Arshag D Mooradian

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Narrative review: a rational approach to starting insulin therapy
    Arshag D Mooradian
    St Louis University School of Medicine, St Louis, Missouri, USA
    Ann Intern Med 145:125-34. 2006
  2. doi request reprint Dyslipidemia in type 2 diabetes mellitus
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Nat Clin Pract Endocrinol Metab 5:150-9. 2009
  3. doi request reprint Subclinical hypothyroidism in the elderly: to treat or not to treat?
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, 32209, USA
    Am J Ther 18:477-86. 2011
  4. doi request reprint Diabetes mellitus in older adults
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Am J Ther 19:145-59. 2012
  5. doi request reprint Obesity-related changes in high-density lipoprotein metabolism
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA
    Obesity (Silver Spring) 16:1152-60. 2008
  6. ncbi request reprint Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri, USA
    Am J Ther 14:41-5. 2007
  7. doi request reprint Glucose-induced endoplasmic reticulum stress is independent of oxidative stress: A mechanistic explanation for the failure of antioxidant therapy in diabetes
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Free Radic Biol Med 50:1140-3. 2011
  8. doi request reprint Special considerations with insulin therapy in older adults with diabetes mellitus
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, USA
    Drugs Aging 28:429-38. 2011
  9. ncbi request reprint Asymptomatic hyperthyroidism in older adults: is it a distinct clinical and laboratory entity?
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    Drugs Aging 25:371-80. 2008
  10. doi request reprint The business of academic medicine is a business like no other: a perspective
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Health Care Manag (Frederick) 28:344-50. 2009

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Narrative review: a rational approach to starting insulin therapy
    Arshag D Mooradian
    St Louis University School of Medicine, St Louis, Missouri, USA
    Ann Intern Med 145:125-34. 2006
    ..The emergence of multiple insulin products has provided new opportunities to achieve diabetes control. However, the number of options has raised concerns about the optimal choices of products...
  2. doi request reprint Dyslipidemia in type 2 diabetes mellitus
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Nat Clin Pract Endocrinol Metab 5:150-9. 2009
    ..Although drug therapy for dyslipidemia must be individualized, most people with diabetes mellitus are candidates for statin therapy, and often need treatment with multiple agents to achieve therapeutic goals...
  3. doi request reprint Subclinical hypothyroidism in the elderly: to treat or not to treat?
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, 32209, USA
    Am J Ther 18:477-86. 2011
    ....
  4. doi request reprint Diabetes mellitus in older adults
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Am J Ther 19:145-59. 2012
    ..The goals of diabetes care in older adults are to enhance quality of life without subjecting the residents to inappropriate interventions...
  5. doi request reprint Obesity-related changes in high-density lipoprotein metabolism
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA
    Obesity (Silver Spring) 16:1152-60. 2008
    ..The emergence of glucose intolerance or a genetic predisposition to familial combined hyperlipidemia will further modify the plasma lipid phenotype in obese people (11,12,13,14,15)...
  6. ncbi request reprint Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri, USA
    Am J Ther 14:41-5. 2007
    ..Statins reduce albumin excretion rate and retard the progression of diabetic nephropathy. Whether statins alter size selectivity of glomerular filtration in diabetic rats is not known...
  7. doi request reprint Glucose-induced endoplasmic reticulum stress is independent of oxidative stress: A mechanistic explanation for the failure of antioxidant therapy in diabetes
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Free Radic Biol Med 50:1140-3. 2011
    ..These observations provide a novel mechanistic explanation for the failure of antioxidant therapy in interventional clinical trials...
  8. doi request reprint Special considerations with insulin therapy in older adults with diabetes mellitus
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, USA
    Drugs Aging 28:429-38. 2011
    ..The goal of diabetes care in older adults is to enhance quality of life without subjecting individuals to complicated treatment regimens that may interfere with their independence in carrying out daily activities...
  9. ncbi request reprint Asymptomatic hyperthyroidism in older adults: is it a distinct clinical and laboratory entity?
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    Drugs Aging 25:371-80. 2008
    ..Asymptomatic hyperthyroidism may well be a syndrome that is currently under-diagnosed...
