Research Topics
| B S MooreSummaryAffiliation: University of Arizona Country: USA Publications
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Detail Information
Publications
Exploiting marine actinomycete biosynthetic pathways for drug discoveryBradley S Moore
College of Pharmacy, University of Arizona, Tucson, AZ 85721 027, USA
Antonie Van Leeuwenhoek 87:49-57. 2005..Our preliminary investigation into the biosynthesis of neomarinone, a rare marine actinomycete-derived meroterpenoid, is also presented...- Biosynthesis and attachment of novel bacterial polyketide synthase starter unitsBradley S Moore
Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
Nat Prod Rep 19:70-99. 2002..Natural, unnatural, and engineered starter units associated with type I and type II PKSs are reported. The literature through early 2001 is reviewed, and 240 references cited... - Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropicaLaura L Beer
College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
Org Lett 9:845-8. 2007.... - Engineering biodiversity with type II polyketide synthase genesB S Moore
Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
Antonie Van Leeuwenhoek 78:391-8. 2000..Engineering studies with the Streptomyces coelicolor whiE (spore pigment) and the 'Streptomyces maritimus' enterocin type II PKS provide additional insight on designing diverse assemblies of aromatic, as well as nonaromatic, polyketides... - Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalconeBradley S Moore
Division of Medicinal Chemistry, College of Pharmacy, P O Box 210207, University of Arizona, Tucson, AZ 85721, USA
J Nat Prod 65:1956-62. 2002..A homology model of THNS based upon the known three-dimensional structure of CHS was constructed to explore the structural and mechanistic details of this new subclass of bacterial PKSs... - Mutasynthesis of enterocin and wailupemycin analoguesJohn A Kalaitzis
College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
J Am Chem Soc 125:9290-1. 2003..This study represents the first mutasynthesis experiments with iterative type II PKSs... - Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthaseJohn A Kalaitzis
College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
J Nat Prod 67:1419-22. 2004.... - Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase geneLongkuan Xiang
College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
J Biol Chem 277:32505-9. 2002.... - Biochemical characterization of a prokaryotic phenylalanine ammonia lyaseLongkuan Xiang
College of Pharmacy, University of Arizona, Tucson, Arizona 85721-0207, USA
J Bacteriol 187:4286-9. 2005..Recombinant EncP is specific for L-phenylalanine and shares many biochemical features with eukaryotic PALs, which are substantially larger proteins by approximately 200 amino acid residues... - Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus"Longkuan Xiang
College of Pharmacy, Department of Chemistry, University of Arizona, Tucson 85721, USA
J Bacteriol 185:399-404. 2003..These experiments provide further support that benzoyl-CoA is formed in a novel bacterial pathway that resembles the eukaryotic assembly of benzoyl-CoA from phenylalanine via a beta-oxidative path... - Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2)Miho Izumikawa
College of Pharmacy, University of Arizona, 1703 E. Mabel, Tucson, AZ 85721-0207, USA
J Ind Microbiol Biotechnol 30:510-5. 2003..97+/-0.19 micro M, k(cat)=0.75+/-0.04 min(-1)) than the wild-type enzyme... - Mutational analysis of the enterocin favorskii biosynthetic rearrangementLongkuan Xiang
College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
Org Lett 4:957-60. 2002..Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported... - Biosynthesis of marine natural products: microorganisms (Part A)Bradley S Moore
College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721-0207, USA
Nat Prod Rep 22:580-93. 2005 - EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactionsLongkuan Xiang
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 101:15609-14. 2004.... - Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanismMiho Izumikawa
College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
J Am Chem Soc 128:1428-9. 2006.... - Biosynthesis and structural revision of neomarinoneJohn A Kalaitzis
College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
Org Lett 5:4449-52. 2003..NMR characterization of [U-(13)C(6)]glucose-enriched neomarinone led to the structural revision of structure 4a to 4b, which was confirmed by extensive 2D NMR spectrometry with unlabeled compound... - Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclizationJulia E Becker
College of Pharmacy, University of Arizona, Tucson, AZ 85721-0207, USA
Gene 325:35-42. 2004.... - Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene clusterJaclyn M Winter
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
J Biol Chem 282:16362-8. 2007..These data not only revealed the molecular basis behind the biosynthesis of these novel meroterpenoid natural products but also resulted in the first in vivo verification of vanadium-dependent haloperoxidases... - Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediatesMichael B Austin
Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 279:45162-74. 2004.... - Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreductionChristian Hertweck
, Beutenbergstrasse 11a, 07745 Jena, Germany
Chem Biol 11:461-8. 2004..This strongly implies that EncD reduces the polyketide chain during elongation rather than after its complete assembly, as suggested for most type II PKSs... - Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropicaDaniel W Udwary
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
Proc Natl Acad Sci U S A 104:10376-81. 2007..This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies... - Enzymatic total synthesis of enterocin polyketidesQian Cheng
Scripps Institution of Oceanograph, USA
Nat Chem Biol 3:557-8. 2007..To our knowledge, our results represent the first in vitro assembly of a complete type II polyketide synthase enzymatic pathway to natural products... - Unraveling the biosynthesis of the sporolide cyclohexenone building blockRyan P McGlinchey
Scripps Institution of Oceanography and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA
J Am Chem Soc 130:2406-7. 2008 - Discovery and characterization of a marine bacterial SAM-dependent chlorinaseAlessandra S Eustáquio
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nat Chem Biol 4:69-74. 2008.... - Molecular evidence for a uniform microbial community in sponges from different oceansUte Hentschel
Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, D 97070 Wurzburg, Germany
Appl Environ Microbiol 68:4431-40. 2002..A picture emerges where sponges can be viewed as highly concentrated reservoirs of so far uncultured and elusive marine microorganisms... - Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterizationMichelle C Moffitt
Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA
Biochemistry 46:1004-12. 2007..Structure elucidation by protein X-ray crystallography confirmed that the two cyanobacterial PALs are similar in tertiary and quatenary structure to plant and yeast PALs as well as the mechanistically related histidine ammonia lyases... - Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyasesGordon V Louie
Howard Hughes Medical Institute, Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Chem Biol 13:1327-38. 2006.... - Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome miningLijiang Song
Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K
J Am Chem Soc 128:14754-5. 2006.... - Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthaseMichael B Austin
Howard Hughes Medical Institute, Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nat Chem Biol 2:494-502. 2006..The crystal structure of a steely C-terminal domain confirms conservation of the homodimeric type III PKS fold. These findings suggest new bioengineering strategies for expanding the scope of fatty acid and polyketide biosynthesis... - Biosynthesis of marine natural products: macroorganisms (Part B)Bradley S Moore
Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA
Nat Prod Rep 23:615-29. 2006 - Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2Bin Zhao
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Biol Chem 280:11599-607. 2005..The flaviolin molecules form a quasi-planar three-molecule stack including the heme of CYP158A2, suggesting that oxidative C-C coupling of these phenolic molecules leads to the production of flaviolin dimers... - Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitorsRyan P McGlinchey
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
J Am Chem Soc 130:7822-3. 2008....