Patrick S Moore

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The conundrum of causality in tumor virology: the cases of KSHV and MCV
    Patrick S Moore
    Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, United States Electronic address
    Semin Cancer Biol 26:4-12. 2014
  2. pmc Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus
    Xi Liu
    Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:17079-90. 2011
  3. pmc Why do viruses cause cancer? Highlights of the first century of human tumour virology
    Patrick S Moore
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Cancer 10:878-89. 2010
  4. pmc Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin?
    Patrick S Moore
    Molecular Virology Program, Hillman Cancer Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Annu Rev Microbiol 57:609-39. 2003
  5. pmc Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
    Roland Houben
    Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Virol 84:7064-72. 2010
  6. doi request reprint Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
  7. pmc Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
    Masahiro Shuda
    Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 121:3623-34. 2011
  8. pmc Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
  9. pmc Cellular and viral factors regulating Merkel cell polyomavirus replication
    Huichen Feng
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22468. 2011
  10. pmc T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 105:16272-7. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The conundrum of causality in tumor virology: the cases of KSHV and MCV
    Patrick S Moore
    Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, United States Electronic address
    Semin Cancer Biol 26:4-12. 2014
    ..These two viruses reveal some of the challenges and opportunities for inferring viral cancer causation in the age of molecular biology. ..
  2. pmc Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus
    Xi Liu
    Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:17079-90. 2011
    ..MCV has evolved a novel mechanism to target hVam6p that may contribute to viral uncoating or egress through lysosomal processing during virus replication...
  3. pmc Why do viruses cause cancer? Highlights of the first century of human tumour virology
    Patrick S Moore
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Cancer 10:878-89. 2010
    ..This Timeline article describes common features of human tumour viruses and discusses how new technologies can be used to identify infectious causes of cancer...
  4. pmc Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin?
    Patrick S Moore
    Molecular Virology Program, Hillman Cancer Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Annu Rev Microbiol 57:609-39. 2003
    ..The immune evasion strategies employed by KSHV, by targeting tumor suppressor pathways activated during immune system signaling, may lead to inadvertent cell proliferation and tumorigenesis in susceptible hosts...
  5. pmc Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
    Roland Houben
    Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Virol 84:7064-72. 2010
    ..Our study provides the first direct experimental evidence that TA expression is necessary for the maintenance of MCV-positive MCC and that MCV is the infectious cause of MCV-positive MCC...
  6. doi request reprint Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  7. pmc Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
    Masahiro Shuda
    Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 121:3623-34. 2011
    ..Thus, MCV sT is an oncoprotein, and its effects on dysregulated cap-dependent translation have clinical implications for the prevention, diagnosis, and treatment of MCV-related cancers...
  8. pmc Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
    ..Our study demonstrates that MCV is a widespread but previously unrecognized human infection...
  9. pmc Cellular and viral factors regulating Merkel cell polyomavirus replication
    Huichen Feng
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22468. 2011
    ..MCV-HF is a molecular clone that can be readily manipulated to investigate factors affecting MCV replication...
  10. pmc T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 105:16272-7. 2008
    ..Because these mutations render the virus replication-incompetent, MCV is not a "passenger virus" that secondarily infects MCC tumors...
  11. pmc The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication
    Hyun Jin Kwun
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Virol 83:12118-28. 2009
    ..The MCV origin provides a novel model for eukaryotic replication from a defined DNA element and illustrates the selective pressure within tumors to abrogate independent MCV replication...
  12. pmc Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice
    Anna Guastafierro
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Virol Methods 187:6-14. 2013
    ..Hence, MS-1 is an early passage cell line that provides a useful in vitro model to characterize MCV-positive MCC...
  13. pmc Survivin is a therapeutic target in Merkel cell carcinoma
    Reety Arora
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Sci Transl Med 4:133ra56. 2012
    ..Identifying the cellular pathways, such as those involving survivin, that are targeted by tumor viruses can lead to rapid and rational identification of drug candidates for treating virus-induced cancers...
  14. pmc Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7
    Hyun Jin Kwun
    Cancer Virology Program, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cell Host Microbe 14:125-35. 2013
    ..Thus, MCV has evolved a regulatory system involving SCF(Fbw7) that controls viral replication but also contributes to host cell transformation. ..
  15. pmc Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiation
    Tuna Toptan
    Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Virol 87:2744-55. 2013
    ..KSHV overcomes its limited genetic coding capacity by generating alternatively initiated protein isoforms that may have distinct biological functions...
  16. pmc Asymptomatic primary Merkel cell polyomavirus infection among adults
    Yanis L Tolstov
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 17:1371-80. 2011
    ..In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations...
  17. pmc Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection
    A Scott Laney
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Research Pavilion Suite 1 8, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 44:3734-41. 2006
    ....
  18. pmc Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor
    Lindsay R Dresang
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e80543. 2013
    ..These results suggest that survivin targeting is a promising therapeutic approach for most but not all MCV-positive MCCs. ..
  19. pmc Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells
    Adriana Forero
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 191:1476-85. 2013
    ..Taken together, these results suggest a dual role for IRF4 in regulating ISG induction and KSHV lytic reactivation in primary effusion lymphoma cells. ..
  20. pmc A sensitive non-radioactive northern blot method to detect small RNAs
    Sang Woo Kim
    Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Nucleic Acids Res 38:e98. 2010
    ..A detailed protocol of LED is provided in the Supplementary Data...
  21. pmc Transcriptional analysis of latent and inducible Kaposi's sarcoma-associated herpesvirus transcripts in the K4 to K7 region
    Jennifer L Taylor
    Hillman Cancer Center, Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    J Virol 79:15099-106. 2005
    ..This alternatively spliced transcript may contribute to KSHV adaptive immune evasion during latent infection. Other transcripts are inducible, including a 6.1-kb transcript that is the largest transcript found in the KSHV genome to date...
  22. pmc Merkel cell carcinoma: a virus-induced human cancer
    Yuan Chang
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Pathol 7:123-44. 2012
    ..Identification of this tumor virus has led to new opportunities for early diagnosis and targeted treatment of MCC...
  23. pmc Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Virol 81:11332-40. 2007
    ..It provides, for the first time, quantitative evidence against some classes of viral etiology when no viral transcripts are found, thereby reducing the uncertainty involved in new pathogen discovery...
  24. pmc Characterization of viral and human RNAs smaller than canonical MicroRNAs
    Zhihua Li
    Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Virol 83:12751-8. 2009
    ..We postulate that approximately 30% of usRNAs could have evolved to participate in biological processes, including gene silencing...
  25. pmc MCV and Merkel cell carcinoma: a molecular success story
    Reety Arora
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States
    Curr Opin Virol 2:489-98. 2012
    ..In four years, the cause, diagnosis and therapy for an intractable cancer has been changed due to the molecular discovery of MCV...
  26. pmc The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation
    Hyun Jin Kwun
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Virology 412:357-65. 2011
    ..Although LANA1 and EBV EBNA1 are functionally similar, they appear to use different mechanisms to evade host cytotoxic T lymphocyte surveillance...
  27. pmc Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs
    Zhihua Li
    School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nucleic Acids Res 40:6787-99. 2012
    ..We suggest that endogenous 3' tRFs have a role in regulating the unwarranted expression of endogenous viruses through the RNA interference pathway...
  28. pmc Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
    ..Thus, MCV may be a contributing factor in the pathogenesis of MCC...
  29. pmc Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing
    Hyun Jin Kwun
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Virol 81:8225-35. 2007
    ..Simple strategies to eliminate these viral inhibitory regions may markedly improve vaccine effectiveness by maximizing CTL responses...
  30. ncbi request reprint Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension
    A Scott Laney
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Chest 127:762-7. 2005
    ..We conducted a case-control study of patients with PPH and pulmonary hypertension (PH) associated with other disorders (secondary PH) to look for evidence of KSHV infection...
  31. pmc Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes
    Lindsay R Dresang
    Cancer Virology Program, University of Pittsburgh Cancer Institute Hillman Cancer Research Pavilion 5117 Centre Ave, Pittsburgh, PA 15213 USA
    BMC Genomics 12:625. 2011
    ....
  32. ncbi request reprint Seroprevalence of Kaposi's sarcoma-associated herpesvirus in various populations in Cuba
    Vivian Kouri
    Institute of Tropical Medicine, Virology Department, Havana, Cuba
    Rev Panam Salud Publica 15:320-5. 2004
    ..Little is known about the prevalence and distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) infection in the Caribbean. The aim of this study was to determine rates of KSHV seropositivity in various populations in Cuba...
  33. ncbi request reprint Transmission of human herpesvirus 8 by blood transfusion
    Patrick S Moore
    N Engl J Med 356:88; author reply 89. 2007
  34. ncbi request reprint Transplanting cancer: donor-cell transmission of Kaposi sarcoma
    Patrick S Moore
    Nat Med 9:506-8. 2003
  35. ncbi request reprint Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells
    Massimo Donadelli
    Department of Neurological and Vision Sciences, Universita di Verona, Verona, Italy
    Mol Carcinog 38:59-69. 2003
    ..These findings suggest that inhibitors of HDAC may represent a novel therapeutic strategy for treatment of pancreatic cancer...
  36. ncbi request reprint Viral IL-6-induced cell proliferation and immune evasion of interferon activity
    Malini Chatterjee
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Science 298:1432-5. 2002
    ..Viral IL-6 bypasses the gp80 regulatory checkpoint by binding directly to the gp130 transducer molecule, resulting in tumor cell autocrine dependence on the viral cytokine for proliferation and survival...

