Maria Morabito

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons
    Maria A Morabito
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:865-76. 2004
  2. ncbi Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene
    Holger Patzke
    Department of Pathology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:2769-78. 2003
  3. ncbi The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner
    Rani Dhavan
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:7879-91. 2002
  4. ncbi Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors
    Shuo Zhang
    University of Massachusetts Medical School, Department of Cell Biology, Waltham, Massachusetts 02452, USA
    J Neurosci 28:415-24. 2008

Research Grants

  1. Regulation of synapses by cdk5-dependent phosphorylation
    Maria Morabito; Fiscal Year: 2007

Collaborators

  • Li Huei Tsai
  • Morgan H Sheng
  • Shuo Zhang
  • Holger Patzke
  • Rani Dhavan
  • June Liu
  • James E Crandall
  • Lambert Edelmann
  • Upendra Maddineni
  • Ramses Ayala
  • Michael K Ahlijanian
  • Janet Volker
  • Pieter Dikkes
  • Paul L Greer
  • Lianna R Orlando

Detail Information

Publications4

  1. ncbi Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons
    Maria A Morabito
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:865-76. 2004
    ....
  2. ncbi Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene
    Holger Patzke
    Department of Pathology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:2769-78. 2003
    ..Our results show that p25 can substitute for p35/Cdk5 under certain circumstances during development. In addition, they suggest that p25 may have lost some functions of p35...
  3. ncbi The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner
    Rani Dhavan
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:7879-91. 2002
    ....
  4. ncbi Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors
    Shuo Zhang
    University of Massachusetts Medical School, Department of Cell Biology, Waltham, Massachusetts 02452, USA
    J Neurosci 28:415-24. 2008
    ..This study provides a novel molecular mechanism for the regulation of the surface expression of NR2B-containing NMDA receptors and gives insight into the Cdk5-dependent regulation of synaptic plasticity...

Research Grants5

  1. Regulation of synapses by cdk5-dependent phosphorylation
    Maria Morabito; Fiscal Year: 2007
    ..These results will be relevant to neurodegenerative and psychiatric disorders associated with synaptic dysfunction, such as Alzheimer's, Huntington's, and schizophrenia. ..