelin and amelogenin
    Daming Fan
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street CSA 103, Los Angeles, CA 90033, USA
    J Struct Biol 166:88-94. 2009
  9. pmc The role of secondary structure in the entropically driven amelogenin self-assembly
    Rajamani Lakshminarayanan
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles, California 90033, USA
    Biophys J 93:3664-74. 2007
  10. pmc Dissecting amelogenin protein nanospheres: characterization of metastable oligomers
    Keith M Bromley
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 286:34643-53. 2011

Research Grants

  1. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET M OLDAK; Fiscal Year: 2010
  2. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2009
  3. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2009
  4. ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATION
    JANET OLDAK; Fiscal Year: 2007
  5. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
  6. MATRIX-BASED MINERAL (MBM) ENAMEL BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2004
  7. AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTH
    JANET OLDAK; Fiscal Year: 2002
  8. INTRINSICALLY DISORDERED PROTEINS IN BIOMINERALIZATION
    JANET M OLDAK; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Assembly of amelogenin proteolytic products and control of octacalcium phosphate crystal morphology
    J Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Connect Tissue Res 44:58-64. 2003
    ..This remarkable finding indicates that the observed modulation effect by amelogenin on OCP crystal morphology is not due to alteration of calcium diffusion into the gels but is the result of direct amelogenin-mineral interactions...
  2. ncbi request reprint Amelogenin supra-molecular assembly in vitro compared with the architecture of the forming enamel matrix
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, Calif 90033, USA
    Cells Tissues Organs 181:202-18. 2005
    ....
  3. ncbi request reprint On the formation of amelogenin microribbons
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Eur J Oral Sci 114:289-96; discussion 327-9, 382. 2006
    ....
  4. pmc Protein-mediated enamel mineralization
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Front Biosci 17:1996-2023. 2012
    ..The chapter will conclude by discussing the potential of enamel for regrowth...
  5. ncbi request reprint The emergence of "nanospheres" as basic structural components adopted by amelogenin
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA Room 103, Los Angeles, CA 90033, USA
    J Dent Res 86:487-90. 2007
  6. pmc Amelogenin-enamelin association in phosphate-buffered saline
    Xiudong Yang
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Eur J Oral Sci 119:351-6. 2011
    ..Our study provides novel insights into understanding the possible cooperation between enamelin and amelogenin in macromolecular co-assembly and in controlling enamel mineral formation...
  7. ncbi request reprint Supramolecular assembly of amelogenin nanospheres into birefringent microribbons
    Chang Du
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Science 307:1450-4. 2005
    ....
  8. ncbi request reprint In vitro study on the interaction between the 32 kDa enamelin and amelogenin
    Daming Fan
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street CSA 103, Los Angeles, CA 90033, USA
    J Struct Biol 166:88-94. 2009
    ..Our current studies provide novel insights into understanding possible cooperation between enamelin and amelogenin in macromolecular self-assembly and in controlling enamel mineral formation...
  9. pmc The role of secondary structure in the entropically driven amelogenin self-assembly
    Rajamani Lakshminarayanan
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles, California 90033, USA
    Biophys J 93:3664-74. 2007
    ..The data are direct evidence for the notion that hydrophobic interactions are the main driving force for amelogenin self-assembly...
  10. pmc Dissecting amelogenin protein nanospheres: characterization of metastable oligomers
    Keith M Bromley
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 286:34643-53. 2011
    ..We further suggest that oligomeric structures might be functional components during maturation of enamel apatite...
  11. pmc Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T point mutations
    Keith M Bromley
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA
    Cells Tissues Organs 194:284-90. 2011
    ..e. premature aggregation) of mutant amelogenins may have a profound effect on intra- and extracellular processes such as amelogenin secretion, proteolysis, and its interactions with nonamelogenins as well as with the forming mineral...
  12. pmc The cooperation of enamelin and amelogenin in controlling octacalcium phosphate crystal morphology
    Daming Fan
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA
    Cells Tissues Organs 194:194-8. 2011
    ..5 in PBS buffer. Our present study provides novel insights into the possible cooperation between enamelin and amelogenin in macromolecular coassembly and in controlling enamel mineral formation...
  13. pmc The 32kDa enamelin undergoes conformational transitions upon calcium binding
    Daming Fan
    University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street CSA 103, Los Angeles, CA 90033, USA
    J Struct Biol 163:109-15. 2008
    ..Our current biophysical studies on the 32 kDa enamelin structure provide novel insights towards understanding the enamelin-mineral interaction and subsequently the functions of enamelin during enamel formation...
  14. pmc Enamel inspired nanocomposite fabrication through amelogenin supramolecular assembly
    Yuwei Fan
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Biomaterials 28:3034-42. 2007
