B S Moore

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Exploiting marine actinomycete biosynthetic pathways for drug discovery
    Bradley S Moore
    College of Pharmacy, University of Arizona, Tucson, AZ 85721 027, USA
    Antonie Van Leeuwenhoek 87:49-57. 2005
  2. ncbi request reprint Biosynthesis and attachment of novel bacterial polyketide synthase starter units
    Bradley S Moore
    Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
    Nat Prod Rep 19:70-99. 2002
  3. ncbi request reprint Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica
    Laura L Beer
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    Org Lett 9:845-8. 2007
  4. ncbi request reprint Engineering biodiversity with type II polyketide synthase genes
    B S Moore
    Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
    Antonie Van Leeuwenhoek 78:391-8. 2000
  5. ncbi request reprint Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone
    Bradley S Moore
    Division of Medicinal Chemistry, College of Pharmacy, P O Box 210207, University of Arizona, Tucson, AZ 85721, USA
    J Nat Prod 65:1956-62. 2002
  6. ncbi request reprint Mutasynthesis of enterocin and wailupemycin analogues
    John A Kalaitzis
    College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 125:9290-1. 2003
  7. ncbi request reprint Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase
    John A Kalaitzis
    College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Nat Prod 67:1419-22. 2004
  8. ncbi request reprint Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene
    Longkuan Xiang
    College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 277:32505-9. 2002
  9. pmc Biochemical characterization of a prokaryotic phenylalanine ammonia lyase
    Longkuan Xiang
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721 0207, USA
    J Bacteriol 187:4286-9. 2005
  10. pmc Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus"
    Longkuan Xiang
    College of Pharmacy, Department of Chemistry, University of Arizona, Tucson 85721, USA
    J Bacteriol 185:399-404. 2003

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Exploiting marine actinomycete biosynthetic pathways for drug discovery
    Bradley S Moore
    College of Pharmacy, University of Arizona, Tucson, AZ 85721 027, USA
    Antonie Van Leeuwenhoek 87:49-57. 2005
    ..Our preliminary investigation into the biosynthesis of neomarinone, a rare marine actinomycete-derived meroterpenoid, is also presented...
  2. ncbi request reprint Biosynthesis and attachment of novel bacterial polyketide synthase starter units
    Bradley S Moore
    Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
    Nat Prod Rep 19:70-99. 2002
    ..Natural, unnatural, and engineered starter units associated with type I and type II PKSs are reported. The literature through early 2001 is reviewed, and 240 references cited...
  3. ncbi request reprint Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica
    Laura L Beer
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    Org Lett 9:845-8. 2007
    ....
  4. ncbi request reprint Engineering biodiversity with type II polyketide synthase genes
    B S Moore
    Division of Medicinal Chemistry, College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
    Antonie Van Leeuwenhoek 78:391-8. 2000
    ..Engineering studies with the Streptomyces coelicolor whiE (spore pigment) and the 'Streptomyces maritimus' enterocin type II PKS provide additional insight on designing diverse assemblies of aromatic, as well as nonaromatic, polyketides...
  5. ncbi request reprint Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone
    Bradley S Moore
    Division of Medicinal Chemistry, College of Pharmacy, P O Box 210207, University of Arizona, Tucson, AZ 85721, USA
    J Nat Prod 65:1956-62. 2002
    ..A homology model of THNS based upon the known three-dimensional structure of CHS was constructed to explore the structural and mechanistic details of this new subclass of bacterial PKSs...
  6. ncbi request reprint Mutasynthesis of enterocin and wailupemycin analogues
    John A Kalaitzis
    College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 125:9290-1. 2003
    ..This study represents the first mutasynthesis experiments with iterative type II PKSs...
  7. ncbi request reprint Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase
    John A Kalaitzis
    College of Pharmacy and Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Nat Prod 67:1419-22. 2004
    ....
  8. ncbi request reprint Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene
    Longkuan Xiang
    College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 277:32505-9. 2002
    ....
  9. pmc Biochemical characterization of a prokaryotic phenylalanine ammonia lyase
    Longkuan Xiang
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721 0207, USA
    J Bacteriol 187:4286-9. 2005
    ..Recombinant EncP is specific for L-phenylalanine and shares many biochemical features with eukaryotic PALs, which are substantially larger proteins by approximately 200 amino acid residues...
  10. pmc Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus"
    Longkuan Xiang
    College of Pharmacy, Department of Chemistry, University of Arizona, Tucson 85721, USA
    J Bacteriol 185:399-404. 2003
    ..These experiments provide further support that benzoyl-CoA is formed in a novel bacterial pathway that resembles the eukaryotic assembly of benzoyl-CoA from phenylalanine via a beta-oxidative path...
  11. ncbi request reprint Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2)
    Miho Izumikawa
    College of Pharmacy, University of Arizona, 1703 E Mabel, Tucson, AZ 85721 0207, USA
    J Ind Microbiol Biotechnol 30:510-5. 2003
    ..97+/-0.19 micro M, k(cat)=0.75+/-0.04 min(-1)) than the wild-type enzyme...