Research Grants13

  1. Emerging Technologies Applied to the Discovery of Human Tumor Viruses
    Patrick Moore; Fiscal Year: 2007
    ..This also completes development of DTS technology, allowing us to fully optimize its performance for application to other suspected infectious tumors ASSESSMENT: ..
  2. Protein Biomarkers for a New Human Polyomavirus in AIDS-related Malignancies
    Patrick S Moore; Fiscal Year: 2010
    ..These are required to understand human infection with this virus and to develop effective vaccines and drugs against MCPyV. ..
  3. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick S Moore; Fiscal Year: 2010
    ..Finally, we seek to generate a model system for MCV tumorigenesis that will be useful for drug screening and prevention. ..
  4. Protein Biomarkers for a New Human Polyomavirus in AIDS-related Malignancies
    Patrick Moore; Fiscal Year: 2009
    ..These are required to understand human infection with this virus and to develop effective vaccines and drugs against MCPyV. ..
  5. Enhanced Cell-mediated Immunogenicity of KSHV LANA1 Protein
    Patrick Moore; Fiscal Year: 2009
    ..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..
  6. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick Moore; Fiscal Year: 2009
    ..Finally, we seek to generate a model system for MCV tumorigenesis that will be useful for drug screening and prevention. ..
  7. Enhanced Cell-mediated Immunogenicity of KSHV LANA1 Protein
    Patrick Moore; Fiscal Year: 2007
    ..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..
  8. Enhanced Cell-mediated Immunogenicity of KSHV LANA1 Protein
    Patrick Moore; Fiscal Year: 2006
    ..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..
  9. Enhanced Cell-mediated Immunogenicity of KSHV LANA1 Protein
    Patrick S Moore; Fiscal Year: 2010
    ..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..