B B Moore

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2
    Megan N Ballinger
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan, Ann Arbor, MI, USA
    Respir Res 12:155. 2011
  2. pmc Pulmonary fibrosis induced by γ-herpesvirus in aged mice is associated with increased fibroblast responsiveness to transforming growth factor-β
    Payal N Naik
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 67:714-25. 2012
  3. ncbi request reprint Murine models of pulmonary fibrosis
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 294:L152-60. 2008
  4. pmc The role of CCL12 in the recruitment of fibrocytes and lung fibrosis
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, 48109 0642, USA
    Am J Respir Cell Mol Biol 35:175-81. 2006
  5. ncbi request reprint Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
  6. pmc CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 166:675-84. 2005
  7. ncbi request reprint Opposing roles of leukotrienes and prostaglandins in fibrotic lung disease
    Bethany B Moore
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6220 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Expert Rev Clin Immunol 2:87-100. 2006
  8. pmc PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation
    Leah L N Hubbard
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, USA
    Am J Respir Cell Mol Biol 45:1050-8. 2011
  9. ncbi request reprint Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2
    Bethany B Moore
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 284:L342-9. 2003
  10. ncbi request reprint Protection from pulmonary fibrosis in the absence of CCR2 signaling
    B B Moore
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 167:4368-77. 2001

Research Grants

  1. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2007
  2. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
  3. PGE2 Regulation of Host Defense post-BMT
    Bethany B Moore; Fiscal Year: 2010
  4. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
  5. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
  6. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
  7. Fibrocyte Phenotypes as Biomarkers in IPFnet Patients
    Bethany B Moore; Fiscal Year: 2010

Detail Information

Publications61

  1. pmc Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2
    Megan N Ballinger
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan, Ann Arbor, MI, USA
    Respir Res 12:155. 2011
    ..This study examines the relationship between alveolar macrophage (AM) host defense and production of lipid mediators during the neonatal period compared to adult AMs...
  2. pmc Pulmonary fibrosis induced by γ-herpesvirus in aged mice is associated with increased fibroblast responsiveness to transforming growth factor-β
    Payal N Naik
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 67:714-25. 2012
    ..Increased responsiveness to transforming growth factor-β was verified by increased collagen III and fibronectin messenger RNA after treatment in vitro with transforming growth factor-β...
  3. ncbi request reprint Murine models of pulmonary fibrosis
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 294:L152-60. 2008
    ..In this review, we will summarize the characteristics, advantages, and disadvantages of many of the currently utilized murine models of pulmonary fibrosis...
  4. pmc The role of CCL12 in the recruitment of fibrocytes and lung fibrosis
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, 48109 0642, USA
    Am J Respir Cell Mol Biol 35:175-81. 2006
    ..As murine CCL12 is homologous to human CCL2, we suggest that the pathobiology of murine CCL12 in fibroproliferation may correlate to human CCL2 biology...
  5. ncbi request reprint Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
    ..Our results for the first time link EP2 receptor loss on fibroblasts following fibrotic lung injury to altered suppression by PGE(2) and thus identify a novel fibrogenic mechanism...
  6. pmc CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 166:675-84. 2005
    ..This is the first report describing expression of CCR2 on lung fibrocytes and demonstrating that CCR2 regulates both recruitment and activation of these cells after respiratory injury...
  7. ncbi request reprint Opposing roles of leukotrienes and prostaglandins in fibrotic lung disease
    Bethany B Moore
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6220 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Expert Rev Clin Immunol 2:87-100. 2006
    ....
  8. pmc PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation
    Leah L N Hubbard
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, USA
    Am J Respir Cell Mol Biol 45:1050-8. 2011
    ..These data suggest that PGE(2) signaling up-regulates IRAK-M independently of PTEN and that these molecules differentially inhibit opsonized and nonopsonized phagocytosis of P. aeruginosa...
