Research Topics
Genomes and Genes | Patrick S MooreSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Why do viruses cause cancer? Highlights of the first century of human tumour virologyPatrick S Moore
Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Nat Rev Cancer 10:878-89. 2010..This Timeline article describes common features of human tumour viruses and discusses how new technologies can be used to identify infectious causes of cancer...
Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin?Patrick S Moore
Molecular Virology Program, Hillman Cancer Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
Annu Rev Microbiol 57:609-39. 2003..The immune evasion strategies employed by KSHV, by targeting tumor suppressor pathways activated during immune system signaling, may lead to inadvertent cell proliferation and tumorigenesis in susceptible hosts...
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigensRoland Houben
Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
J Virol 84:7064-72. 2010..Our study provides the first direct experimental evidence that TA expression is necessary for the maintenance of MCV-positive MCC and that MCV is the infectious cause of MCV-positive MCC...- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumorsMasahiro Shuda
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Int J Cancer 125:1243-9. 2009..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV... - Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulatorMasahiro Shuda
Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA
J Clin Invest 121:3623-34. 2011..Thus, MCV sT is an oncoprotein, and its effects on dysregulated cap-dependent translation have clinical implications for the prevention, diagnosis, and treatment of MCV-related cancers... - Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassaysYanis L Tolstov
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Int J Cancer 125:1250-6. 2009..Our study demonstrates that MCV is a widespread but previously unrecognized human infection... - Cellular and viral factors regulating Merkel cell polyomavirus replicationHuichen Feng
Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e22468. 2011..MCV-HF is a molecular clone that can be readily manipulated to investigate factors affecting MCV replication... - Survivin is a therapeutic target in Merkel cell carcinomaReety Arora
Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Sci Transl Med 4:133ra56. 2012..Identifying the cellular pathways, such as those involving survivin, that are targeted by tumor viruses can lead to rapid and rational identification of drug candidates for treating virus-induced cancers... - T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusMasahiro Shuda
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 105:16272-7. 2008..Because these mutations render the virus replication-incompetent, MCV is not a "passenger virus" that secondarily infects MCC tumors... - Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiationTuna Toptan
Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Virol 87:2744-55. 2013..KSHV overcomes its limited genetic coding capacity by generating alternatively initiated protein isoforms that may have distinct biological functions... - The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replicationHyun Jin Kwun
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Virol 83:12118-28. 2009..The MCV origin provides a novel model for eukaryotic replication from a defined DNA element and illustrates the selective pressure within tumors to abrogate independent MCV replication... - Asymptomatic primary Merkel cell polyomavirus infection among adultsYanis L Tolstov
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Emerg Infect Dis 17:1371-80. 2011..In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations... - Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infectionA Scott Laney
Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Research Pavilion Suite 1.8, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
J Clin Microbiol 44:3734-41. 2006.... - Transcriptional analysis of latent and inducible Kaposi's sarcoma-associated herpesvirus transcripts in the K4 to K7 regionJennifer L Taylor
Hillman Cancer Center, Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite 1.8, Pittsburgh, PA 15213, USA
J Virol 79:15099-106. 2005..This alternatively spliced transcript may contribute to KSHV adaptive immune evasion during latent infection. Other transcripts are inducible, including a 6.1-kb transcript that is the largest transcript found in the KSHV genome to date... - A sensitive non-radioactive northern blot method to detect small RNAsSang Woo Kim
Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Nucleic Acids Res 38:e98. 2010..A detailed protocol of LED is provided in the Supplementary Data... - Merkel cell carcinoma: a virus-induced human cancerYuan Chang
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Annu Rev Pathol 7:123-44. 2012..Identification of this tumor virus has led to new opportunities for early diagnosis and targeted treatment of MCC... - MCV and Merkel cell carcinoma: a molecular success storyReety Arora
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States
Curr Opin Virol 2:489-98. 2012..In four years, the cause, diagnosis and therapy for an intractable cancer has been changed due to the molecular discovery of MCV... - Characterization of viral and human RNAs smaller than canonical MicroRNAsZhihua Li
Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Virol 83:12751-8. 2009..We postulate that approximately 30% of usRNAs could have evolved to participate in biological processes, including gene silencing... - Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinomaHuichen Feng
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
J Virol 81:11332-40. 2007..It provides, for the first time, quantitative evidence against some classes of viral etiology when no viral transcripts are found, thereby reducing the uncertainty involved in new pathogen discovery... - Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma miceAnna Guastafierro
Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
J Virol Methods 187:6-14. 2013..Hence, MS-1 is an early passage cell line that provides a useful in vitro model to characterize MCV-positive MCC... - The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentationHyun Jin Kwun
Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
Virology 412:357-65. 2011..Although LANA1 and EBV EBNA1 are functionally similar, they appear to use different mechanisms to evade host cytotoxic T lymphocyte surveillance... - Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleusXi Liu
Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 286:17079-90. 2011..MCV has evolved a novel mechanism to target hVam6p that may contribute to viral uncoating or egress through lysosomal processing during virus replication... - Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAsZhihua Li
School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nucleic Acids Res 40:6787-99. 2012..We suggest that endogenous 3' tRFs have a role in regulating the unwarranted expression of endogenous viruses through the RNA interference pathway... - Clonal integration of a polyomavirus in human Merkel cell carcinomaHuichen Feng
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
Science 319:1096-100. 2008..Thus, MCV may be a contributing factor in the pathogenesis of MCC... - Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processingHyun Jin Kwun
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
J Virol 81:8225-35. 2007..Simple strategies to eliminate these viral inhibitory regions may markedly improve vaccine effectiveness by maximizing CTL responses... - Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertensionA Scott Laney
University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
Chest 127:762-7. 2005..CONCLUSION: Our data do not support KSHV infection having a significant role in PPH or non-HIV-associated secondary PH compared to age- and gender-matched control subjects... - Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genesLindsay R Dresang
Cancer Virology Program, University of Pittsburgh Cancer Institute Hillman Cancer Research Pavilion 5117 Centre Ave, Pittsburgh, PA 15213 USA
BMC Genomics 12:625. 2011.... - Seroprevalence of Kaposi's sarcoma-associated herpesvirus in various populations in CubaVivian Kouri
Institute of Tropical Medicine, Virology Department, Havana, Cuba
Rev Panam Salud Publica 15:320-5. 2004..Little is known about the prevalence and distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) infection in the Caribbean. The aim of this study was to determine rates of KSHV seropositivity in various populations in Cuba... - Transmission of human herpesvirus 8 by blood transfusionPatrick S Moore
N Engl J Med 356:88; author reply 89. 2007 - Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cellsMassimo Donadelli
Department of Neurological and Vision Sciences, , Verona, Italy
Mol Carcinog 38:59-69. 2003..These findings suggest that inhibitors of HDAC may represent a novel therapeutic strategy for treatment of pancreatic cancer... - Transplanting cancer: donor-cell transmission of Kaposi sarcomaPatrick S Moore
Nat Med 9:506-8. 2003 - Viral IL-6-induced cell proliferation and immune evasion of interferon activityMalini Chatterjee
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Science 298:1432-5. 2002..Viral IL-6 bypasses the gp80 regulatory checkpoint by binding directly to the gp130 transducer molecule, resulting in tumor cell autocrine dependence on the viral cytokine for proliferation and survival...
Research Grants
- Emerging Technologies Applied to the Discovery of Human Tumor VirusesPatrick Moore; Fiscal Year: 2007..This also completes development of DTS technology, allowing us to fully optimize its performance for application to other suspected infectious tumors ASSESSMENT: ..
- Protein Biomarkers for a New Human Polyomavirus in AIDS-related MalignanciesPatrick S Moore; Fiscal Year: 2010..These are required to understand human infection with this virus and to develop effective vaccines and drugs against MCPyV. ..
- Role of a new polyomavirus in Merkel cell carcinomaPatrick S Moore; Fiscal Year: 2010..Finally, we seek to generate a model system for MCV tumorigenesis that will be useful for drug screening and prevention. ..
- Role of a new polyomavirus in Merkel cell carcinomaPatrick Moore; Fiscal Year: 2009..Finally, we seek to generate a model system for MCV tumorigenesis that will be useful for drug screening and prevention. ..
- Enhanced Cell-mediated Immunogenicity of KSHV LANA1 ProteinPatrick Moore; Fiscal Year: 2007..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..
- Enhanced Cell-mediated Immunogenicity of KSHV LANA1 ProteinPatrick S Moore; Fiscal Year: 2010..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..