Nathaniel J Moorman
Affiliation: University of North Carolina
Lenarcic E, Ziehr B, Moorman N. An unbiased proteomics approach to identify human cytomegalovirus RNA-associated proteins. Virology. 2015;481:13-23 pubmed publisher
Ziehr B, Vincent H, Moorman N. Human Cytomegalovirus pTRS1 and pIRS1 Antagonize Protein Kinase R To Facilitate Virus Replication. J Virol. 2016;90:3839-3848 pubmed publisher
..Our results suggest that inhibiting pTRS1 and pIRS1 function or restoring PKR activity during infection may be a successful strategy to limit HCMV disease. ..
Vincent H, Ziehr B, Moorman N. Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation. Viruses. 2016;8:97 pubmed publisher
..Here we review key regulatory steps in mRNA translation, and the strategies used by HCMV to maintain protein synthesis in infected cells. ..
Arend K, Lenarcic E, Moorman N. The 5' Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication. J Virol. 2018;92: pubmed publisher
..These translational regulatory events could potentially be targeted by novel antiviral therapeutics that limit IE1 and IE2 mRNA translation and thus inhibit lytic replication or prevent HCMV reactivation. ..
Ziehr B, Lenarcic E, Cecil C, Moorman N. The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication. Virology. 2016;489:194-201 pubmed publisher
..Our results demonstrate that eIF4AIII is required for efficient HCMV replication, and suggest that eIF4A family helicases may be a new class of targets for the development of host-directed antiviral therapeutics. ..
Arend K, Ziehr B, Vincent H, Moorman N. Multiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection. J Virol. 2016;90:8855-65 pubmed publisher
..Our results suggest that alternative promoters may allow for IE1 and IE2 expression when MIEP activity is limiting, as occurs in latently infected cells. ..
Vincent H, Ziehr B, Moorman N. Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1. J Virol. 2017;91: pubmed publisher
..This study furthered our understanding of how HCMV evades inhibition by PKR and identified new strategies for how PKR activity might be restored during infection to limit HCMV disease. ..
Arend K, Lenarcic E, Vincent H, Rashid N, Lazear E, McDonald I, et al
. Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals. Mol Cell Proteomics. 2017;16:S263-S276 pubmed publisher
..These results show the utility of MIB-MS kinome profiling for identifying existing kinase inhibitors that can potentially be repurposed as novel antiviral drugs. ..
Sanders W, Long K, Rivera B, Vincent H, Heise M, Rodriguez Orengo J, et al
. Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico. Genome Announc. 2017;5: pubmed publisher
..The results show that currently circulating chikungunya strains in Puerto Rico are closely related. ..