CHRISTOPHER C MOORE
Affiliation: University of Virginia
- Point-of-care lactate testing predicts mortality of severe sepsis in a predominantly HIV type 1-infected patient population in UgandaCHRISTOPHER C MOORE
Department of Internal Medicine, Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, VA 22908, USA
Clin Infect Dis 46:215-22. 2008..Therefore, we evaluated the ability of a hand-held portable whole-blood lactate (PWBL) analyzer to predict mortality of patients who are admitted to the hospital with severe sepsis...
- Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injuryCHRISTOPHER C MOORE
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
J Infect Dis 198:1407-14. 2008..Eukaryotic translation initiation factor 5A (eIF5A) is a regulator of apoptosis as well as inflammatory cell activation, making it a potential target for sepsis therapy...
- An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis modelsCHRISTOPHER C MOORE
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Box 801342, Charlottesville, VA 22908, USA
BMC Infect Dis 8:141. 2008..Here we describe molecular and cellular responses, as well as survival, in A 2A adenosine receptor (AR) agonist treated and untreated animals during experimental sepsis...
- Treatment of severe sepsis with artemether-lumefantrine is associated with decreased mortality in Ugandan patients without malariaCHRISTOPHER C MOORE
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
Am J Trop Med Hyg 80:723-8. 2009..7%, SE = 15.2 versus 58.3%, SE = 3.7; Log rank chi(2) 3.94, P = 0.041). Research into the properties of A-L is needed to improve treatment of sepsis without compromising malarial susceptibility...
- Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case reportKathryn Dort
Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA
AIDS Res Ther 6:10. 2009..Practitioners of HIV medicine should be aware of the potential negative interaction of injected triamcinolone and ritonavir...
- Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected populationShevin T Jacob
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
PLoS ONE 4:e7782. 2009..We conducted a prospective observational study reporting the management and outcomes of severely septic patients in two Ugandan hospitals. We describe their epidemiology, management, and clinical correlates for mortality...
- Enrichment of HIV-1 subtype AD recombinants in a Ugandan cohort of severely septic patientsNajah I Doka
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
PLoS ONE 7:e48356. 2012..Given the differences in HIV-1 disease progression based on subtype, we examined HIV-1 subtype distribution and disease outcomes among hospitalized patients with severe sepsis...
- The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*Shevin T Jacob
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA
Crit Care Med 40:2050-8. 2012..In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers...
- Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future researchShevin T Jacob
International Respiratory and Severe Illness Center INTERSECT, Department of Medicine, University of Washington, 325 9th Ave, Box 359927, Seattle, WA 98104, USA
BMC Med 11:107. 2013....
- Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosisRituparna Das
Department of Medicine, Yale School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 110:E2997-3006. 2013..Our data place MIF in a crucial upstream position in the innate immune response to mycobacteria and suggest that commonly occurring low expression MIF alleles confer an increased risk of TB disease in some populations. ..
- Handheld point-of-care cerebrospinal fluid lactate testing predicts bacterial meningitis in UgandaAlbert Majwala
Department of Internal Medicine, Mbarara Regional Referral Hospital, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
Am J Trop Med Hyg 88:127-31. 2013..CSF POCL testing had excellent use in the diagnosis of bacterial meningitis, and it may be useful where CSF analyses are delayed or laboratory infrastructure is limited...
- Malaria is an uncommon cause of adult sepsis in south-western UgandaMary A Auma
Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA
Malar J 12:146. 2013..However, diagnostic limitations can make distinction between malaria and other infections challenging. Therefore, the objective of this study was to determine the relative contribution of malaria to adult sepsis in south-western Uganda...
- The effects of A2A adenosine receptor agonists in sepsisChristopher Moore; Fiscal Year: 2007..e., endotoxemia. These aims are proposed to identify crucial components in sepsis pathophysiology and characterize what is potentially a useful tool in the therapeutic arsenal used to combat sepsis. ..