  9. ncbi request reprint Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2
    Bethany B Moore
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 284:L342-9. 2003
    ..Diminished PGE(2) production by AECs results in enhanced fibroproliferation. Thus an important profibrotic mechanism of MCP-1/CCR2 interactions is to limit PGE(2) production in AECs after injury, thus promoting fibrogenesis...
  10. ncbi request reprint Protection from pulmonary fibrosis in the absence of CCR2 signaling
    B B Moore
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 167:4368-77. 2001
    ..CCR2(-/-) mice have increased levels of GM-CSF and reduced levels of TNF-alpha compared with FITC-treated CCR2(+/+) mice. Thus, CCR2 signaling promotes a profibrotic cytokine cascade following FITC administration...
  11. ncbi request reprint GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism
    B B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    J Immunol 165:4032-9. 2000
    ..These data demonstrate that GM-CSF deficiency results in enhanced fibrogenesis in bleomycin-induced pulmonary fibrosis and indicate that one mechanism for this effect is impaired production of the potent antifibrotic eicosanoid, PGE2...
  12. ncbi request reprint Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
    Jill E Kolodsick
    Department of Internal Medicine, Graduate Program in Immunology, Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 172:4068-76. 2004
    ..Thus, IL-13 mediates its profibrotic actions through direct effects on fibroblast production of extracellular matrix...
  13. ncbi request reprint Impaired functional activity of alveolar macrophages from GM-CSF-deficient mice
    R Paine
    Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1210-8. 2001
    ..Thus, in the absence of GM-CSF, AM functional capabilities for host defense were significantly impaired but were restored by lung-specific expression of GM-CSF...
  14. pmc Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression
    Rommel L Sagana
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:32264-71. 2009
    ..This is the first description, to our knowledge, of PI3K/PTEN balance directing GPCR expression, and provides a novel mechanism for cellular effects of PTEN...
  15. pmc Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function
    Kevin M Vannella
    Immunology Graduate Program, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:7883-90. 2007
    ..These data provide mechanistic insight into the therapeutic benefit of leukotriene synthesis inhibitors and CysLT1 receptor antagonists in animal models of fibrosis...
  16. pmc Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant
    Leah L N Hubbard
    Immunology Graduate Program, University of Michigan, Ann Arbor, Michigan, USA
    Exp Lung Res 34:263-75. 2008
    ..Additionally, both protocols resulted in impaired pulmonary host defense associated with overproduction of prostaglandin E(2) and I(2) by AMs and impaired AM phagocytosis post bone marrow transplant...
  17. ncbi request reprint A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
    Gerhard C Hildebrandt
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
    Blood 103:2417-26. 2004
    ....
  18. pmc Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: implications for treatment of fibrotic diseases
    Ragini Vittal
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Pharmacol Exp Ther 321:35-44. 2007
    ....
  19. pmc Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice
    N Hattori
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    J Clin Invest 106:1341-50. 2000
    ..We conclude that protection from fibrosis by PAI-1 deficiency is dependent upon increased proteolytic activity of the plasminogen activation system; however, complete removal of fibrin is not sufficient to protect the lung...
  20. ncbi request reprint Role of T- and B-lymphocytes in pulmonary host defences
    B B Moore
    Dept of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA
    Eur Respir J 18:846-56. 2001
    ..Lymphocytes determine the specificity of the immune response and orchestrate effector limbs of the immune response...
  21. ncbi request reprint Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent
    Vibha Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor 48109 0642, USA
    Am J Respir Cell Mol Biol 27:752-8. 2002
    ..These alterations in AEC phenotype likely contribute to the propensity for pulmonary fibrosis observed in COX-2-deficient mice...
  22. pmc The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice
    Kristy A Bauman
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 120:1950-60. 2010
    ..These studies demonstrate crosstalk between plasminogen activation and PGE2 generation in the lung and provide a mechanism for the well-known antifibrotic actions of the fibrinolytic pathway...
  23. ncbi request reprint The role of macrophage inflammatory protein-1 alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection
    M A Olszewski
    Veterans Affairs Hospital and Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:6429-36. 2000
    ..neoformans...