  10. doi request reprint The business of academic medicine is a business like no other: a perspective
    Arshag D Mooradian
    Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Health Care Manag (Frederick) 28:344-50. 2009
    ..Perhaps the most important feature that distinguishes academic medicine from the other businesses is that its workforce is medical professionals who have a fiduciary relationship with their customers...
  11. ncbi request reprint Thyroid hormone responsive protein (THRP) mediates thyroid hormone-induced cytotoxicity in primary neuronal cultures
    Michael J Haas
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Exp Brain Res 160:424-32. 2005
    ..6 compared with 145+/-16.9, P<0.05). Co-transfection of THRP with wild-type c-Abl did not alter the effect of THRP on cell survival. It is concluded that THRP is an important factor in TH-induced neuronal cell death...
  12. ncbi request reprint Statins prevent dextrose-induced endothelial barrier dysfunction, possibly through inhibition of superoxide formation
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University, St Louis, MO 63104, USA
    Diabetes 55:474-9. 2006
    ....
  13. ncbi request reprint Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Saint Louis University Medical School, St Louis, MO 63104, USA
    Diabetes 54:2977-82. 2005
    ....
  14. ncbi request reprint Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2
    Mohamad H Horani
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO, USA
    Metabolism 53:174-81. 2004
    ..It is concluded that COX inhibition with INDO or ASA downregulates apoAI expression at the transcriptional level. This effect could not be attributed to either arachidonic acid excess or to a deficiency in various prostanoids tested...
  15. doi request reprint Effects of antioxidants on glucose-induced oxidative stress and endoplasmic reticulum stress in endothelial cells
    Mae Sheikh-Ali
    Department of Medicine, University of Florida, Jacksonville, United States
    Diabetes Res Clin Pract 87:161-6. 2010
    ..To test the extent of coupling between these two stresses, the effect of antioxidant vitamins on glucose-induced oxidative stress and ER stress in endothelial cells were studied...
  16. ncbi request reprint Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators
    Kent R Wehmeier
    Division of Endocrinology, Department of Medicine, University of Florida, 653 1 West 8th Street, 4th Floor LRC, Jacksonville, FL 32209, USA
    Biochim Biophys Acta 1780:264-73. 2008
    ..Gel shift assays showed that none of the treatments resulted in a change in site A binding activity. These results indicate that VDR modulators in hepatocytes and intestinal cells differentially regulate expression of the apo A-I gene...
  17. ncbi request reprint Induction of the apolipoprotein AI promoter by Sp1 is repressed by saturated fatty acids
    Michael J Haas
    Department of Internal Medicine, St Louis University School of Medicine, MO, USA
    Metabolism 53:1342-8. 2004
    ..3% +/- 1.6%). Stearic acid treatment did not alter Sp1-DNA binding as measured by gel shift analysis. Therefore, saturated fatty acids blunt Sp1 induction of apo AI promoter probably at a step beyond DNA binding...
  18. doi request reprint Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells
    Mae Sheikh-Ali
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Jacksonville, Florida, USA
    Nutrition 26:1146-50. 2010
    ..To investigate whether these cellular stresses are independent or causally linked, we determined whether or not specific glycolytic intermediates that induce oxidative stress also induce ER stress...
  19. ncbi request reprint Effect of chromium on apolipoprotein A-I expression in HepG2 cells
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri, USA
    Nutrition 19:353-7. 2003
    ..Some but not all clinical trials have associated use of chromium supplements with improved insulin sensitivity and lipid profile including increased high-density lipoprotein cholesterol levels...
  20. ncbi request reprint The effect of glucosamine on Serum HDL cholesterol and apolipoprotein AI levels in people with diabetes
    Stewart G Albert
    Department of Internal Medicine, Division of Endocrinology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Diabetes Care 30:2800-3. 2007
    ..The hypothesis is that the neutraceutical glucosamine, when given in conventional doses (1,500 mg/day) may increase apoAI and HDL cholesterol levels in subjects with diabetes and low HDL cholesterol...
  21. ncbi request reprint Effect of glucosamine on apolipoprotein AI mRNA stabilization and expression in HepG2 cells
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, Saint Louis University School of Medicine, St Louis, MO, USA
    Metabolism 53:766-71. 2004
    ..6 to 16.6 hours. These findings suggest that increases in apoAI gene expression by glucosamine occur primarily through stabilizing apoAI mRNA...