    ....
  15. pmc Immunogold labeling of amelogenin in developing porcine enamel revealed by field emission scanning electron microscopy
    Chang Du
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, Calif 90033, USA
    Cells Tissues Organs 189:207-11. 2009
    ..The preferential localization of amelogenin in vivo on enamel crystals strongly supports its direct function in controlling crystal morphology...
  16. pmc Controlled remineralization of enamel in the presence of amelogenin and fluoride
    Yuwei Fan
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, HSC, Los Angeles, CA 90033, USA
    Biomaterials 30:478-83. 2009
    ..Biomimetic synthesis of the amelogenin fluoridated hydroxyapatite nano-composite is one of the primary steps towards the development and design of novel biomaterial for future application in reparative and restorative dentistry...
  17. ncbi request reprint Assembly and processing of an engineered amelogenin proteolytic product (rP148)
    Zhi Sun
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Eur J Oral Sci 114:59-63; discussion 93-5, 379-80. 2006
    ..We further demonstrate that MMP-20 digests rP148 in a manner that generates a similar proteolytic pattern, as would be expected to occur in vivo...
  18. pmc Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin
    Rodrigo S Lacruz
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e18028. 2011
    ..We speculate that increased AMEL nanosphere size may influence enamel formation in strepsirrhine primates...
  19. pmc Amelogenin "nanorods" formation during proteolysis by Mmp-20
    Xiudong Yang
    Center for Craniofacial Molecular Biology, University of Southern California, Herman Ostrow School of Dentistry, 2250 Alcazar St, Los Angeles, CA 90033, USA
    J Struct Biol 176:220-8. 2011
    ....
  20. pmc Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins
    Rajamani Lakshminarayanan
    Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, California 90033, USA
    J Biol Chem 285:40593-603. 2010
    ..Therefore, we propose that, like a number of other human diseases, AI appears to be due to the destabilization of the secondary structure as a result of amelogenin mutations...
  21. ncbi request reprint Tissue engineering strategies for the future generation of dental implants
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California, USA
    Periodontol 2000 41:157-76. 2006
  22. pmc Analysis of secondary structure and self-assembly of amelogenin by variable temperature circular dichroism and isothermal titration calorimetry
    Rajamani Lakshminarayanan
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, 90033, USA
    Proteins 76:560-9. 2009
    ..We conclude that the assembly properties of amelogenin are due to complementarity between the hydrophobic and PPII helix prone regions...
  23. ncbi request reprint Analysis of self-assembly and apatite binding properties of amelogenin proteins lacking the hydrophilic C-terminal
    Janet Moradian-Oldak
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Matrix Biol 21:197-205. 2002
    ..These structure-functional analyses suggest that the hydrophilic carboxy-terminal plays critical functional roles in mineralization of enamel and that the lack of this segment causes abnormal mineralization...
  24. doi request reprint Tooth regeneration: challenges and opportunities for biomedical material research
    Chang Du
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Biomed Mater 1:R10-7. 2006
    ..The current practices in tooth tissue engineering approaches and applications of biomimetic carriers or scaffolds are also discussed...
  25. pmc Localization and quantitative co-localization of enamelin with amelogenin
    Victoria Gallon
    Center for Craniofacial Molecular Biology, University of Southern California, Herman Ostrow School of Dentistry, Los Angeles, CA 90033, USA
    J Struct Biol 183:239-49. 2013
    ....
  26. pmc An amelogenin-chitosan matrix promotes assembly of an enamel-like layer with a dense interface
    Qichao Ruan
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Acta Biomater 9:7289-97. 2013
    ..Our studies introduce an amelogenin-containing chitosan hydrogel as a promising biomaterial for enamel repair and demonstrate the potential of applying protein-directed assembly to biomimetic reconstruction of complex biomaterials...

Research Grants18

  1. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET M OLDAK; Fiscal Year: 2010
    ..Moreover, this study will have a significant impact on the field of biomineralization, molecular self-assembly, protein structure, and understanding of pathological enamel formation. ..
  2. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2009
    ..Moreover, this study will have a significant impact on the field of biomineralization, molecular self-assembly, protein structure, and understanding of pathological enamel formation. ..
  3. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2009
    ..Moreover, this study will have a significant impact on the field of biomineralization, molecular self-assembly, protein structure, and understanding of pathological enamel formation. ..
  4. ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATION
    JANET OLDAK; Fiscal Year: 2007
    ..abstract_text> ..
  5. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  6. MATRIX-BASED MINERAL (MBM) ENAMEL BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2004
    ....
  7. AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTH
    JANET OLDAK; Fiscal Year: 2002
    ....
  8. INTRINSICALLY DISORDERED PROTEINS IN BIOMINERALIZATION
    JANET M OLDAK; Fiscal Year: 2010
    ..The outcomes of our study will therefore have the potential to improve treatments for repair and regeneration of oral, dental and craniofacial tissues. ..