  24. pmc CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen
    John J Osterholzer
    Pulmonary and Critical Care Medicine Section, Medical Service, Department of Veterans Affairs Health System, 2215 Fuller Road, Ann Arbor, MI 48105, USA
    J Immunol 175:874-83. 2005
    ..The recruitment of circulating immature DC represents a potential therapeutic step at which to modulate immunological lung diseases...
  25. ncbi request reprint Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation
    Charles I Ojielo
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    J Immunol 171:4416-24. 2003
    ..Thus, despite restoration of peripheral blood count, phagocytic defects in the AMs of BMT mice persist and may contribute to the increased risk of infection seen in the postengraftment period...
  26. ncbi request reprint Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation
    Megan N Ballinger
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Immunol 177:5499-508. 2006
    ..Genetic reduction of cyclooxygenase-2 in BMT mice also had similar effects. These data clearly demonstrate that overproduction of PGE2 post-BMT is a critical factor determining impaired host defense against pathogens...
  27. ncbi request reprint Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome
    Gerhard C Hildebrandt
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 173:2050-9. 2004
    ..Therefore, approaches focusing on the abrogation of these interactions may prove successful in preventing or treating lung injury that occurs in this setting...
  28. pmc Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa
    Megan N Ballinger
    Immunology Graduate Program, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 34:766-74. 2006
    ..Defects in AM function may be related to diminished levels of IFN-gamma and TNF-alpha postinfection. Thus, GM-CSF-/- mice are more susceptible to lung infection with P. aeruginosa as a result of impaired AM function...
  29. pmc Latent herpesvirus infection augments experimental pulmonary fibrosis
    Kevin M Vannella
    Graduate Program in Immunology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 181:465-77. 2010
    ..Accumulating evidence implicates herpesviruses as cofactors (either initiating or exacerbating agents) of fibrotic lung disease, but a role for latent herpesvirus infection has not been studied...
  30. doi request reprint A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation
    Leah L N Hubbard
    Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 184:6299-308. 2010
    ..Therefore, strategies to limit IRAK-M elevation post-BMT may be efficacious in reducing patient susceptibility to infection...
  31. pmc Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation
    Megan N Ballinger
    The Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 295:L114-22. 2008
    ..These results highlight the complex regulation of GM-CSF and innate immunity post-BMT...
  32. ncbi request reprint Lung cells from neonates show a mesenchymal stem cell phenotype
    Kenneth T Hennrick
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Respir Crit Care Med 175:1158-64. 2007
    ..Mesenchymal stem cells have been isolated from adult bone marrow, peripheral blood, adipose tissue, trabecular bone, articular synovium, and bronchial submucosa...
  33. pmc Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus
    Tracy R McMillan
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Crit Care Med 177:771-80. 2008
    ..In some cases, acute deterioration is associated with infection. Herpesviruses have been associated with this disease. Fibrocytes have also been shown to be important in the pathogenesis of pulmonary fibrosis...
  34. ncbi request reprint Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation
    Ryan P Charbeneau
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1103-11. 2003
    ..In conclusion, these data demonstrate that GM-CSF regulates PGE(2) production in pulmonary fibroblasts and AECs and thus plays an important role in limiting fibroproliferation...
  35. pmc Induction of TGF-beta 1, not regulatory T cells, impairs antiviral immunity in the lung following bone marrow transplant
    Stephanie M Coomes
    Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 184:5130-40. 2010
    ..Thus, our results indicate that overexpression of TGF-beta1 following myeloablative conditioning post-BMT results in impaired effector T cell responses to viral infection...
  36. pmc Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia
    E S Choi
    Department of Pathology, University of Michigan Medical School, Room 5214, Medical Science I, 1301 Catherine Road, Ann Arbor, MI 48109 0602, USA
    J Clin Pathol 59:28-39. 2006
    ..The triggers of the fibroproliferative process in IIP remain enigmatic but recent attention has been directed towards chemokine involvement in this process...