  22. doi request reprint Induction of apolipoprotein A-I gene expression by glucagon-like peptide-1 and exendin-4 in hepatocytes but not intestinal cells
    Joe M Chehade
    Division of Endocrinology, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA
    Metabolism 62:265-74. 2013
    ..Recent clinical trials suggest that diabetics treated with glucagon-like peptide-1 (GLP-1) have normalized lipid levels, including an increase in plasma high-density lipoprotein cholesterol (HDLc) levels...
  23. ncbi request reprint Microarray analysis of thyroid hormone-induced changes in mRNA expression in the adult rat brain
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, Saint Louis University, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Neurosci Lett 365:14-8. 2004
    ..The present study underscores the paucity of TH responsive genes in adult cerebral tissue...
  24. doi request reprint Estrogen-dependent inhibition of dextrose-induced endoplasmic reticulum stress and superoxide generation in endothelial cells
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Free Radic Biol Med 52:2161-7. 2012
    ..These results indicate that dextrose-induced endoplasmic reticulum stress and superoxide generation are reversed by estradiol and testosterone; however, the latter requires aromatase-dependent conversion to estradiol...
  25. ncbi request reprint Inhibition of apolipoprotein AI gene expression by tumor necrosis factor alpha: roles for MEK/ERK and JNK signaling
    Ann Beers
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Biochemistry 45:2408-13. 2006
    ..These results suggest that TNF alpha suppresses apoAI promoter activity through both the MEK/ERK and JNK pathways but is not mediated by either p38 MAP kinase activity or NF-kappaB activation...
  26. ncbi request reprint Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1)
    Arshag D Mooradian
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, St Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mech Ageing Dev 124:143-6. 2003
    ..280+/-0.030 vs. 0.956+/-0.038), P<0.001. It is concluded that aging in rats may alter the molecular anatomy of the BBB by altering the content of select structural proteins of tight junctions...
  27. ncbi request reprint Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3
    Kent Wehmeier
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Biochim Biophys Acta 1737:16-26. 2005
    ..This effect requires the VDR as well as a vitamin D response element in the apo AI promoter...
  28. ncbi request reprint The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Endocr Rev 27:2-16. 2006
    ..Because there are multiple mechanisms involved in the regulation of serum HDLc levels, changes in gene transcription do not necessarily correlate with clinical observations on serum levels of HDLc...
  29. ncbi request reprint Ascorbic acid and alpha-tocopherol down-regulate apolipoprotein A-I gene expression in HepG2 and Caco-2 cell lines
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Metabolism 55:159-67. 2006
    ..The previously described ARE is not a response element for the ascorbate or alpha-tocopherol...
  30. ncbi request reprint Saturated, unsaturated, and trans-fatty acids modulate oxidative burst induced by high dextrose in human umbilical vein endothelial cells
    Mohamad H Horani
    Division of Endocrinology, Diabetes and Metabolism, St Louis University School of Medicine, St Louis, Missouri, USA
    Nutrition 22:123-7. 2006
    ..We determined whether hyperglycemia-induced oxidative burst is augmented in the presence of saturated, unsaturated, and trans-fatty acids (FAs)...
  31. doi request reprint Nicotinic acid induces apolipoprotein A-I gene expression in HepG2 and Caco-2 cell lines
    Michael J Haas
    Division of Endocrinology, Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Metabolism 60:1790-6. 2011
    ..Nicotinic acid may increase apo A-I protein synthesis in the liver and small intestine. Induction of apo A-I gene by nicotinic acid requires a nicotinic acid responsive element in the apo A-I promoter...
  32. doi request reprint The antioxidant paradox in diabetes mellitus
    Mae Sheikh-Ali
    Department of Medicine, University of Florida College of Medicine, Jacksonville, 32209, USA
    Am J Ther 18:266-78. 2011
    ..quot;..
