Melissa J Moore

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. Cenik C, Chua H, Singh G, Akef A, Snyder M, Palazzo A, et al. A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification. RNA. 2017;23:270-283 pubmed publisher
  2. Singh G, Kucukural A, Cenik C, Leszyk J, Shaffer S, Weng Z, et al. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell. 2012;151:750-764 pubmed publisher
    ..Further, their protection of long mRNA stretches from nuclease digestion suggests that endogenous EJCs and SR proteins cooperate to promote mRNA packaging and compaction. ..
  3. Metkar M, Özadam H, Lajoie B, Imakaev M, Mirny L, Dekker J, et al. Higher-Order Organization Principles of Pre-translational mRNPs. Mol Cell. 2018;72:715-726.e3 pubmed publisher
    ..Polymer analysis of proximity ligation data for hundreds of mRNA species demonstrates that nascent and pre-translational mammalian mRNAs are compacted by their associated proteins into linear rod-like structures. ..
  4. Heyer E, Özadam H, Ricci E, Cenik C, Moore M. An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments. Nucleic Acids Res. 2015;43:e2 pubmed publisher
    ..Because all enzymatic reactions were optimized and driven to apparent completion, sequence diversity and species abundance in the input sample are well preserved. ..
  5. Chen W, Moore J, Özadam H, Shulha H, Rhind N, Weng Z, et al. Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling. Cell. 2018;173:1031-1044.e13 pubmed publisher
  6. Heyer E, Moore M. Redefining the Translational Status of 80S Monosomes. Cell. 2016;164:757-69 pubmed publisher
    ..Importantly, mRNAs encoding low-abundance regulatory proteins tend to be enriched in the monosome fraction. Our data highlight the importance of monosomes for the translation of highly regulated mRNAs. ..
  7. Serebrov V, Moore M. Single Molecule Approaches in RNA-Protein Interactions. Adv Exp Med Biol. 2016;907:89-106 pubmed publisher
    ..We also provide a thorough overview of single molecule colocalization microscopy and the essential protein and RNA tagging and detection techniques. ..
  8. Moore M, Proudfoot N. Pre-mRNA processing reaches back to transcription and ahead to translation. Cell. 2009;136:688-700 pubmed publisher
    ..The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven. ..
  9. Mou H, Smith J, Peng L, Yin H, Moore J, Zhang X, et al. CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Genome Biol. 2017;18:108 pubmed publisher
    ..Exon skipping adds to the unexpected outcomes that must be accounted for, and perhaps taken advantage of, in CRISPR experiments. ..

More Information

Publications10

  1. Ashar Patel A, Kaymaz Y, Rajakumar A, Bailey J, Karumanchi S, Moore M. FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia. Sci Rep. 2017;7:12139 pubmed publisher
    ..These three isoforms thus represent potential targets for therapeutic RNA interference (RNAi) in both early and late presentations. ..