  37. ncbi request reprint Gamma delta-T cells are critical for survival and early proinflammatory cytokine gene expression during murine Klebsiella pneumonia
    T A Moore
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 165:2643-50. 2000
    ....
  38. pmc Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99
    Yanmei Zhang
    VA Ann Arbor Health System, Ann Arbor, Michigan 48105, USA
    Am J Pathol 175:2489-500. 2009
    ..These data indicate that the Th2 immune bias is a crucial mechanism for pulmonary virulence of H99, whereas other mechanisms are largely responsible for its central nervous system tropism and systemic dissemination...
  39. pmc PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    Peedikayil E Thomas
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007
    ..Taken together, our results demonstrate that PGE(2) has the potential to limit TGF-beta1-induced myofibroblast differentiation via adhesion-dependent, but Smad-independent, pathways...
  40. pmc An essential role for fibronectin extra type III domain A in pulmonary fibrosis
    Andres F Muro
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 177:638-45. 2008
    ..Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen...
  41. pmc Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury
    Ragini Vittal
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Pathol 166:367-75. 2005
    ..Thus, targeting of prosurvival signaling pathways in fibroblasts/myofibroblasts may provide a novel and effective strategy for anti-fibrotic therapy of treatment-unresponsive fibrotic disorders...
  42. ncbi request reprint Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Immunol 178:1628-34. 2007
    ....
  43. pmc Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway
    Eric S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Exp Cell Res 316:2644-53. 2010
    ..Thus, our results demonstrate that the PI3K/Akt/mTOR axis is instrumental in FN transcription and alternative splicing, which regulates cell behavior...
  44. pmc New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis
    Lei Sun
    Division of Critical Care Medicine, C S Mott Children s Hospital, Department of Pediatrics and Communicable Disease, Univ of Michigan Medical School, Ann Arbor, 48109, USA
    Am J Physiol Lung Cell Mol Physiol 300:L341-53. 2011
    ..These results indicate that overexpression of IL-10 induces fibrosis, in part, by fibrocyte recruitment and M(2) macrophage activation, and likely in a CCL2/CCR2 axis...
  45. pmc Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 32:135-41. 2005
    ..Collectively, these data describe the novel mechanistic finding that PGE(2), via the EP2 receptor, decreases tyrosine phosphorylation on PTEN, resulting in increased PTEN enzyme activity and inhibition of fibroblast migration...
  46. ncbi request reprint Protection from pulmonary fibrosis in leukotriene-deficient mice
    Marc Peters-Golden
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 165:229-35. 2002
    ....
  47. pmc Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 37:562-70. 2007
    ..We conclude that PGE2 suppresses the microbicidal activity of AMs through the G(s)-coupled EP2/EP4 receptors, with increased cAMP inhibiting the assembly and activation of p47phox...
  48. pmc Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
    Thomas H Sisson
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, 6301 MSRB III, Ann Arbor, MI 48109 5642, USA
    Am J Respir Crit Care Med 181:254-63. 2010
    ..Although these findings are compelling, there are no studies that demonstrate a direct role for the alveolar epithelium or, more specifically, type II cells in the scarring process...
  49. pmc Obligatory role for interleukin-13 in obstructive lesion development in airway allografts
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0644, USA
    Am J Pathol 169:47-60. 2006
    ..These human and murine data implicate IL-13 as a critical effector cytokine driving cellular recruitment and subsequent fibrosis in clinical and ex-perimental BO...
  50. ncbi request reprint Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs
    Michal A Olszewski
    The Veterans Administration Ann Arbor Healthcare System, Ann Arbor, Michigan 48105 2303, USA
    Am J Respir Crit Care Med 176:921-9. 2007
    ..Staphylococcus aureus is a major pathogen complicating postsurgical care. Objectives: To test the effect of sterile laparotomy (LAP) on pulmonary clearance of S. aureus in a murine model...