  33. ncbi request reprint Suppression of apolipoprotein AI gene expression in HepG2 cells by TNF alpha and IL-1beta
    Michael J Haas
    Department of Internal Medicine, School of Medicine, St Louis University, Health Sciences Center, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Biochim Biophys Acta 1623:120-8. 2003
    ..These studies suggest that inflammatory cytokines down-regulate apoAI expression at least partly through inhibition of binding of the nuclear factors to site A of the apoAI promoter...
  34. ncbi request reprint The effects of recombinant human growth hormone (rhGH) supplementation on adipokines and C-reactive protein in obese subjects
    Stewart G Albert
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Growth Horm IGF Res 17:19-25. 2007
    ..This study was undertaken to determine whether these rhGH-induced changes occur in obese subjects during rhGH supplementation...
  35. ncbi request reprint Transcriptional control of apolipoprotein A-I gene expression in diabetes
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Diabetes 53:513-20. 2004
    ..Identifying the mechanisms that modulate apo A-I gene expression will aid in the new development of therapeutic agents that increase plasma apo A-I and HDL concentrations...
  36. doi request reprint Regulation of high-density lipoprotein by inflammatory cytokines: establishing links between immune dysfunction and cardiovascular disease
    Michael J Haas
    Department of Medicine, University of Florida College of Medicine, 653 1 West Eighth Street, Jacksonville, FL 32209, USA
    Diabetes Metab Res Rev 26:90-9. 2010
    ..In this review, several of these connections are described and cytokine signalling related to HDLc is examined...
  37. ncbi request reprint Suppression of hyperglycemia-induced superoxide formation and endothelin-1 gene expression by carvedilol
    Mohamad H Horani
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Ther 13:2-7. 2006
    ..These findings suggest that CV not only prevents dextrose-induced SO generation in endothelial cells but may also have favorable effects on gene expression and cell survival...
  38. doi request reprint Endoplasmic reticulum stress in HepG2 cells inhibits apolipoprotein A-I secretion
    Emad Naem
    The Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Florida, Jacksonville College of Medicine, Jacksonville, FL 32209, USA
    Life Sci 92:72-80. 2013
    ....
  39. ncbi request reprint Effect of thyroid hormone responsive protein (THRP) expression on PC12 cell survival
    Michael J Haas
    Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Exp Brain Res 150:75-84. 2003
    ..the effect of THRP on cell viability is not modulated by c-Abl tyrosine kinase; and (4). the effect of T(3 )treatment on PC12 cell survival may be mediated by THRP...
  40. ncbi request reprint Aspirin sensitivity of platelet aggregation in diabetes mellitus
    Stewart G Albert
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Diabetes Res Clin Pract 70:195-9. 2005
    ..Thus, the lack of aspirin protection in diabetes may be due to undefined aspects of platelet function...
  41. ncbi request reprint Glucagon-like peptide-1 response to acarbose in elderly type 2 diabetic subjects
    Mary Jeanne Deleon
    Division of Endocrinology, Diabetes and Metabolism, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Diabetes Res Clin Pract 56:101-6. 2002
    ....
  42. doi request reprint Therapeutic interventions to enhance apolipoprotein A-I-mediated cardioprotection
    Michael J Haas
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    Drugs 70:805-21. 2010
    ....
  43. doi request reprint 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression
    Kent R Wehmeier
    Division of Endocrinology, Department of Medicine, University of Florida College of Medicine, Jacksonville, FL, United States
    Life Sci 88:110-6. 2011
    ..To determine if 24, 25-(OH)(2)D(3) modulates apo A-I gene expression, HepG2 hepatocytes and Caco-2 intestinal cells were treated with 24, 25-(OH)(2)D(3) or its precursor 25-OHD(3)...
  44. doi request reprint Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia
    Emad Naem
    Department of Medicine, University of Florida, Jacksonville College of Medicine, Jacksonville, FL, USA
    Life Sci 91:64-9. 2012
    ..To determine the molecular basis of this observation, the effect of activation of the aryl hydrocarbon receptor (AhR) on apo A-I gene expression was examined...
  45. ncbi request reprint Drug therapy of diabetes in the elderly
    Ralph Oiknine
    Department of Internal Medicine, St Louis University School of Medicine, 1402 South Grand Boulevard, MO, St Louis 63104, USA
    Biomed Pharmacother 57:231-9. 2003
    ..In this review, the various pharmacologic agents available for the management of diabetes will be reviewed and some pertinent clinical guidelines will be suggested...