  12. ncbi request reprint Mutational analysis of the enterocin favorskii biosynthetic rearrangement
    Longkuan Xiang
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    Org Lett 4:957-60. 2002
    ..Inactivation of either gene terminated enterocin production and caused the accumulation of four nonrearranged, nonmethylated polyketides. The structure elucidation of the new wailupemycins E-G is reported...
  13. ncbi request reprint Biosynthesis of marine natural products: microorganisms (Part A)
    Bradley S Moore
    College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721 0207, USA
    Nat Prod Rep 22:580-93. 2005
  14. pmc EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions
    Longkuan Xiang
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 101:15609-14. 2004
    ....
  15. pmc Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism
    Miho Izumikawa
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    J Am Chem Soc 128:1428-9. 2006
    ....
  16. ncbi request reprint Biosynthesis and structural revision of neomarinone
    John A Kalaitzis
    College of Pharmacy and the Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    Org Lett 5:4449-52. 2003
    ..NMR characterization of [U-(13)C(6)]glucose-enriched neomarinone led to the structural revision of structure 4a to 4b, which was confirmed by extensive 2D NMR spectrometry with unlabeled compound...
  17. ncbi request reprint Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization
    Julia E Becker
    College of Pharmacy, University of Arizona, Tucson, AZ 85721 0207, USA
    Gene 325:35-42. 2004
    ....
  18. ncbi request reprint Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster
    Jaclyn M Winter
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
    J Biol Chem 282:16362-8. 2007
    ..These data not only revealed the molecular basis behind the biosynthesis of these novel meroterpenoid natural products but also resulted in the first in vivo verification of vanadium-dependent haloperoxidases...
  19. ncbi request reprint Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates
    Michael B Austin
    Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 279:45162-74. 2004
    ....
  20. ncbi request reprint Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction
    Christian Hertweck
    Hans Knöll Institute for Natural Products Research, Beutenbergstrasse 11a, 07745 Jena, Germany
    Chem Biol 11:461-8. 2004
    ..This strongly implies that EncD reduces the polyketide chain during elongation rather than after its complete assembly, as suggested for most type II PKSs...
  21. pmc Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    Daniel W Udwary
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
    Proc Natl Acad Sci U S A 104:10376-81. 2007
    ..This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies...
  22. ncbi request reprint Enzymatic total synthesis of enterocin polyketides
    Qian Cheng
    Scripps Institution of Oceanograph, USA
    Nat Chem Biol 3:557-8. 2007
    ..To our knowledge, our results represent the first in vitro assembly of a complete type II polyketide synthase enzymatic pathway to natural products...
  23. doi request reprint Unraveling the biosynthesis of the sporolide cyclohexenone building block
    Ryan P McGlinchey
    Scripps Institution of Oceanography and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA
    J Am Chem Soc 130:2406-7. 2008
  24. pmc Discovery and characterization of a marine bacterial SAM-dependent chlorinase
    Alessandra S Eustáquio
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Chem Biol 4:69-74. 2008
    ....
  25. doi request reprint Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
    Alessandra S Eustáquio
    Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0204, USA
    Angew Chem Int Ed Engl 47:3936-8. 2008
  26. pmc Molecular evidence for a uniform microbial community in sponges from different oceans
    Ute Hentschel
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, D 97070 Wurzburg, Germany
    Appl Environ Microbiol 68:4431-40. 2002
    ..A picture emerges where sponges can be viewed as highly concentrated reservoirs of so far uncultured and elusive marine microorganisms...
  27. pmc Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization
    Michelle C Moffitt
    Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA
    Biochemistry 46:1004-12. 2007
    ..Structure elucidation by protein X-ray crystallography confirmed that the two cyanobacterial PALs are similar in tertiary and quatenary structure to plant and yeast PALs as well as the mechanistically related histidine ammonia lyases...
  28. pmc Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases
    Gordon V Louie
    Howard Hughes Medical Institute, Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Chem Biol 13:1327-38. 2006
    ....
  29. pmc Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining
    Lijiang Song
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, U K
    J Am Chem Soc 128:14754-5. 2006
    ....
  30. pmc Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase
    Michael B Austin
    Howard Hughes Medical Institute, Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Chem Biol 2:494-502. 2006
    ..The crystal structure of a steely C-terminal domain confirms conservation of the homodimeric type III PKS fold. These findings suggest new bioengineering strategies for expanding the scope of fatty acid and polyketide biosynthesis...
  31. ncbi request reprint Biosynthesis of marine natural products: macroorganisms (Part B)
    Bradley S Moore
    Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Nat Prod Rep 23:615-29. 2006
  32. ncbi request reprint Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2
    Bin Zhao
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 280:11599-607. 2005
    ..The flaviolin molecules form a quasi-planar three-molecule stack including the heme of CYP158A2, suggesting that oxidative C-C coupling of these phenolic molecules leads to the production of flaviolin dimers...
  33. ncbi request reprint Engineered biosynthesis of phenyl-substituted polyketides
    Jose Garcia-Bernardo
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Chembiochem 5:1129-31. 2004
  34. pmc Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
    Ryan P McGlinchey
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
    J Am Chem Soc 130:7822-3. 2008
    ....