  51. ncbi request reprint Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation
    Jill E Kolodsick
    Department of Internal Medicine, University of Michigan School of Medicine, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 29:537-44. 2003
    ..Our results demonstrate that PGE2 inhibits transition of fibroblasts to myofibroblasts by an EP2 receptor-activated pathway. Augmenting this pathway may serve as a potent antifibrotic therapeutic strategy...
  52. ncbi request reprint Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability
    Svetlana M Stamatovic
    Department of Neurosurgery, Pulmonary and Critical Care Medicine, Ann Arbor, MI 48109 0532, USA
    J Cereb Blood Flow Metab 25:593-606. 2005
    ..Our results suggest that, besides its main function of recruiting leukocytes at sites of inflammation, MCP-1 also plays a role in 'opening' the BBB...
  53. pmc Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP)
    Julie M Rumble
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Cell Immunol 259:82-9. 2009
    ..These differences could be rescued by restoration of XIAP. These data provide insight into the differing roles of XIAP and SAP in the pathogenesis of XLP...
  54. pmc Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation
    Megan N Ballinger
    University of Michigan, Ann Arbor, MI, USA
    Arch Immunol Ther Exp (Warsz) 55:1-12. 2007
    ..Of therapeutic interest, strategies which limit production of prostaglandins can improve pulmonary host defense in animal HSCT models, which suggests that this may also be beneficial for human HSCT recipients...
  55. pmc Latent infection by γherpesvirus stimulates profibrotic mediator release from multiple cell types
    Joshua S Stoolman
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, USA
    Am J Physiol Lung Cell Mol Physiol 300:L274-85. 2011
    ....
  56. pmc Prostaglandin E2 and the pathogenesis of pulmonary fibrosis
    Paul D Bozyk
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 45:445-52. 2011
    ..This review highlights these recent advances and offers new insights into the potential ways that PGE(2) and its downstream signals can be regulated for therapeutic benefit in a disease that has no validated treatment options...
  57. ncbi request reprint p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    Guido T Bommer
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Curr Biol 17:1298-307. 2007
    ..The role of p53 in transcription of other types of RNAs, such as microRNAs (miRNAs) is essentially unknown...
  58. ncbi request reprint The absence of donor-derived IL-13 exacerbates the severity of acute graft-versus-host disease following allogeneic bone marrow transplantation
    Gerhard C Hildebrandt
    Department of Hematology and Oncology, University of Regensburg Medical School, D 93053 Regensburg, Germany
    Pediatr Blood Cancer 50:911-4. 2008
    ..Thus, donor-derived IL-13 may have a role in modulating inflammatory cytokine release that is associated with aGVHD...
  59. ncbi request reprint Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice
    David E Nethery
    Dept of Internal Medicine, Pulmonary and Critical Care Division, Univ Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Appl Physiol 99:298-307. 2005
    ..08 units bleomycin) resulted in 80% mortality of nontransgenic mice, but only 35% mortality of DNHER3 transgenic mice (P = 0.04). Thus inhibition of HER2/HER3 signaling protects against pulmonary fibrosis and improves survival...
  60. pmc Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors
    Kimberly E White
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Immunol 180:637-46. 2008
    ..Such mechanisms may drive the fibroproliferative response to ALI...
  61. pmc Acute exacerbations of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California, USA
    Am J Respir Crit Care Med 176:636-43. 2007
    ..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed...

Research Grants13

  1. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2007
    ....
  2. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  3. PGE2 Regulation of Host Defense post-BMT
    Bethany B Moore; Fiscal Year: 2010
    ....
  4. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
    ..abstract_text> ..
  5. PGE2 Regulation of Host Defense post-BMT
    Bethany Moore; Fiscal Year: 2009
    ....
  6. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..
  7. Fibrocyte Phenotypes as Biomarkers in IPFnet Patients
    Bethany B Moore; Fiscal Year: 2010
    ..Our proposed studies would be the first to provide longitudinal and cross sectional analyses of fibrocyte phenotypes as biomarkers in human fibrotic lung disease. (End of Abstract) ..