  46. ncbi request reprint Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression
    Joe M Chehade
    Department of Internal Medicine, St Louis University School of Medicine, Missouri 63104, USA
    Neurochem Res 27:249-52. 2002
    ..038 respectively. These differences did not achieve statistical significance. It is concluded that diabetes alters the molecular anatomy of the tight junctions in cerebral tissue by altering the content of select structural proteins...
  47. doi request reprint The emerging evidence for vitamin D-mediated regulation of apolipoprotein A-I synthesis
    Sarada Jaimungal
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA
    Nutr Res 31:805-12. 2011
    ..Our objectives are to determine if plasma vitamin D levels correlate with plasma HDLc and apo A-I and, if so, offer speculation as to how apo A-I in the context of high vitamin D levels provides enhanced atheroprotection...
  48. ncbi request reprint Apolipoprotein A-I expression in rats is not altered by troglitazone
    Arshag D Mooradian
    The Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, St Louis University Medical School, St Louis, MO 63104, USA
    Exp Biol Med (Maywood) 227:1001-5. 2002
    ..However, peroxisome proliferator activator receptor (PPAR) agonists that have significant PPAR alpha activity in addition to their PPAR gamma effects, may well be able to induce apoA-I expression...
  49. ncbi request reprint Rapid adaptive down regulation of oxidative burst induced by high dextrose in human umbilical vein endothelial cells
    Mohamad H Horani
    Division of Endocrinology, Diabetes and Metabolism, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Diabetes Res Clin Pract 66:7-12. 2004
    ..It is concluded that increased oxidative load in sustained chronic hyperglycemia is probably the result of depletion of antioxidant pool rather than secondary to sustained increase in SO production...
  50. doi request reprint Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids
    Michael J Haas
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA
    Obesity (Silver Spring) 20:721-9. 2012
    ..These results indicate that ECs directly suppress apo A-I gene expression in both hepatocytes and intestinal cells, contributing to the decrease in serum HDLc in obese individuals...
  51. ncbi request reprint The role of thiazolidinediones in the treatment of patients with type 2 diabetes mellitus
    Arshag D Mooradian
    Division of Endocrinology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Treat Endocrinol 1:13-20. 2002
    ..However, the lack of a long-term safety record, and the cost, would limit the widespread acceptance of this class of agents as first-line therapy...
  52. ncbi request reprint A critical appraisal of the role of insulin analogues in the management of diabetes mellitus
    Ralph Oiknine
    Division of Endocrinology, Department of Internal Medicine, Diabetes, and Metabolism, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Drugs 65:325-40. 2005
    ..Although novel insulin analogues are promising 'designer drugs' in our armamentarium to overcome some of the limitations of conventional insulin therapy, cost may be a limiting factor for some patients...
  53. ncbi request reprint Transient dyslipidemia mimicking the plasma lipid profile of Tangier disease in a diabetic patient with gram negative sepsis
    Carlos Palacio
    Department of Medicine, University of Florida, 653 1 West Eighth Street, Jacksonville, FL 32209, USA
    Ann Clin Lab Sci 41:150-3. 2011
    ..Experimental evidence in the literature suggests that similar lipid changes may occur due to cytokines released during sepsis. Clinicians should be aware of these changes to avoid misdiagnosis of lipid disorders...
  54. ncbi request reprint Recent trials of antioxidant therapy: what should we be telling our patients?
    Bibi I Hasnain
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO 63104, USA
    Cleve Clin J Med 71:327-34. 2004
    ..We review important studies of the effects of four antioxidants (vitamins A, C, and E, and beta carotene) and analyze whether the current evidence supports or confirms or rejects the presumed protective role...
  55. ncbi request reprint Antioxidants and diabetes
    Arshag D Mooradian
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 11:107-22; discussion 122-5. 2006
    ..Future studies should focus on identifying reliable markers of oxidation to incorporate these measurements in the clinical interventional trial...
  56. ncbi request reprint Astrocytic and neuronal biochemical markers in the sera of subjects with diabetes mellitus
    Meri R Hovsepyan
    Department of Internal Medicine, Saint Louis University Medical School, Saint Louis, MO 63104, USA
    Neurosci Lett 369:224-7. 2004
    ..These studies suggest that diabetes in humans may be associated with alterations in the BBB integrity that allow the emergence of antibodies against neuronal antigens...
  57. ncbi request reprint Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity
    Stewart G Albert
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Clin Endocrinol Metab 89:695-701. 2004
    ..In conclusion, in obesity, rhGH normalized IGF-I levels, induced loss of BW from BF, and improved lipid profile without untoward effects on insulin sensitivity...
  58. ncbi request reprint Barriers related to mammography use for breast cancer screening among minority women
    Irene Alexandraki
    Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida 32209, USA
    J Natl Med Assoc 102:206-18. 2010
    ..The purpose of this review was to better understand possible social, economic, cultural, behavioral, and systems barriers to breast cancer screening among minority women...
  59. doi request reprint A comparative study of unscheduled hospital readmissions in a resident-staffed teaching service and a hospitalist-based service
    Carlos Palacio
    Department of Medicine, University of Florida College of Medicine at Jacksonville, Jacksonville, FL 32209, USA
    South Med J 102:145-9. 2009
    ..The rate of unscheduled readmissions is an important quality indicator with financial implications for hospitals...
  60. doi request reprint Inflammation, high-density lipoprotein and cardiovascular dysfunction
    Michael J Haas
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, Florida, USA
    Curr Opin Infect Dis 24:265-72. 2011
    ..This review describes the evidence that supports the hypothesis that high-density lipoprotein (HDL) is atheroprotective due to its antiinflammatory effects and benefits on vascular health...
  61. doi request reprint The thyroid hormone responsive protein (THRP) has a critical role in the embryogenesis of Xenopus laevis
    Wayland Lim
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida College of Medicine, 653 1 West 8th Street L14, Jacksonville, FL 32209, United States
    Neurosci Lett 488:272-4. 2011
    ..These observations suggest that THRP over-expression in early development is not compatible with completion of early embryogenesis and that a different strategy needs to be employed to investigate THRP function in this model...
  62. ncbi request reprint Effects of dehydroepiandrosterone on rat apolipoprotein AI gene expression in the human hepatoma cell line, HepG2
    Mary Jeanne Deleon
    Division of Endocrinology, Diabetes, and Metabolism, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Metabolism 51:376-9. 2002
    ..It remains to be established if the transcriptional effects we observed are mediated through an androgen response element...
  63. ncbi request reprint Cardiovascular disease in type 2 diabetes mellitus: current management guidelines
    Arshag D Mooradian
    Division of Endocrinology, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO 63104, USA
    Arch Intern Med 163:33-40. 2003
    ..In this communication, some of these landmark studies are reviewed and some practical guidelines of management are suggested...
  64. ncbi request reprint Antioxidant vitamins and their influence in diabetes mellitus
    Bibi Hasanain
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    Curr Diab Rep 2:448-56. 2002
    ..Given the lack of data to substantiate the benefit and safety of ingestion of antioxidant vitamins in excess of the recommended dietary allowance, physicians should avoid the recommendation of vitamin supplementation to their patients...
  65. ncbi request reprint Towards single-tablet therapy for type 2 diabetes mellitus. Rationale and recent developments
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Treat Endocrinol 3:279-87. 2004
    ..The advantages of combining several agents in one tablet include convenience and enhanced adherence to therapy. The main disadvantage is the loss of administration flexibility...
  66. ncbi request reprint Effect of diabetes on the blood brain barrier
    Mohamad H Horani
    Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, 63104, USA
    Curr Pharm Des 9:833-40. 2003
    ..The present communication briefly reviews the Diabetes-related changes in the central nervous system and discusses some of the mechanisms underlying these changes...
  67. ncbi request reprint Management of obesity in the elderly: special considerations
    Mohamad H Horani
    Division of Endocrinology, Department of Internal Medicine, Diabetes and Metabolism, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Treat Endocrinol 1:387-98. 2002
    ..Management should emphasize lifestyle modifications, while the use of pharmacologic agents such as sibutramine and orlistat should be reserved for select groups of patients who do not respond to lifestyle modification...
  68. ncbi request reprint Management of the cardinal features of andropause
    Arshag D Mooradian
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University, St Louis, MO 63104, USA
    Am J Ther 13:145-60. 2006
    ..Many with erectile failure, suffer silently regardless of its etiology. In this review, we suggest some practical guidelines for the management of these conditions...
  69. ncbi request reprint Effect of growth hormone replacement on BMD in adult-onset growth hormone deficiency
    Peter J Snyder
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, Philadelphia, PA 19104 6149, USA
    J Bone Miner Res 22:762-70. 2007
    ..To determine if replacement of GH improves BMD in adult-onset GHD, we administered GH in physiologic amounts to men and women with GHD. GH replacement significantly increased spine BMD in the men by 3.8%...
  70. doi request reprint Black cohosh for the management of menopausal symptoms : a systematic review of clinical trials
    Carlos Palacio
    Department of Medicine, University of Florida, College of Medicine, Jacksonville, Florida, USA
    Drugs Aging 26:23-36. 2009
    ..The benefits of black cohosh in the management of climacteric symptoms remain to be proven. Case studies suggest an additional unexplored area of adverse events that also needs to be addressed...
  71. ncbi request reprint Aronow's "Should the NCEP III guidelines be changed in elderly and younger persons at high risk for cardiovascular events?" Commentary
    Arshag D Mooradian
    Division of Endocrinology, Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA
    J Gerontol A Biol Sci Med Sci 60:598; author reply 602. 2005
  72. ncbi request reprint Increasing access to health care providers through medical home model may abolish racial disparity in diabetes care: evidence from a cross-sectional study
    Kenyatta Lee
    Department of Family and Community Medicine, University of Florida College of Medicine, J 653 1 W Eighth St, Jacksonville, FL 32209, USA
    J Natl Med Assoc 103:250-6. 2011
    ..We hypothesized that the medical home model is an effective intervention to decreasing health care disparities in minority patients with diabetes...
  73. doi request reprint Resource-based relative value scale analysis between teaching and nonteaching hospitalist services
    Irene Alexandraki
    Department of Medicine, University of Florida, Jacksonville, FL 32209, USA
    Health Care Manag (Frederick) 28:81-5. 2009
    ....
  74. ncbi request reprint Partial characterization of a cerebral thyroid hormone-responsive protein
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Arch Biochem Biophys 399:6-11. 2002
    ..These studies demonstrate that THRP and Abi-2 have distinct tissue distribution and distinct biological properties...
  75. ncbi request reprint Familial dyslipidaemias: an overview of genetics, pathophysiology and management
    Sahar B Hachem
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Drugs 66:1949-69. 2006
    ..A bile acid binding agent is an option if the serum TG levels do not exceed 200 mg/dL (5.65 mmol/L), otherwise a fibrate or nicotinic acid should be considered. The decision to treat a particular person has to be individualised...
  76. ncbi request reprint Severe insulin resistance associated with subcutaneous amyloid deposition
    Stewart G Albert
    Diabetes Res Clin Pract 75:374-6. 2007
    ..These findings may add insight into the role of insulin-degrading enzymes in the etiology of subcutaneous insulin resistance syndromes...
  77. ncbi request reprint Insulin induction of apolipoprotein AI, role of Sp1
    Johnny K Lam
    Endocrine Research Group, Department of Medicine, The Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
    Biochemistry 42:2680-90. 2003
    ..In summary, the IRCE alone can mediate the stimulatory effects of insulin, bpv, and PDBu, and Sp1 enhances these responses that may arise from phosphorylation of the protein...
  78. ncbi request reprint Pubertal changes in serum leptin levels in adolescents with type 1 diabetes mellitus: a controlled longitudinal study
    Susan E Myers
    Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA
    J Pediatr Endocrinol Metab 17:1653-62. 2004
    ..The potential role of leptin in initiation of pubertal development is not easily demonstrable in observational studies...
  79. ncbi request reprint 2006-2007 American Diabetes Association Nutrition Recommendations: issues for practice translation
    Judith Wylie-Rosett
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Am Diet Assoc 107:1296-304. 2007